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The map label for this gene is lpdA [C]

Identifier: 39995949

GI number: 39995949

Start: 901546

End: 902880

Strand: Reverse

Name: lpdA [C]

Synonym: GSU0843

Alternate gene names: 39995949

Gene position: 902880-901546 (Counterclockwise)

Preceding gene: 39995950

Following gene: 39995948

Centisome position: 23.67

GC content: 62.85

Gene sequence:

>1335_bases
ATGAAAACGGTAATTATTGGCGGAGTAGCCGGCGGGTTGTCCGCCGCCAGCCAGATCAAGCGCGCGGACCGGGATGCAGA
GGTGATTGTCCTGGAAAAGTCCGGCGATCCTTCCTACGCCGCGTGCGGCATGCCCTATAACCTCTTCTTCAAGGATACGC
CGGTGGAAGCGCTCTATGCCCTGAGCCTCGACACGATCCGGAACGGACGTGGCATCGACTACCGGCTCCGCCATGAAGCT
GTCGCCATCGACCCCCGGCGGCAGGAGGTTACGGTTGTCGACCATGAGCAGAACCGGGAGTACCGCGAACGCTACGACTT
CCTGGTCTATGCCACGGGCAACCGGCCCGCCCCCCTTCCCTTGCCCGGATTCGATGATCCGGCGGTCTGCTACTTCAAGA
CCCTGGACGACACGAGGCGGGTCAAACGTCTGATCCATGACCAGGCACCAGCCTGTGCGATTCTGGTGGGGGCCGGGTAT
ACCAATCTGGAGGTGGCCGACGTCCTCTACAACATGAAGATCCGGCCGGTTATCGTGGAAAAGGCCCCGGCGATCCTCCC
CGCCTTTGCAGCGGAGATCCGGGATAAGGTGATGGAGAAGATTGCTGAAAAGGGGATCGAATTCCACGCCGGCGTGGACG
TCCAGGGGAAGGAAGGCGCCACGGTACGGACCACTGCAGGCGATTTCGACGCCGGCCTCGTGGTCGTTGCCATCGGCGTG
AAGCCGAACACCGGCCTCTTCGCCGCGGCCGGGGGCGAGCTCGGGGCGGCCGGGGCCGTCAAAGTCGACCAGTTCCTGCA
GACGAACCTCCCCGGCGTCTTTGCCGCCGGGGACTGCGCAGAGCACTATGTCCGCCAACTGGGGAGAAACAGCTACATGC
CGCTCGGCCCCGTGGCCAATAAACAGGGGCGTCTTGCGGGCAACAACATCGCTCACCGCGATGCCATGACGATGTTTCAC
GGCATCGATCAGACCGCGGCGTTCAAGTTTTTCGACCTGACGATTGCCACGACCGGCCTCAACGAACGACAGCTTCGGGA
GATGGGGACAGATTTCGGGAAAATCCACGTGGACACACCGACAAGGGGATCATTCCCCGGAGGAGGCACCATGCGGACCG
TGCTTCTGTTCGAGAAGGGAACCGGCCTGCTCCTCGGCGGCCAGATGGTGGGACAGGACGTGGTGGCGAAACGGCTCGAC
GTCCTTGCCGTCGCCGTGTACAAGCAGATGACCGTTTTCGAGCTGGCGGAGCTCGATCTGAGCTACGCGCCCCCCTACGC
ACCGGTGTGGGATCCTCTCCTCATTGCGGCGAACCAGGCGGTCAAGGCCGTGTGA

Upstream 100 bases:

>100_bases
CATGGGGATAGTGATGGTTTTGGTTCTGCCGCTTTTTTTCCCGTTTTGAGACGGCTGGAGAAAGCCGGACAAATCAGCTC
AACCCCGTGGAGGTGATCAG

Downstream 100 bases:

>100_bases
CCTGATGCCTGTCCTGTTCGGCAAGAATTTTCCTGCCACGCAGGAGGCTCCCTTGGTGGCAGGAACACAATTCCGGACAG
ACACAACGTAGCGAAATGCA

Product: NADH oxidase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MKTVIIGGVAGGLSAASQIKRADRDAEVIVLEKSGDPSYAACGMPYNLFFKDTPVEALYALSLDTIRNGRGIDYRLRHEA
VAIDPRRQEVTVVDHEQNREYRERYDFLVYATGNRPAPLPLPGFDDPAVCYFKTLDDTRRVKRLIHDQAPACAILVGAGY
TNLEVADVLYNMKIRPVIVEKAPAILPAFAAEIRDKVMEKIAEKGIEFHAGVDVQGKEGATVRTTAGDFDAGLVVVAIGV
KPNTGLFAAAGGELGAAGAVKVDQFLQTNLPGVFAAGDCAEHYVRQLGRNSYMPLGPVANKQGRLAGNNIAHRDAMTMFH
GIDQTAAFKFFDLTIATTGLNERQLREMGTDFGKIHVDTPTRGSFPGGGTMRTVLLFEKGTGLLLGGQMVGQDVVAKRLD
VLAVAVYKQMTVFELAELDLSYAPPYAPVWDPLLIAANQAVKAV

Sequences:

>Translated_444_residues
MKTVIIGGVAGGLSAASQIKRADRDAEVIVLEKSGDPSYAACGMPYNLFFKDTPVEALYALSLDTIRNGRGIDYRLRHEA
VAIDPRRQEVTVVDHEQNREYRERYDFLVYATGNRPAPLPLPGFDDPAVCYFKTLDDTRRVKRLIHDQAPACAILVGAGY
TNLEVADVLYNMKIRPVIVEKAPAILPAFAAEIRDKVMEKIAEKGIEFHAGVDVQGKEGATVRTTAGDFDAGLVVVAIGV
KPNTGLFAAAGGELGAAGAVKVDQFLQTNLPGVFAAGDCAEHYVRQLGRNSYMPLGPVANKQGRLAGNNIAHRDAMTMFH
GIDQTAAFKFFDLTIATTGLNERQLREMGTDFGKIHVDTPTRGSFPGGGTMRTVLLFEKGTGLLLGGQMVGQDVVAKRLD
VLAVAVYKQMTVFELAELDLSYAPPYAPVWDPLLIAANQAVKAV
>Mature_444_residues
MKTVIIGGVAGGLSAASQIKRADRDAEVIVLEKSGDPSYAACGMPYNLFFKDTPVEALYALSLDTIRNGRGIDYRLRHEA
VAIDPRRQEVTVVDHEQNREYRERYDFLVYATGNRPAPLPLPGFDDPAVCYFKTLDDTRRVKRLIHDQAPACAILVGAGY
TNLEVADVLYNMKIRPVIVEKAPAILPAFAAEIRDKVMEKIAEKGIEFHAGVDVQGKEGATVRTTAGDFDAGLVVVAIGV
KPNTGLFAAAGGELGAAGAVKVDQFLQTNLPGVFAAGDCAEHYVRQLGRNSYMPLGPVANKQGRLAGNNIAHRDAMTMFH
GIDQTAAFKFFDLTIATTGLNERQLREMGTDFGKIHVDTPTRGSFPGGGTMRTVLLFEKGTGLLLGGQMVGQDVVAKRLD
VLAVAVYKQMTVFELAELDLSYAPPYAPVWDPLLIAANQAVKAV

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=320, Percent_Identity=27.1875, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI65787454, Length=320, Percent_Identity=27.1875, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI21389617, Length=320, Percent_Identity=27.1875, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1786307, Length=321, Percent_Identity=24.6105919003115, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=222, Percent_Identity=26.1261261261261, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47968; Mature: 47968

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVIIGGVAGGLSAASQIKRADRDAEVIVLEKSGDPSYAACGMPYNLFFKDTPVEALYA
CCEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCEEEEEECCCHHHHEE
LSLDTIRNGRGIDYRLRHEAVAIDPRRQEVTVVDHEQNREYRERYDFLVYATGNRPAPLP
EEHHHHCCCCCCCEEEECCEEEECCCCCEEEEEECCCCHHHHHHCCEEEEECCCCCCCCC
LPGFDDPAVCYFKTLDDTRRVKRLIHDQAPACAILVGAGYTNLEVADVLYNMKIRPVIVE
CCCCCCCCEEEEEECHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCEEEEEEEC
KAPAILPAFAAEIRDKVMEKIAEKGIEFHAGVDVQGKEGATVRTTAGDFDAGLVVVAIGV
CCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEEEECCCCCCCEEEEEEEC
KPNTGLFAAAGGELGAAGAVKVDQFLQTNLPGVFAAGDCAEHYVRQLGRNSYMPLGPVAN
CCCCCEEEECCCCCCCCCCHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCC
KQGRLAGNNIAHRDAMTMFHGIDQTAAFKFFDLTIATTGLNERQLREMGTDFGKIHVDTP
CCCCCCCCCCHHHHHHHHHHCCCCHHEEEEEEEEEEECCCCHHHHHHHCCCCCEEEECCC
TRGSFPGGGTMRTVLLFEKGTGLLLGGQMVGQDVVAKRLDVLAVAVYKQMTVFELAELDL
CCCCCCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SYAPPYAPVWDPLLIAANQAVKAV
CCCCCCCCCCCHHHHCCCHHHHCC
>Mature Secondary Structure
MKTVIIGGVAGGLSAASQIKRADRDAEVIVLEKSGDPSYAACGMPYNLFFKDTPVEALYA
CCEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCEEEEEECCCHHHHEE
LSLDTIRNGRGIDYRLRHEAVAIDPRRQEVTVVDHEQNREYRERYDFLVYATGNRPAPLP
EEHHHHCCCCCCCEEEECCEEEECCCCCEEEEEECCCCHHHHHHCCEEEEECCCCCCCCC
LPGFDDPAVCYFKTLDDTRRVKRLIHDQAPACAILVGAGYTNLEVADVLYNMKIRPVIVE
CCCCCCCCEEEEEECHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCEEEEEEEC
KAPAILPAFAAEIRDKVMEKIAEKGIEFHAGVDVQGKEGATVRTTAGDFDAGLVVVAIGV
CCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEEEECCCCCCCEEEEEEEC
KPNTGLFAAAGGELGAAGAVKVDQFLQTNLPGVFAAGDCAEHYVRQLGRNSYMPLGPVAN
CCCCCEEEECCCCCCCCCCHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCC
KQGRLAGNNIAHRDAMTMFHGIDQTAAFKFFDLTIATTGLNERQLREMGTDFGKIHVDTP
CCCCCCCCCCHHHHHHHHHHCCCCHHEEEEEEEEEEECCCCHHHHHHHCCCCCEEEECCC
TRGSFPGGGTMRTVLLFEKGTGLLLGGQMVGQDVVAKRLDVLAVAVYKQMTVFELAELDL
CCCCCCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SYAPPYAPVWDPLLIAANQAVKAV
CCCCCCCCCCCHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]