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The map label for this gene is manC [H]

Identifier: 39996304

GI number: 39996304

Start: 1305384

End: 1306457

Strand: Direct

Name: manC [H]

Synonym: GSU1202

Alternate gene names: 39996304

Gene position: 1305384-1306457 (Clockwise)

Preceding gene: 39996303

Following gene: 39996305

Centisome position: 34.22

GC content: 64.99

Gene sequence:

>1074_bases
ATGTACGTCGTCATCCTCGCCGGCGGCTCCGGCACCCGTTTCTGGCCCCTGTCGCGCAAGGCCCACCCCAAACAGCTCAT
GTCGGTCTTTGGCGGGAAGTCCATGCTGCAACGGACCGTGGAGCGGGTAATCCCCCTCAATCCCAAGCGTATCCTGGTGG
TCACCAACCATCTGCAGGCGGACGAAACCCGGCGCCAGCTGGAGTACCTGAGAGGAATACGCATCGATGTGATCGAGGAG
CCCATGGGGCGCAATACGGCGCCGGCCATTTCTCTGGCCGCCACCCTCATCGCCCGCCACGATCCGGAAGCGGTCATGGC
GGTGCTGCCGGCCGACCACTACATTGCCGACGAGGATGCCTTCTGTGCCGCTCTCCAGCGGGGGCGCGAGCCGGCCATGA
ACGGCTGGCTGGTCACCTTCGGCATCCTTCCGGACCGGCCCGAAACCGGCTACGGCTATATCGAGGCCGACCGGCACCTG
CGGGGAGACGGTCCATACCCGGTCAAACGTTTCGTGGAAAAACCCGATGCGGCCACTGCGGCCCAGTACCTGGCCGCCGG
CGGGTTCTACTGGAACAGCGGCATGTTCATGTGGCGCGCCGACGTGATCCTCGACCGGATCGCCAACCACATGCCCGATC
TGGCCCGCGCCTTTGCCGGCATTGCCTTCGATGCCGACATCTGGGAACCGGCCGACCTCGCTCCCCAGATTGAGGCCGTC
TACGCCATGGTTTCCGGCCAGTCCATCGACTACGGCGTCATGGAGAAGGCTGACAACGTGCTGGTGCTACCCGCCTCCTT
CGGCTGGAGCGATGTGGGCAGCTGGAGCGCGCTGCCCGGCTTGATTGCCCCCGACGGCGACGGTACCGTCCGCCTCGCCG
GCGAGACCGTCATCAGTGTTGACTCGGCTGGCTGTGTGGTGCGCGGTGAAAAACTCGTGGCACTGGTGGGCGTCAGAGAC
CTGGTTGTCGTCGACACCCCCGATGCCCTGATGGTCTGCGCCAGGGATGGGGCCCAGGATGTCAGGAAGATAGTGGAAGA
ACTGGAGCGTCGCGGGCTGAAGCAGTATCTCTGA

Upstream 100 bases:

>100_bases
TTTTTCCCCGTCAGACGCAGGGATGAAGGGCCCGGCTAACCCCGGCTTCACCTCATTCCTGCGTCTTCGTCGTCAGCTTG
AATCTCCCGGAGGGCTCCCC

Downstream 100 bases:

>100_bases
TTGTGACGGGCCCGTGGCCAGTCGTGATATCGCACCTTCCACGCGGGGATTTCGTTGCCAATGACCCCATTCGAATATCT
ACTTTTAGGTGTTTCCCTTC

Product: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase, truncation

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MYVVILAGGSGTRFWPLSRKAHPKQLMSVFGGKSMLQRTVERVIPLNPKRILVVTNHLQADETRRQLEYLRGIRIDVIEE
PMGRNTAPAISLAATLIARHDPEAVMAVLPADHYIADEDAFCAALQRGREPAMNGWLVTFGILPDRPETGYGYIEADRHL
RGDGPYPVKRFVEKPDAATAAQYLAAGGFYWNSGMFMWRADVILDRIANHMPDLARAFAGIAFDADIWEPADLAPQIEAV
YAMVSGQSIDYGVMEKADNVLVLPASFGWSDVGSWSALPGLIAPDGDGTVRLAGETVISVDSAGCVVRGEKLVALVGVRD
LVVVDTPDALMVCARDGAQDVRKIVEELERRGLKQYL

Sequences:

>Translated_357_residues
MYVVILAGGSGTRFWPLSRKAHPKQLMSVFGGKSMLQRTVERVIPLNPKRILVVTNHLQADETRRQLEYLRGIRIDVIEE
PMGRNTAPAISLAATLIARHDPEAVMAVLPADHYIADEDAFCAALQRGREPAMNGWLVTFGILPDRPETGYGYIEADRHL
RGDGPYPVKRFVEKPDAATAAQYLAAGGFYWNSGMFMWRADVILDRIANHMPDLARAFAGIAFDADIWEPADLAPQIEAV
YAMVSGQSIDYGVMEKADNVLVLPASFGWSDVGSWSALPGLIAPDGDGTVRLAGETVISVDSAGCVVRGEKLVALVGVRD
LVVVDTPDALMVCARDGAQDVRKIVEELERRGLKQYL
>Mature_357_residues
MYVVILAGGSGTRFWPLSRKAHPKQLMSVFGGKSMLQRTVERVIPLNPKRILVVTNHLQADETRRQLEYLRGIRIDVIEE
PMGRNTAPAISLAATLIARHDPEAVMAVLPADHYIADEDAFCAALQRGREPAMNGWLVTFGILPDRPETGYGYIEADRHL
RGDGPYPVKRFVEKPDAATAAQYLAAGGFYWNSGMFMWRADVILDRIANHMPDLARAFAGIAFDADIWEPADLAPQIEAV
YAMVSGQSIDYGVMEKADNVLVLPASFGWSDVGSWSALPGLIAPDGDGTVRLAGETVISVDSAGCVVRGEKLVALVGVRD
LVVVDTPDALMVCARDGAQDVRKIVEELERRGLKQYL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=363, Percent_Identity=41.8732782369146, Blast_Score=248, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 39057; Mature: 39057

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVVILAGGSGTRFWPLSRKAHPKQLMSVFGGKSMLQRTVERVIPLNPKRILVVTNHLQA
CEEEEEECCCCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCH
DETRRQLEYLRGIRIDVIEEPMGRNTAPAISLAATLIARHDPEAVMAVLPADHYIADEDA
HHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEECCCHH
FCAALQRGREPAMNGWLVTFGILPDRPETGYGYIEADRHLRGDGPYPVKRFVEKPDAATA
HHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCEECCCCCHHHHHHHCCCCHHHH
AQYLAAGGFYWNSGMFMWRADVILDRIANHMPDLARAFAGIAFDADIWEPADLAPQIEAV
HHHHHCCCEEECCCEEEEHHHHHHHHHHHHCHHHHHHHHCCEECCCCCCCCCCCHHHHHH
YAMVSGQSIDYGVMEKADNVLVLPASFGWSDVGSWSALPGLIAPDGDGTVRLAGETVISV
HHHHCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEEEE
DSAGCVVRGEKLVALVGVRDLVVVDTPDALMVCARDGAQDVRKIVEELERRGLKQYL
CCCCEEEECCEEEEEECCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYVVILAGGSGTRFWPLSRKAHPKQLMSVFGGKSMLQRTVERVIPLNPKRILVVTNHLQA
CEEEEEECCCCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCH
DETRRQLEYLRGIRIDVIEEPMGRNTAPAISLAATLIARHDPEAVMAVLPADHYIADEDA
HHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEECCCHH
FCAALQRGREPAMNGWLVTFGILPDRPETGYGYIEADRHLRGDGPYPVKRFVEKPDAATA
HHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCEECCCCCHHHHHHHCCCCHHHH
AQYLAAGGFYWNSGMFMWRADVILDRIANHMPDLARAFAGIAFDADIWEPADLAPQIEAV
HHHHHCCCEEECCCEEEEHHHHHHHHHHHHCHHHHHHHHCCEECCCCCCCCCCCHHHHHH
YAMVSGQSIDYGVMEKADNVLVLPASFGWSDVGSWSALPGLIAPDGDGTVRLAGETVISV
HHHHCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEEEE
DSAGCVVRGEKLVALVGVRDLVVVDTPDALMVCARDGAQDVRKIVEELERRGLKQYL
CCCCEEEECCEEEEEECCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7515042; 9004408 [H]