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The map label for this gene is gcvPB [H]

Identifier: 39995486

GI number: 39995486

Start: 412325

End: 413770

Strand: Direct

Name: gcvPB [H]

Synonym: GSU0378

Alternate gene names: 39995486

Gene position: 412325-413770 (Clockwise)

Preceding gene: 39995485

Following gene: 39995487

Centisome position: 10.81

GC content: 64.18

Gene sequence:

>1446_bases
ATGGAACTGATCTTCGAAAAGTCGGTGACCGGCCGCCGGGGCGTCCGGCTCCCGGCCAGTGACGTCCCTCCGGCTCCTCC
CCTTTCGGCGGTGCTTGCCCGTGACGGGGCGCCGGATCTGCCCCAGGTGAGCGAACTGGACGTGGTGCGCCACTTCACCA
CCCTGTCGCGGCGCAATTTTTCGGTGGATACCCACTTCTATCCGTTGGGCTCCTGCACCATGAAGTACAATGCCAAGGCC
CTGGAGGAGGCGGCAAAGCTTTTTGCCCCCTATCACCCCATGGTGCCGCTCCTGCCCCATGGCGCATCCTTCAGCCAGGG
AAGCCTGGGGCTCGTGCACGGGCTGGGCGAGGCCCTGGCCGAGATCACCGGCATGGACGAAGTGACCTGCCAGCCCCTGG
CCGGCGCCCACGGCGAGATGACCGGCATCATGCTCATCGCCGCCTACCACGAGGCAAAGGGGAACCGGAAAAAATACGTG
GTGGTCCCCGATTCATCCCACGGCACCAACCCGGCCTCGGCCGCCATGGTGGGCTACGAGATCATCACCGTTCCCACGGC
CCCTTACGGGGACATGGACCTGGAGAAATACCGCGCGGTCATGACCGACGAGGTGGCGGCGGTCATGATGACCTGCCCCA
ACACCCTGGGACTCTTTAATCCCCACATCCGGGAGATCTGCGACATCGCCCACGACCACGACGCCCTCATGTACTACGAC
GGGGCCAACCTGAACGCCATCCTCGGCAAGGTGCGGCCCGGCGACGTGGGGTTCGACGTGATCCACGTGAATCTTCACAA
GACCTTCGGCACCCCCCACGGCGGGGGTGGGCCGGGGAGCGGCCCCGTGGGGGTGAAGAAGCTGCTGGCCTCCTATCTGC
CGGGGCCGCGCGTGGTGAAGAACAGCGACGGCGATTATTCCGTCATTCCCCATTCCCACGAGAGCATCGGTCGCACTGCG
GGGTTCTTCGGCAACTTCGGAGTCATGGCCAAGGCCTTTGCCTATATCACCATGCTCGGACGGGAAGGGCTCATCCAGGT
GAGCGAGCAGGCGGTCCTGAACGCCAACTACATCATGGCCCGGCTGAAGGACGTCTACGACCTCCCCTACGACCAGACCT
GCATGCACGAATGCGTCTTTTCGGCAGCAAGGCAGGCGCGGAACGGCGTCCATGCCATCGATATCGCCAAGTTCCTCATC
GACCGCGGTTTCCATCCCCCTACGGTCTACTTTCCCCTCATCGTCAAGGAGGCGATCATGATCGAGCCCACCGAGACCGA
GAGCAAGGAGACCATGGACGCTTTCATCGAGGCCATGCGCGATGCCGCCGACCTGGCGGAGAGGAATCCGGCCGCCTTTG
CCGAACTGCCGCGGACCATGCCCATCACCCGTCCGGACGAGACCAAGGCAGCCCGCGAGCAGAACGTGTGCTACTTCGGG
TGCTGA

Upstream 100 bases:

>100_bases
CTTACTACCCGGACATGGAGAAGTGCATGGTGGTGACGGTGACCGAAAGGCGGACCAGGGCCGAGATCGACGCCTTTGCC
CGGCAACTGGAGGGTGCGTT

Downstream 100 bases:

>100_bases
TGGAGCCGCCGGCCTGGCGCCTCATCGATACCGGCCCCCTGGACGGCCCACGGAACATGGCGGTGGACGAGGCGCTCCTC
CGCCACTTCGGCCAGGGGGC

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MELIFEKSVTGRRGVRLPASDVPPAPPLSAVLARDGAPDLPQVSELDVVRHFTTLSRRNFSVDTHFYPLGSCTMKYNAKA
LEEAAKLFAPYHPMVPLLPHGASFSQGSLGLVHGLGEALAEITGMDEVTCQPLAGAHGEMTGIMLIAAYHEAKGNRKKYV
VVPDSSHGTNPASAAMVGYEIITVPTAPYGDMDLEKYRAVMTDEVAAVMMTCPNTLGLFNPHIREICDIAHDHDALMYYD
GANLNAILGKVRPGDVGFDVIHVNLHKTFGTPHGGGGPGSGPVGVKKLLASYLPGPRVVKNSDGDYSVIPHSHESIGRTA
GFFGNFGVMAKAFAYITMLGREGLIQVSEQAVLNANYIMARLKDVYDLPYDQTCMHECVFSAARQARNGVHAIDIAKFLI
DRGFHPPTVYFPLIVKEAIMIEPTETESKETMDAFIEAMRDAADLAERNPAAFAELPRTMPITRPDETKAAREQNVCYFG
C

Sequences:

>Translated_481_residues
MELIFEKSVTGRRGVRLPASDVPPAPPLSAVLARDGAPDLPQVSELDVVRHFTTLSRRNFSVDTHFYPLGSCTMKYNAKA
LEEAAKLFAPYHPMVPLLPHGASFSQGSLGLVHGLGEALAEITGMDEVTCQPLAGAHGEMTGIMLIAAYHEAKGNRKKYV
VVPDSSHGTNPASAAMVGYEIITVPTAPYGDMDLEKYRAVMTDEVAAVMMTCPNTLGLFNPHIREICDIAHDHDALMYYD
GANLNAILGKVRPGDVGFDVIHVNLHKTFGTPHGGGGPGSGPVGVKKLLASYLPGPRVVKNSDGDYSVIPHSHESIGRTA
GFFGNFGVMAKAFAYITMLGREGLIQVSEQAVLNANYIMARLKDVYDLPYDQTCMHECVFSAARQARNGVHAIDIAKFLI
DRGFHPPTVYFPLIVKEAIMIEPTETESKETMDAFIEAMRDAADLAERNPAAFAELPRTMPITRPDETKAAREQNVCYFG
C
>Mature_481_residues
MELIFEKSVTGRRGVRLPASDVPPAPPLSAVLARDGAPDLPQVSELDVVRHFTTLSRRNFSVDTHFYPLGSCTMKYNAKA
LEEAAKLFAPYHPMVPLLPHGASFSQGSLGLVHGLGEALAEITGMDEVTCQPLAGAHGEMTGIMLIAAYHEAKGNRKKYV
VVPDSSHGTNPASAAMVGYEIITVPTAPYGDMDLEKYRAVMTDEVAAVMMTCPNTLGLFNPHIREICDIAHDHDALMYYD
GANLNAILGKVRPGDVGFDVIHVNLHKTFGTPHGGGGPGSGPVGVKKLLASYLPGPRVVKNSDGDYSVIPHSHESIGRTA
GFFGNFGVMAKAFAYITMLGREGLIQVSEQAVLNANYIMARLKDVYDLPYDQTCMHECVFSAARQARNGVHAIDIAKFLI
DRGFHPPTVYFPLIVKEAIMIEPTETESKETMDAFIEAMRDAADLAERNPAAFAELPRTMPITRPDETKAAREQNVCYFG
C

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=428, Percent_Identity=40.6542056074766, Blast_Score=251, Evalue=8e-67,
Organism=Escherichia coli, GI1789269, Length=411, Percent_Identity=40.3892944038929, Blast_Score=261, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI17535605, Length=406, Percent_Identity=39.9014778325123, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI32564013, Length=356, Percent_Identity=40.7303370786517, Blast_Score=229, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6323843, Length=408, Percent_Identity=41.421568627451, Blast_Score=263, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24645648, Length=408, Percent_Identity=39.2156862745098, Blast_Score=244, Evalue=7e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 52175; Mature: 52175

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIFEKSVTGRRGVRLPASDVPPAPPLSAVLARDGAPDLPQVSELDVVRHFTTLSRRNF
CCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
SVDTHFYPLGSCTMKYNAKALEEAAKLFAPYHPMVPLLPHGASFSQGSLGLVHGLGEALA
CCCCEEEECCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
EITGMDEVTCQPLAGAHGEMTGIMLIAAYHEAKGNRKKYVVVPDSSHGTNPASAAMVGYE
HHCCCCCCCCCCCCCCCCCCEEEEEEEEEHHCCCCCEEEEEEECCCCCCCCHHHHEEEEE
IITVPTAPYGDMDLEKYRAVMTDEVAAVMMTCPNTLGLFNPHIREICDIAHDHDALMYYD
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEC
GANLNAILGKVRPGDVGFDVIHVNLHKTFGTPHGGGGPGSGPVGVKKLLASYLPGPRVVK
CCCCHHHEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
NSDGDYSVIPHSHESIGRTAGFFGNFGVMAKAFAYITMLGREGLIQVSEQAVLNANYIMA
CCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
RLKDVYDLPYDQTCMHECVFSAARQARNGVHAIDIAKFLIDRGFHPPTVYFPLIVKEAIM
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHEE
IEPTETESKETMDAFIEAMRDAADLAERNPAAFAELPRTMPITRPDETKAAREQNVCYFG
ECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHCCCEEEC
C
C
>Mature Secondary Structure
MELIFEKSVTGRRGVRLPASDVPPAPPLSAVLARDGAPDLPQVSELDVVRHFTTLSRRNF
CCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
SVDTHFYPLGSCTMKYNAKALEEAAKLFAPYHPMVPLLPHGASFSQGSLGLVHGLGEALA
CCCCEEEECCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
EITGMDEVTCQPLAGAHGEMTGIMLIAAYHEAKGNRKKYVVVPDSSHGTNPASAAMVGYE
HHCCCCCCCCCCCCCCCCCCEEEEEEEEEHHCCCCCEEEEEEECCCCCCCCHHHHEEEEE
IITVPTAPYGDMDLEKYRAVMTDEVAAVMMTCPNTLGLFNPHIREICDIAHDHDALMYYD
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEC
GANLNAILGKVRPGDVGFDVIHVNLHKTFGTPHGGGGPGSGPVGVKKLLASYLPGPRVVK
CCCCHHHEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
NSDGDYSVIPHSHESIGRTAGFFGNFGVMAKAFAYITMLGREGLIQVSEQAVLNANYIMA
CCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
RLKDVYDLPYDQTCMHECVFSAARQARNGVHAIDIAKFLIDRGFHPPTVYFPLIVKEAIM
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHEE
IEPTETESKETMDAFIEAMRDAADLAERNPAAFAELPRTMPITRPDETKAAREQNVCYFG
ECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHCCCEEEC
C
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA