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The map label for this gene is gpsA

Identifier: 39995117

GI number: 39995117

Start: 10674

End: 11681

Strand: Direct

Name: gpsA

Synonym: GSU0006

Alternate gene names: 39995117

Gene position: 10674-11681 (Clockwise)

Preceding gene: 39995116

Following gene: 39995118

Centisome position: 0.28

GC content: 64.98

Gene sequence:

>1008_bases
ATGAGTGAACGTATCGGTGTGATCGGAGCGGGAAGCTGGGGAACGACGCTGGCGAATCTGTTGGCCCGAAAGGGGCTTGA
CGTGACACTCTGGGCCTATGAGGCCGAGTTGGTGGAAGAGATGCGTGCAACGCGGGTCAACTCCCTTTTTCTCCCCGGCA
TCGAACTCGCTCCCGCCCTTTCGTTCACCAACTCCCTGGAGGAGGCGGCCACCGGGAAGGACTTCCTGGTTCTCGTTTCG
CCCTCCCAGGTGATGCGCGGAGTGCTGGCGCAACTGGCGCCGCTGCTGCGTCCCGGCGTGGTGCTGGTGAACGCCTCCAA
GGGGATAGAGCTCGACACCCTCATGACCATGGACCAAGTCTGCGCGGCGGTACTGCCGCCGGAGGTCGCCCGGTGTTTCA
GCGTCCTGTCCGGACCGAGCTTTGCCCGCGAAGTCTCCCTTGAGATGCCGACGGCGGTGGTGGCGGCTTCGGGCGACCCT
GCCGTGGCTGCGGCAGTGCAGCGTCTCTTCACCACGCCGTCCTTCCGGGTCTACACCAATACCGACGTGGTGGGAGTTGA
GATCGGCGGTGCCCTCAAGAACGTCATTGCCGTGGCGGCCGGGATCTCGGACGGTCTGGGCCTCGGCCACAATACCCGTG
CAGCCCTGATCACCCGCGGCCTGGCAGAGATGACCCGACTGGGGCTCTCCATGGGGGCCCAGCCGGAAACTTTTGCGGGC
CTTGCCGGCATGGGTGACCTGGTGCTCACGTGCACCGGAGACCTTTCGCGCAACCGGACCGTTGGCATGAAGCTGGGCCA
GGGGATGAAGCTGGCTGATGTCCTGGGAGAGATGCGCATGGTGGCGGAGGGGGTGAAAACCGCCGAGTCGGCGTACCGTC
TTGCCCGCCGGACAGGGGTCGAGATGCCGATAACCGAGAAGGTCTACCAGGTGCTCCACGAGGACAAGCCGGCCCGCCAG
GCAGTAATGGAACTCATGACCCGCGACCTCAAGGCGGAGCGCTGGTAA

Upstream 100 bases:

>100_bases
GATACGAGTTCCCACCTACGCGTCGGGACGAGGAGTATGAAGGGGAGTGGGACTAGTGGTGCTCGGCACAGGAGCACATC
ATCGGTTGGGAGTGGCGGAC

Downstream 100 bases:

>100_bases
GAGATCATGGGGCCTCGCCGTCTCTTCACACTGAGTAGCACCGTTCGTGTATCCGTGCCCGAAAGAGACCGGAGACGGTC
TCGCTGAAGGGATTGCAATG

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSERIGVIGAGSWGTTLANLLARKGLDVTLWAYEAELVEEMRATRVNSLFLPGIELAPALSFTNSLEEAATGKDFLVLVS
PSQVMRGVLAQLAPLLRPGVVLVNASKGIELDTLMTMDQVCAAVLPPEVARCFSVLSGPSFAREVSLEMPTAVVAASGDP
AVAAAVQRLFTTPSFRVYTNTDVVGVEIGGALKNVIAVAAGISDGLGLGHNTRAALITRGLAEMTRLGLSMGAQPETFAG
LAGMGDLVLTCTGDLSRNRTVGMKLGQGMKLADVLGEMRMVAEGVKTAESAYRLARRTGVEMPITEKVYQVLHEDKPARQ
AVMELMTRDLKAERW

Sequences:

>Translated_335_residues
MSERIGVIGAGSWGTTLANLLARKGLDVTLWAYEAELVEEMRATRVNSLFLPGIELAPALSFTNSLEEAATGKDFLVLVS
PSQVMRGVLAQLAPLLRPGVVLVNASKGIELDTLMTMDQVCAAVLPPEVARCFSVLSGPSFAREVSLEMPTAVVAASGDP
AVAAAVQRLFTTPSFRVYTNTDVVGVEIGGALKNVIAVAAGISDGLGLGHNTRAALITRGLAEMTRLGLSMGAQPETFAG
LAGMGDLVLTCTGDLSRNRTVGMKLGQGMKLADVLGEMRMVAEGVKTAESAYRLARRTGVEMPITEKVYQVLHEDKPARQ
AVMELMTRDLKAERW
>Mature_334_residues
SERIGVIGAGSWGTTLANLLARKGLDVTLWAYEAELVEEMRATRVNSLFLPGIELAPALSFTNSLEEAATGKDFLVLVSP
SQVMRGVLAQLAPLLRPGVVLVNASKGIELDTLMTMDQVCAAVLPPEVARCFSVLSGPSFAREVSLEMPTAVVAASGDPA
VAAAVQRLFTTPSFRVYTNTDVVGVEIGGALKNVIAVAAGISDGLGLGHNTRAALITRGLAEMTRLGLSMGAQPETFAGL
AGMGDLVLTCTGDLSRNRTVGMKLGQGMKLADVLGEMRMVAEGVKTAESAYRLARRTGVEMPITEKVYQVLHEDKPARQA
VMELMTRDLKAERW

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=347, Percent_Identity=30.5475504322767, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI24307999, Length=349, Percent_Identity=28.3667621776504, Blast_Score=124, Evalue=9e-29,
Organism=Escherichia coli, GI1790037, Length=329, Percent_Identity=47.112462006079, Blast_Score=290, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI193210136, Length=353, Percent_Identity=30.5949008498584, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI32564403, Length=353, Percent_Identity=30.5949008498584, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI32564399, Length=344, Percent_Identity=30.8139534883721, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17507425, Length=337, Percent_Identity=26.7062314540059, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193210134, Length=335, Percent_Identity=28.955223880597, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324513, Length=343, Percent_Identity=27.6967930029155, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6320181, Length=347, Percent_Identity=28.5302593659942, Blast_Score=119, Evalue=7e-28,
Organism=Drosophila melanogaster, GI22026922, Length=349, Percent_Identity=28.3667621776504, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17136204, Length=333, Percent_Identity=29.1291291291291, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17136202, Length=333, Percent_Identity=29.1291291291291, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17136200, Length=333, Percent_Identity=29.1291291291291, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI45551945, Length=235, Percent_Identity=29.3617021276596, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281362270, Length=235, Percent_Identity=29.3617021276596, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648969, Length=194, Percent_Identity=29.8969072164948, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_GEOSL (P61740)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951068.1
- ProteinModelPortal:   P61740
- SMR:   P61740
- GeneID:   2688677
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0006
- NMPDR:   fig|243231.1.peg.6
- TIGR:   GSU0006
- HOGENOM:   HBG586392
- OMA:   SQTLRGN
- ProtClustDB:   PRK00094
- BioCyc:   GSUL243231:GSU_0006-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 35502; Mature: 35371

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 193-193 BINDING 107-107 BINDING 107-107 BINDING 142-142 BINDING 257-257 BINDING 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERIGVIGAGSWGTTLANLLARKGLDVTLWAYEAELVEEMRATRVNSLFLPGIELAPAL
CCCCEEEEECCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SFTNSLEEAATGKDFLVLVSPSQVMRGVLAQLAPLLRPGVVLVNASKGIELDTLMTMDQV
HHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHH
CAAVLPPEVARCFSVLSGPSFAREVSLEMPTAVVAASGDPAVAAAVQRLFTTPSFRVYTN
HHHHCCHHHHHHHHHHCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEC
TDVVGVEIGGALKNVIAVAAGISDGLGLGHNTRAALITRGLAEMTRLGLSMGAQPETFAG
CCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LAGMGDLVLTCTGDLSRNRTVGMKLGQGMKLADVLGEMRMVAEGVKTAESAYRLARRTGV
HCCCCCEEEEECCCCCCCCEECHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EMPITEKVYQVLHEDKPARQAVMELMTRDLKAERW
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SERIGVIGAGSWGTTLANLLARKGLDVTLWAYEAELVEEMRATRVNSLFLPGIELAPAL
CCCEEEEECCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SFTNSLEEAATGKDFLVLVSPSQVMRGVLAQLAPLLRPGVVLVNASKGIELDTLMTMDQV
HHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHH
CAAVLPPEVARCFSVLSGPSFAREVSLEMPTAVVAASGDPAVAAAVQRLFTTPSFRVYTN
HHHHCCHHHHHHHHHHCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEC
TDVVGVEIGGALKNVIAVAAGISDGLGLGHNTRAALITRGLAEMTRLGLSMGAQPETFAG
CCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LAGMGDLVLTCTGDLSRNRTVGMKLGQGMKLADVLGEMRMVAEGVKTAESAYRLARRTGV
HCCCCCEEEEECCCCCCCCEECHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EMPITEKVYQVLHEDKPARQAVMELMTRDLKAERW
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA