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The map label for this gene is hisC [H]

Identifier: 57234524

GI number: 57234524

Start: 635286

End: 636392

Strand: Direct

Name: hisC [H]

Synonym: DET0689

Alternate gene names: 57234524

Gene position: 635286-636392 (Clockwise)

Preceding gene: 57234525

Following gene: 57234522

Centisome position: 43.22

GC content: 49.77

Gene sequence:

>1107_bases
TTGTCCGTATCGCCTAAGCCGCAGGTAGAAAAATTAAAGCCGTGTTACCACGGCGGGCCGAACTATGCCGAGCTTAGAAA
ACTGGGTATCAGCCCGGATGCGGTTATGGATTTTTCGGTAAGCTCAAATCCCTATCCGGCACCTGTTGAGCTCAAAAACG
CCCTTTGCTCTTTGGTTATTGACCGCTACCCTGATTCAGATTCTGCCGAACTAAAAGAATACCTGGCAGGCAGGCTTTCA
CTTAAGCCCGAAAACCTGATTATGGGCAACGGCTCTATGGAAATTATCCGTCTGGTTGCCGGGGCATATTTCGGGGTGGG
GGATACGGTTTTAATACTCAAACCCACCTTCGGGGAATATGAACTGGCAGCAGAAGTGGCCGGTGCGGATATAATTGAGC
AGTGGGCAGACGAAGAGAGCGGCTTTAAGTTTGATTTGGATTTAACCTGCCGCATTATTAAAAAACACCAGCCCAAAGCG
GTATTTATCTGCAATCCCAATAACCCTACCGGGGTTTATCTTTCCAAAGCGGATATTGAAAAAGTGCTGAGCGTCTGCAC
TGATACCCTGCTGGTGCTGGACGAAGCTTATATAGCCTTTGCTGAAGGCGGCTGGAAATCAACAGATTTGCTCGAAACGG
GCAATATTATAGTTATCCGCTCTATGACCAAAGATTGCGCTTTGGCCGGGCTGAGGCTTGGTTATGGCATGGCTTCGGCG
GAGATAATAACCAACCTCAAAAAGGTCTGTCCGCCGTGGAATGTTAATTCTGCCGCCCAGAAAGCCGGGCTTGTTTGCCT
GTGTCACCCCAGCTATCTGGCGGAATCTGAGAAAAAGATAAAGGCCTCTAAGGAGTATCTCAGGCAGGGTTTTGCAGGCT
TGGGCTTTAGAGTGCTGCCCTCCGAGACCAATTTTTTCCTGCTGAAAGTGAAAAAGGCCGCGGATTTCCGTTCGGCACTC
CTTAAGCACGGGCTTATGGTGCGGGACTGCACTTCATTCGGCTTGCCACAGTATGTCCGTATTGCTCCCCGCACCCAAAG
TGAGTGTGAACGCCTGCTTGCGGTTGCGGCTGAATTGAAAAGTAAGTCTGAGATTTATCCAGCCTGA

Upstream 100 bases:

>100_bases
AATATCAGGGAGCTTGTTCCCCAAACTATCAGCCGTTCGCTGCTGCTTATAAACAGTGCGGCCTTTATCTGGGTTTTAAT
AAGCGCGGGAGTGATTTATT

Downstream 100 bases:

>100_bases
TTGACTGACAGGGTTTTGTCTGATATAGTTTTTAATGGTGATTAGCAAACGGAACACGGTTTGAATCCGTGGCGGTCCCG
CCGCTGTAACCGGGGACTTT

Product: histidinol-phosphate aminotransferase, putative

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSVSPKPQVEKLKPCYHGGPNYAELRKLGISPDAVMDFSVSSNPYPAPVELKNALCSLVIDRYPDSDSAELKEYLAGRLS
LKPENLIMGNGSMEIIRLVAGAYFGVGDTVLILKPTFGEYELAAEVAGADIIEQWADEESGFKFDLDLTCRIIKKHQPKA
VFICNPNNPTGVYLSKADIEKVLSVCTDTLLVLDEAYIAFAEGGWKSTDLLETGNIIVIRSMTKDCALAGLRLGYGMASA
EIITNLKKVCPPWNVNSAAQKAGLVCLCHPSYLAESEKKIKASKEYLRQGFAGLGFRVLPSETNFFLLKVKKAADFRSAL
LKHGLMVRDCTSFGLPQYVRIAPRTQSECERLLAVAAELKSKSEIYPA

Sequences:

>Translated_368_residues
MSVSPKPQVEKLKPCYHGGPNYAELRKLGISPDAVMDFSVSSNPYPAPVELKNALCSLVIDRYPDSDSAELKEYLAGRLS
LKPENLIMGNGSMEIIRLVAGAYFGVGDTVLILKPTFGEYELAAEVAGADIIEQWADEESGFKFDLDLTCRIIKKHQPKA
VFICNPNNPTGVYLSKADIEKVLSVCTDTLLVLDEAYIAFAEGGWKSTDLLETGNIIVIRSMTKDCALAGLRLGYGMASA
EIITNLKKVCPPWNVNSAAQKAGLVCLCHPSYLAESEKKIKASKEYLRQGFAGLGFRVLPSETNFFLLKVKKAADFRSAL
LKHGLMVRDCTSFGLPQYVRIAPRTQSECERLLAVAAELKSKSEIYPA
>Mature_367_residues
SVSPKPQVEKLKPCYHGGPNYAELRKLGISPDAVMDFSVSSNPYPAPVELKNALCSLVIDRYPDSDSAELKEYLAGRLSL
KPENLIMGNGSMEIIRLVAGAYFGVGDTVLILKPTFGEYELAAEVAGADIIEQWADEESGFKFDLDLTCRIIKKHQPKAV
FICNPNNPTGVYLSKADIEKVLSVCTDTLLVLDEAYIAFAEGGWKSTDLLETGNIIVIRSMTKDCALAGLRLGYGMASAE
IITNLKKVCPPWNVNSAAQKAGLVCLCHPSYLAESEKKIKASKEYLRQGFAGLGFRVLPSETNFFLLKVKKAADFRSALL
KHGLMVRDCTSFGLPQYVRIAPRTQSECERLLAVAAELKSKSEIYPA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=344, Percent_Identity=28.7790697674419, Blast_Score=130, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=26.1904761904762, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40285; Mature: 40154

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSPKPQVEKLKPCYHGGPNYAELRKLGISPDAVMDFSVSSNPYPAPVELKNALCSLVI
CCCCCCCCHHHCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
DRYPDSDSAELKEYLAGRLSLKPENLIMGNGSMEIIRLVAGAYFGVGDTVLILKPTFGEY
HCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCH
ELAAEVAGADIIEQWADEESGFKFDLDLTCRIIKKHQPKAVFICNPNNPTGVYLSKADIE
HHHHHHHHHHHHHHHCCCCCCEEEEECHHEEEEECCCCCEEEEECCCCCCEEEEEHHHHH
KVLSVCTDTLLVLDEAYIAFAEGGWKSTDLLETGNIIVIRSMTKDCALAGLRLGYGMASA
HHHHHHHHHHHHHHHHHEEEECCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHCCCHHH
EIITNLKKVCPPWNVNSAAQKAGLVCLCHPSYLAESEKKIKASKEYLRQGFAGLGFRVLP
HHHHHHHHHCCCCCCCHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
SETNFFLLKVKKAADFRSALLKHGLMVRDCTSFGLPQYVRIAPRTQSECERLLAVAAELK
CCCCEEEEEEECHHHHHHHHHHCCCEEEEHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
SKSEIYPA
CCCCCCCC
>Mature Secondary Structure 
SVSPKPQVEKLKPCYHGGPNYAELRKLGISPDAVMDFSVSSNPYPAPVELKNALCSLVI
CCCCCCCHHHCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
DRYPDSDSAELKEYLAGRLSLKPENLIMGNGSMEIIRLVAGAYFGVGDTVLILKPTFGEY
HCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCH
ELAAEVAGADIIEQWADEESGFKFDLDLTCRIIKKHQPKAVFICNPNNPTGVYLSKADIE
HHHHHHHHHHHHHHHCCCCCCEEEEECHHEEEEECCCCCEEEEECCCCCCEEEEEHHHHH
KVLSVCTDTLLVLDEAYIAFAEGGWKSTDLLETGNIIVIRSMTKDCALAGLRLGYGMASA
HHHHHHHHHHHHHHHHHEEEECCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHCCCHHH
EIITNLKKVCPPWNVNSAAQKAGLVCLCHPSYLAESEKKIKASKEYLRQGFAGLGFRVLP
HHHHHHHHHCCCCCCCHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
SETNFFLLKVKKAADFRSALLKHGLMVRDCTSFGLPQYVRIAPRTQSECERLLAVAAELK
CCCCEEEEEEECHHHHHHHHHHCCCEEEEHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
SKSEIYPA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA