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The map label for this gene is atoC [H]

Identifier: 39995947

GI number: 39995947

Start: 897564

End: 898964

Strand: Reverse

Name: atoC [H]

Synonym: GSU0841

Alternate gene names: 39995947

Gene position: 898964-897564 (Counterclockwise)

Preceding gene: 39995948

Following gene: 39995946

Centisome position: 23.57

GC content: 61.53

Gene sequence:

>1401_bases
ATGGCTGCAATCCTTATTATCGACGATGACGACTCCATGCGCTCTTCCCTGTGGCACATGGTAAAGCGGATGGGGCACCA
GGTGGACAGCGCCCCGACCCTCAGGGAAGGTCTTGAAAAAGCCTCGACTGGAGCATTTGACGTGGTCCTGCTCGATGTGA
GCATGCCGGATGGGAACGGCCTCGACATTCTGCCGGATATCCAGCGGACCCCGGCCGAACCGGAGGTGATCATCATCACC
GGCTACGGCAACCCGGACTCAGCCGAACTGGCCATCAGGAGCGGAGCCTGGGACTACATAGAAAAGGGGACCTCGCTCAA
GGCGATGACCCTGCATCTCGTACGAGCACTCCAATACCGGCAGGAGAAAATTGCCAGCCGCGGTGCGAGCGTCACCGCCC
TCAAGCGTCACGATATCGTCGGCAACAGCCACAAGATCAGGGACTGCCTGGACCTGGTGGCCCAGGCGGCCGCCGGCGAC
ACCTCTGTGATGATTACCGGAGAAACCGGCACAGGTAAGGAACTCTTTGCCCGGGCCATCCACAGCAACAGCCGCCGGGC
CGAAGGCAACTTCGTGGTGGTTGACTGTGCCGCACTGCCGGAAACCCTGGTGGAAAGCCTCTTGTTCGGTCACGAAAAAG
GGACTTTTACGGGCGCGGAAAAAGCCCGGGAAGGGCTCATCCAGCAGGCGCACGGTGGTTCGCTCTTTCTGGACGAGGTC
GGCGAGCTGCCCCTTTCGGTCCAGAAGGCGTTCCTGCGGGTCCTCCAGGAACGCCGGTTCCGTCCCCTTGGCAGTCAGCG
CGAGCAGGTGAGCGATTTTCGTCTCATCTCCGCGACCAACCGGGATCTCGACCAGATGGTGCGCGATGGCGGTTTCCGTG
ACGACCTGCTGTTCCGGCTCCGTGCGTTCGCCATCGAGCTTCCGCCACTTCGGGAGCGCCCGGAGGACATCAAGGAGTTG
GCGCGTCACCATGTGGACAGACTCTGCGAACGCTATGGATTAGCGCCGAAAGGGTTTGCGCCGGAATTCCTAGACACCCT
GGCCCAGCACTCGTGGCCCGGCAACGTGCGTGAACTGGTCAATACGCTGGAGCGGGCACTCGCATCAGCACGCCTGGAAC
CGACCCTCTTCCCCCAGCACCTGCCCCTCGACATCCGCATACAGATCGCGCGGGCAGCAGTGGAGCAACCAGAGCCCGGT
GCAGCGCCCCAGCGGATCACCCAATCGCTGCCCCGGCTCCAGGACTTTCGCGAAACGGTATTCGCCCAGGCCGAAAAACA
ATACCTGCGCGACTTGCTCTCCCTCACCGACAATGATCTCAAGGAAGCGTGCCGCATTGCCGGACTTTCACTCTCCCGCT
TGTATGCCCTTCTCAGTAAGCACGGAATTAAACCGGCATAG

Upstream 100 bases:

>100_bases
CCGTTCGGCAGGCATTGCCGACGTCCTGCGGAAGCCGGTTGACAGAGACGAAATGGCCCGGGCTGTTCGACGGATATTGG
ACAGGAGAGTATAAGAAACC

Downstream 100 bases:

>100_bases
ACCACCCTGCGGTTCCAGTCGTACGGAGCATTCCTGTACGACTGGAACCATTCCCGCCTGACAGGAAAATTCTCTGCCTC
CCCCGAGGCTCCCGCCAGCA

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MAAILIIDDDDSMRSSLWHMVKRMGHQVDSAPTLREGLEKASTGAFDVVLLDVSMPDGNGLDILPDIQRTPAEPEVIIIT
GYGNPDSAELAIRSGAWDYIEKGTSLKAMTLHLVRALQYRQEKIASRGASVTALKRHDIVGNSHKIRDCLDLVAQAAAGD
TSVMITGETGTGKELFARAIHSNSRRAEGNFVVVDCAALPETLVESLLFGHEKGTFTGAEKAREGLIQQAHGGSLFLDEV
GELPLSVQKAFLRVLQERRFRPLGSQREQVSDFRLISATNRDLDQMVRDGGFRDDLLFRLRAFAIELPPLRERPEDIKEL
ARHHVDRLCERYGLAPKGFAPEFLDTLAQHSWPGNVRELVNTLERALASARLEPTLFPQHLPLDIRIQIARAAVEQPEPG
AAPQRITQSLPRLQDFRETVFAQAEKQYLRDLLSLTDNDLKEACRIAGLSLSRLYALLSKHGIKPA

Sequences:

>Translated_466_residues
MAAILIIDDDDSMRSSLWHMVKRMGHQVDSAPTLREGLEKASTGAFDVVLLDVSMPDGNGLDILPDIQRTPAEPEVIIIT
GYGNPDSAELAIRSGAWDYIEKGTSLKAMTLHLVRALQYRQEKIASRGASVTALKRHDIVGNSHKIRDCLDLVAQAAAGD
TSVMITGETGTGKELFARAIHSNSRRAEGNFVVVDCAALPETLVESLLFGHEKGTFTGAEKAREGLIQQAHGGSLFLDEV
GELPLSVQKAFLRVLQERRFRPLGSQREQVSDFRLISATNRDLDQMVRDGGFRDDLLFRLRAFAIELPPLRERPEDIKEL
ARHHVDRLCERYGLAPKGFAPEFLDTLAQHSWPGNVRELVNTLERALASARLEPTLFPQHLPLDIRIQIARAAVEQPEPG
AAPQRITQSLPRLQDFRETVFAQAEKQYLRDLLSLTDNDLKEACRIAGLSLSRLYALLSKHGIKPA
>Mature_465_residues
AAILIIDDDDSMRSSLWHMVKRMGHQVDSAPTLREGLEKASTGAFDVVLLDVSMPDGNGLDILPDIQRTPAEPEVIIITG
YGNPDSAELAIRSGAWDYIEKGTSLKAMTLHLVRALQYRQEKIASRGASVTALKRHDIVGNSHKIRDCLDLVAQAAAGDT
SVMITGETGTGKELFARAIHSNSRRAEGNFVVVDCAALPETLVESLLFGHEKGTFTGAEKAREGLIQQAHGGSLFLDEVG
ELPLSVQKAFLRVLQERRFRPLGSQREQVSDFRLISATNRDLDQMVRDGGFRDDLLFRLRAFAIELPPLRERPEDIKELA
RHHVDRLCERYGLAPKGFAPEFLDTLAQHSWPGNVRELVNTLERALASARLEPTLFPQHLPLDIRIQIARAAVEQPEPGA
APQRITQSLPRLQDFRETVFAQAEKQYLRDLLSLTDNDLKEACRIAGLSLSRLYALLSKHGIKPA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=466, Percent_Identity=38.412017167382, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1790437, Length=458, Percent_Identity=39.7379912663755, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1788905, Length=460, Percent_Identity=36.9565217391304, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=35.7601713062098, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI1789087, Length=234, Percent_Identity=51.2820512820513, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082117, Length=234, Percent_Identity=50, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1789233, Length=328, Percent_Identity=38.109756097561, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI87081872, Length=330, Percent_Identity=39.0909090909091, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI87082152, Length=337, Percent_Identity=37.6854599406528, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI1786524, Length=290, Percent_Identity=38.6206896551724, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1787583, Length=230, Percent_Identity=39.5652173913043, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789828, Length=260, Percent_Identity=38.4615384615385, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87081858, Length=317, Percent_Identity=29.9684542586751, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51677; Mature: 51545

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAILIIDDDDSMRSSLWHMVKRMGHQVDSAPTLREGLEKASTGAFDVVLLDVSMPDGNG
CEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCC
LDILPDIQRTPAEPEVIIITGYGNPDSAELAIRSGAWDYIEKGTSLKAMTLHLVRALQYR
CCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCHHHHHCCCCHHHHHHHHHHHHHHH
QEKIASRGASVTALKRHDIVGNSHKIRDCLDLVAQAAAGDTSVMITGETGTGKELFARAI
HHHHHHCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
HSNSRRAEGNFVVVDCAALPETLVESLLFGHEKGTFTGAEKAREGLIQQAHGGSLFLDEV
HCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEHHHH
GELPLSVQKAFLRVLQERRFRPLGSQREQVSDFRLISATNRDLDQMVRDGGFRDDLLFRL
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHH
RAFAIELPPLRERPEDIKELARHHVDRLCERYGLAPKGFAPEFLDTLAQHSWPGNVRELV
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHH
NTLERALASARLEPTLFPQHLPLDIRIQIARAAVEQPEPGAAPQRITQSLPRLQDFRETV
HHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
FAQAEKQYLRDLLSLTDNDLKEACRIAGLSLSRLYALLSKHGIKPA
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AAILIIDDDDSMRSSLWHMVKRMGHQVDSAPTLREGLEKASTGAFDVVLLDVSMPDGNG
EEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCC
LDILPDIQRTPAEPEVIIITGYGNPDSAELAIRSGAWDYIEKGTSLKAMTLHLVRALQYR
CCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCHHHHHCCCCHHHHHHHHHHHHHHH
QEKIASRGASVTALKRHDIVGNSHKIRDCLDLVAQAAAGDTSVMITGETGTGKELFARAI
HHHHHHCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
HSNSRRAEGNFVVVDCAALPETLVESLLFGHEKGTFTGAEKAREGLIQQAHGGSLFLDEV
HCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEHHHH
GELPLSVQKAFLRVLQERRFRPLGSQREQVSDFRLISATNRDLDQMVRDGGFRDDLLFRL
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHH
RAFAIELPPLRERPEDIKELARHHVDRLCERYGLAPKGFAPEFLDTLAQHSWPGNVRELV
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHH
NTLERALASARLEPTLFPQHLPLDIRIQIARAAVEQPEPGAAPQRITQSLPRLQDFRETV
HHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
FAQAEKQYLRDLLSLTDNDLKEACRIAGLSLSRLYALLSKHGIKPA
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]