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The map label for this gene is hemN [H]

Identifier: 57234372

GI number: 57234372

Start: 784776

End: 785912

Strand: Direct

Name: hemN [H]

Synonym: DET0858

Alternate gene names: 57234372

Gene position: 784776-785912 (Clockwise)

Preceding gene: 57234373

Following gene: 57234362

Centisome position: 53.4

GC content: 48.28

Gene sequence:

>1137_bases
ATGACAGACACCAGCCTTGCCTTATATCTCCACTTCCCTTTTTGCCTGCAAAAATGCGGATACTGCTCGTTTGTTTCTTA
CCCTGCAAGATTGGATTGCCTGCCTGATTATGTAAAATGCCTTAGAAAAGAAATAAAGTCCAGGGCAAGCGGGCTTTACT
TTCACAGCCTGTATTTTGGCGGCGGCACACCCAGCCTCTTATCCCCTTCGCAAGTGGCAGATATTTTAGCCGGTATACGC
ACTGCGGCACATTTGTTGCCGGATGCGGAAATTACCTTTGAGGCAAATCCCGGTACGCTGGCCCTGCCTTATCTTCCAGA
AATAAAAAGCCTGGGCATAAACCGCTTAAGTCTGGGTATCCAAAGCTTTTCGGGTGCCGAACTGACAATGCTTGGGCGGC
TGCATAATGCCGCAAAAGCCCGTCAAGCATATAAACAGGCCAGAGCTGCCGGCTTTAATAATATCAGCCTTGACCTTATA
TATGGCCTGCCGGATTCCAGCGTTAGTTCTTTTAAAAAAAATCTGGCAGAAGCGCTGGCACTTGCTCCGGAACATATCTC
ACTTTACGGCCTGACTTTAGAAGAAGATACACCTATGTACCGGCAGGTGCAAGAAGGATTGCTGCCTGAAATAAATGCCG
AAACTGCGGCTGACCAGTATCAAGCCGCCGAAGACATACTGGCGAAAGCCGGATACCGCCATTATGAGATATCTAACTGG
GCTAAACCGGGATACGAAAGCCGCCATAACCTTACCTACTGGCAAAACAGGCCGTATCTGGGTCTGGGAGCGGCCGGGCA
CTCCTTTCTTGAGAATTGGCGGCTGGCAAATACCTCCAGCCTGGATGAATATTTAAACAGATGGCAAAATGACCTCCCGC
CGACGCCATCTGAAAATATATATCTAGATTTGGAAAATCAACTGGCTGAAACCATCATACTGGGTCTTCGGCTGGATAAG
GGTATAACTGCCGAAGATATTGAAAACCGCTTCGGGCAACATGTGATGGACAAATATTTTCCGGTTATACAGGAATGCAC
GGGCCTGGGCCTTTTAGAAAAATCTGATGGCGGTATCAGCCTGACTCCCAGAGGACGCTTGCTTTCAAACGAGGTTTTCT
GGCGTTTCTTGCCTTAA

Upstream 100 bases:

>100_bases
TCTAGCGGTTGCTACCAGGGTATATACCCTAAGCGATGGTGTTTTAATACCGTTTGAACCTTCTACTGCCTCCGCTGCCC
AATCCTGATATAATACTTTT

Downstream 100 bases:

>100_bases
AGGTGAAAATACGCTAATTTATATATCCGGCAGTATACAAGTGTATAGTTAAAAGTTGGTGATATGAGTCAATCCGCTAC
AAGAAATTTCTGCATTATTG

Product: oxygen-independent coproporphyrinogen III oxidase, putative

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTDTSLALYLHFPFCLQKCGYCSFVSYPARLDCLPDYVKCLRKEIKSRASGLYFHSLYFGGGTPSLLSPSQVADILAGIR
TAAHLLPDAEITFEANPGTLALPYLPEIKSLGINRLSLGIQSFSGAELTMLGRLHNAAKARQAYKQARAAGFNNISLDLI
YGLPDSSVSSFKKNLAEALALAPEHISLYGLTLEEDTPMYRQVQEGLLPEINAETAADQYQAAEDILAKAGYRHYEISNW
AKPGYESRHNLTYWQNRPYLGLGAAGHSFLENWRLANTSSLDEYLNRWQNDLPPTPSENIYLDLENQLAETIILGLRLDK
GITAEDIENRFGQHVMDKYFPVIQECTGLGLLEKSDGGISLTPRGRLLSNEVFWRFLP

Sequences:

>Translated_378_residues
MTDTSLALYLHFPFCLQKCGYCSFVSYPARLDCLPDYVKCLRKEIKSRASGLYFHSLYFGGGTPSLLSPSQVADILAGIR
TAAHLLPDAEITFEANPGTLALPYLPEIKSLGINRLSLGIQSFSGAELTMLGRLHNAAKARQAYKQARAAGFNNISLDLI
YGLPDSSVSSFKKNLAEALALAPEHISLYGLTLEEDTPMYRQVQEGLLPEINAETAADQYQAAEDILAKAGYRHYEISNW
AKPGYESRHNLTYWQNRPYLGLGAAGHSFLENWRLANTSSLDEYLNRWQNDLPPTPSENIYLDLENQLAETIILGLRLDK
GITAEDIENRFGQHVMDKYFPVIQECTGLGLLEKSDGGISLTPRGRLLSNEVFWRFLP
>Mature_377_residues
TDTSLALYLHFPFCLQKCGYCSFVSYPARLDCLPDYVKCLRKEIKSRASGLYFHSLYFGGGTPSLLSPSQVADILAGIRT
AAHLLPDAEITFEANPGTLALPYLPEIKSLGINRLSLGIQSFSGAELTMLGRLHNAAKARQAYKQARAAGFNNISLDLIY
GLPDSSVSSFKKNLAEALALAPEHISLYGLTLEEDTPMYRQVQEGLLPEINAETAADQYQAAEDILAKAGYRHYEISNWA
KPGYESRHNLTYWQNRPYLGLGAAGHSFLENWRLANTSSLDEYLNRWQNDLPPTPSENIYLDLENQLAETIILGLRLDKG
ITAEDIENRFGQHVMDKYFPVIQECTGLGLLEKSDGGISLTPRGRLLSNEVFWRFLP

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=265, Percent_Identity=43.7735849056604, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI1789325, Length=266, Percent_Identity=39.8496240601504, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082341, Length=395, Percent_Identity=26.3291139240506, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42120; Mature: 41989

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTSLALYLHFPFCLQKCGYCSFVSYPARLDCLPDYVKCLRKEIKSRASGLYFHSLYFG
CCCCCEEEEEECHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEC
GGTPSLLSPSQVADILAGIRTAAHLLPDAEITFEANPGTLALPYLPEIKSLGINRLSLGI
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCHHHCCCHHHHHHH
QSFSGAELTMLGRLHNAAKARQAYKQARAAGFNNISLDLIYGLPDSSVSSFKKNLAEALA
HCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LAPEHISLYGLTLEEDTPMYRQVQEGLLPEINAETAADQYQAAEDILAKAGYRHYEISNW
CCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCC
AKPGYESRHNLTYWQNRPYLGLGAAGHSFLENWRLANTSSLDEYLNRWQNDLPPTPSENI
CCCCCCCCCCCEEECCCCCEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCE
YLDLENQLAETIILGLRLDKGITAEDIENRFGQHVMDKYFPVIQECTGLGLLEKSDGGIS
EEEEHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEE
LTPRGRLLSNEVFWRFLP
ECCCCCCCCCCCEEEECC
>Mature Secondary Structure 
TDTSLALYLHFPFCLQKCGYCSFVSYPARLDCLPDYVKCLRKEIKSRASGLYFHSLYFG
CCCCEEEEEECHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEC
GGTPSLLSPSQVADILAGIRTAAHLLPDAEITFEANPGTLALPYLPEIKSLGINRLSLGI
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCHHHCCCHHHHHHH
QSFSGAELTMLGRLHNAAKARQAYKQARAAGFNNISLDLIYGLPDSSVSSFKKNLAEALA
HCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LAPEHISLYGLTLEEDTPMYRQVQEGLLPEINAETAADQYQAAEDILAKAGYRHYEISNW
CCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCC
AKPGYESRHNLTYWQNRPYLGLGAAGHSFLENWRLANTSSLDEYLNRWQNDLPPTPSENI
CCCCCCCCCCCEEECCCCCEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCE
YLDLENQLAETIILGLRLDKGITAEDIENRFGQHVMDKYFPVIQECTGLGLLEKSDGGIS
EEEEHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEE
LTPRGRLLSNEVFWRFLP
ECCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]