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The map label for this gene is degS [H]

Identifier: 39996394

GI number: 39996394

Start: 1408577

End: 1409731

Strand: Direct

Name: degS [H]

Synonym: GSU1292

Alternate gene names: 39996394

Gene position: 1408577-1409731 (Clockwise)

Preceding gene: 39996393

Following gene: 39996395

Centisome position: 36.93

GC content: 58.79

Gene sequence:

>1155_bases
GTGTTCGGCACAACTATCCTTGCCCTGGCCTTTGCTCTTCTCTACCTGCGCCGCTGGCAACAGCTCAAGCGTGAGGTTGC
CCGGCGCATCGAGGCGGAGCGACTGTTCCGGGAAACGTTCGAACATATCAAACTCCTGGCAATTCAGTTGGATACGCACG
GTAACCTGGTCTTCTGCAACGACTATTTTCTCCAGCTTGTGGGGTGGGAGCGCCGGGAAGTGATCGGGGTCAACTGGTTC
GAGCGCTTCGTTCCTCCCGACCAGAAGACAGTCAAGCGGATATTCTACTCGTCTCTCGATACGGGAAACATCCCGGTCCA
CGTCCAGAATGACATCGTCACCTGCGGCGGCAGGCGGCTATTCATCTCATGGACCAATACGGTAATCCGCGACAGCTCGG
GGGGCATCATCGGCACCATGAGCATCGGCGACGATATCACCGAGCGCACCAAGGCTGAAAATGCACTGCTCAGCTACCAG
GAAGAATTCAGAAACTTGGCCGCGGAGCTGTCGTTGGCCGAGGAGCGCGAGCGTCGCCGGCTTTCCACCGACCTGCACGA
TCTCATCGGCCAGACCCTGGCCTTTGCCAAGATTCGAGCCCATTCGCTCAGGGAGCATGTGGCGGAGGATGGTCTGACCC
AATGGGGAGAACTCACCGGGCTCCTGGACCAGTCGATCCAGGAGGTCCGCTCCCTCATATTTCAGATCAGCCCGCCGATT
CTCTATGAGGTGGGGCTTGAAGCCGCCCTTGAATGGCTGGGGGAAAATTTTCAGGATAACCACCGGTTTCGCGTCAATTT
CAGTGACGATGGCACACTCAAACCCCTGAGGGAGGAGATCAAGGTTACTCTCTTCCAGGTGGTGCGTGAGGTGCTCATTA
ATGCGGCGAAGCATGCATCCCCCGACACGGTGCAGATAGACATCCGCGGCCTGGGGGAGTCCGTCCGCATAACGGTCAGG
GATGACGGCCGTGGATTCGACGTGGCAAAGGCAGCCCACAAGTCCAGGGATAAGGCGGGCGGAGGGTTCGGTCTTTTCAA
TATCCGCCAACGGATCGAACGCCTGGGCGGCTCACTGGCGATAGAGTCGTCCCCCGGGGCCGGGACTATGGTCACCGTCG
TCGCACCTCTTGACCTTGCACGTGACACCCATTGA

Upstream 100 bases:

>100_bases
GCGCCGACCGGATTCTTCACAAGCCCTTCACCCGTGATGCGCTGCTCAATCTGGTGAACGAGCTCATTTCTTCCTGAGTC
ACATGATCAAGGACGTTTCA

Downstream 100 bases:

>100_bases
TAATTACACCCAAAAACGTTATTGTAACAAACCGATACATTGCAGTATACATACGTTGGGGAAGGGAATCGGTCCACAGC
CGATGGTTCTGCAGATTGTG

Product: sensory box histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MFGTTILALAFALLYLRRWQQLKREVARRIEAERLFRETFEHIKLLAIQLDTHGNLVFCNDYFLQLVGWERREVIGVNWF
ERFVPPDQKTVKRIFYSSLDTGNIPVHVQNDIVTCGGRRLFISWTNTVIRDSSGGIIGTMSIGDDITERTKAENALLSYQ
EEFRNLAAELSLAEERERRRLSTDLHDLIGQTLAFAKIRAHSLREHVAEDGLTQWGELTGLLDQSIQEVRSLIFQISPPI
LYEVGLEAALEWLGENFQDNHRFRVNFSDDGTLKPLREEIKVTLFQVVREVLINAAKHASPDTVQIDIRGLGESVRITVR
DDGRGFDVAKAAHKSRDKAGGGFGLFNIRQRIERLGGSLAIESSPGAGTMVTVVAPLDLARDTH

