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The map label for this gene is yhfN [H]

Identifier: 39995427

GI number: 39995427

Start: 348883

End: 350127

Strand: Direct

Name: yhfN [H]

Synonym: GSU0318

Alternate gene names: 39995427

Gene position: 348883-350127 (Clockwise)

Preceding gene: 39995426

Following gene: 39995440

Centisome position: 9.15

GC content: 61.04

Gene sequence:

>1245_bases
ATGACTTTGACGATCCTCGCCTGTTACCTCGCGGTCCTCACCTTCGAGCATCTGCTCCGCATAATGAACCTCAAACATCT
CAGGCGCCAGGGTACAACGGTCCCCGATGGCTTCGCCGGCGCGGTGGATGAAGGGAGCCTTCGCACTGCAACTGCCTATA
CCCTCGACCGGAGTCGCCTGGGGATTGCGGAATCACTGGTCGACAGCGGCCTCCTTGTCGGGTTTCTCTTCGCGGGGATC
CTTCCTCTCTTCGACCGCTGGGTTGCCTCGCTGACCTCCTCGTTCATCCTCGGGGGTGTCGTCTTCTTTCTGCTTCTCTC
CCTCGTTCAGAGTGCACTGGCGATCCCCTTCGGACTCTATGAAACATTCGTCATTGAGCGTCGGTACGGCTTTACCACCA
TAACGCCGAAGCTCTGGTGGTCCGACCTGCTTAAGTCGACATGTATTTCAATGACGCTTGCCACGCTCATGATTTCCGGC
GCTTTCGCCCTGGTTGCATGGAGTCCCCTGCACTGGTGGCTCTGGGTCTGGGGCTTTCTCGCGTTTCTGACCCTGTTTCT
CATGTACCTCTCACCGTATGTCATCGAGCCGTTGTTCAACCGCTACGAGCCGGTGAAGACCGAAGGGCTGGAAGAAGAGA
TCCGTGCCATGGCCGAGCGGGCCGGACTCAGGGTGAGCCGGGTTATGCAGGTGGATGCCTCCCGGCGCAGCCGCCACTCC
AATGCCTACTTTACCGGCATCGGCCGGGTGAAGCGCATCGTGCTGTACGATACGCTGCTGGGCCAGATGACCCACGCGGA
GATTCTGGCGGTCCTGGCCCATGAGATCGGCCACTGGAAGCTCGGACACATCCGCCGGAGGCTTATTGCCGGTCAGGCAG
GTGCCCTTGCCGCTGCCTGGCTGGCGTGGCGGGTCACATCATGGGAGGGGCTGCCCGGACTTCTCGGGATGACGGAGGCG
ACGTTTCCGGCCCGGCTCGTGATCGTCGGCTTCATCGGTACCTTGGCGCTCTTTCCGCTCACGCCCCTGTTTGCCTGGTT
GTCGCGCCGGCAGGAGCGGGAGGCCGACCGATTCGCAGTGGAGCTCTGCGAAAATCCCGCATCGCTCGCTACGGCGCTGG
TTAAACTTTCCCGGGAAAATCTCTCCAATCTCCATCCGCACCCCCTCTACGCAGCATTTCACTATTCCCACCCGCCGGTG
GTTGAACGGGTGCAAGGGCTGCTGGCGCTGGCGCGAAAAGAATGA

Upstream 100 bases:

>100_bases
GATCATTCGGTGCATGCACGGGGAGGGGCAACAGCTCCTCCCCTTTTCCGTTCCAGGCCCAATTCTCGACAACCGTTGTC
CCCTGATGTATCCTTCCCCC

Downstream 100 bases:

>100_bases
TCTGTGCGAGTGTGGACGGCAGTGGAGGCAGGGCGTTACTGAAGAAGAGGCTTTGAGAGGGTTCCCCGGATCGGCAGCCG
GTAGTGACCCGGCGTTATCA

Product: M48 family peptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTLTILACYLAVLTFEHLLRIMNLKHLRRQGTTVPDGFAGAVDEGSLRTATAYTLDRSRLGIAESLVDSGLLVGFLFAGI
LPLFDRWVASLTSSFILGGVVFFLLLSLVQSALAIPFGLYETFVIERRYGFTTITPKLWWSDLLKSTCISMTLATLMISG
AFALVAWSPLHWWLWVWGFLAFLTLFLMYLSPYVIEPLFNRYEPVKTEGLEEEIRAMAERAGLRVSRVMQVDASRRSRHS
NAYFTGIGRVKRIVLYDTLLGQMTHAEILAVLAHEIGHWKLGHIRRRLIAGQAGALAAAWLAWRVTSWEGLPGLLGMTEA
TFPARLVIVGFIGTLALFPLTPLFAWLSRRQEREADRFAVELCENPASLATALVKLSRENLSNLHPHPLYAAFHYSHPPV
VERVQGLLALARKE

Sequences:

>Translated_414_residues
MTLTILACYLAVLTFEHLLRIMNLKHLRRQGTTVPDGFAGAVDEGSLRTATAYTLDRSRLGIAESLVDSGLLVGFLFAGI
LPLFDRWVASLTSSFILGGVVFFLLLSLVQSALAIPFGLYETFVIERRYGFTTITPKLWWSDLLKSTCISMTLATLMISG
AFALVAWSPLHWWLWVWGFLAFLTLFLMYLSPYVIEPLFNRYEPVKTEGLEEEIRAMAERAGLRVSRVMQVDASRRSRHS
NAYFTGIGRVKRIVLYDTLLGQMTHAEILAVLAHEIGHWKLGHIRRRLIAGQAGALAAAWLAWRVTSWEGLPGLLGMTEA
TFPARLVIVGFIGTLALFPLTPLFAWLSRRQEREADRFAVELCENPASLATALVKLSRENLSNLHPHPLYAAFHYSHPPV
VERVQGLLALARKE
>Mature_413_residues
TLTILACYLAVLTFEHLLRIMNLKHLRRQGTTVPDGFAGAVDEGSLRTATAYTLDRSRLGIAESLVDSGLLVGFLFAGIL
PLFDRWVASLTSSFILGGVVFFLLLSLVQSALAIPFGLYETFVIERRYGFTTITPKLWWSDLLKSTCISMTLATLMISGA
FALVAWSPLHWWLWVWGFLAFLTLFLMYLSPYVIEPLFNRYEPVKTEGLEEEIRAMAERAGLRVSRVMQVDASRRSRHSN
AYFTGIGRVKRIVLYDTLLGQMTHAEILAVLAHEIGHWKLGHIRRRLIAGQAGALAAAWLAWRVTSWEGLPGLLGMTEAT
FPARLVIVGFIGTLALFPLTPLFAWLSRRQEREADRFAVELCENPASLATALVKLSRENLSNLHPHPLYAAFHYSHPPVV
ERVQGLLALARKE

Specific function: Seems To Regulate The Expression Of Speb. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=439, Percent_Identity=29.1571753986333, Blast_Score=171, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17505484, Length=416, Percent_Identity=28.8461538461538, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322577, Length=445, Percent_Identity=28.0898876404494, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI19922414, Length=438, Percent_Identity=29.4520547945205, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI78707252, Length=408, Percent_Identity=27.6960784313726, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI78707254, Length=408, Percent_Identity=27.6960784313726, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24654305, Length=352, Percent_Identity=26.9886363636364, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 46396; Mature: 46265

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLTILACYLAVLTFEHLLRIMNLKHLRRQGTTVPDGFAGAVDEGSLRTATAYTLDRSRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GIAESLVDSGLLVGFLFAGILPLFDRWVASLTSSFILGGVVFFLLLSLVQSALAIPFGLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ETFVIERRYGFTTITPKLWWSDLLKSTCISMTLATLMISGAFALVAWSPLHWWLWVWGFL
HHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFLTLFLMYLSPYVIEPLFNRYEPVKTEGLEEEIRAMAERAGLRVSRVMQVDASRRSRHS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
NAYFTGIGRVKRIVLYDTLLGQMTHAEILAVLAHEIGHWKLGHIRRRLIAGQAGALAAAW
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
LAWRVTSWEGLPGLLGMTEATFPARLVIVGFIGTLALFPLTPLFAWLSRRQEREADRFAV
HHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELCENPASLATALVKLSRENLSNLHPHPLYAAFHYSHPPVVERVQGLLALARKE
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]