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The map label for this gene is gcvPA [H]

Identifier: 39995485

GI number: 39995485

Start: 410988

End: 412334

Strand: Direct

Name: gcvPA [H]

Synonym: GSU0377

Alternate gene names: 39995485

Gene position: 410988-412334 (Clockwise)

Preceding gene: 39995484

Following gene: 39995486

Centisome position: 10.78

GC content: 67.56

Gene sequence:

>1347_bases
ATGAGCGGCGCCGACTACTGCCCCAACTCGCCGGAGGAGGTCCGCCGGATGCTGGACGCTGTCGGCGTCGCCGACATTGA
TGACCTTTTCCGCCCGATTTCCCCCGCCCTGCGGGCGAAATCCTTCGATCTGCCGCCGGGGATGTCGGAGTTCGAGATGC
TGCACCGGCTCCAGACCCTGGCGGGCAGGAACGCTCAGGGCCTGGTCCACTTCGTGGGGGGCGGCTTCCATGATCACCTG
ATCCCGGCCGTGGTGGACCATCTGGCGTCCCGTCCCGAATTCTACACCGCCTATACCCCCTACCAGCCCGAGTGTTCCCA
GGGAACGCTCCAGGCCCTCTTCGAGTATCAGACCGCCATCTGTCGGCTGACCGGCATGGAGGTTGCCAATGCCTCCCTCT
ACGACGGCGGCACGGCCCTGGCCGAGGCCGCCCTCATGGCCCTGCGGATCACGGGGCGCAGCCGGCTGGTGGTCGATGGC
GCGGTGAACCCGTTCCACCGGGAGATCCTCGCCACCTACCTAGCCAACCTGGACGTGGAACTGGTGGAAATCGCCCCCAA
GGCGGGGATGGAGGACGATGCCCGGCTGCGGGCCGCCATCGACGATGCCACCGCCGCGGTCATTGTCCAGAATCCCGACT
TTTTCGGGACCCTGAGCGACCTTTCCGGGCTCGCGGCCGAGGCCCACGGGGTGGGCGCGCTCCTGGTGGCCTCGGTCTAC
CCGATCTCACTGGGCCTCGTCCGGAGTCCCGGCAGCATGGGGGCCGACATCGTGGTGGGGGACGGCCAAAGCCTCGGCAA
CCCTCTCTCGTTCGGCGGTCCCTCCTTCGGGTTCATCGCCGGTCGGCGCGAACACATCCGCAACCTTCCGGGCCGCATCA
TCGGCGAGACCGTGGACCGGAACGGCGCCCGTGGCTTCGTTCTGACCCTCCAGGCGCGGGAGCAACACATCAAGCGCCAC
AAGGCCACCTCCAACATCTGCAGCAACCAGAGCCTCTGCGCCCTGCGCGGCCTCATCTTCCTCTCGGCCCTGGGGAGCGA
GGGGATGGCGGAGCTCGCCCGCCTGAACCGCGACAAGGCCGAATATGCCAAAGCCGTCCTCGGCGCCGTGCCGGGGGTGG
AGGTGCTGAACAGCGGCTTCACCTTCAACGAGTTCACGGTCTGCCTCCCCAAGGTGGCCGAGGAAGCGGTCGTGGCGCTG
CTCCGCAAGGGGGTGGCGGCCGGAGTTCCCCTGGGGCCTTACTACCCGGACATGGAGAAGTGCATGGTGGTGACGGTGAC
CGAAAGGCGGACCAGGGCCGAGATCGACGCCTTTGCCCGGCAACTGGAGGGTGCGTTATGGAACTGA

Upstream 100 bases:

>100_bases
AGGCGGGGTGGATTGCCTGGATCGAGATGGGGGATACCTCTGAACTGAACGGTCTCCTGACCCGCGAACAGTACGACGAG
TATCTGAAGGGCCTCGAATA

Downstream 100 bases:

>100_bases
TCTTCGAAAAGTCGGTGACCGGCCGCCGGGGCGTCCGGCTCCCGGCCAGTGACGTCCCTCCGGCTCCTCCCCTTTCGGCG
GTGCTTGCCCGTGACGGGGC

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSGADYCPNSPEEVRRMLDAVGVADIDDLFRPISPALRAKSFDLPPGMSEFEMLHRLQTLAGRNAQGLVHFVGGGFHDHL
IPAVVDHLASRPEFYTAYTPYQPECSQGTLQALFEYQTAICRLTGMEVANASLYDGGTALAEAALMALRITGRSRLVVDG
AVNPFHREILATYLANLDVELVEIAPKAGMEDDARLRAAIDDATAAVIVQNPDFFGTLSDLSGLAAEAHGVGALLVASVY
PISLGLVRSPGSMGADIVVGDGQSLGNPLSFGGPSFGFIAGRREHIRNLPGRIIGETVDRNGARGFVLTLQAREQHIKRH
KATSNICSNQSLCALRGLIFLSALGSEGMAELARLNRDKAEYAKAVLGAVPGVEVLNSGFTFNEFTVCLPKVAEEAVVAL
LRKGVAAGVPLGPYYPDMEKCMVVTVTERRTRAEIDAFARQLEGALWN

Sequences:

>Translated_448_residues
MSGADYCPNSPEEVRRMLDAVGVADIDDLFRPISPALRAKSFDLPPGMSEFEMLHRLQTLAGRNAQGLVHFVGGGFHDHL
IPAVVDHLASRPEFYTAYTPYQPECSQGTLQALFEYQTAICRLTGMEVANASLYDGGTALAEAALMALRITGRSRLVVDG
AVNPFHREILATYLANLDVELVEIAPKAGMEDDARLRAAIDDATAAVIVQNPDFFGTLSDLSGLAAEAHGVGALLVASVY
PISLGLVRSPGSMGADIVVGDGQSLGNPLSFGGPSFGFIAGRREHIRNLPGRIIGETVDRNGARGFVLTLQAREQHIKRH
KATSNICSNQSLCALRGLIFLSALGSEGMAELARLNRDKAEYAKAVLGAVPGVEVLNSGFTFNEFTVCLPKVAEEAVVAL
LRKGVAAGVPLGPYYPDMEKCMVVTVTERRTRAEIDAFARQLEGALWN
>Mature_447_residues
SGADYCPNSPEEVRRMLDAVGVADIDDLFRPISPALRAKSFDLPPGMSEFEMLHRLQTLAGRNAQGLVHFVGGGFHDHLI
PAVVDHLASRPEFYTAYTPYQPECSQGTLQALFEYQTAICRLTGMEVANASLYDGGTALAEAALMALRITGRSRLVVDGA
VNPFHREILATYLANLDVELVEIAPKAGMEDDARLRAAIDDATAAVIVQNPDFFGTLSDLSGLAAEAHGVGALLVASVYP
ISLGLVRSPGSMGADIVVGDGQSLGNPLSFGGPSFGFIAGRREHIRNLPGRIIGETVDRNGARGFVLTLQAREQHIKRHK
ATSNICSNQSLCALRGLIFLSALGSEGMAELARLNRDKAEYAKAVLGAVPGVEVLNSGFTFNEFTVCLPKVAEEAVVALL
RKGVAAGVPLGPYYPDMEKCMVVTVTERRTRAEIDAFARQLEGALWN

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=349, Percent_Identity=35.8166189111748, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI1789269, Length=369, Percent_Identity=33.8753387533875, Blast_Score=171, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17535605, Length=350, Percent_Identity=38.5714285714286, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323843, Length=366, Percent_Identity=34.9726775956284, Blast_Score=220, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24645648, Length=373, Percent_Identity=37.5335120643432, Blast_Score=229, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 47965; Mature: 47834

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGADYCPNSPEEVRRMLDAVGVADIDDLFRPISPALRAKSFDLPPGMSEFEMLHRLQTL
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHH
AGRNAQGLVHFVGGGFHDHLIPAVVDHLASRPEFYTAYTPYQPECSQGTLQALFEYQTAI
HCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
CRLTGMEVANASLYDGGTALAEAALMALRITGRSRLVVDGAVNPFHREILATYLANLDVE
HHHHCCHHCCCCCCCCHHHHHHHHHHHHEECCCCEEEEECCCCHHHHHHHHHHHHCCCEE
LVEIAPKAGMEDDARLRAAIDDATAAVIVQNPDFFGTLSDLSGLAAEAHGVGALLVASVY
EEEECCCCCCCCCHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHHHHHCCCHHHHHHHHH
PISLGLVRSPGSMGADIVVGDGQSLGNPLSFGGPSFGFIAGRREHIRNLPGRIIGETVDR
HHHEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCHHCCCHHHHHCCCCHHHHHHHCC
NGARGFVLTLQAREQHIKRHKATSNICSNQSLCALRGLIFLSALGSEGMAELARLNRDKA
CCCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHH
EYAKAVLGAVPGVEVLNSGFTFNEFTVCLPKVAEEAVVALLRKGVAAGVPLGPYYPDMEK
HHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
CMVVTVTERRTRAEIDAFARQLEGALWN
EEEEEEECCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SGADYCPNSPEEVRRMLDAVGVADIDDLFRPISPALRAKSFDLPPGMSEFEMLHRLQTL
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHH
AGRNAQGLVHFVGGGFHDHLIPAVVDHLASRPEFYTAYTPYQPECSQGTLQALFEYQTAI
HCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
CRLTGMEVANASLYDGGTALAEAALMALRITGRSRLVVDGAVNPFHREILATYLANLDVE
HHHHCCHHCCCCCCCCHHHHHHHHHHHHEECCCCEEEEECCCCHHHHHHHHHHHHCCCEE
LVEIAPKAGMEDDARLRAAIDDATAAVIVQNPDFFGTLSDLSGLAAEAHGVGALLVASVY
EEEECCCCCCCCCHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHHHHHCCCHHHHHHHHH
PISLGLVRSPGSMGADIVVGDGQSLGNPLSFGGPSFGFIAGRREHIRNLPGRIIGETVDR
HHHEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCHHCCCHHHHHCCCCHHHHHHHCC
NGARGFVLTLQAREQHIKRHKATSNICSNQSLCALRGLIFLSALGSEGMAELARLNRDKA
CCCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHH
EYAKAVLGAVPGVEVLNSGFTFNEFTVCLPKVAEEAVVALLRKGVAAGVPLGPYYPDMEK
HHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
CMVVTVTERRTRAEIDAFARQLEGALWN
EEEEEEECCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA