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The map label for this gene is wecB [H]

Identifier: 308513313

GI number: 308513313

Start: 2457829

End: 2459001

Strand: Reverse

Name: wecB [H]

Synonym: NA

Alternate gene names: 308513313

Gene position: 2459001-2457829 (Counterclockwise)

Preceding gene: 39997342

Following gene: 39997340

Centisome position: 64.47

GC content: 64.71

Gene sequence:

>1173_bases
GTGAATACAGTAATAAACGTAATGACCATTTTTGGAACCCGCCCCGAAGCCATCAAGATGGCGCCGGTGGTGCGGGAGCT
CCAGCGCCGGCCGGACCGGTTCCGCAGTCTTGTGTGCGTCACGGCCCAGCACCGCCAGATGCTCGACCAGGTGCTTGATC
TGTTCGATCTCCGTCCCGATTTCGACCTCGACATCATGAAGCCGGGCCAGGATCTCTACGATGTGACGGCCAATGTGCTC
CTGGGTATGCGGAATGTGCTCAGGGAGGTGACCCCCGATATCATCCTCGTCCACGGCGATACCACCACGACCATGGCGGC
GGCCCTGGCCGGCTACTACGCGCGCATCCCGGTGGGGCACGTGGAGGCGGGGCTGCGGACTCATAACAAGTTCGCGCCAT
TCCCCGAGGAGATCAATCGGCAGGTGGCGGGGGTGGTGTGTGATCTCCATTTTGCCCCAACGGAGCAGGCGCGGGCAAAC
CTGCTCAGGGAGGGGGTTGCCGATTCGGCGATCGTCGTTACCGGCAACACGGTGGTGGACGCACTTCTTTCGATCGTCGA
CCGCATCGGGCATGACGACAAGCTGACCCGGGAGATGGAGGCCCGATTTTCGTTCCTCGACCCGAACCGACGCCTGGTGC
TCGTCACCGGCCACCGGCGGGAGAATTTCGGCGAAGGGTTCGAGAACATCTGCCACGCCCTGGTGGAGCTTGCCCGCCGC
CACGACGACGTGGAAATCCTCTACCCGGTGCACCTGAATCCCAATGTGCAGGAGCCGGTGAAGAGAATCCTCGGCGGGGA
GGGGGCAGCCAATATTCACCTGGTTGATCCGCTGGACTACCTTCCCTTTGTGTACGCCATGAACCGGGCTCACCTGATCA
TCACCGATTCCGGCGGGGTGCAGGAAGAGGCTCCCTCCCTCGGCAAGCCGGTCCTGGTCATGCGCGAGACGACCGAGCGG
CCCGAGGCGGTGGCCGCCGGAACGGTCAGGCTCGTGGGGACGGATTTCGACCGGATCGTTGCCGAGGCCACGCTGCTTCT
GTCCGACGCAGAGGCCTACGGGGTCATGAGCCGCGCCCACAATCCCTACGGCGACGGCCGGGCCGCCGGCCGGATCGCGG
CCGCACTGGAGGCGTGGGGAACCGCCCGCTGTGCCGGCGCCTCTGCCGATTGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:
NA

Sequences:

>Translated_390_residues
MNTVINVMTIFGTRPEAIKMAPVVRELQRRPDRFRSLVCVTAQHRQMLDQVLDLFDLRPDFDLDIMKPGQDLYDVTANVL
LGMRNVLREVTPDIILVHGDTTTTMAAALAGYYARIPVGHVEAGLRTHNKFAPFPEEINRQVAGVVCDLHFAPTEQARAN
LLREGVADSAIVVTGNTVVDALLSIVDRIGHDDKLTREMEARFSFLDPNRRLVLVTGHRRENFGEGFENICHALVELARR
HDDVEILYPVHLNPNVQEPVKRILGGEGAANIHLVDPLDYLPFVYAMNRAHLIITDSGGVQEEAPSLGKPVLVMRETTER
PEAVAAGTVRLVGTDFDRIVAEATLLLSDAEAYGVMSRAHNPYGDGRAAGRIAAALEAWGTARCAGASAD
>Mature_390_residues
MNTVINVMTIFGTRPEAIKMAPVVRELQRRPDRFRSLVCVTAQHRQMLDQVLDLFDLRPDFDLDIMKPGQDLYDVTANVL
LGMRNVLREVTPDIILVHGDTTTTMAAALAGYYARIPVGHVEAGLRTHNKFAPFPEEINRQVAGVVCDLHFAPTEQARAN
LLREGVADSAIVVTGNTVVDALLSIVDRIGHDDKLTREMEARFSFLDPNRRLVLVTGHRRENFGEGFENICHALVELARR
HDDVEILYPVHLNPNVQEPVKRILGGEGAANIHLVDPLDYLPFVYAMNRAHLIITDSGGVQEEAPSLGKPVLVMRETTER
PEAVAAGTVRLVGTDFDRIVAEATLLLSDAEAYGVMSRAHNPYGDGRAAGRIAAALEAWGTARCAGASAD

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=373, Percent_Identity=62.4664879356568, Blast_Score=474, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42876; Mature: 42876

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVINVMTIFGTRPEAIKMAPVVRELQRRPDRFRSLVCVTAQHRQMLDQVLDLFDLRPD
CCCCEEEHEEECCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FDLDIMKPGQDLYDVTANVLLGMRNVLREVTPDIILVHGDTTTTMAAALAGYYARIPVGH
CCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCHH
VEAGLRTHNKFAPFPEEINRQVAGVVCDLHFAPTEQARANLLREGVADSAIVVTGNTVVD
HHHHHHCCCCCCCCHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCHHHH
ALLSIVDRIGHDDKLTREMEARFSFLDPNRRLVLVTGHRRENFGEGFENICHALVELARR
HHHHHHHHHCCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHC
HDDVEILYPVHLNPNVQEPVKRILGGEGAANIHLVDPLDYLPFVYAMNRAHLIITDSGGV
CCCEEEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCC
QEEAPSLGKPVLVMRETTERPEAVAAGTVRLVGTDFDRIVAEATLLLSDAEAYGVMSRAH
CCCCCCCCCCEEEEECCCCCCCHHHCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCC
NPYGDGRAAGRIAAALEAWGTARCAGASAD
CCCCCCCHHHHHHHHHHHHCCHHCCCCCCC
>Mature Secondary Structure
MNTVINVMTIFGTRPEAIKMAPVVRELQRRPDRFRSLVCVTAQHRQMLDQVLDLFDLRPD
CCCCEEEHEEECCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FDLDIMKPGQDLYDVTANVLLGMRNVLREVTPDIILVHGDTTTTMAAALAGYYARIPVGH
CCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCHH
VEAGLRTHNKFAPFPEEINRQVAGVVCDLHFAPTEQARANLLREGVADSAIVVTGNTVVD
HHHHHHCCCCCCCCHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCHHHH
ALLSIVDRIGHDDKLTREMEARFSFLDPNRRLVLVTGHRRENFGEGFENICHALVELARR
HHHHHHHHHCCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHC
HDDVEILYPVHLNPNVQEPVKRILGGEGAANIHLVDPLDYLPFVYAMNRAHLIITDSGGV
CCCEEEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCC
QEEAPSLGKPVLVMRETTERPEAVAAGTVRLVGTDFDRIVAEATLLLSDAEAYGVMSRAH
CCCCCCCCCCEEEEECCCCCCCHHHCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCC
NPYGDGRAAGRIAAALEAWGTARCAGASAD
CCCCCCCHHHHHHHHHHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]