Click here to switch to the map view.

The map label for this gene is degP [H]

Identifier: 39995440

GI number: 39995440

Start: 361506

End: 362900

Strand: Direct

Name: degP [H]

Synonym: GSU0331

Alternate gene names: 39995440

Gene position: 361506-362900 (Clockwise)

Preceding gene: 39995427

Following gene: 39995441

Centisome position: 9.48

GC content: 58.14

Gene sequence:

>1395_bases
ATGAAAATGGTGTCCTTGCGGTTCCTTAAGACCATGCTCACCGTTATCTGCCTGATGGCGTTGTCGGCGGGAGAAGTCCC
AGCCAAAGTCATGGCTCCCGATTTTGTCACACTTGCCGAAAAGCTGAAGCCAACCGTCGTCAACATCAGTACATCAAAGA
ATCCGGCCCAGACAGCTCGCCCCCGTCGCCAACCCTCTCCCTTCAATGACCCGTTCCATGATTTCTTCGATCGCTTTTTT
GACGAGGCACCTCGCCGTCAGCAACGGGAACGGAGTCTCGGCTCCGGGTTCATCATCAGTGATCAGGGCTTTATCATCAC
CAATAACCATGTGGTTGCCGGTGCCGACGAGATCAAGGTGCGCCTCTCCGACGGCCGCGAGTTCAAGGCGGAATTGAAGG
GCGCCGACGAAAAACTCGACCTGGCCCTCATCAAGATTGAGTCCAAAGATCAACTCCCCGTTGCGATTCTCGGCAACAGC
GATGAAATCAAAGTGGGCGAGTGGGTGATGGCGATCGGCAATCCGTTCGGCCTTGCCCAGACCGTTACCGCCGGAATCGT
CAGCGCCACCGGTCGCGTCATCGGCAGCGGGCCCTATGACGATTTCATCCAGACCGATGCCTCCATTAACCCCGGTAACT
CGGGAGGCCCCCTTTTCAGCGCCGAAGGAAAAGTCATCGGCATCAATACCGCCATCATCGCCGGCGGTCAGGGAATCGGG
TTTGCCATCCCCATCAACATGGCCAAAGATGTCATTCCCCAGCTCGAGGAAAAGGGAAAGGTCATCCGCGGCTGGCTTGG
GGTGACGGTTCAGCCCATAACTCCCGATCTGGCCCGCTCGTTTGGCCTTGAGGGAGAGCGGGGTGCGCTCATCGCCGACG
TGGTGAAGGATGGCCCCGCCGCCAAGGCCGGACTCAAGAGCGGGGATATCGTGCTTGAATTCGACGGTAAGAAAATCCGG
GAAATGAACGAGCTCCCGCGTATCGTAGCCGCCACCCCTGTGGGGAAGGCCGCATTGGTCAAGGTGCTGCGTGATGGCAA
GATGCAGGATGTCGAAGTATCTGTCGGGCGCTTGGCGGATACGGGCGATGAGTCAGATCAGAAGAATGGTGAAGATAAAC
TTGGCATGGCAGTCAGGGAGCTGACACGCGATCTTGCCGCGCGGATGGGGCTTAAGGAGACTCAGGGCGTCGTTGTCACG
GGTGTCAAGTCTGGCAGTCTGGCCGAGGAAGCGGGAATCCTGCCGGGCGATATCGTTCGGGAGATAGGAGGGCGTTCCAT
TACTACTATGGCGGATTACGAAACAGCGATCCGAGCCGTGAAGAAGGGAGACGTAGTCCGCTTTCTGCTGCGCCGCGGCG
GTGGCAACCACTTCCTGGCAATCCGGGTCGAATAG

Upstream 100 bases:

>100_bases
CCGCTGGTGCGGCATCTGCAAGGGGTTTAGCCGCCCTCTGGTTGACAAACAACCCCTCGATTATTACATTTATCGGGTCA
ATTTTACTGAGGAGGTCCGT

Downstream 100 bases:

>100_bases
CCTGGCTTCATACTTCAGAAGAAGGGGCATGTCTGCGGACATGCCCCTTCTTTATTGATTACAAGGAGATATCCTATGGT
TATTTCAGTAGAGGCTGCCG

Product: trypsin domain/PDZ domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKMVSLRFLKTMLTVICLMALSAGEVPAKVMAPDFVTLAEKLKPTVVNISTSKNPAQTARPRRQPSPFNDPFHDFFDRFF
DEAPRRQQRERSLGSGFIISDQGFIITNNHVVAGADEIKVRLSDGREFKAELKGADEKLDLALIKIESKDQLPVAILGNS
DEIKVGEWVMAIGNPFGLAQTVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFSAEGKVIGINTAIIAGGQGIG
FAIPINMAKDVIPQLEEKGKVIRGWLGVTVQPITPDLARSFGLEGERGALIADVVKDGPAAKAGLKSGDIVLEFDGKKIR
EMNELPRIVAATPVGKAALVKVLRDGKMQDVEVSVGRLADTGDESDQKNGEDKLGMAVRELTRDLAARMGLKETQGVVVT
GVKSGSLAEEAGILPGDIVREIGGRSITTMADYETAIRAVKKGDVVRFLLRRGGGNHFLAIRVE

Sequences:

>Translated_464_residues
MKMVSLRFLKTMLTVICLMALSAGEVPAKVMAPDFVTLAEKLKPTVVNISTSKNPAQTARPRRQPSPFNDPFHDFFDRFF
DEAPRRQQRERSLGSGFIISDQGFIITNNHVVAGADEIKVRLSDGREFKAELKGADEKLDLALIKIESKDQLPVAILGNS
DEIKVGEWVMAIGNPFGLAQTVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFSAEGKVIGINTAIIAGGQGIG
FAIPINMAKDVIPQLEEKGKVIRGWLGVTVQPITPDLARSFGLEGERGALIADVVKDGPAAKAGLKSGDIVLEFDGKKIR
EMNELPRIVAATPVGKAALVKVLRDGKMQDVEVSVGRLADTGDESDQKNGEDKLGMAVRELTRDLAARMGLKETQGVVVT
GVKSGSLAEEAGILPGDIVREIGGRSITTMADYETAIRAVKKGDVVRFLLRRGGGNHFLAIRVE
>Mature_464_residues
MKMVSLRFLKTMLTVICLMALSAGEVPAKVMAPDFVTLAEKLKPTVVNISTSKNPAQTARPRRQPSPFNDPFHDFFDRFF
DEAPRRQQRERSLGSGFIISDQGFIITNNHVVAGADEIKVRLSDGREFKAELKGADEKLDLALIKIESKDQLPVAILGNS
DEIKVGEWVMAIGNPFGLAQTVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFSAEGKVIGINTAIIAGGQGIG
FAIPINMAKDVIPQLEEKGKVIRGWLGVTVQPITPDLARSFGLEGERGALIADVVKDGPAAKAGLKSGDIVLEFDGKKIR
EMNELPRIVAATPVGKAALVKVLRDGKMQDVEVSVGRLADTGDESDQKNGEDKLGMAVRELTRDLAARMGLKETQGVVVT
GVKSGSLAEEAGILPGDIVREIGGRSITTMADYETAIRAVKKGDVVRFLLRRGGGNHFLAIRVE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=277, Percent_Identity=39.7111913357401, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI22129776, Length=254, Percent_Identity=40.5511811023622, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI24308541, Length=261, Percent_Identity=37.9310344827586, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI7019477, Length=250, Percent_Identity=35.2, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1786356, Length=467, Percent_Identity=36.6167023554604, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1789629, Length=445, Percent_Identity=34.8314606741573, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI1789630, Length=315, Percent_Identity=38.4126984126984, Blast_Score=199, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24646839, Length=285, Percent_Identity=36.4912280701754, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 49592; Mature: 49592

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMVSLRFLKTMLTVICLMALSAGEVPAKVMAPDFVTLAEKLKPTVVNISTSKNPAQTAR
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHCCCEEEEEECCCCCHHHCC
PRRQPSPFNDPFHDFFDRFFDEAPRRQQRERSLGSGFIISDQGFIITNNHVVAGADEIKV
CCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEEEECCCEEEECCEEEECCCEEEE
RLSDGREFKAELKGADEKLDLALIKIESKDQLPVAILGNSDEIKVGEWVMAIGNPFGLAQ
EECCCCCHHHHHCCCCCCEEEEEEEECCCCCCCEEEECCCCCEECCCEEEECCCCCCHHH
TVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFSAEGKVIGINTAIIAGGQGIG
HHHHHHHHHCCCEECCCCCHHHHCCCCCCCCCCCCCCEEECCCCEEEEEEEEEECCCCCE
FAIPINMAKDVIPQLEEKGKVIRGWLGVTVQPITPDLARSFGLEGERGALIADVVKDGPA
EEEEHHHHHHHHHHHHHCCCEEEEEECEEEECCCHHHHHHHCCCCCCCCCHHHHHCCCCC
AKAGLKSGDIVLEFDGKKIREMNELPRIVAATPVGKAALVKVLRDGKMQDVEVSVGRLAD
HHCCCCCCCEEEEECCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCEEEEEHHHCCC
TGDESDQKNGEDKLGMAVRELTRDLAARMGLKETQGVVVTGVKSGSLAEEAGILPGDIVR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHCCCCCHHHHH
EIGGRSITTMADYETAIRAVKKGDVVRFLLRRGGGNHFLAIRVE
HHCCCEEEEHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure
MKMVSLRFLKTMLTVICLMALSAGEVPAKVMAPDFVTLAEKLKPTVVNISTSKNPAQTAR
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHCCCEEEEEECCCCCHHHCC
PRRQPSPFNDPFHDFFDRFFDEAPRRQQRERSLGSGFIISDQGFIITNNHVVAGADEIKV
CCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEEEECCCEEEECCEEEECCCEEEE
RLSDGREFKAELKGADEKLDLALIKIESKDQLPVAILGNSDEIKVGEWVMAIGNPFGLAQ
EECCCCCHHHHHCCCCCCEEEEEEEECCCCCCCEEEECCCCCEECCCEEEECCCCCCHHH
TVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFSAEGKVIGINTAIIAGGQGIG
HHHHHHHHHCCCEECCCCCHHHHCCCCCCCCCCCCCCEEECCCCEEEEEEEEEECCCCCE
FAIPINMAKDVIPQLEEKGKVIRGWLGVTVQPITPDLARSFGLEGERGALIADVVKDGPA
EEEEHHHHHHHHHHHHHCCCEEEEEECEEEECCCHHHHHHHCCCCCCCCCHHHHHCCCCC
AKAGLKSGDIVLEFDGKKIREMNELPRIVAATPVGKAALVKVLRDGKMQDVEVSVGRLAD
HHCCCCCCCEEEEECCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCEEEEEHHHCCC
TGDESDQKNGEDKLGMAVRELTRDLAARMGLKETQGVVVTGVKSGSLAEEAGILPGDIVR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHCCCCCHHHHH
EIGGRSITTMADYETAIRAVKKGDVVRFLLRRGGGNHFLAIRVE
HHCCCEEEEHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]