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The map label for this gene is adk

Identifier: 57234758

GI number: 57234758

Start: 455875

End: 456525

Strand: Direct

Name: adk

Synonym: DET0495

Alternate gene names: 57234758

Gene position: 455875-456525 (Clockwise)

Preceding gene: 57234767

Following gene: 57234757

Centisome position: 31.02

GC content: 52.07

Gene sequence:

>651_bases
GTGTATAATGTTATTTTCCTTGGCGCCCCGGGTTCGGGTAAAGGCACACAAGGTGAAGTAGTCGCTAAAGAGCTTAGGCT
GGCGCATATGGCCACCGGTGATTTATTTCGTAAGGCTATAGAGCGCGGTGATGAGCTGGGTGATACGGTTAAGTCCTATA
TGGAACGGGGCGAGCTGGTGCCGGATGAGATTACCATTAGTGTAGTCCTTAAGCACCTTGCTGGCTTGAAAGATGTTAGC
GGGATTATTCTGGACGGATTCCCCCGGAGCCTGCGTCAGGCCGAGGCGCTGGATGAGGCGCTGGTAAAGCAGGGAGAGGG
AATCGGCAGAGTAATATATATAAATGTGCCGGAAGATGAGCTGGTCCGGCGCTTAAGCGGACGCTGGGTTTGCCGGAGCT
GTCAGTCACCTTATCAGTGTGGCTGTGCTGAGGTAGCCGAGGGGAAGTGCAGCCGCTGTCAGGGTGAGCTGTATCAGCGC
CCTGATGACACACCCGAAACCGTAAAGGAAAGGCTCAAGGTGTATTTTAGCAAAACGGCACCGCTTATTGAGTACTATCG
CTCAAAGGGCAAGCTGAGTGAGATTGATGGTATGGCTGAGATAACAGAGGTGACCAAGCGGATTGTATCAGCTATAAAGT
GCGGTAAATAA

Upstream 100 bases:

>100_bases
TATGCTGATTGTGGTCGGTGTAGCTCTGGATACTATGAAACAGCTCGAGGCGCAGCTTGTAATGCGGCGTTACGAGGGCT
TTATTAAGTAGGCAAGAATA

Downstream 100 bases:

>100_bases
CCGGTTTATGACCATAATACTGAAAACCGAAAAAGAGATTGCTATAATGCGGCGGGCCGGTCATATACTGGCAGCTGCTT
TAGAAGAAGTTAAGAAGAAT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MYNVIFLGAPGSGKGTQGEVVAKELRLAHMATGDLFRKAIERGDELGDTVKSYMERGELVPDEITISVVLKHLAGLKDVS
GIILDGFPRSLRQAEALDEALVKQGEGIGRVIYINVPEDELVRRLSGRWVCRSCQSPYQCGCAEVAEGKCSRCQGELYQR
PDDTPETVKERLKVYFSKTAPLIEYYRSKGKLSEIDGMAEITEVTKRIVSAIKCGK

Sequences:

>Translated_216_residues
MYNVIFLGAPGSGKGTQGEVVAKELRLAHMATGDLFRKAIERGDELGDTVKSYMERGELVPDEITISVVLKHLAGLKDVS
GIILDGFPRSLRQAEALDEALVKQGEGIGRVIYINVPEDELVRRLSGRWVCRSCQSPYQCGCAEVAEGKCSRCQGELYQR
PDDTPETVKERLKVYFSKTAPLIEYYRSKGKLSEIDGMAEITEVTKRIVSAIKCGK
>Mature_216_residues
MYNVIFLGAPGSGKGTQGEVVAKELRLAHMATGDLFRKAIERGDELGDTVKSYMERGELVPDEITISVVLKHLAGLKDVS
GIILDGFPRSLRQAEALDEALVKQGEGIGRVIYINVPEDELVRRLSGRWVCRSCQSPYQCGCAEVAEGKCSRCQGELYQR
PDDTPETVKERLKVYFSKTAPLIEYYRSKGKLSEIDGMAEITEVTKRIVSAIKCGK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=209, Percent_Identity=37.799043062201, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI7524346, Length=210, Percent_Identity=37.6190476190476, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=38.8888888888889, Blast_Score=140, Evalue=6e-34,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=34.8484848484849, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=34.8484848484849, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=34.8484848484849, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=34.8484848484849, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI4502011, Length=215, Percent_Identity=26.9767441860465, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI28144897, Length=216, Percent_Identity=30.0925925925926, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI28144899, Length=216, Percent_Identity=30.0925925925926, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI7706497, Length=211, Percent_Identity=25.1184834123223, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1786680, Length=207, Percent_Identity=37.6811594202899, Blast_Score=130, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17552384, Length=205, Percent_Identity=37.0731707317073, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=210, Percent_Identity=29.5238095238095, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=215, Percent_Identity=29.7674418604651, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17537943, Length=201, Percent_Identity=30.8457711442786, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=197, Percent_Identity=30.9644670050761, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=33.953488372093, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=34.3589743589744, Blast_Score=111, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6322828, Length=215, Percent_Identity=27.906976744186, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=34.4339622641509, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17737899, Length=198, Percent_Identity=35.8585858585859, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24645822, Length=198, Percent_Identity=35.8585858585859, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI221459597, Length=202, Percent_Identity=27.2277227722772, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21356893, Length=202, Percent_Identity=27.2277227722772, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17647141, Length=212, Percent_Identity=24.5283018867925, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24663208, Length=212, Percent_Identity=24.5283018867925, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_DEHE1 (Q3Z960)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181239.1
- HSSP:   P69440
- ProteinModelPortal:   Q3Z960
- SMR:   Q3Z960
- STRING:   Q3Z960
- GeneID:   3230227
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0495
- NMPDR:   fig|243164.3.peg.757
- TIGR:   DET0495
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   CLSK837474
- BioCyc:   DETH243164:DET_0495-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 23860; Mature: 23860

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNVIFLGAPGSGKGTQGEVVAKELRLAHMATGDLFRKAIERGDELGDTVKSYMERGELV
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
PDEITISVVLKHLAGLKDVSGIILDGFPRSLRQAEALDEALVKQGEGIGRVIYINVPEDE
CHHHHHHHHHHHHHCHHHHCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHH
LVRRLSGRWVCRSCQSPYQCGCAEVAEGKCSRCQGELYQRPDDTPETVKERLKVYFSKTA
HHHHHHCCHHHHHCCCCHHCCHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCH
PLIEYYRSKGKLSEIDGMAEITEVTKRIVSAIKCGK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYNVIFLGAPGSGKGTQGEVVAKELRLAHMATGDLFRKAIERGDELGDTVKSYMERGELV
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
PDEITISVVLKHLAGLKDVSGIILDGFPRSLRQAEALDEALVKQGEGIGRVIYINVPEDE
CHHHHHHHHHHHHHCHHHHCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHH
LVRRLSGRWVCRSCQSPYQCGCAEVAEGKCSRCQGELYQRPDDTPETVKERLKVYFSKTA
HHHHHHCCHHHHHCCCCHHCCHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCH
PLIEYYRSKGKLSEIDGMAEITEVTKRIVSAIKCGK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA