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The map label for this gene is icd [H]

Identifier: 57234731

GI number: 57234731

Start: 426851

End: 427930

Strand: Direct

Name: icd [H]

Synonym: DET0450

Alternate gene names: 57234731

Gene position: 426851-427930 (Clockwise)

Preceding gene: 57234732

Following gene: 57234730

Centisome position: 29.04

GC content: 50.0

Gene sequence:

>1080_bases
ATGTCTCATAACGTAACCCTTATACCCGGTGACGGGATTGGCCCTGAAATATCTGAGGCAACCCGCCGGGTACTGGAAGC
TACCGGTGTAAAGTTTAACTGGGAGATAGTAAATGCCGGTGCGGATGTGGTAGCCGAATATGGCACGCCTCTACCGGATA
TGGTGCTTGAATCCATTCGTAAAAACAAGGTTGCCATCAAAGGGCCGGTGACTACCCCGGTCGGCTCAGGGTTTAGAAGT
GTAAATGTGGGTATGCGCAAGGCTCTTAATCTTTATACCTGCCTGCGCCCCTGCAAGACCTATCCCGGTGTTCCCTCCCG
CTATGACAATGTGGATATTGTTATCGTGCGGGAAAACATGGAAGACCTGTATGCCGGTATTGAGTTTGAAAAGGGCAGCC
CCGAAGCCCTAAGGCTTATAGAGTTTATCAAAGAGAATAAAAAGGTTGAAATACGGGCGGATTCGGGTATCAGCATAAAG
CCTATCAGCGTGTTCGGCACCGAACGCATATTCCGCTGGGCTTTTAAATATGCCCGGGACAACAAACGCAAAAGGGTTAC
GGCTGTCCACAAAGCTAATATCATGAAATATTCTGACGGGCTTTTCCTGGCTATAGGCCGCAAAGTGGCCGAGGAATACC
CGGAGATAGAGTTTGAAGACCGTATTGTAGACAATATGACTATGCAGCTGGTCAAAAACCCCTCCCAGTTTGATATTCTG
GTCTGCCCAAATCTGTACGGGGACATTCTGTCTGATTTGTGTGCCGGGTTGGTGGGCGGCCTGGGGGTTGCACCGGGTGC
TAATATCGGTGATGAGTATGCCCTGTTTGAGCCTACCCATGGCTCTGCCCCCAAGTACAAGGGGATGAATAAGGTAAACC
CCATGGCCATGATGCTTTCCGGGGTGCTGATGCTTCGCTACCTGAAAGAGGAAAAGGCCGCTGATAAGCTGGAAAATGCT
ATTGCAGCTGTTATTGCCGAAGGCAAGAGTGTTACCTATGATATGCTTTCACCTGACAAACAGGCGGCGGCGGTAGGCAC
TTCGCAGGTGGCAGACGCCATAATAGCCAAAATGAAATAA

Upstream 100 bases:

>100_bases
CCCCCGCCATGCTGAAGATACTTGATGAGGGAGGTGTCATGCCCTATATAAAGAAATACGGTGATTTCAAGCTTAACGAA
GTTTAAGGAGTTTTATTCTG

Downstream 100 bases:

>100_bases
AAGTGCGGCTAGTCTTATGGGTATTGTACCCTCAGGCTTAGCTGCCTGAATTGATAACAGGTGAGGAAGAAAATAAATGC
CCAAAATTAGTGTCATAGGT

Product: isocitrate dehydrogenase, putative

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSHNVTLIPGDGIGPEISEATRRVLEATGVKFNWEIVNAGADVVAEYGTPLPDMVLESIRKNKVAIKGPVTTPVGSGFRS
VNVGMRKALNLYTCLRPCKTYPGVPSRYDNVDIVIVRENMEDLYAGIEFEKGSPEALRLIEFIKENKKVEIRADSGISIK
PISVFGTERIFRWAFKYARDNKRKRVTAVHKANIMKYSDGLFLAIGRKVAEEYPEIEFEDRIVDNMTMQLVKNPSQFDIL
VCPNLYGDILSDLCAGLVGGLGVAPGANIGDEYALFEPTHGSAPKYKGMNKVNPMAMMLSGVLMLRYLKEEKAADKLENA
IAAVIAEGKSVTYDMLSPDKQAAAVGTSQVADAIIAKMK

Sequences:

>Translated_359_residues
MSHNVTLIPGDGIGPEISEATRRVLEATGVKFNWEIVNAGADVVAEYGTPLPDMVLESIRKNKVAIKGPVTTPVGSGFRS
VNVGMRKALNLYTCLRPCKTYPGVPSRYDNVDIVIVRENMEDLYAGIEFEKGSPEALRLIEFIKENKKVEIRADSGISIK
PISVFGTERIFRWAFKYARDNKRKRVTAVHKANIMKYSDGLFLAIGRKVAEEYPEIEFEDRIVDNMTMQLVKNPSQFDIL
VCPNLYGDILSDLCAGLVGGLGVAPGANIGDEYALFEPTHGSAPKYKGMNKVNPMAMMLSGVLMLRYLKEEKAADKLENA
IAAVIAEGKSVTYDMLSPDKQAAAVGTSQVADAIIAKMK
>Mature_358_residues
SHNVTLIPGDGIGPEISEATRRVLEATGVKFNWEIVNAGADVVAEYGTPLPDMVLESIRKNKVAIKGPVTTPVGSGFRSV
NVGMRKALNLYTCLRPCKTYPGVPSRYDNVDIVIVRENMEDLYAGIEFEKGSPEALRLIEFIKENKKVEIRADSGISIKP
ISVFGTERIFRWAFKYARDNKRKRVTAVHKANIMKYSDGLFLAIGRKVAEEYPEIEFEDRIVDNMTMQLVKNPSQFDILV
CPNLYGDILSDLCAGLVGGLGVAPGANIGDEYALFEPTHGSAPKYKGMNKVNPMAMMLSGVLMLRYLKEEKAADKLENAI
AAVIAEGKSVTYDMLSPDKQAAAVGTSQVADAIIAKMK

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=334, Percent_Identity=44.6107784431138, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI4758582, Length=357, Percent_Identity=38.9355742296919, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI28178838, Length=328, Percent_Identity=41.1585365853659, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI28178816, Length=339, Percent_Identity=41.2979351032448, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI28178821, Length=339, Percent_Identity=41.2979351032448, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI28178819, Length=180, Percent_Identity=50.5555555555556, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1787381, Length=389, Percent_Identity=41.6452442159383, Blast_Score=277, Evalue=7e-76,
Organism=Escherichia coli, GI87081683, Length=377, Percent_Identity=35.8090185676393, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI1788101, Length=372, Percent_Identity=30.9139784946237, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71986051, Length=335, Percent_Identity=45.9701492537313, Blast_Score=301, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI25144293, Length=346, Percent_Identity=39.0173410404624, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17505779, Length=337, Percent_Identity=40.3560830860534, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17550882, Length=361, Percent_Identity=36.8421052631579, Blast_Score=223, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6324709, Length=360, Percent_Identity=39.4444444444444, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6324291, Length=359, Percent_Identity=38.4401114206128, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6322097, Length=372, Percent_Identity=36.5591397849462, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6319830, Length=383, Percent_Identity=30.5483028720627, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24643270, Length=338, Percent_Identity=45.2662721893491, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24643268, Length=338, Percent_Identity=45.2662721893491, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24661184, Length=361, Percent_Identity=39.612188365651, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI161078635, Length=325, Percent_Identity=39.0769230769231, Blast_Score=237, Evalue=8e-63,
Organism=Drosophila melanogaster, GI161078637, Length=325, Percent_Identity=39.0769230769231, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI161078633, Length=325, Percent_Identity=39.0769230769231, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24650122, Length=325, Percent_Identity=39.0769230769231, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI161078639, Length=331, Percent_Identity=37.4622356495468, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI281362242, Length=336, Percent_Identity=40.7738095238095, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24648872, Length=336, Percent_Identity=40.7738095238095, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI20130355, Length=336, Percent_Identity=31.25, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45550436, Length=332, Percent_Identity=22.8915662650602, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 39371; Mature: 39240

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHNVTLIPGDGIGPEISEATRRVLEATGVKFNWEIVNAGADVVAEYGTPLPDMVLESIR
CCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCCCCHHHHHHHHH
KNKVAIKGPVTTPVGSGFRSVNVGMRKALNLYTCLRPCKTYPGVPSRYDNVDIVIVRENM
HCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCH
EDLYAGIEFEKGSPEALRLIEFIKENKKVEIRADSGISIKPISVFGTERIFRWAFKYARD
HHHHCCCEECCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHC
NKRKRVTAVHKANIMKYSDGLFLAIGRKVAEEYPEIEFEDRIVDNMTMQLVKNPSQFDIL
CCHHHHHHHHHHHEEEECCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEE
VCPNLYGDILSDLCAGLVGGLGVAPGANIGDEYALFEPTHGSAPKYKGMNKVNPMAMMLS
ECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHH
GVLMLRYLKEEKAADKLENAIAAVIAEGKSVTYDMLSPDKQAAAVGTSQVADAIIAKMK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SHNVTLIPGDGIGPEISEATRRVLEATGVKFNWEIVNAGADVVAEYGTPLPDMVLESIR
CCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCCCCHHHHHHHHH
KNKVAIKGPVTTPVGSGFRSVNVGMRKALNLYTCLRPCKTYPGVPSRYDNVDIVIVRENM
HCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCH
EDLYAGIEFEKGSPEALRLIEFIKENKKVEIRADSGISIKPISVFGTERIFRWAFKYARD
HHHHCCCEECCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHC
NKRKRVTAVHKANIMKYSDGLFLAIGRKVAEEYPEIEFEDRIVDNMTMQLVKNPSQFDIL
CCHHHHHHHHHHHEEEECCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEE
VCPNLYGDILSDLCAGLVGGLGVAPGANIGDEYALFEPTHGSAPKYKGMNKVNPMAMMLS
ECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHH
GVLMLRYLKEEKAADKLENAIAAVIAEGKSVTYDMLSPDKQAAAVGTSQVADAIIAKMK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9325430; 9389475 [H]