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The map label for this gene is metC-1 [H]

Identifier: 39996047

GI number: 39996047

Start: 1014277

End: 1015410

Strand: Direct

Name: metC-1 [H]

Synonym: GSU0944

Alternate gene names: 39996047

Gene position: 1014277-1015410 (Clockwise)

Preceding gene: 39996046

Following gene: 39996048

Centisome position: 26.59

GC content: 65.34

Gene sequence:

>1134_bases
ATGAACATCGCGACGCAGGCAGCACAGATCGGTCTCGACTGGGATACCCGCACCGGGGCGGTGACGGTACCCATCTACCA
GACGGCAACCTTCCGGCATCCGGGATTGGGCCAGAGCACGGGCTACGATTATTCCCGCTCCGGCAACCCCACCCGCCAGG
CCCTGGAAGAGGGGATCGCCCGGCTGGACGGCGGCGCCAGGGGATTTGCCTATGCCTCGGGCATGGCTGCCATCGCCAAT
CTCCTCCTGCTCTTCAAGAGCGGCGACCACCTGGTGGTGACCGAGGACCTCTACGGCGGCACCTGCCGTCTCTTCGACCA
GATTCTGGTCCAGTACGGCCTCTCGTTCACCTATGTGGACACGAGCGATCCTGAGGCGGTGCGGGACGCCATCCGTCCCG
AGACCAGGGCCCTGTTCGTGGAGTCCCTCACCAACCCGCTCCTCAAGGTCGCCGATATCGCGGCCCTCTCGACCCTCTGC
CGCGAGCGGGGGCTGCTTTGTATCGTGGACAACACCTTCCTCACTCCCTATCTTCTGCGGCCCCTGGATCTCGGGGCCGA
CATCACGGTCTACAGCGGCACCAAGTACCTGTCCGGGCACAACGACACGGTGTCGGGGCTGGTCGTGGTCAAGGAGCCGG
CCCTGGCCGAGCGGGTCTACTTCCTCCAGAATTCCGTGGGCGCAGTGCTGGGGCCCCAGGATGCGTGGCTCACCATCCGG
GGGATGAAGACCCTGTCGGTGCGACTGGACCGCCAGCAGGAAAACGCCGGCCGGATCGCCGAATGGCTGGCGCGGCATCC
GCGGGTGCCACGGGTCTTCTATCCGGGGCTGCCGGGCCATCCGGGCCACGAACTGCTGGCGCGCCAGGCCCGGGGCTTCG
GCGCCATGATCGCTTTCGAGGTGGATGATAAGGCTCTGGTGGAGCGTTTGCTCCTCAAGACGGAATTGATATCATTCGCG
GAAAGCCTCGGCGGCGTTGAAACCCTGATCACCTTTCCCCAGGTTCAGACCCATGCGGACATCCCGCCGGAGGTTCGGGA
GCGGCTCGGCATCAATGACGTGCTCCTGCGCCTTTCGGTGGGGATCGAGGATGCGGACGACCTTATCGCCGACCTGTCCC
GGGCATTCGCGTAA

Upstream 100 bases:

>100_bases
GACCGACAGGTTTCGGGAGATAAGGAAGAGCGTGACACCTCACGGTGAATCGAATCCTCTTCCGCACCCCGGAAGGGGAT
TTTTCATTGTGGAGGAAACC

Downstream 100 bases:

>100_bases
GAAATGGAGGACATCATGAAATTCGGCACCCGCATCATCCATACGGGCCGTGAGATCGATCCGACCACCGGAGCGCTCTC
GGTTCCCATTTACCAGACGT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MNIATQAAQIGLDWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYSRSGNPTRQALEEGIARLDGGARGFAYASGMAAIAN
LLLLFKSGDHLVVTEDLYGGTCRLFDQILVQYGLSFTYVDTSDPEAVRDAIRPETRALFVESLTNPLLKVADIAALSTLC
RERGLLCIVDNTFLTPYLLRPLDLGADITVYSGTKYLSGHNDTVSGLVVVKEPALAERVYFLQNSVGAVLGPQDAWLTIR
GMKTLSVRLDRQQENAGRIAEWLARHPRVPRVFYPGLPGHPGHELLARQARGFGAMIAFEVDDKALVERLLLKTELISFA
ESLGGVETLITFPQVQTHADIPPEVRERLGINDVLLRLSVGIEDADDLIADLSRAFA

Sequences:

>Translated_377_residues
MNIATQAAQIGLDWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYSRSGNPTRQALEEGIARLDGGARGFAYASGMAAIAN
LLLLFKSGDHLVVTEDLYGGTCRLFDQILVQYGLSFTYVDTSDPEAVRDAIRPETRALFVESLTNPLLKVADIAALSTLC
RERGLLCIVDNTFLTPYLLRPLDLGADITVYSGTKYLSGHNDTVSGLVVVKEPALAERVYFLQNSVGAVLGPQDAWLTIR
GMKTLSVRLDRQQENAGRIAEWLARHPRVPRVFYPGLPGHPGHELLARQARGFGAMIAFEVDDKALVERLLLKTELISFA
ESLGGVETLITFPQVQTHADIPPEVRERLGINDVLLRLSVGIEDADDLIADLSRAFA
>Mature_377_residues
MNIATQAAQIGLDWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYSRSGNPTRQALEEGIARLDGGARGFAYASGMAAIAN
LLLLFKSGDHLVVTEDLYGGTCRLFDQILVQYGLSFTYVDTSDPEAVRDAIRPETRALFVESLTNPLLKVADIAALSTLC
RERGLLCIVDNTFLTPYLLRPLDLGADITVYSGTKYLSGHNDTVSGLVVVKEPALAERVYFLQNSVGAVLGPQDAWLTIR
GMKTLSVRLDRQQENAGRIAEWLARHPRVPRVFYPGLPGHPGHELLARQARGFGAMIAFEVDDKALVERLLLKTELISFA
ESLGGVETLITFPQVQTHADIPPEVRERLGINDVLLRLSVGIEDADDLIADLSRAFA

Specific function: The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=365, Percent_Identity=44.9315068493151, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI299473759, Length=365, Percent_Identity=41.0958904109589, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI25453487, Length=364, Percent_Identity=40.6593406593407, Blast_Score=273, Evalue=2e-73,
Organism=Escherichia coli, GI1790375, Length=375, Percent_Identity=43.4666666666667, Blast_Score=314, Evalue=6e-87,
Organism=Escherichia coli, GI1789383, Length=343, Percent_Identity=34.1107871720117, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17560056, Length=369, Percent_Identity=40.3794037940379, Blast_Score=294, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17538055, Length=369, Percent_Identity=40.1084010840108, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=38.6920980926431, Blast_Score=262, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319307, Length=385, Percent_Identity=41.038961038961, Blast_Score=278, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6321254, Length=394, Percent_Identity=35.2791878172589, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6321170, Length=332, Percent_Identity=32.2289156626506, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6323333, Length=409, Percent_Identity=31.5403422982885, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=384, Percent_Identity=29.1666666666667, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922554, Length=378, Percent_Identity=42.8571428571429, Blast_Score=325, Evalue=4e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41166; Mature: 41166

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIATQAAQIGLDWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYSRSGNPTRQALEEGIA
CCCCCCHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RLDGGARGFAYASGMAAIANLLLLFKSGDHLVVTEDLYGGTCRLFDQILVQYGLSFTYVD
HCCCCCCCHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEC
TSDPEAVRDAIRPETRALFVESLTNPLLKVADIAALSTLCRERGLLCIVDNTFLTPYLLR
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHC
PLDLGADITVYSGTKYLSGHNDTVSGLVVVKEPALAERVYFLQNSVGAVLGPQDAWLTIR
HHCCCCCEEEECCCEEECCCCCCEEEEEEEECCHHHHHHHHHHHCCCCEECCCCCEEEEE
GMKTLSVRLDRQQENAGRIAEWLARHPRVPRVFYPGLPGHPGHELLARQARGFGAMIAFE
CCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEEE
VDDKALVERLLLKTELISFAESLGGVETLITFPQVQTHADIPPEVRERLGINDVLLRLSV
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHCCHHHEEHEEEC
GIEDADDLIADLSRAFA
CCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNIATQAAQIGLDWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYSRSGNPTRQALEEGIA
CCCCCCHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RLDGGARGFAYASGMAAIANLLLLFKSGDHLVVTEDLYGGTCRLFDQILVQYGLSFTYVD
HCCCCCCCHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEC
TSDPEAVRDAIRPETRALFVESLTNPLLKVADIAALSTLCRERGLLCIVDNTFLTPYLLR
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHC
PLDLGADITVYSGTKYLSGHNDTVSGLVVVKEPALAERVYFLQNSVGAVLGPQDAWLTIR
HHCCCCCEEEECCCEEECCCCCCEEEEEEEECCHHHHHHHHHHHCCCCEECCCCCEEEEE
GMKTLSVRLDRQQENAGRIAEWLARHPRVPRVFYPGLPGHPGHELLARQARGFGAMIAFE
CCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEEE
VDDKALVERLLLKTELISFAESLGGVETLITFPQVQTHADIPPEVRERLGINDVLLRLSV
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHCCHHHEEHEEEC
GIEDADDLIADLSRAFA
CCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]