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The map label for this gene is yitJ [H]

Identifier: 39995966

GI number: 39995966

Start: 919385

End: 920290

Strand: Reverse

Name: yitJ [H]

Synonym: GSU0860

Alternate gene names: 39995966

Gene position: 920290-919385 (Counterclockwise)

Preceding gene: 308513290

Following gene: 39995965

Centisome position: 24.13

GC content: 66.23

Gene sequence:

>906_bases
ATGACCGGTACGCCGTCATCACTCAGCGCCGCCCTCGCCGCAGGCCACTTCGTCGTCACAACGGAGATCTGCCCGCCCAA
GGGGAGCAATTGTACCGAATTCCTCCGCAAGGCCCGGGCCCTGCGCCAGGCCGTCGATGCCGTGAACGTCACCGACAACC
AGGGGGCCAACATGCGGATTTCCCCCCTGGCGCCGGCGGCGCTGCTGGTACGGGAAGGGATCGAGCCCATCCTTCAGCTC
ACCTGTCGCGACCGCAACCGGATGGCGCTCCAGAGCGAACTGCTGGCCGCCTCTGCCCTGGGGATCACCAACGTGCTGGC
GCTCACCGGCGACTTCATCACCTTCGGCGATCACCGGGAGGCCAAGCCGGTGTTCGACCTGGACTCGGTTCAGCTCCTGC
GGATCATTACCGGGCTCAATGAAGGACGGGACCTCTCGAGGACGGCCCTGACCGGCGCCACTTCGTTCTTTGCCGGAGCC
GCGGCGGCCCCCGAAGCGGAGCCTTTTGCACTCACCCTCTCCAAGCTGGCGAAGAAAGCTGCTGCCGGAGCCCGATTCCT
CCAGACCCAGGCAGTCTTCTCGCCGGAGCGGTTCGCCCGGTTCGCCGATGCGACGCGCCCTCTAGGCATGAAAATCATCG
CAGGCATCCTGTTGCTGAAGTCGCCCGGCATGGCCCGTTACGTGACCGAACGGGTGCCGGGCCTCAAGGTCCCCCCCGAA
CTTGTTGCGGAGCTAGAGAGTGCCAGTGATCCGCTGGCCGCCGGCGTCGAGATAGCCCGGCGGACCGTGGCGGCGGTCAG
ACCCTTCTGCGACGGAGTCCACATCATGGCCATGGGGCGGGAGGACCTGGTCCCCGCCATCGTTGCCGGTGTGGAACGGG
ACAGTCAGGAACACACTACGATCTGA

Upstream 100 bases:

>100_bases
CCCGCCTCCACGGTCAGGTGGAAACGGGTCCCCTGGCCGAAACCACTCCCCCTGCCGACTTCTCCACCTGCCGCCGGCCG
GCGGACCTGAAACTCGACAA

Downstream 100 bases:

>100_bases
AAGGAGTCGGATCATGCAGGTAAAAAAAGCGGTATTCCCGGTGGCGGGACTCGGTACCCGGTTTCTTCCGGCAACCAAAT
CATCTCCCAAGGAGATGCTC

Product: methylenetetrahydrofolate reductase

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTGTPSSLSAALAAGHFVVTTEICPPKGSNCTEFLRKARALRQAVDAVNVTDNQGANMRISPLAPAALLVREGIEPILQL
TCRDRNRMALQSELLAASALGITNVLALTGDFITFGDHREAKPVFDLDSVQLLRIITGLNEGRDLSRTALTGATSFFAGA
AAAPEAEPFALTLSKLAKKAAAGARFLQTQAVFSPERFARFADATRPLGMKIIAGILLLKSPGMARYVTERVPGLKVPPE
LVAELESASDPLAAGVEIARRTVAAVRPFCDGVHIMAMGREDLVPAIVAGVERDSQEHTTI

Sequences:

>Translated_301_residues
MTGTPSSLSAALAAGHFVVTTEICPPKGSNCTEFLRKARALRQAVDAVNVTDNQGANMRISPLAPAALLVREGIEPILQL
TCRDRNRMALQSELLAASALGITNVLALTGDFITFGDHREAKPVFDLDSVQLLRIITGLNEGRDLSRTALTGATSFFAGA
AAAPEAEPFALTLSKLAKKAAAGARFLQTQAVFSPERFARFADATRPLGMKIIAGILLLKSPGMARYVTERVPGLKVPPE
LVAELESASDPLAAGVEIARRTVAAVRPFCDGVHIMAMGREDLVPAIVAGVERDSQEHTTI
>Mature_300_residues
TGTPSSLSAALAAGHFVVTTEICPPKGSNCTEFLRKARALRQAVDAVNVTDNQGANMRISPLAPAALLVREGIEPILQLT
CRDRNRMALQSELLAASALGITNVLALTGDFITFGDHREAKPVFDLDSVQLLRIITGLNEGRDLSRTALTGATSFFAGAA
AAPEAEPFALTLSKLAKKAAAGARFLQTQAVFSPERFARFADATRPLGMKIIAGILLLKSPGMARYVTERVPGLKVPPEL
VAELESASDPLAAGVEIARRTVAAVRPFCDGVHIMAMGREDLVPAIVAGVERDSQEHTTI

Specific function: Unknown

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 31865; Mature: 31734

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTPSSLSAALAAGHFVVTTEICPPKGSNCTEFLRKARALRQAVDAVNVTDNQGANMRI
CCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
SPLAPAALLVREGIEPILQLTCRDRNRMALQSELLAASALGITNVLALTGDFITFGDHRE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
AKPVFDLDSVQLLRIITGLNEGRDLSRTALTGATSFFAGAAAAPEAEPFALTLSKLAKKA
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AAGARFLQTQAVFSPERFARFADATRPLGMKIIAGILLLKSPGMARYVTERVPGLKVPPE
HHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHH
LVAELESASDPLAAGVEIARRTVAAVRPFCDGVHIMAMGREDLVPAIVAGVERDSQEHTT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHCCCCCCCCCC
I
C
>Mature Secondary Structure 
TGTPSSLSAALAAGHFVVTTEICPPKGSNCTEFLRKARALRQAVDAVNVTDNQGANMRI
CCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
SPLAPAALLVREGIEPILQLTCRDRNRMALQSELLAASALGITNVLALTGDFITFGDHRE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
AKPVFDLDSVQLLRIITGLNEGRDLSRTALTGATSFFAGAAAAPEAEPFALTLSKLAKKA
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AAGARFLQTQAVFSPERFARFADATRPLGMKIIAGILLLKSPGMARYVTERVPGLKVPPE
HHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHH
LVAELESASDPLAAGVEIARRTVAAVRPFCDGVHIMAMGREDLVPAIVAGVERDSQEHTT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHCCCCCCCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]