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The map label for this gene is hisG-1

Identifier: 39996630

GI number: 39996630

Start: 1678319

End: 1679194

Strand: Reverse

Name: hisG-1

Synonym: GSU1530

Alternate gene names: 39996630

Gene position: 1679194-1678319 (Counterclockwise)

Preceding gene: 39996631

Following gene: 39996584

Centisome position: 44.03

GC content: 62.67

Gene sequence:

>876_bases
ATGAGCGGCCTTCTCAATTTCGGCGTGCCCAAGGGCAGCCTCGAAAACGCAACGGTCGAGCTGTTCCGCAAGGCCGGCTG
GCAGATCAGCATCTCCTCCCGCAGCTACTTCCCCGGCGTTGACGACGACGAGATGAACTGCAAGCTCATCCGGCCCCAGG
AAATGGGGAAATACGTTGAGCGCGGCACCATCGACGCTGGCATTGCCGGCCGCGACTGGGTGAGGGAAAACGAGTCGGAC
GTGGTGGAAGTCTGCGAGATGGTCTACTCCAAGGTCTCCCGCCGGCCCGCCCGCTGGGTCCTGGTGGTTACCAGGGACTC
CGCCGTGCAGAAGCCGGAGGACCTCCACGGGGCCACCATCTCCACCGAACTGGTGGGCTTCACCAAGCGGTACTTTGCCG
AGCGCAACATCCCGGTAACCGTTGAATTCTCCTGGGGCGCCACCGAGGCAAAGGTGGTTGACGGCCTCTGCGACGCCATC
GTGGAAGTGACCGAAACGGGGTCTACCATCAAGGCCAACGGCCTGCGGATCGTCTGCGACCTGATGGAGTCGGTGCCGGT
TCTGATCGCCAACAAGGCCGCCTGGGCCGATCCGTGGAAGCGCGAGAAGATCGAGACCATCGCCACCCTCCTCAAATCGG
CCCTTGCCGCCGAGGGAATGGTGGGCCTCAAGATGAACGCCCCCAATGACCAGCTGGAGGCAATCACCCGCGTGCTGCCG
AGCCTCAAGAACCCTACCGTGTCCCACCTCTTCAACTCGGACTGGGTCTCCATCGAGAGCATCCTCCCGGAAAAGGAGGT
CCGGCGCATCGTTCCCGAGCTGATCAAGCTCGGCGCCGAGGGGATCGTGGAGTATCCGCTGAACAAGATCATCTAA

Upstream 100 bases:

>100_bases
GCCACACGGGCAACCGGAGCTGCTTCTACGTCCGATGGGAGGACGGCCAGTGGGTCGAGCACTCCGAGCCCCTGTTCGAT
CCGGCGGAGGTGTACAAGAA

Downstream 100 bases:

>100_bases
CGCCGGGAAACCGGCTGTTGCACACAAAAGGGCCTGCCCCGTCCGGGTGCAGGCCCTTTGTGTTCGAGCTCTGCCGATGA
CTTACGTCACGGGCCGCCGG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT 1; ATP-PRTase 1

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSGLLNFGVPKGSLENATVELFRKAGWQISISSRSYFPGVDDDEMNCKLIRPQEMGKYVERGTIDAGIAGRDWVRENESD
VVEVCEMVYSKVSRRPARWVLVVTRDSAVQKPEDLHGATISTELVGFTKRYFAERNIPVTVEFSWGATEAKVVDGLCDAI
VEVTETGSTIKANGLRIVCDLMESVPVLIANKAAWADPWKREKIETIATLLKSALAAEGMVGLKMNAPNDQLEAITRVLP
SLKNPTVSHLFNSDWVSIESILPEKEVRRIVPELIKLGAEGIVEYPLNKII

Sequences:

>Translated_291_residues
MSGLLNFGVPKGSLENATVELFRKAGWQISISSRSYFPGVDDDEMNCKLIRPQEMGKYVERGTIDAGIAGRDWVRENESD
VVEVCEMVYSKVSRRPARWVLVVTRDSAVQKPEDLHGATISTELVGFTKRYFAERNIPVTVEFSWGATEAKVVDGLCDAI
VEVTETGSTIKANGLRIVCDLMESVPVLIANKAAWADPWKREKIETIATLLKSALAAEGMVGLKMNAPNDQLEAITRVLP
SLKNPTVSHLFNSDWVSIESILPEKEVRRIVPELIKLGAEGIVEYPLNKII
>Mature_290_residues
SGLLNFGVPKGSLENATVELFRKAGWQISISSRSYFPGVDDDEMNCKLIRPQEMGKYVERGTIDAGIAGRDWVRENESDV
VEVCEMVYSKVSRRPARWVLVVTRDSAVQKPEDLHGATISTELVGFTKRYFAERNIPVTVEFSWGATEAKVVDGLCDAIV
EVTETGSTIKANGLRIVCDLMESVPVLIANKAAWADPWKREKIETIATLLKSALAAEGMVGLKMNAPNDQLEAITRVLPS
LKNPTVSHLFNSDWVSIESILPEKEVRRIVPELIKLGAEGIVEYPLNKII

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=285, Percent_Identity=24.9122807017544, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320896, Length=291, Percent_Identity=27.1477663230241, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS11_GEOSL (P60804)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952581.1
- ProteinModelPortal:   P60804
- SMR:   P60804
- GeneID:   2687288
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1530
- NMPDR:   fig|243231.1.peg.1519
- TIGR:   GSU1530
- HOGENOM:   HBG391868
- OMA:   SWGATEA
- ProtClustDB:   PRK00489
- BioCyc:   GSUL243231:GSU_1530-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32216; Mature: 32085

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLLNFGVPKGSLENATVELFRKAGWQISISSRSYFPGVDDDEMNCKLIRPQEMGKYVE
CCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHH
RGTIDAGIAGRDWVRENESDVVEVCEMVYSKVSRRPARWVLVVTRDSAVQKPEDLHGATI
CCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCCCH
STELVGFTKRYFAERNIPVTVEFSWGATEAKVVDGLCDAIVEVTETGSTIKANGLRIVCD
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
LMESVPVLIANKAAWADPWKREKIETIATLLKSALAAEGMVGLKMNAPNDQLEAITRVLP
HHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
SLKNPTVSHLFNSDWVSIESILPEKEVRRIVPELIKLGAEGIVEYPLNKII
CCCCCHHHHHHCCCCEEHHHHCCHHHHHHHHHHHHHHCCCHHHHCCHHHCC
>Mature Secondary Structure 
SGLLNFGVPKGSLENATVELFRKAGWQISISSRSYFPGVDDDEMNCKLIRPQEMGKYVE
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHH
RGTIDAGIAGRDWVRENESDVVEVCEMVYSKVSRRPARWVLVVTRDSAVQKPEDLHGATI
CCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCCCH
STELVGFTKRYFAERNIPVTVEFSWGATEAKVVDGLCDAIVEVTETGSTIKANGLRIVCD
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
LMESVPVLIANKAAWADPWKREKIETIATLLKSALAAEGMVGLKMNAPNDQLEAITRVLP
HHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
SLKNPTVSHLFNSDWVSIESILPEKEVRRIVPELIKLGAEGIVEYPLNKII
CCCCCHHHHHHCCCCEEHHHHCCHHHHHHHHHHHHHHCCCHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA