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The map label for this gene is nadA

Identifier: 39995132

GI number: 39995132

Start: 32106

End: 33020

Strand: Reverse

Name: nadA

Synonym: GSU0021

Alternate gene names: 39995132

Gene position: 33020-32106 (Counterclockwise)

Preceding gene: 39995134

Following gene: 39995131

Centisome position: 0.87

GC content: 62.19

Gene sequence:

>915_bases
ATGCACGCCAACGACATCAGACAGGACATACGGAAGCTCCTGAAGGAGCGTAACGCTGTGCTCCTGGCCCACAACTACAT
GAGGGACGAGGTGCAGGAGATTGCCGACATAACCGGTGACTCACTCGCCCTCTCCCAGGAGGCGGCCCGCACCGACGCGG
ACGTCATCGTTTTCTGCGGAGTTCACTTCATGGCCGAGTCAGCCTCGATCCTCTCGCCGGACAAAACGGTCCTTCTGCCG
CGCATGGACGCCGGCTGCCCCATGGCAGACATGGTGACCGCCGAGGCGTTGCTGGAGATGAAGGCCCGCCACCCCGACGT
ACCTGTCGTCACCTACGTGAACTCTTCGGCGGCGGTTAAGGCCGTCAGCGACATCTGCTGCACCTCGGCCAATGCTGTGA
AGGTTGTGAATTCCCTCCCGGACCCGGAGGTAATCTTCGTTCCCGACCGCAACCTGGGACAGTTCGTGGCAAAGCAGTCC
GACAAGACGTTCCACTTCTGGGACGGCTTCTGCCCCACCCACGAACGGCTGAAGCCCGCCGACGTCCAGAGGCTCAAGGA
AGCCCACCCCGACGCTCTCTTCATCTGCCATCCCGAGTGCAACCCCTTGGTCGTGGCCCTGGCGGACCATGTCTGCTCCA
CGAGCGGTATGTATGACTTCTGCCGCACGAATCCGGCCAAACGGTTCATCATCGGCACCGAGGCGGGGATTCTCTACCGG
CTCCGGCTTGAGAATCCGGACAAGGAATTCATCCTCGCCTCGCCGGCGCTTGTCTGCCCCAATATGAAGCTGACCTCCCT
GGAAGATGTGCTGGCGAGCCTGCAGACCATGTCGCCGGTGGTGAAAGTCCCCGAAGAAATCCGGGTCCCGGCCAAGCTCG
CCCTGGACCGGATGATCGCCATCCCCCGGGACTGA

Upstream 100 bases:

>100_bases
TAGAAGGCGGCCTAAAGGGTTTGACAGCACGGCGAACATTGATTACCATCTACCCCATTTCGCGCCGTATACGGGCGCCT
GCGACACGGGAGAGCGCGCC

Downstream 100 bases:

>100_bases
CACCGGACCTACCATAACAGCCAGAGGTATCCCATGATTCGCCCCTTCAAGGGAATGAGCCCGCAAATCGATCCGTCCGC
GTTCATTGCCGACACCGCCG

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MHANDIRQDIRKLLKERNAVLLAHNYMRDEVQEIADITGDSLALSQEAARTDADVIVFCGVHFMAESASILSPDKTVLLP
RMDAGCPMADMVTAEALLEMKARHPDVPVVTYVNSSAAVKAVSDICCTSANAVKVVNSLPDPEVIFVPDRNLGQFVAKQS
DKTFHFWDGFCPTHERLKPADVQRLKEAHPDALFICHPECNPLVVALADHVCSTSGMYDFCRTNPAKRFIIGTEAGILYR
LRLENPDKEFILASPALVCPNMKLTSLEDVLASLQTMSPVVKVPEEIRVPAKLALDRMIAIPRD

Sequences:

>Translated_304_residues
MHANDIRQDIRKLLKERNAVLLAHNYMRDEVQEIADITGDSLALSQEAARTDADVIVFCGVHFMAESASILSPDKTVLLP
RMDAGCPMADMVTAEALLEMKARHPDVPVVTYVNSSAAVKAVSDICCTSANAVKVVNSLPDPEVIFVPDRNLGQFVAKQS
DKTFHFWDGFCPTHERLKPADVQRLKEAHPDALFICHPECNPLVVALADHVCSTSGMYDFCRTNPAKRFIIGTEAGILYR
LRLENPDKEFILASPALVCPNMKLTSLEDVLASLQTMSPVVKVPEEIRVPAKLALDRMIAIPRD
>Mature_304_residues
MHANDIRQDIRKLLKERNAVLLAHNYMRDEVQEIADITGDSLALSQEAARTDADVIVFCGVHFMAESASILSPDKTVLLP
RMDAGCPMADMVTAEALLEMKARHPDVPVVTYVNSSAAVKAVSDICCTSANAVKVVNSLPDPEVIFVPDRNLGQFVAKQS
DKTFHFWDGFCPTHERLKPADVQRLKEAHPDALFICHPECNPLVVALADHVCSTSGMYDFCRTNPAKRFIIGTEAGILYR
LRLENPDKEFILASPALVCPNMKLTSLEDVLASLQTMSPVVKVPEEIRVPAKLALDRMIAIPRD

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=310, Percent_Identity=37.0967741935484, Blast_Score=198, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_GEOSL (Q74H71)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951083.1
- HSSP:   O57767
- ProteinModelPortal:   Q74H71
- SMR:   Q74H71
- GeneID:   2688595
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0021
- NMPDR:   fig|243231.1.peg.21
- TIGR:   GSU0021
- HOGENOM:   HBG291157
- OMA:   CHPECNP
- ProtClustDB:   PRK09375
- BioCyc:   GSUL243231:GSU_0021-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 33546; Mature: 33546

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: BINDING 24-24 BINDING 41-41 BINDING 112-112 BINDING 129-129 BINDING 197-197 BINDING 214-214

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHANDIRQDIRKLLKERNAVLLAHNYMRDEVQEIADITGDSLALSQEAARTDADVIVFCG
CCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEC
VHFMAESASILSPDKTVLLPRMDAGCPMADMVTAEALLEMKARHPDVPVVTYVNSSAAVK
HHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHH
AVSDICCTSANAVKVVNSLPDPEVIFVPDRNLGQFVAKQSDKTFHFWDGFCPTHERLKPA
HHHHHHHCCCCHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCEEEEECCCCCCHHCCCHH
DVQRLKEAHPDALFICHPECNPLVVALADHVCSTSGMYDFCRTNPAKRFIIGTEAGILYR
HHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHCCCCCHHHHHCCCCCEEEEECCCCEEEE
LRLENPDKEFILASPALVCPNMKLTSLEDVLASLQTMSPVVKVPEEIRVPAKLALDRMIA
EEECCCCCCEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHC
IPRD
CCCC
>Mature Secondary Structure
MHANDIRQDIRKLLKERNAVLLAHNYMRDEVQEIADITGDSLALSQEAARTDADVIVFCG
CCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEC
VHFMAESASILSPDKTVLLPRMDAGCPMADMVTAEALLEMKARHPDVPVVTYVNSSAAVK
HHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHH
AVSDICCTSANAVKVVNSLPDPEVIFVPDRNLGQFVAKQSDKTFHFWDGFCPTHERLKPA
HHHHHHHCCCCHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCEEEEECCCCCCHHCCCHH
DVQRLKEAHPDALFICHPECNPLVVALADHVCSTSGMYDFCRTNPAKRFIIGTEAGILYR
HHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHCCCCCHHHHHCCCCCEEEEECCCCEEEE
LRLENPDKEFILASPALVCPNMKLTSLEDVLASLQTMSPVVKVPEEIRVPAKLALDRMIA
EEECCCCCCEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHC
IPRD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA