The gene/protein map for NC_002939 is currently unavailable.
Definition Geobacter sulfurreducens PCA chromosome, complete genome.
Accession NC_002939
Length 3,814,139

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The map label for this gene is pyrC

Identifier: 39996374

GI number: 39996374

Start: 1386623

End: 1387900

Strand: Direct

Name: pyrC

Synonym: GSU1272

Alternate gene names: 39996374

Gene position: 1386623-1387900 (Clockwise)

Preceding gene: 39996373

Following gene: 39996375

Centisome position: 36.35

GC content: 64.16

Gene sequence:

>1278_bases
ATGAACCTGCTGATAAAAGGTGGGAGGGTGATTGACCCGTCCCAGGGAATTGACGAAGTTCTGGATATCCTCGTGGAGAA
TGGCGCAATCAAGGAACTCGGCAAGGGACTCGCGGCTCCGGCCGGGGCCGGGGTCGTGGACGCCGCCGGCCTGATCGTCA
CGCCGGGCCTCATTGATATGCATGTGCACCTGCGGGACCCGGGGCTCGAGTACAAGGAAGATATCGTAACAGGCACCAGG
GCGGCTGCGGCCGGCGGCTTCACGTCGGTGGCCTGCATGCCCAACACCAAGCCGGTGAACGACAACAAGGCCGTGACCAG
CTACATCGTCGCCAAGGCCAAGGCCGAGGGGCTCGTCAACGTCTTCCCCGTGGGGTCCATTACTCAGGGGAGCAAGGGGG
ATGCCCTGGCCGAGATGGGGGACCTGAAGGAAGCAGGCTGCGTGGCGGTTTCCGACGACGGCCGGCCCGTGACCAGTTCC
GAGCTCATGCGCCGGGCCCTGGAGTACGCCAAGGGAATGGGAATCATGGTCATCTCCCATGCCGAGGATCTCTCCCTGGT
GGGCGAGGGGGTCATGAACGAGGGCTTCGTCTCCACGGAGCTGGGGCTCAAGGGAATACCCTGGGCCGCCGAGGACGCTG
CCACCGCCCGTGACGTGTACCTGGCCGAGTTCACCAACTCGCCGCTCCACATCGCCCACGTCTCCACAATGGGGTCATTG
CGGATCATCCGTAACGCCAAGGCCCGCGGCGTGAAGGTTACCTGCGAGACGGCGCCCCACTACTTCAGCCTCACCGACGA
TGCAGTGCGCGGCTACAACACCAATGCCAAGATGAATCCGCCGCTCCGTACGGCCGATGATCTGGCCGCGGTCAAAGAGG
CCCTGAAGGACGGCACCATCGACGCCATCGCCACCGACCACGCCCCCCACCATCTGGATGAGAAGGACGTGGAGTTCAAC
GTGGCTTTGAACGGCATCATCGGCCTGGAAACCTCCCTGCCGCTGTCGCTGAAGCTGGTGGAGGAGGGAGTGTTGACCCT
GCCGGCACTGGTTGAGAAGATGGCGTGCAACCCGGCCGCGATTCTCGGCATTGACCGGGGCACGCTCCGGCAAGGCGCGG
TTGCCGACATCACGGTTATTGATCCGGCGGCCGTCTGGACGGTGGAGGCCGGTGCGCTCGCCAGCAAGTCCAAGAACTCA
CCCTTCCTCGGCTGGGAGATGAAAGGTGCCGCGGCATACACCATCGTCGGCGGCACGGTGGTCCACAGCAGAGGATGA

Upstream 100 bases:

>100_bases
GATGGCGATGTTGTACCACGTGAGCGGCGGTGAGCTGGCCACCGAGTGAGCCGGCTGTTCGGGATACTTTAACCAACCGA
GATTCGTGAGGGGTGATGAT

Downstream 100 bases:

>100_bases
AATCCGGGCGCGCCGCTTGCCGCGCCCGTTGAAGAGCGGAACCGGGCGCGGCAAGCAGCGCCCTTACGCACAATACACAG
GAGCATGTTCATGAAAGCAG

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNLLIKGGRVIDPSQGIDEVLDILVENGAIKELGKGLAAPAGAGVVDAAGLIVTPGLIDMHVHLRDPGLEYKEDIVTGTR
AAAAGGFTSVACMPNTKPVNDNKAVTSYIVAKAKAEGLVNVFPVGSITQGSKGDALAEMGDLKEAGCVAVSDDGRPVTSS
ELMRRALEYAKGMGIMVISHAEDLSLVGEGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTNSPLHIAHVSTMGSL
RIIRNAKARGVKVTCETAPHYFSLTDDAVRGYNTNAKMNPPLRTADDLAAVKEALKDGTIDAIATDHAPHHLDEKDVEFN
VALNGIIGLETSLPLSLKLVEEGVLTLPALVEKMACNPAAILGIDRGTLRQGAVADITVIDPAAVWTVEAGALASKSKNS
PFLGWEMKGAAAYTIVGGTVVHSRG

Sequences:

>Translated_425_residues
MNLLIKGGRVIDPSQGIDEVLDILVENGAIKELGKGLAAPAGAGVVDAAGLIVTPGLIDMHVHLRDPGLEYKEDIVTGTR
AAAAGGFTSVACMPNTKPVNDNKAVTSYIVAKAKAEGLVNVFPVGSITQGSKGDALAEMGDLKEAGCVAVSDDGRPVTSS
ELMRRALEYAKGMGIMVISHAEDLSLVGEGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTNSPLHIAHVSTMGSL
RIIRNAKARGVKVTCETAPHYFSLTDDAVRGYNTNAKMNPPLRTADDLAAVKEALKDGTIDAIATDHAPHHLDEKDVEFN
VALNGIIGLETSLPLSLKLVEEGVLTLPALVEKMACNPAAILGIDRGTLRQGAVADITVIDPAAVWTVEAGALASKSKNS
PFLGWEMKGAAAYTIVGGTVVHSRG
>Mature_425_residues
MNLLIKGGRVIDPSQGIDEVLDILVENGAIKELGKGLAAPAGAGVVDAAGLIVTPGLIDMHVHLRDPGLEYKEDIVTGTR
AAAAGGFTSVACMPNTKPVNDNKAVTSYIVAKAKAEGLVNVFPVGSITQGSKGDALAEMGDLKEAGCVAVSDDGRPVTSS
ELMRRALEYAKGMGIMVISHAEDLSLVGEGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTNSPLHIAHVSTMGSL
RIIRNAKARGVKVTCETAPHYFSLTDDAVRGYNTNAKMNPPLRTADDLAAVKEALKDGTIDAIATDHAPHHLDEKDVEFN
VALNGIIGLETSLPLSLKLVEEGVLTLPALVEKMACNPAAILGIDRGTLRQGAVADITVIDPAAVWTVEAGALASKSKNS
PFLGWEMKGAAAYTIVGGTVVHSRG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=416, Percent_Identity=32.2115384615385, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI190194363, Length=444, Percent_Identity=26.5765765765766, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI4503375, Length=463, Percent_Identity=28.9416846652268, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4503051, Length=449, Percent_Identity=25.6124721603563, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI62422571, Length=449, Percent_Identity=25.6124721603563, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI19923821, Length=467, Percent_Identity=27.1948608137045, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4503377, Length=450, Percent_Identity=25.1111111111111, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4503379, Length=453, Percent_Identity=24.9448123620309, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786722, Length=440, Percent_Identity=29.7727272727273, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87082175, Length=445, Percent_Identity=26.5168539325843, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193204318, Length=418, Percent_Identity=29.1866028708134, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17539558, Length=459, Percent_Identity=25.7080610021786, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI86575075, Length=446, Percent_Identity=25.1121076233184, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322218, Length=389, Percent_Identity=28.2776349614396, Blast_Score=112, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24642586, Length=378, Percent_Identity=31.4814814814815, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI18859883, Length=460, Percent_Identity=29.3478260869565, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_GEOSL (Q74DP4)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952325.1
- HSSP:   O66990
- ProteinModelPortal:   Q74DP4
- SMR:   Q74DP4
- GeneID:   2686576
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1272
- NMPDR:   fig|243231.1.peg.1263
- TIGR:   GSU1272
- HOGENOM:   HBG724623
- OMA:   GIFAEKE
- ProtClustDB:   CLSK828273
- BioCyc:   GSUL243231:GSU_1272-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 44258; Mature: 44258

