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The map label for this gene is Hgd [H]

Identifier: 39996551

GI number: 39996551

Start: 1588799

End: 1589665

Strand: Direct

Name: Hgd [H]

Synonym: GSU1451

Alternate gene names: 39996551

Gene position: 1588799-1589665 (Clockwise)

Preceding gene: 39996550

Following gene: 39996553

Centisome position: 41.66

GC content: 59.4

Gene sequence:

>867_bases
ATGCTGAGAAAAGTCGGTTTCTTGGGGTTGGGTACGGTCGGGCGGCACATGGCTGCCAACCTCTTGAAGGGGAATTACGA
ACTGGCGGTTTATGATTCTGACCCGGCAGCGGTTGCTGATCTGGCGGCCCTGGGCGCCACGGGAGCAGCCACGCCCCGTG
AGGTTGCCAAGGGAAGGGATATCGTCATCCACATCCGTCCCGAGAAAGAGCGGCTTCGTCCCGACATCTACGGTCCTGAC
GGGATTTTCGCGGGTATTGACCCCGGCACGATCCTTGTCGACATGGGAACCCACTCTCTGACGAGCACCATGGAGATGGC
CGATGAGGCCGCCAAGCATCGCGTCATGTTCCTTGACGCGCCGGTGTGGGGAACCAAGGAGCATGCCGCCAACGGCCTGT
TGACCATCCTGGCGGGAGGGGATCCCTCGCTGGTCGGGCGCTGCCGCGAACTGTTCTCCTTCTTTGGGCTGAATATCATC
CATGTGGGAAGCATCGGAGACGCTACCCGGATGAAGTTTGTGGTGAACCTGGTCCAGGCCGAACTCATGCAAGCCCTTGC
CGAGTCCATCGTGTTCGGAGAGAAGCTTGGATTTACCGCTGACCGGATTCTTGAAGTGCTCGATTCGGGCGGAGTGGCCT
CGCCCCTCTTCCACTCAAAGGGGCGCAGCATTGCCCGTGGTGATTTCACCCGGAATCTGGCCCTTAAATACGTGCACGAA
CAACTGGAGCTGGTGCTGGAAAAGGCTGAAAAACTGGGTCTGGAACTGCCGGCAGCCAAGGTGGCCTGCGCCACCTATGA
GCAGGGCGTCAAGGACGGGCGGGGTGAGGAAGACTTCTCTTCGGTCGTGAAGGTGCTCAGAAAATAA

Upstream 100 bases:

>100_bases
CCGTATTTTTTAAACTGGACTATTGTCTCGGCGCACAAGAGCATGTACTATTGTGAACCATCCGTGACAGTGTTTTATCA
TGCGAACCAGGAGGCATTAT

Downstream 100 bases:

>100_bases
CAGCATTTCCGGAAAGCTGCATTGTCGATGTTCCCAAAAGGGGGGGCCGTTCAGACGGCTCCCCCTTTTGCCTTGTGGCT
GGCCCGGGGACGGCTGCGCT

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MLRKVGFLGLGTVGRHMAANLLKGNYELAVYDSDPAAVADLAALGATGAATPREVAKGRDIVIHIRPEKERLRPDIYGPD
GIFAGIDPGTILVDMGTHSLTSTMEMADEAAKHRVMFLDAPVWGTKEHAANGLLTILAGGDPSLVGRCRELFSFFGLNII
HVGSIGDATRMKFVVNLVQAELMQALAESIVFGEKLGFTADRILEVLDSGGVASPLFHSKGRSIARGDFTRNLALKYVHE
QLELVLEKAEKLGLELPAAKVACATYEQGVKDGRGEEDFSSVVKVLRK

Sequences:

>Translated_288_residues
MLRKVGFLGLGTVGRHMAANLLKGNYELAVYDSDPAAVADLAALGATGAATPREVAKGRDIVIHIRPEKERLRPDIYGPD
GIFAGIDPGTILVDMGTHSLTSTMEMADEAAKHRVMFLDAPVWGTKEHAANGLLTILAGGDPSLVGRCRELFSFFGLNII
HVGSIGDATRMKFVVNLVQAELMQALAESIVFGEKLGFTADRILEVLDSGGVASPLFHSKGRSIARGDFTRNLALKYVHE
QLELVLEKAEKLGLELPAAKVACATYEQGVKDGRGEEDFSSVVKVLRK
>Mature_288_residues
MLRKVGFLGLGTVGRHMAANLLKGNYELAVYDSDPAAVADLAALGATGAATPREVAKGRDIVIHIRPEKERLRPDIYGPD
GIFAGIDPGTILVDMGTHSLTSTMEMADEAAKHRVMFLDAPVWGTKEHAANGLLTILAGGDPSLVGRCRELFSFFGLNII
HVGSIGDATRMKFVVNLVQAELMQALAESIVFGEKLGFTADRILEVLDSGGVASPLFHSKGRSIARGDFTRNLALKYVHE
QLELVLEKAEKLGLELPAAKVACATYEQGVKDGRGEEDFSSVVKVLRK

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=29.7872340425532, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=27.8350515463918, Blast_Score=111, Evalue=9e-25,
Organism=Escherichia coli, GI145693186, Length=279, Percent_Identity=28.3154121863799, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=29.8611111111111, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=29.2253521126761, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=25.2631578947368, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17557316, Length=205, Percent_Identity=32.1951219512195, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI28574115, Length=278, Percent_Identity=25.1798561151079, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24655230, Length=293, Percent_Identity=26.2798634812287, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19922568, Length=293, Percent_Identity=26.2798634812287, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30924; Mature: 30924

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKVGFLGLGTVGRHMAANLLKGNYELAVYDSDPAAVADLAALGATGAATPREVAKGRD
CCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHCCCE
IVIHIRPEKERLRPDIYGPDGIFAGIDPGTILVDMGTHSLTSTMEMADEAAKHRVMFLDA
EEEEECCCHHHCCCCCCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCEEEEEEC
PVWGTKEHAANGLLTILAGGDPSLVGRCRELFSFFGLNIIHVGSIGDATRMKFVVNLVQA
CCCCCHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
ELMQALAESIVFGEKLGFTADRILEVLDSGGVASPLFHSKGRSIARGDFTRNLALKYVHE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHH
QLELVLEKAEKLGLELPAAKVACATYEQGVKDGRGEEDFSSVVKVLRK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLRKVGFLGLGTVGRHMAANLLKGNYELAVYDSDPAAVADLAALGATGAATPREVAKGRD
CCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHCCCE
IVIHIRPEKERLRPDIYGPDGIFAGIDPGTILVDMGTHSLTSTMEMADEAAKHRVMFLDA
EEEEECCCHHHCCCCCCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCEEEEEEC
PVWGTKEHAANGLLTILAGGDPSLVGRCRELFSFFGLNIIHVGSIGDATRMKFVVNLVQA
CCCCCHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
ELMQALAESIVFGEKLGFTADRILEVLDSGGVASPLFHSKGRSIARGDFTRNLALKYVHE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHH
QLELVLEKAEKLGLELPAAKVACATYEQGVKDGRGEEDFSSVVKVLRK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA