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The map label for this gene is loN-1 [H]

Identifier: 308513292

GI number: 308513292

Start: 990895

End: 993201

Strand: Direct

Name: loN-1 [H]

Synonym: NA

Alternate gene names: 308513292

Gene position: 990895-993201 (Clockwise)

Preceding gene: 39996025

Following gene: 39996027

Centisome position: 25.98

GC content: 65.45

Gene sequence:

>2307_bases
GTGTCGATATCAGTCCCCGCCGTTCTTCCGCTCTTTCCCCTCCGGGAGATCGTCGCCTTTCCCTATATGATCTTCCCGCT
GTTCCTCAAGGACGACGAACTGACCGCGTTCGAGGACATGCTCGGCCACGAGCAGATGGTGGTGCTCGCCCGGACCCGGG
AAGAGGCGGTGCCCGGCCAGACGCCACAGCTCTGCGAGATCGGCACCCTCTGCAAGGTGAACCAGATCTACCGGCTTCCC
GAGGGGGGCGGCAAGGTGGTCCTGGAGGGGGTCGTGCGGGTACGGATCCTGGACGTGGCGGATACGCTTCCCCACATCCA
GGTCCGCTGTGAGGTGGTCCACGAGTTCTTCGAGAAGTCAGTGGTTTCCGAAGCTCTGGTCCAGAGTCTCAACGCACTCC
TCAAGATCGCTCTTTCGTATGGTCGCCCCCTGCCGGACGACGTCATGAAGATGATCGACCTGATCGACAACCCGGCCCGG
CTGGCGGACCTGGTGGCCCTCTACGTGAACCTCCCCCTGGACGAGCAGCAGCGGCTCCTGGAGACCGTGGACCCCCTTGA
GCGGCTCAAGAAGGTGTACATGCACCTGACTGCCGAGGTGCAACGGCTCCAGGTGAAGGGCGAAGTGCAGGCCGAAGTGA
CCCGCCGGGTGGGGAAGAGCCAGAAGGAGTACCTGCTGCGGGAGCAGATGAAGCAGATCCAGGAGGAGCTTGGCGAGGAG
GACCCGCGCGGCACCGAGATGACCGAGCTGCGGAGCCGGATCCAGAACGCCGGCATGCCCGACGAGGTCCGCAAGATCGC
CGACAAGGAACTCAAGCGGCTGGACCGGATCAATCCTTCGTCCCCCGAATACACGGTGGCCCGCACCTATCTGGACTACC
TGGCCGGCATGCCCTGGGGCAGGTCGACGGCGGACAACCATGACATCAACCAGGCCGAGGCGGTGCTGGACGAAGACCAC
TACGACCTGAAGAAGGTCAAGGAACGGATTCTCGAATACCTGGCCGTCCGGACCCTGCGCGAGAGGATGAAGGGGCCGAT
CCTCTGCTTCGTGGGCCCGCCGGGGGTGGGAAAGACGAGCCTCGGCAAGTCCATCGCCCGGGCCCTGGGGCGGAAGTTCA
TCCGGATGTCCCTGGGGGGGATGCGGGACGAGGCGGAAATCCGCGGCCACCGCCGCACCTACATCGGCGCGCTTCCGGGC
CGGATCATTCAGGAGATCTTCCGCTGCGGCAGCAACAACCCGGTTTTCATGCTCGACGAGGTGGACAAGATCGGCCTCGA
TTTCCGAGGCGACCCGGCCAGCGCGCTCCTGGAGGTGCTCGACCCGGAACAGAACAGCACCTTCACCGACCACTATCTGG
ACGTGCCCTTCGATCTCTCCAACGTCATGTTCATCACCACGGCCAACCTGTTGGACCCGGTGCCGGCGGCCCTCAAGGAC
CGGATGGAGGTGATCCGGCTCTCGGGCTACACCGACGAGGAGAAGGAAAAGATCGCGGTCCGCTACCTCATCCCCAAGGA
GGTTGAGGAAAACGGCCTCTCCGCCACCCCTCCCGCCTTTGCGTCTGCCGCTATTTACAAGATCATCGGCGACTACACCC
GGGAGGCCGGGGTGCGCAACCTGCAGCGGAGCATCGCATCGGTCTGCCGCAAGGTGGCCAAGGAGATCACCCAGGGCAAG
CCCCTGCGGGAGACCATCACCCCCGAGGTGGTGGAGGAGTTTCTGGGGCCCCGCACCTTCTTCAACGAGGTGGCGGCGGA
ACAGGATCGGGTCGGCGTGGTGACGGGGCTCGCCTGGACCGAGACCGGCGGGGACATTCTCTTCGTGGAGGCGACCCGCA
TGAAGGGGAAGCGGGATCTGATCCTGACCGGCAGCCTGGGGGACGTGATGAAGGAGTCGGCCCGGACCGCCCTTTCCTAC
GTGCGCGCCACCTGCGCGGACTGGGGGATCGACGAGGGGGCCTTCGAGGACAGCGATCTCCACATCCACGTGCCGGCCGG
GGCTATTCCCAAGGACGGCCCGTCCGCCGGGCTCACCATGGTGACCGCCATCGTGTCGCTGCTGTCGGGACGGCCGGCCC
GGCGCGACGTGGCCATGACCGGCGAGATCAGCCTCACCGGCCGGGCGCTGGCCATCGGCGGCCTTAAGGAGAAGGTCCTG
GCGGCCCGGCGGGCCGGGGTCAAGACCGTGGTGGCGCCCTCGCGCAACCGGGAGAACCTTGAGGATATCCCCGACGACGT
GAAGAACGAGCTTACCTTCATCTTTGTGGATGACGTGCATGAGGCGGTGGCTGCCGCGCTCCAGTGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 768; Mature: 767

Protein sequence:
NA

Sequences:

>Translated_768_residues
MSISVPAVLPLFPLREIVAFPYMIFPLFLKDDELTAFEDMLGHEQMVVLARTREEAVPGQTPQLCEIGTLCKVNQIYRLP
EGGGKVVLEGVVRVRILDVADTLPHIQVRCEVVHEFFEKSVVSEALVQSLNALLKIALSYGRPLPDDVMKMIDLIDNPAR
LADLVALYVNLPLDEQQRLLETVDPLERLKKVYMHLTAEVQRLQVKGEVQAEVTRRVGKSQKEYLLREQMKQIQEELGEE
DPRGTEMTELRSRIQNAGMPDEVRKIADKELKRLDRINPSSPEYTVARTYLDYLAGMPWGRSTADNHDINQAEAVLDEDH
YDLKKVKERILEYLAVRTLRERMKGPILCFVGPPGVGKTSLGKSIARALGRKFIRMSLGGMRDEAEIRGHRRTYIGALPG
RIIQEIFRCGSNNPVFMLDEVDKIGLDFRGDPASALLEVLDPEQNSTFTDHYLDVPFDLSNVMFITTANLLDPVPAALKD
RMEVIRLSGYTDEEKEKIAVRYLIPKEVEENGLSATPPAFASAAIYKIIGDYTREAGVRNLQRSIASVCRKVAKEITQGK
PLRETITPEVVEEFLGPRTFFNEVAAEQDRVGVVTGLAWTETGGDILFVEATRMKGKRDLILTGSLGDVMKESARTALSY
VRATCADWGIDEGAFEDSDLHIHVPAGAIPKDGPSAGLTMVTAIVSLLSGRPARRDVAMTGEISLTGRALAIGGLKEKVL
AARRAGVKTVVAPSRNRENLEDIPDDVKNELTFIFVDDVHEAVAAALQ
>Mature_767_residues
SISVPAVLPLFPLREIVAFPYMIFPLFLKDDELTAFEDMLGHEQMVVLARTREEAVPGQTPQLCEIGTLCKVNQIYRLPE
GGGKVVLEGVVRVRILDVADTLPHIQVRCEVVHEFFEKSVVSEALVQSLNALLKIALSYGRPLPDDVMKMIDLIDNPARL
ADLVALYVNLPLDEQQRLLETVDPLERLKKVYMHLTAEVQRLQVKGEVQAEVTRRVGKSQKEYLLREQMKQIQEELGEED
PRGTEMTELRSRIQNAGMPDEVRKIADKELKRLDRINPSSPEYTVARTYLDYLAGMPWGRSTADNHDINQAEAVLDEDHY
DLKKVKERILEYLAVRTLRERMKGPILCFVGPPGVGKTSLGKSIARALGRKFIRMSLGGMRDEAEIRGHRRTYIGALPGR
IIQEIFRCGSNNPVFMLDEVDKIGLDFRGDPASALLEVLDPEQNSTFTDHYLDVPFDLSNVMFITTANLLDPVPAALKDR
MEVIRLSGYTDEEKEKIAVRYLIPKEVEENGLSATPPAFASAAIYKIIGDYTREAGVRNLQRSIASVCRKVAKEITQGKP
LRETITPEVVEEFLGPRTFFNEVAAEQDRVGVVTGLAWTETGGDILFVEATRMKGKRDLILTGSLGDVMKESARTALSYV
RATCADWGIDEGAFEDSDLHIHVPAGAIPKDGPSAGLTMVTAIVSLLSGRPARRDVAMTGEISLTGRALAIGGLKEKVLA
ARRAGVKTVVAPSRNRENLEDIPDDVKNELTFIFVDDVHEAVAAALQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=49.0230905861456, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI21396489, Length=664, Percent_Identity=43.8253012048193, Blast_Score=551, Evalue=1e-157,
Organism=Escherichia coli, GI1786643, Length=764, Percent_Identity=47.1204188481675, Blast_Score=696, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=728, Percent_Identity=40.2472527472528, Blast_Score=519, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17556486, Length=538, Percent_Identity=42.3791821561338, Blast_Score=454, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6319449, Length=666, Percent_Identity=41.2912912912913, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=661, Percent_Identity=41.1497730711044, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24666867, Length=661, Percent_Identity=41.1497730711044, Blast_Score=527, Evalue=1e-149,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 85401; Mature: 85269

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISVPAVLPLFPLREIVAFPYMIFPLFLKDDELTAFEDMLGHEQMVVLARTREEAVPGQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECHHHCCCCC
TPQLCEIGTLCKVNQIYRLPEGGGKVVLEGVVRVRILDVADTLPHIQVRCEVVHEFFEKS
CCCHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHEEEHHHHCCCHHHHHHHHHHHHHHHH
VVSEALVQSLNALLKIALSYGRPLPDDVMKMIDLIDNPARLADLVALYVNLPLDEQQRLL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHH
ETVDPLERLKKVYMHLTAEVQRLQVKGEVQAEVTRRVGKSQKEYLLREQMKQIQEELGEE
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
DPRGTEMTELRSRIQNAGMPDEVRKIADKELKRLDRINPSSPEYTVARTYLDYLAGMPWG
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
RSTADNHDINQAEAVLDEDHYDLKKVKERILEYLAVRTLRERMKGPILCFVGPPGVGKTS
CCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
LGKSIARALGRKFIRMSLGGMRDEAEIRGHRRTYIGALPGRIIQEIFRCGSNNPVFMLDE
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEEC
VDKIGLDFRGDPASALLEVLDPEQNSTFTDHYLDVPFDLSNVMFITTANLLDPVPAALKD
HHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCEEEEEEHHHHCCCCHHHHH
RMEVIRLSGYTDEEKEKIAVRYLIPKEVEENGLSATPPAFASAAIYKIIGDYTREAGVRN
HHHHHHHCCCCCCHHHHEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQRSIASVCRKVAKEITQGKPLRETITPEVVEEFLGPRTFFNEVAAEQDRVGVVTGLAWT
HHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEEEE
ETGGDILFVEATRMKGKRDLILTGSLGDVMKESARTALSYVRATCADWGIDEGAFEDSDL
CCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
HIHVPAGAIPKDGPSAGLTMVTAIVSLLSGRPARRDVAMTGEISLTGRALAIGGLKEKVL
EEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCEEECCCEEEECCHHHHHH
AARRAGVKTVVAPSRNRENLEDIPDDVKNELTFIFVDDVHEAVAAALQ
HHHHCCCEEEECCCCCCCCHHHCCHHHHCCEEEEEEHHHHHHHHHHCC
>Mature Secondary Structure 
SISVPAVLPLFPLREIVAFPYMIFPLFLKDDELTAFEDMLGHEQMVVLARTREEAVPGQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECHHHCCCCC
TPQLCEIGTLCKVNQIYRLPEGGGKVVLEGVVRVRILDVADTLPHIQVRCEVVHEFFEKS
CCCHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHEEEHHHHCCCHHHHHHHHHHHHHHHH
VVSEALVQSLNALLKIALSYGRPLPDDVMKMIDLIDNPARLADLVALYVNLPLDEQQRLL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHH
ETVDPLERLKKVYMHLTAEVQRLQVKGEVQAEVTRRVGKSQKEYLLREQMKQIQEELGEE
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
DPRGTEMTELRSRIQNAGMPDEVRKIADKELKRLDRINPSSPEYTVARTYLDYLAGMPWG
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
RSTADNHDINQAEAVLDEDHYDLKKVKERILEYLAVRTLRERMKGPILCFVGPPGVGKTS
CCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
LGKSIARALGRKFIRMSLGGMRDEAEIRGHRRTYIGALPGRIIQEIFRCGSNNPVFMLDE
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEEC
VDKIGLDFRGDPASALLEVLDPEQNSTFTDHYLDVPFDLSNVMFITTANLLDPVPAALKD
HHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCEEEEEEHHHHCCCCHHHHH
RMEVIRLSGYTDEEKEKIAVRYLIPKEVEENGLSATPPAFASAAIYKIIGDYTREAGVRN
HHHHHHHCCCCCCHHHHEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQRSIASVCRKVAKEITQGKPLRETITPEVVEEFLGPRTFFNEVAAEQDRVGVVTGLAWT
HHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEEEE
ETGGDILFVEATRMKGKRDLILTGSLGDVMKESARTALSYVRATCADWGIDEGAFEDSDL
CCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
HIHVPAGAIPKDGPSAGLTMVTAIVSLLSGRPARRDVAMTGEISLTGRALAIGGLKEKVL
EEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCEEECCCEEEECCHHHHHH
AARRAGVKTVVAPSRNRENLEDIPDDVKNELTFIFVDDVHEAVAAALQ
HHHHCCCEEEECCCCCCCCHHHCCHHHHCCEEEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA