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The map label for this gene is glyS [H]

Identifier: 57234403

GI number: 57234403

Start: 723890

End: 725191

Strand: Direct

Name: glyS [H]

Synonym: DET0787

Alternate gene names: 57234403

Gene position: 723890-725191 (Clockwise)

Preceding gene: 57234411

Following gene: 57234402

Centisome position: 49.25

GC content: 50.08

Gene sequence:

>1302_bases
ATGGATAAAATAGTTTCTTTGGCCCGCCGCCGGGGATTTATATTCCCCAGCAGTGAAATCTACGGCGGCCTGAATAGCTG
CTGGGACTACGGCCCGCTGGGCGTAGAACTGAAGCGCAACGTTAAAGAAGCCTGGTGGCGGTATATGGTACGTGACCGGG
ATGACGTGGTTGGTTTGGATGCCAGTATTATCATGCACCCCCGCGTTTGGGAAGCCAGCGGTCATGTGGCCGGGTTTTCC
GACCCTATGGTGGACTGCAAAAATTGCAAAATGCGCTGGCGCCCCACAGACCTTGCCGAACCCAAATGCCCGGCCTGCGG
CGGTGAGCTTACCGAATCACGCCAGTTTAACCTCATGTTTAAAACCTTTATGGGTCCTGTTGAAGAGGCGGCCAATATTG
TCTATCTGCGGCCGGAAACCGCTCAGGGCATATTTGTAAATTTTGAAAACGTTTTAAATACCACCCGCAAAAAATTGCCC
TTCGGTATTGCCCAGATAGGTAAATCGTTCCGCAACGAAATTACTACCGGTAACTTTATTTTCCGCTCACGCGAGTTTGA
GCAGATGGAATTGGAGTATTTTGTAAAACCGGGTGCGGATGATGCCTGCTTGGAGGAATGGACTCAGTACCGCCTGAACT
GGTATAAAAATCTGGGTATGAATCCTGAAAACCTCAGGCTTCGGGCTCACCGCTCTGACGAACTGGCTCACTATGCCAAG
GGTTGTTATGACGTGGAATACAATTTCCCCATGGGCTGGAGTGAGCTTGAAGGTATAGCCAACAGGCGTGATTTTGACCT
TACCCAGCACTCCAAATACAGCGGCAAGGCACTGGAGTATTTTGACGAAGAAACCAAAGAACACTTTATACCCTATGTAA
TAGAACCCTCAGCCGGGGTTGAACGCTCTACTCTGGCTTTCCTGATTGATGCTTATGCCGAAGAGCCTGACAAGGACGAA
ATACGGACTGTTTTGCACCTGCACCCGGCACTTGCCCCGTACAAGATAGCCGTCTTGCCTCTTTCCAAGAAAGAAATACT
GTCTGATTATGCCCGCAAGATTTATGCTGACCTTAGAAAATGCTGGATGGTAGCTTACGATGACTCCCAGAGTATCGGCC
GCCGTTACCGCCGTCAGGACGAAATAGGTACACCCTACTGCGTTACGGTGGATTTCCAGTCTCTGGAAGATGGCATGGTG
ACCATACGTGACAGGGATAGCATGGATCAAATACGGGTAAAAGTATCCGAACTTAGCTGCATTCTGGCTGCCAAGCTTTC
GGGTGAGCCGTTTAACAGCTGA

Upstream 100 bases:

>100_bases
CATTCCGGTATTTGTCAGGGCTTACAAAACTTTTAACGGCCCGAGTGCAAGCAAAAAGGAGTAATTGACCTTGTCTGAAA
ATGTTTCTCAGCCTGTTTCC

Downstream 100 bases:

>100_bases
TTTGGAGGCGAAATTGAAAATCCTCCACTTTGCAGACCTTCACATAGGGGTGGAGAATTACGGCCGTTTTGACAGTGCAA
CCGGGCTTTCCTCCCGGCTG

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MDKIVSLARRRGFIFPSSEIYGGLNSCWDYGPLGVELKRNVKEAWWRYMVRDRDDVVGLDASIIMHPRVWEASGHVAGFS
DPMVDCKNCKMRWRPTDLAEPKCPACGGELTESRQFNLMFKTFMGPVEEAANIVYLRPETAQGIFVNFENVLNTTRKKLP
FGIAQIGKSFRNEITTGNFIFRSREFEQMELEYFVKPGADDACLEEWTQYRLNWYKNLGMNPENLRLRAHRSDELAHYAK
GCYDVEYNFPMGWSELEGIANRRDFDLTQHSKYSGKALEYFDEETKEHFIPYVIEPSAGVERSTLAFLIDAYAEEPDKDE
IRTVLHLHPALAPYKIAVLPLSKKEILSDYARKIYADLRKCWMVAYDDSQSIGRRYRRQDEIGTPYCVTVDFQSLEDGMV
TIRDRDSMDQIRVKVSELSCILAAKLSGEPFNS

Sequences:

>Translated_433_residues
MDKIVSLARRRGFIFPSSEIYGGLNSCWDYGPLGVELKRNVKEAWWRYMVRDRDDVVGLDASIIMHPRVWEASGHVAGFS
DPMVDCKNCKMRWRPTDLAEPKCPACGGELTESRQFNLMFKTFMGPVEEAANIVYLRPETAQGIFVNFENVLNTTRKKLP
FGIAQIGKSFRNEITTGNFIFRSREFEQMELEYFVKPGADDACLEEWTQYRLNWYKNLGMNPENLRLRAHRSDELAHYAK
GCYDVEYNFPMGWSELEGIANRRDFDLTQHSKYSGKALEYFDEETKEHFIPYVIEPSAGVERSTLAFLIDAYAEEPDKDE
IRTVLHLHPALAPYKIAVLPLSKKEILSDYARKIYADLRKCWMVAYDDSQSIGRRYRRQDEIGTPYCVTVDFQSLEDGMV
TIRDRDSMDQIRVKVSELSCILAAKLSGEPFNS
>Mature_433_residues
MDKIVSLARRRGFIFPSSEIYGGLNSCWDYGPLGVELKRNVKEAWWRYMVRDRDDVVGLDASIIMHPRVWEASGHVAGFS
DPMVDCKNCKMRWRPTDLAEPKCPACGGELTESRQFNLMFKTFMGPVEEAANIVYLRPETAQGIFVNFENVLNTTRKKLP
FGIAQIGKSFRNEITTGNFIFRSREFEQMELEYFVKPGADDACLEEWTQYRLNWYKNLGMNPENLRLRAHRSDELAHYAK
GCYDVEYNFPMGWSELEGIANRRDFDLTQHSKYSGKALEYFDEETKEHFIPYVIEPSAGVERSTLAFLIDAYAEEPDKDE
IRTVLHLHPALAPYKIAVLPLSKKEILSDYARKIYADLRKCWMVAYDDSQSIGRRYRRQDEIGTPYCVTVDFQSLEDGMV
TIRDRDSMDQIRVKVSELSCILAAKLSGEPFNS

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=358, Percent_Identity=30.7262569832402, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI70887790, Length=444, Percent_Identity=24.3243243243243, Blast_Score=122, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI32564541, Length=596, Percent_Identity=28.8590604026846, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17554996, Length=596, Percent_Identity=28.8590604026846, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6325338, Length=586, Percent_Identity=25.4266211604096, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319597, Length=218, Percent_Identity=34.4036697247706, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357965, Length=358, Percent_Identity=32.4022346368715, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24664462, Length=358, Percent_Identity=32.4022346368715, Blast_Score=171, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 50027; Mature: 50027

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIVSLARRRGFIFPSSEIYGGLNSCWDYGPLGVELKRNVKEAWWRYMVRDRDDVVGLD
CCHHHHHHHHCCCCCCCHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECC
ASIIMHPRVWEASGHVAGFSDPMVDCKNCKMRWRPTDLAEPKCPACGGELTESRQFNLMF
CEEEECCEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHEEHH
KTFMGPVEEAANIVYLRPETAQGIFVNFENVLNTTRKKLPFGIAQIGKSFRNEITTGNFI
HHHCCCHHHCCCEEEECCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEE
FRSREFEQMELEYFVKPGADDACLEEWTQYRLNWYKNLGMNPENLRLRAHRSDELAHYAK
EECCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCHHHHHHHC
GCYDVEYNFPMGWSELEGIANRRDFDLTQHSKYSGKALEYFDEETKEHFIPYVIEPSAGV
CEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCC
ERSTLAFLIDAYAEEPDKDEIRTVLHLHPALAPYKIAVLPLSKKEILSDYARKIYADLRK
CHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHH
CWMVAYDDSQSIGRRYRRQDEIGTPYCVTVDFQSLEDGMVTIRDRDSMDQIRVKVSELSC
HEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHE
ILAAKLSGEPFNS
EEEEECCCCCCCC
>Mature Secondary Structure
MDKIVSLARRRGFIFPSSEIYGGLNSCWDYGPLGVELKRNVKEAWWRYMVRDRDDVVGLD
CCHHHHHHHHCCCCCCCHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECC
ASIIMHPRVWEASGHVAGFSDPMVDCKNCKMRWRPTDLAEPKCPACGGELTESRQFNLMF
CEEEECCEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHEEHH
KTFMGPVEEAANIVYLRPETAQGIFVNFENVLNTTRKKLPFGIAQIGKSFRNEITTGNFI
HHHCCCHHHCCCEEEECCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEE
FRSREFEQMELEYFVKPGADDACLEEWTQYRLNWYKNLGMNPENLRLRAHRSDELAHYAK
EECCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCHHHHHHHC
GCYDVEYNFPMGWSELEGIANRRDFDLTQHSKYSGKALEYFDEETKEHFIPYVIEPSAGV
CEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCC
ERSTLAFLIDAYAEEPDKDEIRTVLHLHPALAPYKIAVLPLSKKEILSDYARKIYADLRK
CHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHH
CWMVAYDDSQSIGRRYRRQDEIGTPYCVTVDFQSLEDGMVTIRDRDSMDQIRVKVSELSC
HEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHE
ILAAKLSGEPFNS
EEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA