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The map label for this gene is nouD [H]

Identifier: 39995450

GI number: 39995450

Start: 369296

End: 370468

Strand: Direct

Name: nouD [H]

Synonym: GSU0341

Alternate gene names: 39995450

Gene position: 369296-370468 (Clockwise)

Preceding gene: 39995449

Following gene: 39995451

Centisome position: 9.68

GC content: 52.43

Gene sequence:

>1173_bases
ATGGCTAGCACTGAGATAATGACAGTCAATATGGGACCGCAGCACCCGAGTACGCACGGCGTTCTGCGGATGGTCATCGA
ACTTGATGGAGAGGTTATCCAGAAGATTACTCCGCATATCGGATATCTGCATCGGGGAGTGGAGAAGCTCTCCGAGCATC
GTACCTATCACCAGACCATACCTCTAACTGACCGTCTCGACTACTTGGCGCCGATGAGCAATAACCTCGGCTATGTGTTG
GCGGTTGAAAAGCTTTTGGGTATTGAGATTCCTGAGCGCGCTCAGACAATTCGCGTCATCATGGCTGAGCTCACCCGTCT
CAAATCCCATTTGGTCTGGATTGCCTGCCACGCACTTGATATCGGAGCGATGACAGTCTTCATCTACGCTTTCCGTGAGC
GTGAGATGATCATGAGTCTCTATGAAAAGATATCCGGTGCACGGATGACCAGCAACTACTTCAGGGTCGGTGGACTTTCA
TCCGATGTTTATGACGGGTTCGAAAAGGATGTGCGGGAAGTCATCGACACATTCCCCGGTCACTTCGATACCTACGAAGG
CCTTCTTACCAAAAACACCATCTGGGTCAACCGTACTGTTGGCAATGGCGTGATATCGGCTGAGGATGCCGTCGACTACG
GGATAACCGGTCCTGCACTCCGCGGCTCGGGCGTTGATTGGGATTTGCGTCGTGACAATCCTTACAGTGGCTACGAGAAG
TACTCGTTCAAGGTTCCTGTCGGTGAGAAGTGTGACACCTTTGACCGCTACAAGGTCAGGCTCATTGAAATGCGCGAAGC
GGTCAATATCATCCGCCAAGCACTCGACTCGCTCAAGCCTGGGCCCGTGCTGGCTGACAATCCGCAGGTCACCTACCCGC
CGAAGGAGAATGTTTACAACTCTATCGAAGGCCTCATTCACCACTTCAAGATAGCCAGCGAAGGTTTCCCTGTGCCAGAA
GGTGAGGTGTACCAGTCGGTGGAAGCTCCCAAAGGAGAGCTTGGTTACTACATCGTCAGCGACGGTGGCCCCAAGCCATA
CCGGATGAGAATAAGACCTCCTTCATTTGTAAACTTGGGGGCTATCGAGAAGATGGCTAAGGGATCGATGATTGCCGACT
TGGTTGCAGTCATCGGGACCTTGGATATCGTGCTTGGTGAAATCGACCGGTAA

Upstream 100 bases:

>100_bases
CCCCTGCAGGGGCCTGATCGTGAGCCCTACAAGGGCCGGCTTTCCTGATTTATCGGCTTGCTGAGAGAAAATAACTCCAC
AGGGATACAGAGGCGCACAA

Downstream 100 bases:

>100_bases
TGCCACTGCGATAAAGGAGAGGGAGTAATGAGTAACGCTCCGGCCGAAGCTACAACCACAGAGGAAGTGCCCGTTGAGGA
AATAGACCTCGGGCCAGCCA

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MASTEIMTVNMGPQHPSTHGVLRMVIELDGEVIQKITPHIGYLHRGVEKLSEHRTYHQTIPLTDRLDYLAPMSNNLGYVL
AVEKLLGIEIPERAQTIRVIMAELTRLKSHLVWIACHALDIGAMTVFIYAFREREMIMSLYEKISGARMTSNYFRVGGLS
SDVYDGFEKDVREVIDTFPGHFDTYEGLLTKNTIWVNRTVGNGVISAEDAVDYGITGPALRGSGVDWDLRRDNPYSGYEK
YSFKVPVGEKCDTFDRYKVRLIEMREAVNIIRQALDSLKPGPVLADNPQVTYPPKENVYNSIEGLIHHFKIASEGFPVPE
GEVYQSVEAPKGELGYYIVSDGGPKPYRMRIRPPSFVNLGAIEKMAKGSMIADLVAVIGTLDIVLGEIDR

Sequences:

>Translated_390_residues
MASTEIMTVNMGPQHPSTHGVLRMVIELDGEVIQKITPHIGYLHRGVEKLSEHRTYHQTIPLTDRLDYLAPMSNNLGYVL
AVEKLLGIEIPERAQTIRVIMAELTRLKSHLVWIACHALDIGAMTVFIYAFREREMIMSLYEKISGARMTSNYFRVGGLS
SDVYDGFEKDVREVIDTFPGHFDTYEGLLTKNTIWVNRTVGNGVISAEDAVDYGITGPALRGSGVDWDLRRDNPYSGYEK
YSFKVPVGEKCDTFDRYKVRLIEMREAVNIIRQALDSLKPGPVLADNPQVTYPPKENVYNSIEGLIHHFKIASEGFPVPE
GEVYQSVEAPKGELGYYIVSDGGPKPYRMRIRPPSFVNLGAIEKMAKGSMIADLVAVIGTLDIVLGEIDR
>Mature_389_residues
ASTEIMTVNMGPQHPSTHGVLRMVIELDGEVIQKITPHIGYLHRGVEKLSEHRTYHQTIPLTDRLDYLAPMSNNLGYVLA
VEKLLGIEIPERAQTIRVIMAELTRLKSHLVWIACHALDIGAMTVFIYAFREREMIMSLYEKISGARMTSNYFRVGGLSS
DVYDGFEKDVREVIDTFPGHFDTYEGLLTKNTIWVNRTVGNGVISAEDAVDYGITGPALRGSGVDWDLRRDNPYSGYEKY
SFKVPVGEKCDTFDRYKVRLIEMREAVNIIRQALDSLKPGPVLADNPQVTYPPKENVYNSIEGLIHHFKIASEGFPVPEG
EVYQSVEAPKGELGYYIVSDGGPKPYRMRIRPPSFVNLGAIEKMAKGSMIADLVAVIGTLDIVLGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=384, Percent_Identity=50.78125, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI260898743, Length=378, Percent_Identity=50.2645502645503, Blast_Score=399, Evalue=1e-111,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=42.6356589147287, Blast_Score=347, Evalue=8e-97,
Organism=Escherichia coli, GI1789076, Length=385, Percent_Identity=31.4285714285714, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1788832, Length=390, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17568379, Length=386, Percent_Identity=50, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17555284, Length=388, Percent_Identity=49.2268041237113, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24638644, Length=388, Percent_Identity=49.4845360824742, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=49.2146596858639, Blast_Score=405, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 43714; Mature: 43583

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTEIMTVNMGPQHPSTHGVLRMVIELDGEVIQKITPHIGYLHRGVEKLSEHRTYHQTI
CCCCEEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHCCHHHHCC
PLTDRLDYLAPMSNNLGYVLAVEKLLGIEIPERAQTIRVIMAELTRLKSHLVWIACHALD
CCHHHHHHHCCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEHHHH
IGAMTVFIYAFREREMIMSLYEKISGARMTSNYFRVGGLSSDVYDGFEKDVREVIDTFPG
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEECCCCHHHHHHHHHHHHHHHHHCCC
HFDTYEGLLTKNTIWVNRTVGNGVISAEDAVDYGITGPALRGSGVDWDLRRDNPYSGYEK
CCCCHHCCEECCEEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCC
YSFKVPVGEKCDTFDRYKVRLIEMREAVNIIRQALDSLKPGPVLADNPQVTYPPKENVYN
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEECCCHHHHHH
SIEGLIHHFKIASEGFPVPEGEVYQSVEAPKGELGYYIVSDGGPKPYRMRIRPPSFVNLG
HHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCHH
AIEKMAKGSMIADLVAVIGTLDIVLGEIDR
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASTEIMTVNMGPQHPSTHGVLRMVIELDGEVIQKITPHIGYLHRGVEKLSEHRTYHQTI
CCCEEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHCCHHHHCC
PLTDRLDYLAPMSNNLGYVLAVEKLLGIEIPERAQTIRVIMAELTRLKSHLVWIACHALD
CCHHHHHHHCCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEHHHH
IGAMTVFIYAFREREMIMSLYEKISGARMTSNYFRVGGLSSDVYDGFEKDVREVIDTFPG
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEECCCCHHHHHHHHHHHHHHHHHCCC
HFDTYEGLLTKNTIWVNRTVGNGVISAEDAVDYGITGPALRGSGVDWDLRRDNPYSGYEK
CCCCHHCCEECCEEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCC
YSFKVPVGEKCDTFDRYKVRLIEMREAVNIIRQALDSLKPGPVLADNPQVTYPPKENVYN
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEECCCHHHHHH
SIEGLIHHFKIASEGFPVPEGEVYQSVEAPKGELGYYIVSDGGPKPYRMRIRPPSFVNLG
HHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCHH
AIEKMAKGSMIADLVAVIGTLDIVLGEIDR
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA