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The map label for this gene is glmU [H]

Identifier: 57234692

GI number: 57234692

Start: 483324

End: 484505

Strand: Direct

Name: glmU [H]

Synonym: DET0530

Alternate gene names: 57234692

Gene position: 483324-484505 (Clockwise)

Preceding gene: 57234693

Following gene: 57234691

Centisome position: 32.89

GC content: 48.98

Gene sequence:

>1182_bases
ATGAAACAGGCAGTTATACTGGCGGCCGGTGAAGGACAGCGTCTTAGGCCTTTTACCTCAAGCAAGTCAAAGGTTATGTT
GTCTATTGCGGGTAAGCCACTGCTTGAGTACGTTATTGAATCCCTTGCCCGAAACGGTATCCGGGATATTATTCTGGTAG
TGGGTTATAAACGTGAGCGTATCTTTGATTATTTCGGAGATGGCGGGCATCTGGGGGTAGAGATAACCTATGTCAGTCAG
CCAAACCAGCTGGGTACAGCCCATGCCCTTAAGCAAACCAGAGACAAAATCAGAGGGGATTTTCTGGTATTAAACGGAGA
CCAGCTTATTAGTCCGGCAACCATAGGTGATTTTGTAAAAGAGCCGCCCCAGGCTGTTATGGTAAAAGCTATAAACGGTG
AAGACCCCAGGCGGTACGGGGTGGTAAGCTCTTCGGGCAGGCGTTTGACCTCTATAGAGGAAAAACCCAGTATAGCTAAG
AGCAATTTGATAAATACCGGCATTTACTCCTTTTCAACCCGGGTGTTTGACTATATTGCTGAGCATCTGGATATCCCGAT
GGTCTTGCAGTCCATGATTAAAGACGGGCTGGATATACGGGTAGCAGAAAGCCGGGGTGTCTGGCTGGATATAGTCTACC
CGTGGGATATGCTCTCACTTAATGCAGTTGTCTCAGATACACTCAAGCCGGGCGTAGCCGGTACTATTGAAAGCGGCGTG
GTGATGAAAGGGCCGGTGCTTATCGGCAAAAATACGGTTATCCGCTCCAATTCATATATTACAGGCCCGGTGATAATCGG
TGAGGGTTGTGATATCGGGCCGAGTGTCTGTATTTACCCGTCCACCAGTATTGCAGACAATGTCACTGTCGCCCCTTTCT
GCCAGATAAAAAACAGCCTTATTTACAGCGGTAACAGTATCGGGGTGGCTTCGGTTATTGAAGATTCGGTTATAGACCGG
GGCTGTGTGATTCGCGGCCAGTTCAGCGCCCCTTCCGCCGAGGTGGAAACCCGCATAAATGATGAATTACATAAAATAAA
AGTAGGTACTATGATGGGTGAAGACTGTATGGTGGGGAACGGTGCAGTTCTTCAGGGCGGTACGGTGGTGGGAAATTCCA
GCCGTATAGCCCCTTTAAAAACCCTGTCGGGCAGTATACCTGACGGCAGTCTGGTGGTCTAG

Upstream 100 bases:

>100_bases
GGGCGTCCTTATAGGCGCAGGCAGCCGTATAGGGCCCGGTGCGGTTGTGAGCGGTGTTATTGAACCGAACTCATACATCG
GCTAAGGCGGGGAGTGAAAT

Downstream 100 bases:

>100_bases
AATGTGCGGTATAGTGGGTTACACCGGTAAACGCCAGGCACAGGCTGTTTTATATGATTGTTTGTGCCGTCTGGAGTACC
GCGGGTATGATTCCTGCGGC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKQAVILAAGEGQRLRPFTSSKSKVMLSIAGKPLLEYVIESLARNGIRDIILVVGYKRERIFDYFGDGGHLGVEITYVSQ
PNQLGTAHALKQTRDKIRGDFLVLNGDQLISPATIGDFVKEPPQAVMVKAINGEDPRRYGVVSSSGRRLTSIEEKPSIAK
SNLINTGIYSFSTRVFDYIAEHLDIPMVLQSMIKDGLDIRVAESRGVWLDIVYPWDMLSLNAVVSDTLKPGVAGTIESGV
VMKGPVLIGKNTVIRSNSYITGPVIIGEGCDIGPSVCIYPSTSIADNVTVAPFCQIKNSLIYSGNSIGVASVIEDSVIDR
GCVIRGQFSAPSAEVETRINDELHKIKVGTMMGEDCMVGNGAVLQGGTVVGNSSRIAPLKTLSGSIPDGSLVV

Sequences:

>Translated_393_residues
MKQAVILAAGEGQRLRPFTSSKSKVMLSIAGKPLLEYVIESLARNGIRDIILVVGYKRERIFDYFGDGGHLGVEITYVSQ
PNQLGTAHALKQTRDKIRGDFLVLNGDQLISPATIGDFVKEPPQAVMVKAINGEDPRRYGVVSSSGRRLTSIEEKPSIAK
SNLINTGIYSFSTRVFDYIAEHLDIPMVLQSMIKDGLDIRVAESRGVWLDIVYPWDMLSLNAVVSDTLKPGVAGTIESGV
VMKGPVLIGKNTVIRSNSYITGPVIIGEGCDIGPSVCIYPSTSIADNVTVAPFCQIKNSLIYSGNSIGVASVIEDSVIDR
GCVIRGQFSAPSAEVETRINDELHKIKVGTMMGEDCMVGNGAVLQGGTVVGNSSRIAPLKTLSGSIPDGSLVV
>Mature_393_residues
MKQAVILAAGEGQRLRPFTSSKSKVMLSIAGKPLLEYVIESLARNGIRDIILVVGYKRERIFDYFGDGGHLGVEITYVSQ
PNQLGTAHALKQTRDKIRGDFLVLNGDQLISPATIGDFVKEPPQAVMVKAINGEDPRRYGVVSSSGRRLTSIEEKPSIAK
SNLINTGIYSFSTRVFDYIAEHLDIPMVLQSMIKDGLDIRVAESRGVWLDIVYPWDMLSLNAVVSDTLKPGVAGTIESGV
VMKGPVLIGKNTVIRSNSYITGPVIIGEGCDIGPSVCIYPSTSIADNVTVAPFCQIKNSLIYSGNSIGVASVIEDSVIDR
GCVIRGQFSAPSAEVETRINDELHKIKVGTMMGEDCMVGNGAVLQGGTVVGNSSRIAPLKTLSGSIPDGSLVV

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=401, Percent_Identity=26.6832917705736, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI11761619, Length=413, Percent_Identity=26.3922518159806, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1790224, Length=224, Percent_Identity=30.8035714285714, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788351, Length=184, Percent_Identity=35.3260869565217, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI133931050, Length=405, Percent_Identity=26.1728395061728, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320148, Length=407, Percent_Identity=25.5528255528256, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355443, Length=412, Percent_Identity=27.9126213592233, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24644084, Length=412, Percent_Identity=27.9126213592233, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653912, Length=200, Percent_Identity=31.5, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 42085; Mature: 42085

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQAVILAAGEGQRLRPFTSSKSKVMLSIAGKPLLEYVIESLARNGIRDIILVVGYKRER
CCCEEEEEECCCCEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHH
IFDYFGDGGHLGVEITYVSQPNQLGTAHALKQTRDKIRGDFLVLNGDQLISPATIGDFVK
HHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCEECCCHHHHHHH
EPPQAVMVKAINGEDPRRYGVVSSSGRRLTSIEEKPSIAKSNLINTGIYSFSTRVFDYIA
CCCCEEEEEEECCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
EHLDIPMVLQSMIKDGLDIRVAESRGVWLDIVYPWDMLSLNAVVSDTLKPGVAGTIESGV
HHCCHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCE
VMKGPVLIGKNTVIRSNSYITGPVIIGEGCDIGPSVCIYPSTSIADNVTVAPFCQIKNSL
EEECCEEECCCEEEECCCEEECCEEEECCCCCCCCEEEECCCCCCCCCEEEEHHHCCCCE
IYSGNSIGVASVIEDSVIDRGCVIRGQFSAPSAEVETRINDELHKIKVGTMMGEDCMVGN
EECCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHCCCCEEEEEEEEECCCEEECC
GAVLQGGTVVGNSSRIAPLKTLSGSIPDGSLVV
CEEEECCEEECCCCCCCCHHHHCCCCCCCCEEC
>Mature Secondary Structure
MKQAVILAAGEGQRLRPFTSSKSKVMLSIAGKPLLEYVIESLARNGIRDIILVVGYKRER
CCCEEEEEECCCCEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHH
IFDYFGDGGHLGVEITYVSQPNQLGTAHALKQTRDKIRGDFLVLNGDQLISPATIGDFVK
HHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCEECCCHHHHHHH
EPPQAVMVKAINGEDPRRYGVVSSSGRRLTSIEEKPSIAKSNLINTGIYSFSTRVFDYIA
CCCCEEEEEEECCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
EHLDIPMVLQSMIKDGLDIRVAESRGVWLDIVYPWDMLSLNAVVSDTLKPGVAGTIESGV
HHCCHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCE
VMKGPVLIGKNTVIRSNSYITGPVIIGEGCDIGPSVCIYPSTSIADNVTVAPFCQIKNSL
EEECCEEECCCEEEECCCEEECCEEEECCCCCCCCEEEECCCCCCCCCEEEEHHHCCCCE
IYSGNSIGVASVIEDSVIDRGCVIRGQFSAPSAEVETRINDELHKIKVGTMMGEDCMVGN
EECCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHCCCCEEEEEEEEECCCEEECC
GAVLQGGTVVGNSSRIAPLKTLSGSIPDGSLVV
CEEEECCEEECCCCCCCCHHHHCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]