Click here to switch to the map view.

The map label for this gene is cusS [H]

Identifier: 39995560

GI number: 39995560

Start: 481730

End: 483139

Strand: Direct

Name: cusS [H]

Synonym: GSU0452

Alternate gene names: 39995560

Gene position: 481730-483139 (Clockwise)

Preceding gene: 39995559

Following gene: 39995561

Centisome position: 12.63

GC content: 61.7

Gene sequence:

>1410_bases
TTGTTTTTCAGGTCAATCCGCTTTTCGCTCACCCTTTGGTATGCGGTGACGCTCGCGGTCATTTTGGTTCTGTTCAGCTC
GTTCATCTACCTGGTTCTGAGCAATCAGCTCAACAAGGGGATTGATCGTGAACTGCTGACCGTGGCCGAGGCCGTTGCAA
GCCCGACTCTGGAGCCTTTCCGCCATGCCGCTCCGTCGGTCTTCGACCAGGTGCTCGAAGACTTCATCGGCACGCGCCTG
ACGGGCAAGCACGTCCAGGTGCTCGACGGCTCCGGCGCGGTTGCCGCCTCGTCCAAGAGCATGGAGGAACTGCGCATTCC
TCTGGGCAAGACTGCGTTGCGTCGCGTTCAGGCCGGCAAGGTTTCCTATGAAACCAGGGTCAATCTGGACGTGTATCCGG
TCCGCACCATCGTGTACCCCATCATGACCGACGGCCGGCTCGACCAGATCGTTCTGGTCGGAACGTCCATGCGGGGGCCG
GCCGAGACCCTTGAAAAGGTCCAGCTGGTCTTTGCCGTCTCCATCCCCCTGGCTCTCATCCTGTGGAGCCTGGGCGGATG
GTTCCTGGCGGGCAGGGCGCTGAAACCGGTTGACCTGATAACCCGCAGCGCCCGCAAGATTACTGCCGAAAACCTGGGAC
TGCGCCTGGAGGTCATCAATCCCCAGGACGAGATCGGCCGGCTCGCCACTACGTTCAACGATACCCTGGAACGCCTGGAA
AACGCCTTCAACCGGATCAGGCAATTCACCGGTGACGTCTCCCACGAACTGCGGACGCCCCTCACCATCCTGCGCGGCGA
AGCCGAGGTGGGGCTCAAGTGGGCCAAGGAGCCGGAGGAGTTTCGTGAGCTTCTGCGTAGCAATCTGGAAGAGATCAACC
GGATGTCCAAGATCATCGAGACGCTCCTGGAACTCTCCCGGGTTGAGGGGGGAGTCAAGCTGGAGCTCGCCGATCTGGAT
CTGAGCGACCTTCTTGCCGAACTGGTTCAGCAGTCGCGCCTCATCGCACCGGACAAGAGTCTCCGCATCGCTTTCGTGGG
GCAGGAGCCGGTTACCATCCTCGGCGACTGGCTTCGGCTGCGCCAGGTTTTCATGAACCTGCTGGACAATGCCGTCAAGT
ATACCCCTGCCGATGGGGAGATCTCCGTGGTGGTTGATACGACCGGTGACAGCGCCCGCGTGGCGATCATCGACAGCGGC
CCGGGTATTCCTCCCGAAGATCTGCCGCACATCTTCGAGCGGTTCTACCGGGTCGACAAGGCCCGCAACCGGGCCGACGG
CGGTTGCGGCTTGGGACTCTCCCTGGTCAAGACGTTCGTGGAGGCTCATGGCGGACGCATTGAGGTGGTGAGCGAAGCGG
GCAAGGGGAGCATCTTCACGGTCCTGCTGCCGCGGGTCGTCGCAGGATGA

Upstream 100 bases:

>100_bases
CGTCAACTACCTGCGCAAGAAGATCGACCGGGAGTCCGACAAGAAGCTCATCCACACCGTCCGCGGCGTGGGCTATATCC
TGAAGGAGGAGGATTGATCG

Downstream 100 bases:

>100_bases
TCCCCATGGAACCGATTCTTGTTGTTGCCGCAACCCGGCAGGAGCTGACGCTGCTGATCCGAAGTCTCGGCGCCCGGGAG
CGTGGAGGCGCCGGTCGCCG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MFFRSIRFSLTLWYAVTLAVILVLFSSFIYLVLSNQLNKGIDRELLTVAEAVASPTLEPFRHAAPSVFDQVLEDFIGTRL
TGKHVQVLDGSGAVAASSKSMEELRIPLGKTALRRVQAGKVSYETRVNLDVYPVRTIVYPIMTDGRLDQIVLVGTSMRGP
AETLEKVQLVFAVSIPLALILWSLGGWFLAGRALKPVDLITRSARKITAENLGLRLEVINPQDEIGRLATTFNDTLERLE
NAFNRIRQFTGDVSHELRTPLTILRGEAEVGLKWAKEPEEFRELLRSNLEEINRMSKIIETLLELSRVEGGVKLELADLD
LSDLLAELVQQSRLIAPDKSLRIAFVGQEPVTILGDWLRLRQVFMNLLDNAVKYTPADGEISVVVDTTGDSARVAIIDSG
PGIPPEDLPHIFERFYRVDKARNRADGGCGLGLSLVKTFVEAHGGRIEVVSEAGKGSIFTVLLPRVVAG

Sequences:

>Translated_469_residues
MFFRSIRFSLTLWYAVTLAVILVLFSSFIYLVLSNQLNKGIDRELLTVAEAVASPTLEPFRHAAPSVFDQVLEDFIGTRL
TGKHVQVLDGSGAVAASSKSMEELRIPLGKTALRRVQAGKVSYETRVNLDVYPVRTIVYPIMTDGRLDQIVLVGTSMRGP
AETLEKVQLVFAVSIPLALILWSLGGWFLAGRALKPVDLITRSARKITAENLGLRLEVINPQDEIGRLATTFNDTLERLE
NAFNRIRQFTGDVSHELRTPLTILRGEAEVGLKWAKEPEEFRELLRSNLEEINRMSKIIETLLELSRVEGGVKLELADLD
LSDLLAELVQQSRLIAPDKSLRIAFVGQEPVTILGDWLRLRQVFMNLLDNAVKYTPADGEISVVVDTTGDSARVAIIDSG
PGIPPEDLPHIFERFYRVDKARNRADGGCGLGLSLVKTFVEAHGGRIEVVSEAGKGSIFTVLLPRVVAG
>Mature_469_residues
MFFRSIRFSLTLWYAVTLAVILVLFSSFIYLVLSNQLNKGIDRELLTVAEAVASPTLEPFRHAAPSVFDQVLEDFIGTRL
TGKHVQVLDGSGAVAASSKSMEELRIPLGKTALRRVQAGKVSYETRVNLDVYPVRTIVYPIMTDGRLDQIVLVGTSMRGP
AETLEKVQLVFAVSIPLALILWSLGGWFLAGRALKPVDLITRSARKITAENLGLRLEVINPQDEIGRLATTFNDTLERLE
NAFNRIRQFTGDVSHELRTPLTILRGEAEVGLKWAKEPEEFRELLRSNLEEINRMSKIIETLLELSRVEGGVKLELADLD
LSDLLAELVQQSRLIAPDKSLRIAFVGQEPVTILGDWLRLRQVFMNLLDNAVKYTPADGEISVVVDTTGDSARVAIIDSG
PGIPPEDLPHIFERFYRVDKARNRADGGCGLGLSLVKTFVEAHGGRIEVVSEAGKGSIFTVLLPRVVAG

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=34.5637583892617, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=35.4014598540146, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=35.8744394618834, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1787894, Length=239, Percent_Identity=32.6359832635983, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1786912, Length=253, Percent_Identity=31.2252964426877, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788279, Length=245, Percent_Identity=30.2040816326531, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=32.0512820512821, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=30.4029304029304, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790861, Length=331, Percent_Identity=27.4924471299094, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789149, Length=260, Percent_Identity=31.5384615384615, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=32.9113924050633, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=30.2904564315353, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789403, Length=280, Percent_Identity=30.7142857142857, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=32.5892857142857, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI87081816, Length=240, Percent_Identity=32.5, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=30.7359307359307, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787374, Length=281, Percent_Identity=27.0462633451957, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789808, Length=231, Percent_Identity=31.6017316017316, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=27.8350515463918, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788713, Length=225, Percent_Identity=26.2222222222222, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790300, Length=278, Percent_Identity=28.4172661870504, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51836; Mature: 51836

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFRSIRFSLTLWYAVTLAVILVLFSSFIYLVLSNQLNKGIDRELLTVAEAVASPTLEPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHH
RHAAPSVFDQVLEDFIGTRLTGKHVQVLDGSGAVAASSKSMEELRIPLGKTALRRVQAGK
HHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECCCCHHHHHCCCCHHHHHHHHCCC
VSYETRVNLDVYPVRTIVYPIMTDGRLDQIVLVGTSMRGPAETLEKVQLVFAVSIPLALI
CCEEEEECEEEEEHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LWSLGGWFLAGRALKPVDLITRSARKITAENLGLRLEVINPQDEIGRLATTFNDTLERLE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
NAFNRIRQFTGDVSHELRTPLTILRGEAEVGLKWAKEPEEFRELLRSNLEEINRMSKIIE
HHHHHHHHHHHHHHHHHHCCHHHEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TLLELSRVEGGVKLELADLDLSDLLAELVQQSRLIAPDKSLRIAFVGQEPVTILGDWLRL
HHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHH
RQVFMNLLDNAVKYTPADGEISVVVDTTGDSARVAIIDSGPGIPPEDLPHIFERFYRVDK
HHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
ARNRADGGCGLGLSLVKTFVEAHGGRIEVVSEAGKGSIFTVLLPRVVAG
HCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MFFRSIRFSLTLWYAVTLAVILVLFSSFIYLVLSNQLNKGIDRELLTVAEAVASPTLEPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHH
RHAAPSVFDQVLEDFIGTRLTGKHVQVLDGSGAVAASSKSMEELRIPLGKTALRRVQAGK
HHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECCCCHHHHHCCCCHHHHHHHHCCC
VSYETRVNLDVYPVRTIVYPIMTDGRLDQIVLVGTSMRGPAETLEKVQLVFAVSIPLALI
CCEEEEECEEEEEHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LWSLGGWFLAGRALKPVDLITRSARKITAENLGLRLEVINPQDEIGRLATTFNDTLERLE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
NAFNRIRQFTGDVSHELRTPLTILRGEAEVGLKWAKEPEEFRELLRSNLEEINRMSKIIE
HHHHHHHHHHHHHHHHHHCCHHHEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TLLELSRVEGGVKLELADLDLSDLLAELVQQSRLIAPDKSLRIAFVGQEPVTILGDWLRL
HHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHH
RQVFMNLLDNAVKYTPADGEISVVVDTTGDSARVAIIDSGPGIPPEDLPHIFERFYRVDK
HHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
ARNRADGGCGLGLSLVKTFVEAHGGRIEVVSEAGKGSIFTVLLPRVVAG
HCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]