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MNLLIKGGRVIDPSQGIDEVLDILVENGAIKELGKGLAAPAGAGVVDAAGLIVTPGLIDM
CCEEEECCEEECCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCEEECCCEEEE
HVHLRDPGLEYKEDIVTGTRAAAAGGFTSVACMPNTKPVNDNKAVTSYIVAKAKAEGLVN
EEEEECCCCCHHHHHHCCCHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEE
VFPVGSITQGSKGDALAEMGDLKEAGCVAVSDDGRPVTSSELMRRALEYAKGMGIMVISH
EEECCCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEC
AEDLSLVGEGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTNSPLHIAHVSTMGSL
CCCHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHEEEEEEECCCCEEEEEECCCCCE
RIIRNAKARGVKVTCETAPHYFSLTDDAVRGYNTNAKMNPPLRTADDLAAVKEALKDGTI
EEEECCCCCCEEEEEECCCCEEECCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCE
DAIATDHAPHHLDEKDVEFNVALNGIIGLETSLPLSLKLVEEGVLTLPALVEKMACNPAA
EEEECCCCCCCCCCCCEEEEEEEEEEEEECCCCCEEEEEHHCCHHHHHHHHHHHCCCCEE
ILGIDRGTLRQGAVADITVIDPAAVWTVEAGALASKSKNSPFLGWEMKGAAAYTIVGGTV
EEECCCCCCCCCCEEEEEEECCCEEEEEECCCHHCCCCCCCEEEEEECCCEEEEEECCEE
VHSRG
EECCC
>Mature Secondary Structure
MNLLIKGGRVIDPSQGIDEVLDILVENGAIKELGKGLAAPAGAGVVDAAGLIVTPGLIDM
CCEEEECCEEECCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCEEECCCEEEE
HVHLRDPGLEYKEDIVTGTRAAAAGGFTSVACMPNTKPVNDNKAVTSYIVAKAKAEGLVN
EEEEECCCCCHHHHHHCCCHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEE
VFPVGSITQGSKGDALAEMGDLKEAGCVAVSDDGRPVTSSELMRRALEYAKGMGIMVISH
EEECCCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEC
AEDLSLVGEGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTNSPLHIAHVSTMGSL
CCCHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHEEEEEEECCCCEEEEEECCCCCE
RIIRNAKARGVKVTCETAPHYFSLTDDAVRGYNTNAKMNPPLRTADDLAAVKEALKDGTI
EEEECCCCCCEEEEEECCCCEEECCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCE
DAIATDHAPHHLDEKDVEFNVALNGIIGLETSLPLSLKLVEEGVLTLPALVEKMACNPAA
EEEECCCCCCCCCCCCEEEEEEEEEEEEECCCCCEEEEEHHCCHHHHHHHHHHHCCCCEE
ILGIDRGTLRQGAVADITVIDPAAVWTVEAGALASKSKNSPFLGWEMKGAAAYTIVGGTV
EEECCCCCCCCCCEEEEEEECCCEEEEEECCCHHCCCCCCCEEEEEECCCEEEEEECCEE
VHSRG
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA