Click here to switch to the map view.

The map label for this gene is czcR [H]

Identifier: 39995559

GI number: 39995559

Start: 481052

End: 481726

Strand: Direct

Name: czcR [H]

Synonym: GSU0451

Alternate gene names: 39995559

Gene position: 481052-481726 (Clockwise)

Preceding gene: 39995558

Following gene: 39995560

Centisome position: 12.61

GC content: 58.37

Gene sequence:

>675_bases
ATGAAGGTTCTCGTGGTCGAAGATGAGAAGAAGGTGTCCAGCTTCATCAAGCGGGGGCTCGAGGAAGAGAAGTACGAGGT
CGATGCCGCGTTCAACGGCGAGGAAGGGCTCAAGATGGCCCTGGACAAGGGCTACGATCTGATCGTTCTCGACGTGATGC
TGCCCAAAAAGGATGGTCTCAGCGTGGTACGTGAGCTCCGGGAGCGCAAGAACAGCACACCGGTTCTGATGCTGACAGCC
AAGGACTCGGTGGAGGATATCGTGGCCGGTCTCGATTCGGGTTCCGACGACTACCTGACCAAGCCCTTCGCTTTTGCTGA
GCTTCTGGCCCGGGTCCGGGCCTTGGTGCGTCGCAGCGAGCAGGATCGCGGGGCAGAGATCCGCTTTGCTGATCTGCGGC
TCGACCCGGTGACCCACAAGGTCTGGCGCAAGGACAAAGAGATCGACCTCACCGCCAAGGAGTATTCGCTGCTCGAGTAC
TTCATGCGGAACCCCAACCAGGTCCTTACCCGCACCATGATCGCCGAGCACGTGTGGGACTACACCTTTGACAGCTTCAC
CAATATCATTGACGTCTACGTCAACTACCTGCGCAAGAAGATCGACCGGGAGTCCGACAAGAAGCTCATCCACACCGTCC
GCGGCGTGGGCTATATCCTGAAGGAGGAGGATTGA

Upstream 100 bases:

>100_bases
AGAAGTCGGTGGAGGAGTCCGCGGCCGAGATCATACAAAAACTCGCTGGTTGAAGAACCCGTCCCGATGAGCGGAGACGG
AGTTAAGAAAGGAGCGCTCA

Downstream 100 bases:

>100_bases
TCGTTGTTTTTCAGGTCAATCCGCTTTTCGCTCACCCTTTGGTATGCGGTGACGCTCGCGGTCATTTTGGTTCTGTTCAG
CTCGTTCATCTACCTGGTTC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKVLVVEDEKKVSSFIKRGLEEEKYEVDAAFNGEEGLKMALDKGYDLIVLDVMLPKKDGLSVVRELRERKNSTPVLMLTA
KDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSEQDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEY
FMRNPNQVLTRTMIAEHVWDYTFDSFTNIIDVYVNYLRKKIDRESDKKLIHTVRGVGYILKEED

Sequences:

>Translated_224_residues
MKVLVVEDEKKVSSFIKRGLEEEKYEVDAAFNGEEGLKMALDKGYDLIVLDVMLPKKDGLSVVRELRERKNSTPVLMLTA
KDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSEQDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEY
FMRNPNQVLTRTMIAEHVWDYTFDSFTNIIDVYVNYLRKKIDRESDKKLIHTVRGVGYILKEED
>Mature_224_residues
MKVLVVEDEKKVSSFIKRGLEEEKYEVDAAFNGEEGLKMALDKGYDLIVLDVMLPKKDGLSVVRELRERKNSTPVLMLTA
KDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSEQDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEY
FMRNPNQVLTRTMIAEHVWDYTFDSFTNIIDVYVNYLRKKIDRESDKKLIHTVRGVGYILKEED

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=51.1111111111111, Blast_Score=220, Evalue=5e-59,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=45.4128440366972, Blast_Score=197, Evalue=6e-52,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=37.219730941704, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=37.5565610859729, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.4801762114537, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=34.841628959276, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=33.1818181818182, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=33.9366515837104, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.8421052631579, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=32.7272727272727, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=31.981981981982, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=31.4159292035398, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=30.5309734513274, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.7359307359307, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1790299, Length=122, Percent_Identity=30.327868852459, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25970; Mature: 25970

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVVEDEKKVSSFIKRGLEEEKYEVDAAFNGEEGLKMALDKGYDLIVLDVMLPKKDGL
CEEEEECCHHHHHHHHHHCCCHHHEEECCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCH
SVVRELRERKNSTPVLMLTAKDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSE
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
QDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEYFMRNPNQVLTRTMIAEHVWD
CCCCCEEEEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YTFDSFTNIIDVYVNYLRKKIDRESDKKLIHTVRGVGYILKEED
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MKVLVVEDEKKVSSFIKRGLEEEKYEVDAAFNGEEGLKMALDKGYDLIVLDVMLPKKDGL
CEEEEECCHHHHHHHHHHCCCHHHEEECCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCH
SVVRELRERKNSTPVLMLTAKDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSE
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
QDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEYFMRNPNQVLTRTMIAEHVWD
CCCCCEEEEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YTFDSFTNIIDVYVNYLRKKIDRESDKKLIHTVRGVGYILKEED
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]