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The map label for this gene is alr

Identifier: 39995713

GI number: 39995713

Start: 641051

End: 642199

Strand: Direct

Name: alr

Synonym: GSU0606

Alternate gene names: 39995713

Gene position: 641051-642199 (Clockwise)

Preceding gene: 39995709

Following gene: 39995714

Centisome position: 16.81

GC content: 65.36

Gene sequence:

>1149_bases
ATGGACAGCCGGCCCACCATTGCTGAAGTCGATCTCGCCGCCCTCCGCCACAACTACGACCTTGTCGTCCGTACGATTCC
CCGGGGGTGCGGAATCCTGGCGGTAGTCAAGGCCGACGCCTACGGCCACGGTTTCATGGATATCGCCCGCGAGTTGGAGA
CACTGGGAGTGACTGCCTTCGGCGTTGCCTTTCTGGCCGAGGGAATTCAACTGCGCAAGAGCGGAATCGATCGTCCCGTC
CTGATCCTGGGAGGGGTTTATCCCGGCCAGGAACGCAAGTGTGTCGGGTTCAATCTGTCCACGGCCCTGTTCAGCCTGGA
GCAGGCGCGGGTTCTGGACGATGCGGCCGGTCGCCTGTATCGCCGGGCCAGGGTCCATGCGAAGATCGATACCGGCATGG
GGCGCCTCGGCATCCCCCACGAGGAGGCGTCGGCCTTTTTTAGCGCCCTGCGGGAGTTGAAGCACCTGGACCTGGAGGGG
ATCATCTCCCACTTCGCCTCCGCCGACGAACTCGACGAGGATGGCCGGCGCTACTCCGATCTCCAGGCGAGCCGGTTTGC
CGCGGCGGTCGCGGCGGCCCGCCACGAGGGGTTCGAGCCTCGCTATGTCCATATCGCCAACAGCGCGGCCGCCTTCGGGA
TGGACCTGCCGTTCTGCAACCTCGTCCGGCCCGGCATCGTCCTCTACGGCGCGCTCCCTTCCGGCGACTTCGAGGGGAAG
ATGGCGCTCAAGCCCATCATGCGCCTGCGCAGTTCCATCGCCATGCTCAAATGGGTGGAACCGGGCACAAGCATCAGCTA
CGCCCGCCGCTTCACCGCTCCCGACCGGCGACTCGTGGCCAGTATTCCGGTTGGCTACGCAGACGGCTACAGCCGTTCTC
TCACCAACCGTGGGGAGGTTGTCGTGCGCGGCCGGCGCGCTCCGGTCGTGGGCACCGTCTGCATGGACTGGATCATGGCC
GACGTGACCCACGTCTCCGGCGTGACCGTTGGCGACGAGGTGACGCTTCTGGGGTGCGACCAGGAGGGAAACTGCGTCCG
TGCCGAAGAACTTGCCGAGTGGGCCGGTACCATCCCCTACGAAATTTTCTGCGGCATCAGCAAGCGGGTGCCGCGCGTCT
ACCTCAACCCGTCGATCAGGCACAGGTGA

Upstream 100 bases:

>100_bases
AATCCCCCACAAGTCAACGGAATTAACATGGATTTGCCGGGCGGGAAGGCGCAGGTTTTCATCCTTTACAGGCGGGGTGA
GAAGTGGTACCTAAAGGGGC

Downstream 100 bases:

>100_bases
GAGAAGGGAAACTCCGATGACCGAAGGCATCAAGCTGACATCGCTCGTCAAAGCAGCCGGCTGAGCGGCCAAGCTGGGCC
CGGCGGGCCTGGAACAAGCG

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDSRPTIAEVDLAALRHNYDLVVRTIPRGCGILAVVKADAYGHGFMDIARELETLGVTAFGVAFLAEGIQLRKSGIDRPV
LILGGVYPGQERKCVGFNLSTALFSLEQARVLDDAAGRLYRRARVHAKIDTGMGRLGIPHEEASAFFSALRELKHLDLEG
IISHFASADELDEDGRRYSDLQASRFAAAVAAARHEGFEPRYVHIANSAAAFGMDLPFCNLVRPGIVLYGALPSGDFEGK
MALKPIMRLRSSIAMLKWVEPGTSISYARRFTAPDRRLVASIPVGYADGYSRSLTNRGEVVVRGRRAPVVGTVCMDWIMA
DVTHVSGVTVGDEVTLLGCDQEGNCVRAEELAEWAGTIPYEIFCGISKRVPRVYLNPSIRHR

Sequences:

>Translated_382_residues
MDSRPTIAEVDLAALRHNYDLVVRTIPRGCGILAVVKADAYGHGFMDIARELETLGVTAFGVAFLAEGIQLRKSGIDRPV
LILGGVYPGQERKCVGFNLSTALFSLEQARVLDDAAGRLYRRARVHAKIDTGMGRLGIPHEEASAFFSALRELKHLDLEG
IISHFASADELDEDGRRYSDLQASRFAAAVAAARHEGFEPRYVHIANSAAAFGMDLPFCNLVRPGIVLYGALPSGDFEGK
MALKPIMRLRSSIAMLKWVEPGTSISYARRFTAPDRRLVASIPVGYADGYSRSLTNRGEVVVRGRRAPVVGTVCMDWIMA
DVTHVSGVTVGDEVTLLGCDQEGNCVRAEELAEWAGTIPYEIFCGISKRVPRVYLNPSIRHR
>Mature_382_residues
MDSRPTIAEVDLAALRHNYDLVVRTIPRGCGILAVVKADAYGHGFMDIARELETLGVTAFGVAFLAEGIQLRKSGIDRPV
LILGGVYPGQERKCVGFNLSTALFSLEQARVLDDAAGRLYRRARVHAKIDTGMGRLGIPHEEASAFFSALRELKHLDLEG
IISHFASADELDEDGRRYSDLQASRFAAAVAAARHEGFEPRYVHIANSAAAFGMDLPFCNLVRPGIVLYGALPSGDFEGK
MALKPIMRLRSSIAMLKWVEPGTSISYARRFTAPDRRLVASIPVGYADGYSRSLTNRGEVVVRGRRAPVVGTVCMDWIMA
DVTHVSGVTVGDEVTLLGCDQEGNCVRAEELAEWAGTIPYEIFCGISKRVPRVYLNPSIRHR

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=375, Percent_Identity=32.8, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1790487, Length=371, Percent_Identity=33.4231805929919, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_GEOSL (Q74FK2)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951664.1
- HSSP:   P0A4X2
- ProteinModelPortal:   Q74FK2
- SMR:   Q74FK2
- GeneID:   2685372
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0606
- NMPDR:   fig|243231.1.peg.602
- TIGR:   GSU0606
- HOGENOM:   HBG712172
- OMA:   PDAHFDL
- ProtClustDB:   CLSK827943
- BioCyc:   GSUL243231:GSU_0606-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 41776; Mature: 41776

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 37-37 ACT_SITE 267-267

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSRPTIAEVDLAALRHNYDLVVRTIPRGCGILAVVKADAYGHGFMDIARELETLGVTAF
CCCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHH
GVAFLAEGIQLRKSGIDRPVLILGGVYPGQERKCVGFNLSTALFSLEQARVLDDAAGRLY
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
RRARVHAKIDTGMGRLGIPHEEASAFFSALRELKHLDLEGIISHFASADELDEDGRRYSD
HHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCHHHH
LQASRFAAAVAAARHEGFEPRYVHIANSAAAFGMDLPFCNLVRPGIVLYGALPSGDFEGK
HHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCCCHHHHCCCCEEEEECCCCCCCCCC
MALKPIMRLRSSIAMLKWVEPGTSISYARRFTAPDRRLVASIPVGYADGYSRSLTNRGEV
HHHHHHHHHHHHHHHEEEECCCCCHHHHHHCCCCCCEEEEECCCCCCCCCHHHCCCCCCE
VVRGRRAPVVGTVCMDWIMADVTHVSGVTVGDEVTLLGCDQEGNCVRAEELAEWAGTIPY
EEECCCCCCHHHHHHHHHHHHHHHHCCEEECCCEEEEECCCCCCEECHHHHHHHHCCCCH
EIFCGISKRVPRVYLNPSIRHR
HEEECHHHCCCEEEECCCCCCC
>Mature Secondary Structure
MDSRPTIAEVDLAALRHNYDLVVRTIPRGCGILAVVKADAYGHGFMDIARELETLGVTAF
CCCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHH
GVAFLAEGIQLRKSGIDRPVLILGGVYPGQERKCVGFNLSTALFSLEQARVLDDAAGRLY
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
RRARVHAKIDTGMGRLGIPHEEASAFFSALRELKHLDLEGIISHFASADELDEDGRRYSD
HHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCHHHH
LQASRFAAAVAAARHEGFEPRYVHIANSAAAFGMDLPFCNLVRPGIVLYGALPSGDFEGK
HHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCCCHHHHCCCCEEEEECCCCCCCCCC
MALKPIMRLRSSIAMLKWVEPGTSISYARRFTAPDRRLVASIPVGYADGYSRSLTNRGEV
HHHHHHHHHHHHHHHEEEECCCCCHHHHHHCCCCCCEEEEECCCCCCCCCHHHCCCCCCE
VVRGRRAPVVGTVCMDWIMADVTHVSGVTVGDEVTLLGCDQEGNCVRAEELAEWAGTIPY
EEECCCCCCHHHHHHHHHHHHHHHHCCEEECCCEEEEECCCCCCEECHHHHHHHHCCCCH
EIFCGISKRVPRVYLNPSIRHR
HEEECHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA