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The map label for this gene is cvrA [H]

Identifier: 39996305

GI number: 39996305

Start: 1306518

End: 1307978

Strand: Direct

Name: cvrA [H]

Synonym: GSU1203

Alternate gene names: 39996305

Gene position: 1306518-1307978 (Clockwise)

Preceding gene: 39996304

Following gene: 39996306

Centisome position: 34.25

GC content: 58.86

Gene sequence:

>1461_bases
ATGACCCCATTCGAATATCTACTTTTAGGTGTTTCCCTTCTGTTGCTGGTGAGCATCCTCGCCAGCAAGGTATCGAGCCG
CCTGGGAGTTCCGGCACTTCTTCTCTTCCTCCTGGTGGGGATGCTGGCCGGTTCCGACGGACCGGGCGGCTTTCAGTTCG
ACAATCCGGTCCTCGTCCAGTCACTTGGCATTGTTGCTCTGGCCTATATCCTTTTTGCCGGAGGACTCGACACCAACTGG
CGATCAGTCCGGCCGGTGCTGGGCCGGGCATTGATCCTCTCTACCCTGGGAGTGTTCGTTACGGCATTGCTGGTCGGCTG
GTTTGTTCATGCGGTCCTTGACTTTTCGTTGCTCGAGGGGCTGCTGGTGGGGGCCATTGTCTCCTCCACCGATGCTGCTG
CTGTGTTTTCGGTGCTCCGTTCTCGCAACGTGAGTCTCAGCGGTGAGCTGAAACCGCTTCTCGAACTGGAGTCGGGCAGC
AACGATCCCATGGCGGTCTTCCTGACCGTTGCCATTATTTCCCTGCTTGTGGATCCCGGAGCCAAGCTCTACCATCTCCC
CCTGCTGGTCCTGTGGCAAATGGTGGTCGGCGGGGCTGCGGGTTATCTCCTGGGCAAGGGGGGAGTTCTTCTGATCAACC
GGCTTCGCCTGGAGTACGAAGGTCTCTACTCGGTGCTCACCCTGACCCTGGTGCTTCTGATTTACAGCGGCACCGTCCTG
CTGAAAGGAAACGGCTTTCTTGCGGTCTACGCTGCGGGGCTGGTCATGGGGAACAGCTCCTTTGTGCAGAAAAAGAGCTT
GGTCCGGTTCCACGACGGTCTTGCCTGGCTGATGCAGATTACCATGTTTCTGATTCTCGGCCTGCAGGTTTTTCCCTCTC
ATCTCGTTCCTGTGACACTCGTGGGGCTGTGTACGGCTGCGTTTCTCATGCTGGTGGCCCGGCCCGTCAGCGTTTTTGCG
ACGCTTCTCTTTACCCCCATGACCGTTCGGGAAAAGACGATGATCTCGTGGGTCGGCTTGCGCGGAGCGGTCCCGATCGT
GCTTGCCACTTTTCCGCTGATGGCCGGTGTTGGCAAGGCGGAGATGATCTTCAACGTTGTCTTTTTTATTGTCTGTTCCT
CGGCGCTTCTCCAGGGGTCCACGATCCCCCTGGCCGCCCGCTGGCTTGGCCTGGATGCACCAATGCTCGCCAAACGCCGG
CGTCCTTTCGAGTTCGAGGCGTCCGACGAGGGTAAAGGAGAGTTGGTCGAAATTGAGATTTCGCCCGTTTCGTTAGCCGT
GAATCGCCAGATCGTCGATCTCCACCTCCCGGCGGGATCGCTTATCGTCCTGATCCAGAGACGAGGGGAGTTCGTTGTCC
CCGGTGGCGGAACACTCATTGAGGCGGGGGACACGGTGCACCTCCTGGCCGACCGCGAGCGTATCGACGAGATACGAGCC
ATGTTCGAGACGCCGTCGTGA

Upstream 100 bases:

>100_bases
GGAAGAACTGGAGCGTCGCGGGCTGAAGCAGTATCTCTGATTGTGACGGGCCCGTGGCCAGTCGTGATATCGCACCTTCC
ACGCGGGGATTTCGTTGCCA

Downstream 100 bases:

>100_bases
CCCCCGGTCGAGGCGCTTGATTCGTTGCCATTCCGCGATTCGTTGAGAGCGAAAGAAACCGAAACGGCGCCCTGACCGCC
GGGCTCCATCATCCAGACGG

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTPFEYLLLGVSLLLLVSILASKVSSRLGVPALLLFLLVGMLAGSDGPGGFQFDNPVLVQSLGIVALAYILFAGGLDTNW
RSVRPVLGRALILSTLGVFVTALLVGWFVHAVLDFSLLEGLLVGAIVSSTDAAAVFSVLRSRNVSLSGELKPLLELESGS
NDPMAVFLTVAIISLLVDPGAKLYHLPLLVLWQMVVGGAAGYLLGKGGVLLINRLRLEYEGLYSVLTLTLVLLIYSGTVL
LKGNGFLAVYAAGLVMGNSSFVQKKSLVRFHDGLAWLMQITMFLILGLQVFPSHLVPVTLVGLCTAAFLMLVARPVSVFA
TLLFTPMTVREKTMISWVGLRGAVPIVLATFPLMAGVGKAEMIFNVVFFIVCSSALLQGSTIPLAARWLGLDAPMLAKRR
RPFEFEASDEGKGELVEIEISPVSLAVNRQIVDLHLPAGSLIVLIQRRGEFVVPGGGTLIEAGDTVHLLADRERIDEIRA
MFETPS

Sequences:

>Translated_486_residues
MTPFEYLLLGVSLLLLVSILASKVSSRLGVPALLLFLLVGMLAGSDGPGGFQFDNPVLVQSLGIVALAYILFAGGLDTNW
RSVRPVLGRALILSTLGVFVTALLVGWFVHAVLDFSLLEGLLVGAIVSSTDAAAVFSVLRSRNVSLSGELKPLLELESGS
NDPMAVFLTVAIISLLVDPGAKLYHLPLLVLWQMVVGGAAGYLLGKGGVLLINRLRLEYEGLYSVLTLTLVLLIYSGTVL
LKGNGFLAVYAAGLVMGNSSFVQKKSLVRFHDGLAWLMQITMFLILGLQVFPSHLVPVTLVGLCTAAFLMLVARPVSVFA
TLLFTPMTVREKTMISWVGLRGAVPIVLATFPLMAGVGKAEMIFNVVFFIVCSSALLQGSTIPLAARWLGLDAPMLAKRR
RPFEFEASDEGKGELVEIEISPVSLAVNRQIVDLHLPAGSLIVLIQRRGEFVVPGGGTLIEAGDTVHLLADRERIDEIRA
MFETPS
>Mature_485_residues
TPFEYLLLGVSLLLLVSILASKVSSRLGVPALLLFLLVGMLAGSDGPGGFQFDNPVLVQSLGIVALAYILFAGGLDTNWR
SVRPVLGRALILSTLGVFVTALLVGWFVHAVLDFSLLEGLLVGAIVSSTDAAAVFSVLRSRNVSLSGELKPLLELESGSN
DPMAVFLTVAIISLLVDPGAKLYHLPLLVLWQMVVGGAAGYLLGKGGVLLINRLRLEYEGLYSVLTLTLVLLIYSGTVLL
KGNGFLAVYAAGLVMGNSSFVQKKSLVRFHDGLAWLMQITMFLILGLQVFPSHLVPVTLVGLCTAAFLMLVARPVSVFAT
LLFTPMTVREKTMISWVGLRGAVPIVLATFPLMAGVGKAEMIFNVVFFIVCSSALLQGSTIPLAARWLGLDAPMLAKRRR
PFEFEASDEGKGELVEIEISPVSLAVNRQIVDLHLPAGSLIVLIQRRGEFVVPGGGTLIEAGDTVHLLADRERIDEIRAM
FETPS

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=472, Percent_Identity=41.1016949152542, Blast_Score=291, Evalue=8e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 52034; Mature: 51903

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPFEYLLLGVSLLLLVSILASKVSSRLGVPALLLFLLVGMLAGSDGPGGFQFDNPVLVQ
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
SLGIVALAYILFAGGLDTNWRSVRPVLGRALILSTLGVFVTALLVGWFVHAVLDFSLLEG
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLVGAIVSSTDAAAVFSVLRSRNVSLSGELKPLLELESGSNDPMAVFLTVAIISLLVDPG
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCC
AKLYHLPLLVLWQMVVGGAAGYLLGKGGVLLINRLRLEYEGLYSVLTLTLVLLIYSGTVL
CHHHHHHHHHHHHHHHCCCCHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LKGNGFLAVYAAGLVMGNSSFVQKKSLVRFHDGLAWLMQITMFLILGLQVFPSHLVPVTL
EECCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLCTAAFLMLVARPVSVFATLLFTPMTVREKTMISWVGLRGAVPIVLATFPLMAGVGKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHH
EMIFNVVFFIVCSSALLQGSTIPLAARWLGLDAPMLAKRRRPFEFEASDEGKGELVEIEI
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEE
SPVSLAVNRQIVDLHLPAGSLIVLIQRRGEFVVPGGGTLIEAGDTVHLLADRERIDEIRA
CCEEEEECCEEEEEECCCCCEEEEEECCCCEEECCCCEEEECCCEEEEECCHHHHHHHHH
MFETPS
HHCCCC
>Mature Secondary Structure 
TPFEYLLLGVSLLLLVSILASKVSSRLGVPALLLFLLVGMLAGSDGPGGFQFDNPVLVQ
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
SLGIVALAYILFAGGLDTNWRSVRPVLGRALILSTLGVFVTALLVGWFVHAVLDFSLLEG
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLVGAIVSSTDAAAVFSVLRSRNVSLSGELKPLLELESGSNDPMAVFLTVAIISLLVDPG
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCC
AKLYHLPLLVLWQMVVGGAAGYLLGKGGVLLINRLRLEYEGLYSVLTLTLVLLIYSGTVL
CHHHHHHHHHHHHHHHCCCCHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LKGNGFLAVYAAGLVMGNSSFVQKKSLVRFHDGLAWLMQITMFLILGLQVFPSHLVPVTL
EECCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLCTAAFLMLVARPVSVFATLLFTPMTVREKTMISWVGLRGAVPIVLATFPLMAGVGKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHH
EMIFNVVFFIVCSSALLQGSTIPLAARWLGLDAPMLAKRRRPFEFEASDEGKGELVEIEI
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEE
SPVSLAVNRQIVDLHLPAGSLIVLIQRRGEFVVPGGGTLIEAGDTVHLLADRERIDEIRA
CCEEEEECCEEEEEECCCCCEEEEEECCCCEEECCCCEEEECCCEEEEECCHHHHHHHHH
MFETPS
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA