| Definition | Geobacter sulfurreducens PCA chromosome, complete genome. |
|---|---|
| Accession | NC_002939 |
| Length | 3,814,139 |
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The map label for this gene is coaBC [H]
Identifier: 39996226
GI number: 39996226
Start: 1208341
End: 1209540
Strand: Direct
Name: coaBC [H]
Synonym: GSU1124
Alternate gene names: 39996226
Gene position: 1208341-1209540 (Clockwise)
Preceding gene: 39996225
Following gene: 39996228
Centisome position: 31.68
GC content: 62.67
Gene sequence:
>1200_bases ATGCTCAAGGGAAAAGAGATCGTTCTCGGTATTTGCGGCGGCATCGCAGTCTACAAAGCCGTTGAACTCGTACGGCTGCT CACGGGGGCAGGAGCGAACGTCCATGTCATCATGACGCGAGCGGCCACGGAGTTCGTGGCTCCGCTCACGTTCCAGACCC TAACCTCCAACCCCGTGCACTCGGAACTCTTCAATCTCATCGCTGAACGGGAAATCGGCCACATTTCGCTGGCGGACCGG GCCGATCTCTTCATCATCGCGCCGGCCACGGCCAACGTGATCGGCAAGATCGCCCACGGTATCGCCGACGACATGCTCAC CACCACGGTCATGGCCACCAGGGCACCGGTTCTGATCGCTCCCGCCATGAACTGCAACATGTACCGCAATCCCCTCTACC AGGAAAACGAGGCGCGACTGAGGCGCCACGGGTACCTGTTCGCGGATCCGGTGCGGGGAATGCTCGCCTGCGGCTGGGAG GGTGAAGGAAAGCTCCAGTCCCCCGAGATCATCTTCGAGGAGGCGGTCACCGCCCTTACGCCGAAGGACCTTGCCGGCGA GCACCTGCTGGTGACGGCCGGGCCGACCCAGGAGGAGATCGATCCGGTCCGCTTCGTGAGCAACCACTCGTCGGGGAAGA TGGGGTATGCCATCGCCCGGGCCGCCCGGCGCCGCGGGGCGGAGGTGACACTGGTCTCAGGCCCCACCTGCCTCGATGCC CCCTGGGGGGTGGAAACGGTGCGGGTTGCGTCGGCCGTGGAGATGCGCGCTGCCGTCATGGCTGCCCTGCCGGCGGCCAC GGTTGTGATCAAGGCCGCAGCCGTGGCCGATTATCGTCCTGTAGTGCGCGCGACGGGAAAGATCAAGAAAAATGCCGACT CGCTGGTGATCGAGTTGGAGAAGAACCCCGACATACTTGCCGAACTTGGAGGAATCAAGGGGGAGCGCCTGCTGGTGGGC TTCGCCGCCGAGACTGCCGATCTGCTTGAAAACGCCCGGAAAAAACTGGTCGCCAAGAATGTTGACATGATGGTCGCCAA TGACGTGAGCCTGGAAGGCGCCGGATTCCACGGCGACACCAATATTGCCCGCCTTCTCTATCGTGACGGGACCAGTGAGG AGCTGCCGCTCATGACCAAGAACGAAATGGCGGCCCTCATTCTTGACCGGGTGGCGGAATTGAGGAAAAAGGCGGGGTAA
Upstream 100 bases:
>100_bases GTCCGGCAACGTCCATCGGCCGGGAGCGGCGGTACAACCCCTACCTGACGGATTAGCGCGCACGCGGAAACCCTGGGAAA CAGTGCGCGGCGGAGGCCCA
Downstream 100 bases:
>100_bases GCGCGGGCCAGGGGCGTCAGGCCGAGGAGAGGATCTGGAGAAGTTTCTGCGGCTCCCAGATGGCTTGGCGGAGGCGTCCT TTGAGGGATGCCACCTGAGC
Product: phosphohistidine phosphatase SixA
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 399; Mature: 399
Protein sequence:
>399_residues MLKGKEIVLGICGGIAVYKAVELVRLLTGAGANVHVIMTRAATEFVAPLTFQTLTSNPVHSELFNLIAEREIGHISLADR ADLFIIAPATANVIGKIAHGIADDMLTTTVMATRAPVLIAPAMNCNMYRNPLYQENEARLRRHGYLFADPVRGMLACGWE GEGKLQSPEIIFEEAVTALTPKDLAGEHLLVTAGPTQEEIDPVRFVSNHSSGKMGYAIARAARRRGAEVTLVSGPTCLDA PWGVETVRVASAVEMRAAVMAALPAATVVIKAAAVADYRPVVRATGKIKKNADSLVIELEKNPDILAELGGIKGERLLVG FAAETADLLENARKKLVAKNVDMMVANDVSLEGAGFHGDTNIARLLYRDGTSEELPLMTKNEMAALILDRVAELRKKAG
Sequences:
>Translated_399_residues MLKGKEIVLGICGGIAVYKAVELVRLLTGAGANVHVIMTRAATEFVAPLTFQTLTSNPVHSELFNLIAEREIGHISLADR ADLFIIAPATANVIGKIAHGIADDMLTTTVMATRAPVLIAPAMNCNMYRNPLYQENEARLRRHGYLFADPVRGMLACGWE GEGKLQSPEIIFEEAVTALTPKDLAGEHLLVTAGPTQEEIDPVRFVSNHSSGKMGYAIARAARRRGAEVTLVSGPTCLDA PWGVETVRVASAVEMRAAVMAALPAATVVIKAAAVADYRPVVRATGKIKKNADSLVIELEKNPDILAELGGIKGERLLVG FAAETADLLENARKKLVAKNVDMMVANDVSLEGAGFHGDTNIARLLYRDGTSEELPLMTKNEMAALILDRVAELRKKAG >Mature_399_residues MLKGKEIVLGICGGIAVYKAVELVRLLTGAGANVHVIMTRAATEFVAPLTFQTLTSNPVHSELFNLIAEREIGHISLADR ADLFIIAPATANVIGKIAHGIADDMLTTTVMATRAPVLIAPAMNCNMYRNPLYQENEARLRRHGYLFADPVRGMLACGWE GEGKLQSPEIIFEEAVTALTPKDLAGEHLLVTAGPTQEEIDPVRFVSNHSSGKMGYAIARAARRRGAEVTLVSGPTCLDA PWGVETVRVASAVEMRAAVMAALPAATVVIKAAAVADYRPVVRATGKIKKNADSLVIELEKNPDILAELGGIKGERLLVG FAAETADLLENARKKLVAKNVDMMVANDVSLEGAGFHGDTNIARLLYRDGTSEELPLMTKNEMAALILDRVAELRKKAG
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=169, Percent_Identity=33.7278106508876, Blast_Score=85, Evalue=1e-16, Organism=Escherichia coli, GI87082301, Length=395, Percent_Identity=48.1012658227848, Blast_Score=317, Evalue=6e-88, Organism=Caenorhabditis elegans, GI17560194, Length=170, Percent_Identity=31.1764705882353, Blast_Score=69, Evalue=4e-12, Organism=Saccharomyces cerevisiae, GI6322762, Length=175, Percent_Identity=30.2857142857143, Blast_Score=70, Evalue=8e-13, Organism=Drosophila melanogaster, GI24657262, Length=192, Percent_Identity=29.6875, Blast_Score=80, Evalue=2e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 42735; Mature: 42735
Theoretical pI: Translated: 6.73; Mature: 6.73
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 3.5 %Met (Translated Protein) 4.5 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 3.5 %Met (Mature Protein) 4.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLKGKEIVLGICGGIAVYKAVELVRLLTGAGANVHVIMTRAATEFVAPLTFQTLTSNPVH CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHCCCEEEHHCCCCHH SELFNLIAEREIGHISLADRADLFIIAPATANVIGKIAHGIADDMLTTTVMATRAPVLIA HHHHHHHHHCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE PAMNCNMYRNPLYQENEARLRRHGYLFADPVRGMLACGWEGEGKLQSPEIIFEEAVTALT ECCCCCHHCCCCCCCHHHHHHHCCCEEECCCCCCEEECCCCCCCCCCCHHHHHHHHHHCC PKDLAGEHLLVTAGPTQEEIDPVRFVSNHSSGKMGYAIARAARRRGAEVTLVSGPTCLDA CCCCCCCEEEEECCCCHHHCCHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCEECC PWGVETVRVASAVEMRAAVMAALPAATVVIKAAAVADYRPVVRATGKIKKNADSLVIELE CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEEC KNPDILAELGGIKGERLLVGFAAETADLLENARKKLVAKNVDMMVANDVSLEGAGFHGDT CCCCHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCEECCCCCCCCC NIARLLYRDGTSEELPLMTKNEMAALILDRVAELRKKAG HHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure MLKGKEIVLGICGGIAVYKAVELVRLLTGAGANVHVIMTRAATEFVAPLTFQTLTSNPVH CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHCCCEEEHHCCCCHH SELFNLIAEREIGHISLADRADLFIIAPATANVIGKIAHGIADDMLTTTVMATRAPVLIA HHHHHHHHHCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE PAMNCNMYRNPLYQENEARLRRHGYLFADPVRGMLACGWEGEGKLQSPEIIFEEAVTALT ECCCCCHHCCCCCCCHHHHHHHCCCEEECCCCCCEEECCCCCCCCCCCHHHHHHHHHHCC PKDLAGEHLLVTAGPTQEEIDPVRFVSNHSSGKMGYAIARAARRRGAEVTLVSGPTCLDA CCCCCCCEEEEECCCCHHHCCHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCEECC PWGVETVRVASAVEMRAAVMAALPAATVVIKAAAVADYRPVVRATGKIKKNADSLVIELE CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEEC KNPDILAELGGIKGERLLVGFAAETADLLENARKKLVAKNVDMMVANDVSLEGAGFHGDT CCCCHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCEECCCCCCCCC NIARLLYRDGTSEELPLMTKNEMAALILDRVAELRKKAG HHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9534248; 9384377 [H]