Sequences:

>Translated_384_residues
MFGTTILALAFALLYLRRWQQLKREVARRIEAERLFRETFEHIKLLAIQLDTHGNLVFCNDYFLQLVGWERREVIGVNWF
ERFVPPDQKTVKRIFYSSLDTGNIPVHVQNDIVTCGGRRLFISWTNTVIRDSSGGIIGTMSIGDDITERTKAENALLSYQ
EEFRNLAAELSLAEERERRRLSTDLHDLIGQTLAFAKIRAHSLREHVAEDGLTQWGELTGLLDQSIQEVRSLIFQISPPI
LYEVGLEAALEWLGENFQDNHRFRVNFSDDGTLKPLREEIKVTLFQVVREVLINAAKHASPDTVQIDIRGLGESVRITVR
DDGRGFDVAKAAHKSRDKAGGGFGLFNIRQRIERLGGSLAIESSPGAGTMVTVVAPLDLARDTH
>Mature_384_residues
MFGTTILALAFALLYLRRWQQLKREVARRIEAERLFRETFEHIKLLAIQLDTHGNLVFCNDYFLQLVGWERREVIGVNWF
ERFVPPDQKTVKRIFYSSLDTGNIPVHVQNDIVTCGGRRLFISWTNTVIRDSSGGIIGTMSIGDDITERTKAENALLSYQ
EEFRNLAAELSLAEERERRRLSTDLHDLIGQTLAFAKIRAHSLREHVAEDGLTQWGELTGLLDQSIQEVRSLIFQISPPI
LYEVGLEAALEWLGENFQDNHRFRVNFSDDGTLKPLREEIKVTLFQVVREVLINAAKHASPDTVQIDIRGLGESVRITVR
DDGRGFDVAKAAHKSRDKAGGGFGLFNIRQRIERLGGSLAIESSPGAGTMVTVVAPLDLARDTH

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=203, Percent_Identity=25.615763546798, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787474, Length=253, Percent_Identity=27.6679841897233, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43449; Mature: 43449

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGTTILALAFALLYLRRWQQLKREVARRIEAERLFRETFEHIKLLAIQLDTHGNLVFCN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEC
DYFLQLVGWERREVIGVNWFERFVPPDQKTVKRIFYSSLDTGNIPVHVQNDIVTCGGRRL
HHHHHHHCCCCHHEECCCHHHHCCCCCHHHHHHHHHHCCCCCCCCEEECCCEEEECCCEE
FISWTNTVIRDSSGGIIGTMSIGDDITERTKAENALLSYQEEFRNLAAELSLAEERERRR
EEEECCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTDLHDLIGQTLAFAKIRAHSLREHVAEDGLTQWGELTGLLDQSIQEVRSLIFQISPPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LYEVGLEAALEWLGENFQDNHRFRVNFSDDGTLKPLREEIKVTLFQVVREVLINAAKHAS
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDTVQIDIRGLGESVRITVRDDGRGFDVAKAAHKSRDKAGGGFGLFNIRQRIERLGGSLA
CCEEEEEEEECCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEE
IESSPGAGTMVTVVAPLDLARDTH
EECCCCCCEEEEEEECHHHHCCCC
>Mature Secondary Structure
MFGTTILALAFALLYLRRWQQLKREVARRIEAERLFRETFEHIKLLAIQLDTHGNLVFCN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEC
DYFLQLVGWERREVIGVNWFERFVPPDQKTVKRIFYSSLDTGNIPVHVQNDIVTCGGRRL
HHHHHHHCCCCHHEECCCHHHHCCCCCHHHHHHHHHHCCCCCCCCEEECCCEEEECCCEE
FISWTNTVIRDSSGGIIGTMSIGDDITERTKAENALLSYQEEFRNLAAELSLAEERERRR
EEEECCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTDLHDLIGQTLAFAKIRAHSLREHVAEDGLTQWGELTGLLDQSIQEVRSLIFQISPPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LYEVGLEAALEWLGENFQDNHRFRVNFSDDGTLKPLREEIKVTLFQVVREVLINAAKHAS
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDTVQIDIRGLGESVRITVRDDGRGFDVAKAAHKSRDKAGGGFGLFNIRQRIERLGGSLA
CCEEEEEEEECCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEE
IESSPGAGTMVTVVAPLDLARDTH
EECCCCCCEEEEEEECHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]