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The map label for this gene is mutS2 [H]

Identifier: 39995654

GI number: 39995654

Start: 579087

End: 581465

Strand: Direct

Name: mutS2 [H]

Synonym: GSU0547

Alternate gene names: 39995654

Gene position: 579087-581465 (Clockwise)

Preceding gene: 39995653

Following gene: 39995656

Centisome position: 15.18

GC content: 68.43

Gene sequence:

>2379_bases
ATGATCAGAACCGAAACCCTCCGTACCCTCGAATTCGATAAAATACTTTCGGCCGTGTCGGGCTACGCCCACAGCGGCGC
CACGCGGGACGAAACCGCCCTGATCCGGCCCCTGGACGACCGGGAGGCCATTGTCCGGCGCTTCGGCCAGGTGGACGAGA
TCCGGCGGCTGCGCCAGCTGGGGATCGATCTTTCCCTCCGCTCCTTCGAGGACATCGCACCGCTGCTGGCGGCAGTCCGC
CCCGACGGCGCGGTGCTGGACCCCACGGAGCTGGTGGTCCTGTTCCCGATCCTGCGGACCATGACCGCCATTGCCAAGCA
GTTCGCCTACCGGACCGACATCCCCCTGCTGCGGGAACTGGCCGGCACCCTGACCGGCTTCCCCGACCTCCTGGACGAGC
TGGAGGTATCCATCGACTCCGAGGGGGAGATCCTCGATTCCGCCTCGCCGCTCCTCTCGGACCTGCGCCAGAAGAAGCGC
CACCTCACCGAGCGGATCAGGCGGCGGCTGGCCGAGATCGTCCGCGAGACCGGGGTCACCACCTTCCTCCAGGACGATTT
CATCACCCAGCGGGGCGGGCGGTGGGTGATCCCGGTGCGGATGGATTCCAAGGGAATGGTCCCCGGCGTGGTGCACGACG
TCTCCAATTCAGGCGAGACCGCCTTCATGGAGCCCCTGGAGATCATCGGCCTGGCCAACGAGCTGGAAAACCTGGTGGCT
GAGGAAAAGGCCGAGATGATCCGCATCGTCCGGACCATCTGCCGGATGATCCGCCAGGAAGCCGACGGCCTGGATGAGCA
GTTCCGCATTCTGGTCCGGCTTGACGTGCTGAACGGCATTGCCTTGTTCGCCGATTCCCTCGGCGCCGAGACCCCCGAGA
TCACCGACGCCCGCTTCATTCGGGTCCGGGAGGGGCGCCACCCGCTCCTGGCGCTCATGGCGCGGGAACGGGGGGTCGGC
CGGGTGGTGCCGCTGGACCTGGGGCTGGGGGGAGCTGAACGTCCTGATTCGCATGTGGCGAATCAGGTCATGGTCATCAC
CGGGCCCAACGCGGGAGGCAAAACCATCTCCCTCAAGACCACCGGCCTCCTTCACCTCATGGCCCTGGCGGGGATTCCGG
TGCCGGCGGCCTCCACTTCGTCGTTCCCCCTGATCTCCGACCTCCTGGTGGACATCGGCGACGAGCAGTCCATCGAGCAG
AGCCTTTCCACCTTCTCGGCCCACGTCTCCAACATCGCCGGCATCCTGGAGCGGGCCGACCGCCGCACCGTGGTGCTGCT
GGACGAACTGGGCACCGGCACCGAGCCGGTCCAGGGGGCGGCCATCTCCTGCGCCGTCCTGGCCGACCTGCAGGACAAGG
GGGCGCTGGTCATCGCCACCACCCACCTGACCGACATCGTGGGCTTCGTCCACAAACGGGACGGCATGGTCAACGCTTCC
ATGGAGTTCGACCGCCAGACCCTCACCCCCCTCTACCGTCTCACCGTGGGCGAGCCGGGCCAGTCCCACGCCCTGGAGAT
CGCTCGCCGGTATGGCCTTCCCGACCGGGTCGTGGCCGTGGCCACCGGCATGCTCTCTCGCATGGAGACTGAATTCCACG
AACTGCTGGCCGAGCTCAAGGACCAGCGCCGGCGCCACGAAGAGGCCCTGGCCGAGGCGGAACGGCTCCGGCGCGATGCC
GAGGAGAAGGCCCGCATCGCCCGCGAGCGGCTGGCCGAGGCCGAGACCCGGCGGCGCGAGGCAACCGAGAAGGCCCTCCA
GGAGGCAAAGGAGATCGTCCGGGCCGCCCGGCGCGACGTGAACGCCATCATCGAGGAAGCCCGCAGGGAGAAGAGCAGGG
AGGCCCGGAAGAAGATCGACGAGGCCGAGGCCGCGGTGGAGGCGAAGCTCCAGGAGTTCCACCCCGAGGAGACCCTTTCC
CTGGATGCCGTCCGCGAGGGCGACACTGTCTTCGTCAAGGCCATCGGCCACGACGGCACCGTCACCGCCGTGGACCGCCG
GACCGGCCGGCTCCGGGTGCGGGCCGGCGCCATGGAACTGGAAGTGGCGGCCACGGACGTTTCCCCGCGCCGGGGCAAGG
CCACCGAGGCCAAAATCCGCACCGGCTCGGGCAGAAGACCGGCGCCGGATGCGGAGACCCCCCGCGAAATCAACCTGATC
GGCCTGCGAGTGGACGACGCCCTGGCGCGGTTGGAGCCCTTCCTGAACCACGCCTCCCTGGAAGGATACGGCGAGCTGCG
GATTGTCCACGGCAAGGGGACCGGCGCCCTGATGCGGGCTGTGCGCGAATACCTTGACGGTCACCCCCTGGTGCGCGAGT
TTCGTCCCGGCGAGCCCTTCGAAGGTGGCGAGGGCGCCACGGTGGTGACGCTGCGGTAA

Upstream 100 bases:

>100_bases
AGAGCCCCCGGGACGTCCGGGTCGAGAAGCTCCGGAAGCAGAAGGCGCGGCGGAAACGGCGGGCCACCACGAAATACGAC
CCAGAGAAGGACAATCAGCA

Downstream 100 bases:

>100_bases
GGCGCACCGCGCCCCGTCGACTCACTCGACGCATTCCTGTTCCTCGAACATGCCGGTGGCACCGATGCTCTCCGCCACCT
TTCGGAAGTGAAAGCCGTAG

Product: MutS2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 792; Mature: 792

Protein sequence:

>792_residues
MIRTETLRTLEFDKILSAVSGYAHSGATRDETALIRPLDDREAIVRRFGQVDEIRRLRQLGIDLSLRSFEDIAPLLAAVR
PDGAVLDPTELVVLFPILRTMTAIAKQFAYRTDIPLLRELAGTLTGFPDLLDELEVSIDSEGEILDSASPLLSDLRQKKR
HLTERIRRRLAEIVRETGVTTFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
EEKAEMIRIVRTICRMIRQEADGLDEQFRILVRLDVLNGIALFADSLGAETPEITDARFIRVREGRHPLLALMARERGVG
RVVPLDLGLGGAERPDSHVANQVMVITGPNAGGKTISLKTTGLLHLMALAGIPVPAASTSSFPLISDLLVDIGDEQSIEQ
SLSTFSAHVSNIAGILERADRRTVVLLDELGTGTEPVQGAAISCAVLADLQDKGALVIATTHLTDIVGFVHKRDGMVNAS
MEFDRQTLTPLYRLTVGEPGQSHALEIARRYGLPDRVVAVATGMLSRMETEFHELLAELKDQRRRHEEALAEAERLRRDA
EEKARIARERLAEAETRRREATEKALQEAKEIVRAARRDVNAIIEEARREKSREARKKIDEAEAAVEAKLQEFHPEETLS
LDAVREGDTVFVKAIGHDGTVTAVDRRTGRLRVRAGAMELEVAATDVSPRRGKATEAKIRTGSGRRPAPDAETPREINLI
GLRVDDALARLEPFLNHASLEGYGELRIVHGKGTGALMRAVREYLDGHPLVREFRPGEPFEGGEGATVVTLR

Sequences:

>Translated_792_residues
MIRTETLRTLEFDKILSAVSGYAHSGATRDETALIRPLDDREAIVRRFGQVDEIRRLRQLGIDLSLRSFEDIAPLLAAVR
PDGAVLDPTELVVLFPILRTMTAIAKQFAYRTDIPLLRELAGTLTGFPDLLDELEVSIDSEGEILDSASPLLSDLRQKKR
HLTERIRRRLAEIVRETGVTTFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
EEKAEMIRIVRTICRMIRQEADGLDEQFRILVRLDVLNGIALFADSLGAETPEITDARFIRVREGRHPLLALMARERGVG
RVVPLDLGLGGAERPDSHVANQVMVITGPNAGGKTISLKTTGLLHLMALAGIPVPAASTSSFPLISDLLVDIGDEQSIEQ
SLSTFSAHVSNIAGILERADRRTVVLLDELGTGTEPVQGAAISCAVLADLQDKGALVIATTHLTDIVGFVHKRDGMVNAS
MEFDRQTLTPLYRLTVGEPGQSHALEIARRYGLPDRVVAVATGMLSRMETEFHELLAELKDQRRRHEEALAEAERLRRDA
EEKARIARERLAEAETRRREATEKALQEAKEIVRAARRDVNAIIEEARREKSREARKKIDEAEAAVEAKLQEFHPEETLS
LDAVREGDTVFVKAIGHDGTVTAVDRRTGRLRVRAGAMELEVAATDVSPRRGKATEAKIRTGSGRRPAPDAETPREINLI
GLRVDDALARLEPFLNHASLEGYGELRIVHGKGTGALMRAVREYLDGHPLVREFRPGEPFEGGEGATVVTLR
>Mature_792_residues
MIRTETLRTLEFDKILSAVSGYAHSGATRDETALIRPLDDREAIVRRFGQVDEIRRLRQLGIDLSLRSFEDIAPLLAAVR
PDGAVLDPTELVVLFPILRTMTAIAKQFAYRTDIPLLRELAGTLTGFPDLLDELEVSIDSEGEILDSASPLLSDLRQKKR
HLTERIRRRLAEIVRETGVTTFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
EEKAEMIRIVRTICRMIRQEADGLDEQFRILVRLDVLNGIALFADSLGAETPEITDARFIRVREGRHPLLALMARERGVG
RVVPLDLGLGGAERPDSHVANQVMVITGPNAGGKTISLKTTGLLHLMALAGIPVPAASTSSFPLISDLLVDIGDEQSIEQ
SLSTFSAHVSNIAGILERADRRTVVLLDELGTGTEPVQGAAISCAVLADLQDKGALVIATTHLTDIVGFVHKRDGMVNAS
MEFDRQTLTPLYRLTVGEPGQSHALEIARRYGLPDRVVAVATGMLSRMETEFHELLAELKDQRRRHEEALAEAERLRRDA
EEKARIARERLAEAETRRREATEKALQEAKEIVRAARRDVNAIIEEARREKSREARKKIDEAEAAVEAKLQEFHPEETLS
LDAVREGDTVFVKAIGHDGTVTAVDRRTGRLRVRAGAMELEVAATDVSPRRGKATEAKIRTGSGRRPAPDAETPREINLI
GLRVDDALARLEPFLNHASLEGYGELRIVHGKGTGALMRAVREYLDGHPLVREFRPGEPFEGGEGATVVTLR

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI26638666, Length=255, Percent_Identity=33.7254901960784, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI4505253, Length=255, Percent_Identity=33.7254901960784, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI36949366, Length=575, Percent_Identity=21.9130434782609, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI284813531, Length=435, Percent_Identity=24.8275862068966, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI26638664, Length=256, Percent_Identity=33.59375, Blast_Score=100, Evalue=9e-21,
Organism=Homo sapiens, GI4504191, Length=273, Percent_Identity=28.2051282051282, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI262231786, Length=198, Percent_Identity=34.8484848484849, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI4557761, Length=269, Percent_Identity=27.5092936802974, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1789089, Length=272, Percent_Identity=28.6764705882353, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17534743, Length=370, Percent_Identity=24.3243243243243, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17508447, Length=272, Percent_Identity=30.5147058823529, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17508445, Length=275, Percent_Identity=25.8181818181818, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539736, Length=367, Percent_Identity=22.3433242506812, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324482, Length=418, Percent_Identity=23.444976076555, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321109, Length=285, Percent_Identity=25.2631578947368, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319935, Length=260, Percent_Identity=28.8461538461538, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321912, Length=319, Percent_Identity=23.1974921630094, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320302, Length=275, Percent_Identity=25.4545454545455, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320047, Length=267, Percent_Identity=24.7191011235955, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664545, Length=307, Percent_Identity=28.0130293159609, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24584320, Length=332, Percent_Identity=25.6024096385542, Blast_Score=93, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 87407; Mature: 87407

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRTETLRTLEFDKILSAVSGYAHSGATRDETALIRPLDDREAIVRRFGQVDEIRRLRQL
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHCCHHHHHHHHHH
GIDLSLRSFEDIAPLLAAVRPDGAVLDPTELVVLFPILRTMTAIAKQFAYRTDIPLLREL
CCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AGTLTGFPDLLDELEVSIDSEGEILDSASPLLSDLRQKKRHLTERIRRRLAEIVRETGVT
HHHHCCCHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
HHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
EEKAEMIRIVRTICRMIRQEADGLDEQFRILVRLDVLNGIALFADSLGAETPEITDARFI
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
RVREGRHPLLALMARERGVGRVVPLDLGLGGAERPDSHVANQVMVITGPNAGGKTISLKT
EEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHCEEEEEECCCCCCCEEEEEH
TGLLHLMALAGIPVPAASTSSFPLISDLLVDIGDEQSIEQSLSTFSAHVSNIAGILERAD
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
RRTVVLLDELGTGTEPVQGAAISCAVLADLQDKGALVIATTHLTDIVGFVHKRDGMVNAS
CCEEEEEECCCCCCCCCCCCCEEHHHEECCCCCCEEEEEEHHHHHHHHHHHHCCCCEECC
MEFDRQTLTPLYRLTVGEPGQSHALEIARRYGLPDRVVAVATGMLSRMETEFHELLAELK
HHHCHHHHCHHHEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DQRRRHEEALAEAERLRRDAEEKARIARERLAEAETRRREATEKALQEAKEIVRAARRDV
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAIIEEARREKSREARKKIDEAEAAVEAKLQEFHPEETLSLDAVREGDTVFVKAIGHDGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHCCCCCEEEEEEECCCCC
VTAVDRRTGRLRVRAGAMELEVAATDVSPRRGKATEAKIRTGSGRRPAPDAETPREINLI
EEEEECCCCEEEEEECCEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEE
GLRVDDALARLEPFLNHASLEGYGELRIVHGKGTGALMRAVREYLDGHPLVREFRPGEPF
EEEHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHCCCCCCC
EGGEGATVVTLR
CCCCCCEEEEEC
>Mature Secondary Structure
MIRTETLRTLEFDKILSAVSGYAHSGATRDETALIRPLDDREAIVRRFGQVDEIRRLRQL
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHCCHHHHHHHHHH
GIDLSLRSFEDIAPLLAAVRPDGAVLDPTELVVLFPILRTMTAIAKQFAYRTDIPLLREL
CCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AGTLTGFPDLLDELEVSIDSEGEILDSASPLLSDLRQKKRHLTERIRRRLAEIVRETGVT
HHHHCCCHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
HHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
EEKAEMIRIVRTICRMIRQEADGLDEQFRILVRLDVLNGIALFADSLGAETPEITDARFI
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
RVREGRHPLLALMARERGVGRVVPLDLGLGGAERPDSHVANQVMVITGPNAGGKTISLKT
EEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHCEEEEEECCCCCCCEEEEEH
TGLLHLMALAGIPVPAASTSSFPLISDLLVDIGDEQSIEQSLSTFSAHVSNIAGILERAD
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
RRTVVLLDELGTGTEPVQGAAISCAVLADLQDKGALVIATTHLTDIVGFVHKRDGMVNAS
CCEEEEEECCCCCCCCCCCCCEEHHHEECCCCCCEEEEEEHHHHHHHHHHHHCCCCEECC
MEFDRQTLTPLYRLTVGEPGQSHALEIARRYGLPDRVVAVATGMLSRMETEFHELLAELK
HHHCHHHHCHHHEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DQRRRHEEALAEAERLRRDAEEKARIARERLAEAETRRREATEKALQEAKEIVRAARRDV
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAIIEEARREKSREARKKIDEAEAAVEAKLQEFHPEETLSLDAVREGDTVFVKAIGHDGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHCCCCCEEEEEEECCCCC
VTAVDRRTGRLRVRAGAMELEVAATDVSPRRGKATEAKIRTGSGRRPAPDAETPREINLI
EEEEECCCCEEEEEECCEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEE
GLRVDDALARLEPFLNHASLEGYGELRIVHGKGTGALMRAVREYLDGHPLVREFRPGEPF
EEEHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHCCCCCCC
EGGEGATVVTLR
CCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA