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The map label for this gene is lexA-1

Identifier: 39995152

GI number: 39995152

Start: 51143

End: 51748

Strand: Direct

Name: lexA-1

Synonym: GSU0041

Alternate gene names: 39995152

Gene position: 51143-51748 (Clockwise)

Preceding gene: 39995151

Following gene: 39995153

Centisome position: 1.34

GC content: 67.33

Gene sequence:

>606_bases
ATGCAGGAACTTGCCCCCCGCCAGCAACAGGTCCTCGCCTTCATCACCGGCTTCATCGCCGAAAACGGCTACCCGCCGAC
CCTGCGGGAAATCGCCGCCCACCTCAAGATAAGCGGCACCCTCGGGGTCTCCAAGCACCTGGAGGCCCTGGAGCGCAAGG
GGTACCTGCGCCGGGAGGCCAACAGCTCGCGGGGGATCGCCCTTGTCGGTCGGACAGACACAGCGCTCTCCCTCCCCGTG
GCGGGAGTGGTCCGGGCCGGGCTCCCCCAGCCGGCCGTGGAGGACATCGAGGAGTATTTCGCCATCGACCGGAGCATGGT
GCGGGGTGGCACCTTCTTTCTGCGGGTCAAGGGTGACTCCATGATCAACGCCGCCATTGTGGAAGGAGATCTGGCCCTGG
TCCGCCCCCAGGCCACGGCGGAGAACCGGGACATCGTGGTCGCCATGGTGGACGGCGAGGCCACCCTCAAGCGCTTCTAC
CGGCAGCGGGACCAGATCCGCCTCCAGCCCGAGAACCCCAACATGGACCCCATCATCATCCGGCCGGGGGAGGGGGACGT
GGCGATCATCGGCAAGGTGGTCGGCATCTACCGACCCCTGGAGTAG

Upstream 100 bases:

>100_bases
CCCCGCCCTGGCGGACGTAGATCGAGCGCCCTTGACAGGTCGCCTGTACGGTGATAGGTTGTCACATGTATACCATGACT
GATGACAACCCGGAGGAGCC

Downstream 100 bases:

>100_bases
AGCGCCATGGAACGGGTAGCACAACAGGTCAAGGTGGCGGCCGTCTTTGCCCCGGGGAGCCGGATCAGACCCGTCTGGTT
CGAGTGGAACCGGGAGAAGC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MQELAPRQQQVLAFITGFIAENGYPPTLREIAAHLKISGTLGVSKHLEALERKGYLRREANSSRGIALVGRTDTALSLPV
AGVVRAGLPQPAVEDIEEYFAIDRSMVRGGTFFLRVKGDSMINAAIVEGDLALVRPQATAENRDIVVAMVDGEATLKRFY
RQRDQIRLQPENPNMDPIIIRPGEGDVAIIGKVVGIYRPLE

Sequences:

>Translated_201_residues
MQELAPRQQQVLAFITGFIAENGYPPTLREIAAHLKISGTLGVSKHLEALERKGYLRREANSSRGIALVGRTDTALSLPV
AGVVRAGLPQPAVEDIEEYFAIDRSMVRGGTFFLRVKGDSMINAAIVEGDLALVRPQATAENRDIVVAMVDGEATLKRFY
RQRDQIRLQPENPNMDPIIIRPGEGDVAIIGKVVGIYRPLE
>Mature_201_residues
MQELAPRQQQVLAFITGFIAENGYPPTLREIAAHLKISGTLGVSKHLEALERKGYLRREANSSRGIALVGRTDTALSLPV
AGVVRAGLPQPAVEDIEEYFAIDRSMVRGGTFFLRVKGDSMINAAIVEGDLALVRPQATAENRDIVVAMVDGEATLKRFY
RQRDQIRLQPENPNMDPIIIRPGEGDVAIIGKVVGIYRPLE

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=199, Percent_Identity=36.6834170854271, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI1787431, Length=122, Percent_Identity=32.7868852459016, Blast_Score=74, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA1_GEOSL (P61608)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951103.1
- ProteinModelPortal:   P61608
- SMR:   P61608
- MEROPS:   S24.001
- GeneID:   2688558
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0041
- NMPDR:   fig|243231.1.peg.41
- TIGR:   GSU0041
- HOGENOM:   HBG679610
- OMA:   ITNHINA
- ProtClustDB:   CLSK827607
- BioCyc:   GSUL243231:GSU_0041-MONOMER
- BRENDA:   3.4.21.88
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 22059; Mature: 22059

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: ACT_SITE 120-120 ACT_SITE 157-157

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQELAPRQQQVLAFITGFIAENGYPPTLREIAAHLKISGTLGVSKHLEALERKGYLRREA
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHCCCHHHCC
NSSRGIALVGRTDTALSLPVAGVVRAGLPQPAVEDIEEYFAIDRSMVRGGTFFLRVKGDS
CCCCCEEEEECCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
MINAAIVEGDLALVRPQATAENRDIVVAMVDGEATLKRFYRQRDQIRLQPENPNMDPIII
EEEEEEEECCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEECCCCCCCEEEE
RPGEGDVAIIGKVVGIYRPLE
ECCCCCEEEEEEHHHHCCCCC
>Mature Secondary Structure
MQELAPRQQQVLAFITGFIAENGYPPTLREIAAHLKISGTLGVSKHLEALERKGYLRREA
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHCCCHHHCC
NSSRGIALVGRTDTALSLPVAGVVRAGLPQPAVEDIEEYFAIDRSMVRGGTFFLRVKGDS
CCCCCEEEEECCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
MINAAIVEGDLALVRPQATAENRDIVVAMVDGEATLKRFYRQRDQIRLQPENPNMDPIII
EEEEEEEECCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEECCCCCCCEEEE
RPGEGDVAIIGKVVGIYRPLE
ECCCCCEEEEEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA