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The map label for this gene is metC-2 [H]

Identifier: 39996048

GI number: 39996048

Start: 1015426

End: 1016562

Strand: Direct

Name: metC-2 [H]

Synonym: GSU0945

Alternate gene names: 39996048

Gene position: 1015426-1016562 (Clockwise)

Preceding gene: 39996047

Following gene: 39996049

Centisome position: 26.62

GC content: 65.79

Gene sequence:

>1137_bases
ATGAAATTCGGCACCCGCATCATCCATACGGGCCGTGAGATCGATCCGACCACCGGAGCGCTCTCGGTTCCCATTTACCA
GACGTCCACCTATCGGCAGGAATCGGTGGACCATTTCGGCAAGTACGATTACGCCCGCTCGGACAACCCCACCCGCGAGG
CCCTTGAGGAAACCGTGGCCCAGCTGGAGAACGGGACGCGGGGATTCGCCTTCGCCTCGGGCATGGCCGCCATCTCCTCC
ACGCTGCTCCTGTTCTCGCCCGGCGATCACCTGGTGGTCTGCGAGGATGTCTATGGCGGTACCTTCCGGGCGCTGACCCA
GCTTTTCAGCCGGCTGGGGGTCGAGTCCACCTTCGTGGACGCCACGGACACGGCCGCCATTGAGGCGGCCTTCCGCCCGA
ACACCAAGGGCCTCTATCTGGAGACCCCCTCCAATCCACTCATGAAGATCACCGACCTGGCCGCCGCGGCCCGCCTGGCC
CGGGAGAGGGGGGCCATCACCCTGGTGGACAACACGTTCATGACTCCCTACCTGCAGCGGCCCCTGGACCTGGGCTGCGA
CGTGGTGCTCCACAGCGGGACCAAGTTCCTGAACGGCCACAGCGATGTGGTCTGCGGCTTTGCCGTGGTGAGGGACCCGG
AGTTGGGGCAGCGGATCAGGTTCATCCAGAATGCCTTCGGCGCCATCCTGGGCCCCCAGGATTCATGGCTCGTGCTGCGG
GGTATCAAGACCCTGCGGGTCCGGATGGAGGAAAGCCAGGCCGGGGCGGTCAAAATTGCCAACTGGCTGGCTGGGGAAAA
ACGGGTGAGCCGGGTTTTCTATCCCGGACTCCCCGATCATCCGGGTCACGATATCCATGGCCGGCAGTCGTCGGGCCCCG
GCGCGGTCCTGTCGTTCACCCTGGATACCGTTGAAACCACCCGCCGCCTGCTGGAGGGGATGCGTCTGGCTGCCTTTGCC
GTGAGCCTCGGCGGGGTGGAAAGCATCATCTCCTATCCCGCCAGGATGTCCCACGCGGCCATGCCGCCGGCCGAGCGGGC
CGCCCGGGGGATCGGCGATACCCTGGTACGGCTTTCCGTGGGGCTTGAGGACGCCGACGACCTCCTGGCCGAGATGGACC
GCCTGATCAACGGCTGA

Upstream 100 bases:

>100_bases
CATCAATGACGTGCTCCTGCGCCTTTCGGTGGGGATCGAGGATGCGGACGACCTTATCGCCGACCTGTCCCGGGCATTCG
CGTAAGAAATGGAGGACATC

Downstream 100 bases:

>100_bases
CACGATGCATGGCCGATAATGAAACGCAATGAAAGGATTAGGGTTTTTGCTGAAGATCAGTTTTTGTTTACTTTTAGCTC
AACTCCCTGCGCATTTCGCC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKFGTRIIHTGREIDPTTGALSVPIYQTSTYRQESVDHFGKYDYARSDNPTREALEETVAQLENGTRGFAFASGMAAISS
TLLLFSPGDHLVVCEDVYGGTFRALTQLFSRLGVESTFVDATDTAAIEAAFRPNTKGLYLETPSNPLMKITDLAAAARLA
RERGAITLVDNTFMTPYLQRPLDLGCDVVLHSGTKFLNGHSDVVCGFAVVRDPELGQRIRFIQNAFGAILGPQDSWLVLR
GIKTLRVRMEESQAGAVKIANWLAGEKRVSRVFYPGLPDHPGHDIHGRQSSGPGAVLSFTLDTVETTRRLLEGMRLAAFA
VSLGGVESIISYPARMSHAAMPPAERAARGIGDTLVRLSVGLEDADDLLAEMDRLING

Sequences:

>Translated_378_residues
MKFGTRIIHTGREIDPTTGALSVPIYQTSTYRQESVDHFGKYDYARSDNPTREALEETVAQLENGTRGFAFASGMAAISS
TLLLFSPGDHLVVCEDVYGGTFRALTQLFSRLGVESTFVDATDTAAIEAAFRPNTKGLYLETPSNPLMKITDLAAAARLA
RERGAITLVDNTFMTPYLQRPLDLGCDVVLHSGTKFLNGHSDVVCGFAVVRDPELGQRIRFIQNAFGAILGPQDSWLVLR
GIKTLRVRMEESQAGAVKIANWLAGEKRVSRVFYPGLPDHPGHDIHGRQSSGPGAVLSFTLDTVETTRRLLEGMRLAAFA
VSLGGVESIISYPARMSHAAMPPAERAARGIGDTLVRLSVGLEDADDLLAEMDRLING
>Mature_378_residues
MKFGTRIIHTGREIDPTTGALSVPIYQTSTYRQESVDHFGKYDYARSDNPTREALEETVAQLENGTRGFAFASGMAAISS
TLLLFSPGDHLVVCEDVYGGTFRALTQLFSRLGVESTFVDATDTAAIEAAFRPNTKGLYLETPSNPLMKITDLAAAARLA
RERGAITLVDNTFMTPYLQRPLDLGCDVVLHSGTKFLNGHSDVVCGFAVVRDPELGQRIRFIQNAFGAILGPQDSWLVLR
GIKTLRVRMEESQAGAVKIANWLAGEKRVSRVFYPGLPDHPGHDIHGRQSSGPGAVLSFTLDTVETTRRLLEGMRLAAFA
VSLGGVESIISYPARMSHAAMPPAERAARGIGDTLVRLSVGLEDADDLLAEMDRLING

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=364, Percent_Identity=42.3076923076923, Blast_Score=301, Evalue=9e-82,
Organism=Homo sapiens, GI299473759, Length=364, Percent_Identity=38.7362637362637, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI25453487, Length=361, Percent_Identity=36.2880886426593, Blast_Score=235, Evalue=4e-62,
Organism=Escherichia coli, GI1790375, Length=374, Percent_Identity=43.5828877005348, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1789383, Length=391, Percent_Identity=31.7135549872123, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17560056, Length=366, Percent_Identity=42.6229508196721, Blast_Score=315, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI17538055, Length=366, Percent_Identity=41.8032786885246, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI71980708, Length=362, Percent_Identity=36.4640883977901, Blast_Score=251, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6319307, Length=382, Percent_Identity=41.8848167539267, Blast_Score=301, Evalue=9e-83,
Organism=Saccharomyces cerevisiae, GI6321254, Length=401, Percent_Identity=34.1645885286783, Blast_Score=224, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6321170, Length=334, Percent_Identity=31.437125748503, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6323333, Length=429, Percent_Identity=30.3030303030303, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321904, Length=390, Percent_Identity=26.1538461538462, Blast_Score=136, Evalue=7e-33,
Organism=Drosophila melanogaster, GI19922554, Length=376, Percent_Identity=42.0212765957447, Blast_Score=315, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41042; Mature: 41042

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGTRIIHTGREIDPTTGALSVPIYQTSTYRQESVDHFGKYDYARSDNPTREALEETVA
CCCCCEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
QLENGTRGFAFASGMAAISSTLLLFSPGDHLVVCEDVYGGTFRALTQLFSRLGVESTFVD
HHHCCCCCHHHHHHHHHHHCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEC
ATDTAAIEAAFRPNTKGLYLETPSNPLMKITDLAAAARLARERGAITLVDNTFMTPYLQR
CCCCHHEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHCC
PLDLGCDVVLHSGTKFLNGHSDVVCGFAVVRDPELGQRIRFIQNAFGAILGPQDSWLVLR
CHHCCCEEEEECCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEC
GIKTLRVRMEESQAGAVKIANWLAGEKRVSRVFYPGLPDHPGHDIHGRQSSGPGAVLSFT
CHHHHHEEECCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCEEEEEE
LDTVETTRRLLEGMRLAAFAVSLGGVESIISYPARMSHAAMPPAERAARGIGDTLVRLSV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHCCCCCHHHHHHCCCHHHEEEEC
GLEDADDLLAEMDRLING
CCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFGTRIIHTGREIDPTTGALSVPIYQTSTYRQESVDHFGKYDYARSDNPTREALEETVA
CCCCCEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
QLENGTRGFAFASGMAAISSTLLLFSPGDHLVVCEDVYGGTFRALTQLFSRLGVESTFVD
HHHCCCCCHHHHHHHHHHHCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEC
ATDTAAIEAAFRPNTKGLYLETPSNPLMKITDLAAAARLARERGAITLVDNTFMTPYLQR
CCCCHHEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHCC
PLDLGCDVVLHSGTKFLNGHSDVVCGFAVVRDPELGQRIRFIQNAFGAILGPQDSWLVLR
CHHCCCEEEEECCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEC
GIKTLRVRMEESQAGAVKIANWLAGEKRVSRVFYPGLPDHPGHDIHGRQSSGPGAVLSFT
CHHHHHEEECCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCEEEEEE
LDTVETTRRLLEGMRLAAFAVSLGGVESIISYPARMSHAAMPPAERAARGIGDTLVRLSV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHCCCCCHHHHHHCCCHHHEEEEC
GLEDADDLLAEMDRLING
CCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]