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The map label for this gene is coaBC [H]

Identifier: 57234778

GI number: 57234778

Start: 401769

End: 402950

Strand: Direct

Name: coaBC [H]

Synonym: DET0429

Alternate gene names: 57234778

Gene position: 401769-402950 (Clockwise)

Preceding gene: 57234779

Following gene: 57234777

Centisome position: 27.34

GC content: 51.02

Gene sequence:

>1182_bases
ATGGATAAGAAAAAGACAGTGGTTCTGGGCATAACCGGCAGTATTTCTGCCTATAAAGCGGCAGATATTGCCTCCAAACT
GGTTGCCGCAGGGTATACGGTTAAAGCGGTCATGACTGAAAACGCCTGCCGTTTTATATCTCCCCTGACTATCCGGACGC
TTAGCCGTCAGCAGGTAGTGACCGGTATGTGGGATATGAATTCCGAATACAGCGTGGAGCATGTCTCTCTGGCAGAGGAA
GCGGCTGTTATTCTGGTTGCTCCGGCTACCGCCAATATAATTGCCGAATTGGCCTGCGGGCTGGCAGGCGATATGATTTC
ATCAACTATTTTAGCCAGCAAAGCCCCGGTTATAATAGCCCCGGCCATGAACGACAATATGTATTCCAATCCTGCCACCC
AGCAGAATATTGCAAAGCTGAAGGAACGGGGTTTTGTATTTGTAGAACCCGAATCAGGCCGCCTGGCCTCAGGCAAAACA
GGGCAGGGGCGCTTAGCTTCCGTAGATACAATACTGGGTTCGGTTACCCAGGTTTTAGGTAAAAACGGACCTTTGGCCGG
GAAAAAACTGGTTATCAGCGCCGGGGGCACCCGTGAGCCGGTTGACCCGGTGCGTTATCTGGGTAACCGCAGTTCTGGCA
AAATGGGCTATGCTCTGGCCGAGGAAGCTGTCAGACGGGGTGCCAGCGTAAGGCTGGTTTCAGGGGCTGTTGATAAACCT
GCCCCTTTTGGGGTTGACATAAAGTATACAGAAACCGCTATGGAAATGTTTATCTCCCTCAGAGAAGCGGTCAAAGGGGC
AGATGCCCTCATTATGACAGCGGCTGTGGCAGATTACCGCCCGGAAAAACCGGCGGCGGATAAGATTAAAAAAGGGGACG
GGGAGCTTGACCTGCACCTGGTAGCCAACCCTGATATTTTGGCCTCGCTGCAGGGTGATTTTGTAAAGGTGGGTTTTGCG
GCTGAAAGCCGTGACCTTATGATAAATGCCGTCAAAAAAATGGCTGACAAAAATCTGGATATTATTGCGGCTAACGATAT
CAGCCAGCCGGACAGCACCTTTGGTTCAGATACCACCCGCCTGACCCTCTTCTTTAAAAACGGGCGGATAGAGGAAATGC
CGCTTATGTCCAAACAGGAAGCGGCCGTGAGACTTCTTGATGAACTTTCAGCTTTGCTTTAA

Upstream 100 bases:

>100_bases
TATCGGTGTATATTAAAAGCAGGAATGTAGGCTGCGGTAAGAGCCTTACTGCTTAAGGGATACTAGCTGAAAAGACTTGC
CGGGGGGAGTGCAGACGGAT

Downstream 100 bases:

>100_bases
AATTTGATTTAATACGCTCAAAATAAGATTATATTGTTCAAGTCAGATGCGGGGTGTTTACCCGGCCGCAGTTTGTGAGG
TTAATTAGTATGGCTCAGTG

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MDKKKTVVLGITGSISAYKAADIASKLVAAGYTVKAVMTENACRFISPLTIRTLSRQQVVTGMWDMNSEYSVEHVSLAEE
AAVILVAPATANIIAELACGLAGDMISSTILASKAPVIIAPAMNDNMYSNPATQQNIAKLKERGFVFVEPESGRLASGKT
GQGRLASVDTILGSVTQVLGKNGPLAGKKLVISAGGTREPVDPVRYLGNRSSGKMGYALAEEAVRRGASVRLVSGAVDKP
APFGVDIKYTETAMEMFISLREAVKGADALIMTAAVADYRPEKPAADKIKKGDGELDLHLVANPDILASLQGDFVKVGFA
AESRDLMINAVKKMADKNLDIIAANDISQPDSTFGSDTTRLTLFFKNGRIEEMPLMSKQEAAVRLLDELSALL

Sequences:

>Translated_393_residues
MDKKKTVVLGITGSISAYKAADIASKLVAAGYTVKAVMTENACRFISPLTIRTLSRQQVVTGMWDMNSEYSVEHVSLAEE
AAVILVAPATANIIAELACGLAGDMISSTILASKAPVIIAPAMNDNMYSNPATQQNIAKLKERGFVFVEPESGRLASGKT
GQGRLASVDTILGSVTQVLGKNGPLAGKKLVISAGGTREPVDPVRYLGNRSSGKMGYALAEEAVRRGASVRLVSGAVDKP
APFGVDIKYTETAMEMFISLREAVKGADALIMTAAVADYRPEKPAADKIKKGDGELDLHLVANPDILASLQGDFVKVGFA
AESRDLMINAVKKMADKNLDIIAANDISQPDSTFGSDTTRLTLFFKNGRIEEMPLMSKQEAAVRLLDELSALL
>Mature_393_residues
MDKKKTVVLGITGSISAYKAADIASKLVAAGYTVKAVMTENACRFISPLTIRTLSRQQVVTGMWDMNSEYSVEHVSLAEE
AAVILVAPATANIIAELACGLAGDMISSTILASKAPVIIAPAMNDNMYSNPATQQNIAKLKERGFVFVEPESGRLASGKT
GQGRLASVDTILGSVTQVLGKNGPLAGKKLVISAGGTREPVDPVRYLGNRSSGKMGYALAEEAVRRGASVRLVSGAVDKP
APFGVDIKYTETAMEMFISLREAVKGADALIMTAAVADYRPEKPAADKIKKGDGELDLHLVANPDILASLQGDFVKVGFA
AESRDLMINAVKKMADKNLDIIAANDISQPDSTFGSDTTRLTLFFKNGRIEEMPLMSKQEAAVRLLDELSALL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=186, Percent_Identity=33.8709677419355, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI87082301, Length=394, Percent_Identity=41.8781725888325, Blast_Score=259, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17560194, Length=184, Percent_Identity=33.695652173913, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=179, Percent_Identity=29.0502793296089, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=28.494623655914, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 41697; Mature: 41697

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKKTVVLGITGSISAYKAADIASKLVAAGYTVKAVMTENACRFISPLTIRTLSRQQVV
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHCCHHHHHCCHHHHH
TGMWDMNSEYSVEHVSLAEEAAVILVAPATANIIAELACGLAGDMISSTILASKAPVIIA
HHHCCCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
PAMNDNMYSNPATQQNIAKLKERGFVFVEPESGRLASGKTGQGRLASVDTILGSVTQVLG
ECCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
KNGPLAGKKLVISAGGTREPVDPVRYLGNRSSGKMGYALAEEAVRRGASVRLVSGAVDKP
CCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
APFGVDIKYTETAMEMFISLREAVKGADALIMTAAVADYRPEKPAADKIKKGDGELDLHL
CCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEE
VANPDILASLQGDFVKVGFAAESRDLMINAVKKMADKNLDIIAANDISQPDSTFGSDTTR
EECCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEE
LTLFFKNGRIEEMPLMSKQEAAVRLLDELSALL
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MDKKKTVVLGITGSISAYKAADIASKLVAAGYTVKAVMTENACRFISPLTIRTLSRQQVV
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHCCHHHHHCCHHHHH
TGMWDMNSEYSVEHVSLAEEAAVILVAPATANIIAELACGLAGDMISSTILASKAPVIIA
HHHCCCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
PAMNDNMYSNPATQQNIAKLKERGFVFVEPESGRLASGKTGQGRLASVDTILGSVTQVLG
ECCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
KNGPLAGKKLVISAGGTREPVDPVRYLGNRSSGKMGYALAEEAVRRGASVRLVSGAVDKP
CCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
APFGVDIKYTETAMEMFISLREAVKGADALIMTAAVADYRPEKPAADKIKKGDGELDLHL
CCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEE
VANPDILASLQGDFVKVGFAAESRDLMINAVKKMADKNLDIIAANDISQPDSTFGSDTTR
EECCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEE
LTLFFKNGRIEEMPLMSKQEAAVRLLDELSALL
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]