| Definition | Dehalococcoides ethenogenes 195, complete genome. |
|---|---|
| Accession | NC_002936 |
| Length | 1,469,720 |
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The map label for this gene is lepA
Identifier: 57234362
GI number: 57234362
Start: 785976
End: 787793
Strand: Direct
Name: lepA
Synonym: DET0859
Alternate gene names: 57234362
Gene position: 785976-787793 (Clockwise)
Preceding gene: 57234372
Following gene: 57234361
Centisome position: 53.48
GC content: 49.67
Gene sequence:
>1818_bases ATGAGTCAATCCGCTACAAGAAATTTCTGCATTATTGCCCACATAGATCACGGCAAATCCACTCTGGCTGACCGCCTGAT AGAAATGACGGGTACACTCCGGCATGATGAAATGTGCGAACAGGTCATGGACAGCATGGAGCTGGAACGTGAGCGCGGCA TAACCATAAAAGCCAAGGCTATCCGCCTGCGCTATCTGTCAAAGGATAGCCATGAATACCGCCTGAACCTTATAGATACT CCCGGACACGTGGATTTTTCCTATGAAGTTTCACGGACTATTGCCGCCTGCGAAGGGGCTATTCTGGTTATAGATGCAAC TCAGGGTATTCAGGCCCAGACTCTAGCCAATGTTTACCTGGCCATAGAGTACAACCTGGAAATTATTCCGGTTATCAATA AGATAGACCTGCCAGGGGCTGATATTCCGCGGGTAATGGGCGAAATTAAAAGCGTACTGGGTTATGACGAAGATGCCGTA ATTCAGATAAGTGCCAAACTGGGTTTGGGCGTGCCGGAACTGCTGGAAGCTATCGTAGCCAGAGTGCCTGCCCCCAAGGG TGATGGCAAGCTGCCCCTGCGGGCGCTTATATTTGATTCGCATTATGACCCTTATAAGGGTGTGGTTGCCTACCTGCGGG TGGCAGACGGGAATATAAACAAGGGTGATGATTTACGCCTGATGGGACAGGGTACGGAATTCAAGGTGCTTGAAGCCGGG TATTTTGCCCCTGCCCAGGTTGCCGCTTTGAGGTTAGACGTAGGTGATGTAGGCTATGTAGCCACTGGACTTAAGTCTGT GGGCGAATGCCGGGTGGGTGATACAGTTACTTTGCAGCACGGGGGTGCAATCCAGCCGCTTATAGGTTATCACCCGGCCA AGGCCATGGTTTTTGCCGGTATTTATCCCACTCAGACAGATGATTATCACGAACTGCGTGAGGCTATGGAAAAGCTGAGT CTGAATGATGCCTCGCTGTCTTATGAACCAGAATCCAGCCCGCTTTTAGGGCATGGTTTCCGCTGCGGTTTTTTGGGGCT GCTCCATCTGGATATAATTGTAGAACGGCTGGAACGTGAGTTTAACCTTTCACTGGTAGTCACCTCCCCCGGTGTCAGCC TGACAGTCACCCGTACCAGCGGTGAGGTTCTTACAGTCGTAAACCCTAACGAGATGCCCCTTCCCCACGAGATTGCCAGT ATTGAAGAGCCGTGGGTTTCGGTAGTGATTATAACGCCCTCAAAATATATCGGTACGGTTATGGATTTGGTCCGGGAAAA TTACGGCGTATATAAAAATACCGAGTATCTGGGGCAGCTGGCTATGAGTGAGCTTGGACAGCGGGTACAGCTTCATTATG ATATGCCGCTTCGTTCCATACTCACCACCTTTCATGACCAGCTTAAGAGCCGGACTCAGGGTTATGCTTCACTGGACTAC GAATTTGTTGGTTACCGCATTGCCAACCTTTCAAAGATAGACGTACTGGTAAATGATGTTGCGGTAGATGCTTTCAGCCG CATTATTCCTCCGGATAAAGCCCATGAAATTGGTGAGGCGCTTGTAAAGAAGCTGAAGGAAATGATACCCCGGCAGCTAT ATCAGGTCACCCTTCAGGCGGCTATCGGCAGCAAGATTGTGGCCCGGGCTGATATATCCGCCAAGCGCAAAGACGTAATT GCCAAATGTTACGGCGGTGATATTACCCGTAAGCGCAAACTTCTGGATAAGCAGAAGGAAGGCAAGAAGAAAATGCGCCA GATTGGCAAAGTGGAAGTGCCCAAAGAAGCATTTCTAAGTGTTTTAAAGCTCCAATAG
Upstream 100 bases:
>100_bases GCTTTCAAACGAGGTTTTCTGGCGTTTCTTGCCTTAAAGGTGAAAATACGCTAATTTATATATCCGGCAGTATACAAGTG TATAGTTAAAAGTTGGTGAT
Downstream 100 bases:
>100_bases CCTGTTTTTTCAGCCTTGCCAAAGGGCATTTAGTGTGTTACAATACCGCCACTTAAGCTACTTTTGGGTATTCTATTGTC TTTTGCATACGTATGTCTTT
Product: GTP-binding protein LepA
Products: NA
Alternate protein names: EF-4; Ribosomal back-translocase LepA
Number of amino acids: Translated: 605; Mature: 604
Protein sequence:
>605_residues MSQSATRNFCIIAHIDHGKSTLADRLIEMTGTLRHDEMCEQVMDSMELERERGITIKAKAIRLRYLSKDSHEYRLNLIDT PGHVDFSYEVSRTIAACEGAILVIDATQGIQAQTLANVYLAIEYNLEIIPVINKIDLPGADIPRVMGEIKSVLGYDEDAV IQISAKLGLGVPELLEAIVARVPAPKGDGKLPLRALIFDSHYDPYKGVVAYLRVADGNINKGDDLRLMGQGTEFKVLEAG YFAPAQVAALRLDVGDVGYVATGLKSVGECRVGDTVTLQHGGAIQPLIGYHPAKAMVFAGIYPTQTDDYHELREAMEKLS LNDASLSYEPESSPLLGHGFRCGFLGLLHLDIIVERLEREFNLSLVVTSPGVSLTVTRTSGEVLTVVNPNEMPLPHEIAS IEEPWVSVVIITPSKYIGTVMDLVRENYGVYKNTEYLGQLAMSELGQRVQLHYDMPLRSILTTFHDQLKSRTQGYASLDY EFVGYRIANLSKIDVLVNDVAVDAFSRIIPPDKAHEIGEALVKKLKEMIPRQLYQVTLQAAIGSKIVARADISAKRKDVI AKCYGGDITRKRKLLDKQKEGKKKMRQIGKVEVPKEAFLSVLKLQ
Sequences:
>Translated_605_residues MSQSATRNFCIIAHIDHGKSTLADRLIEMTGTLRHDEMCEQVMDSMELERERGITIKAKAIRLRYLSKDSHEYRLNLIDT PGHVDFSYEVSRTIAACEGAILVIDATQGIQAQTLANVYLAIEYNLEIIPVINKIDLPGADIPRVMGEIKSVLGYDEDAV IQISAKLGLGVPELLEAIVARVPAPKGDGKLPLRALIFDSHYDPYKGVVAYLRVADGNINKGDDLRLMGQGTEFKVLEAG YFAPAQVAALRLDVGDVGYVATGLKSVGECRVGDTVTLQHGGAIQPLIGYHPAKAMVFAGIYPTQTDDYHELREAMEKLS LNDASLSYEPESSPLLGHGFRCGFLGLLHLDIIVERLEREFNLSLVVTSPGVSLTVTRTSGEVLTVVNPNEMPLPHEIAS IEEPWVSVVIITPSKYIGTVMDLVRENYGVYKNTEYLGQLAMSELGQRVQLHYDMPLRSILTTFHDQLKSRTQGYASLDY EFVGYRIANLSKIDVLVNDVAVDAFSRIIPPDKAHEIGEALVKKLKEMIPRQLYQVTLQAAIGSKIVARADISAKRKDVI AKCYGGDITRKRKLLDKQKEGKKKMRQIGKVEVPKEAFLSVLKLQ >Mature_604_residues SQSATRNFCIIAHIDHGKSTLADRLIEMTGTLRHDEMCEQVMDSMELERERGITIKAKAIRLRYLSKDSHEYRLNLIDTP GHVDFSYEVSRTIAACEGAILVIDATQGIQAQTLANVYLAIEYNLEIIPVINKIDLPGADIPRVMGEIKSVLGYDEDAVI QISAKLGLGVPELLEAIVARVPAPKGDGKLPLRALIFDSHYDPYKGVVAYLRVADGNINKGDDLRLMGQGTEFKVLEAGY FAPAQVAALRLDVGDVGYVATGLKSVGECRVGDTVTLQHGGAIQPLIGYHPAKAMVFAGIYPTQTDDYHELREAMEKLSL NDASLSYEPESSPLLGHGFRCGFLGLLHLDIIVERLEREFNLSLVVTSPGVSLTVTRTSGEVLTVVNPNEMPLPHEIASI EEPWVSVVIITPSKYIGTVMDLVRENYGVYKNTEYLGQLAMSELGQRVQLHYDMPLRSILTTFHDQLKSRTQGYASLDYE FVGYRIANLSKIDVLVNDVAVDAFSRIIPPDKAHEIGEALVKKLKEMIPRQLYQVTLQAAIGSKIVARADISAKRKDVIA KCYGGDITRKRKLLDKQKEGKKKMRQIGKVEVPKEAFLSVLKLQ
Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc
COG id: COG0481
COG function: function code M; Membrane GTPase LepA
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily
Homologues:
Organism=Homo sapiens, GI157426893, Length=607, Percent_Identity=48.4349258649094, Blast_Score=585, Evalue=1e-167, Organism=Homo sapiens, GI94966754, Length=138, Percent_Identity=47.8260869565217, Blast_Score=120, Evalue=3e-27, Organism=Homo sapiens, GI18390331, Length=208, Percent_Identity=36.0576923076923, Blast_Score=113, Evalue=5e-25, Organism=Homo sapiens, GI25306283, Length=150, Percent_Identity=41.3333333333333, Blast_Score=103, Evalue=6e-22, Organism=Homo sapiens, GI19923640, Length=150, Percent_Identity=41.3333333333333, Blast_Score=102, Evalue=7e-22, Organism=Homo sapiens, GI25306287, Length=150, Percent_Identity=41.3333333333333, Blast_Score=102, Evalue=8e-22, Organism=Homo sapiens, GI310132016, Length=108, Percent_Identity=48.1481481481481, Blast_Score=101, Evalue=2e-21, Organism=Homo sapiens, GI310110807, Length=108, Percent_Identity=48.1481481481481, Blast_Score=101, Evalue=2e-21, Organism=Homo sapiens, GI310123363, Length=108, Percent_Identity=48.1481481481481, Blast_Score=101, Evalue=2e-21, Organism=Homo sapiens, GI4503483, Length=146, Percent_Identity=38.3561643835616, Blast_Score=98, Evalue=2e-20, Organism=Homo sapiens, GI217272892, Length=178, Percent_Identity=31.4606741573034, Blast_Score=82, Evalue=2e-15, Organism=Homo sapiens, GI217272894, Length=178, Percent_Identity=31.4606741573034, Blast_Score=82, Evalue=2e-15, Organism=Homo sapiens, GI94966752, Length=74, Percent_Identity=47.2972972972973, Blast_Score=73, Evalue=1e-12, Organism=Homo sapiens, GI34147630, Length=280, Percent_Identity=28.9285714285714, Blast_Score=72, Evalue=2e-12, Organism=Escherichia coli, GI1788922, Length=596, Percent_Identity=50.3355704697987, Blast_Score=582, Evalue=1e-167, Organism=Escherichia coli, GI48994988, Length=509, Percent_Identity=29.2730844793713, Blast_Score=164, Evalue=1e-41, Organism=Escherichia coli, GI1789738, Length=180, Percent_Identity=36.6666666666667, Blast_Score=108, Evalue=1e-24, Organism=Escherichia coli, GI1790835, Length=154, Percent_Identity=31.1688311688312, Blast_Score=83, Evalue=6e-17, Organism=Escherichia coli, GI1789559, Length=257, Percent_Identity=28.0155642023346, Blast_Score=75, Evalue=1e-14, Organism=Escherichia coli, GI1789108, Length=148, Percent_Identity=29.0540540540541, Blast_Score=65, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17557151, Length=616, Percent_Identity=40.2597402597403, Blast_Score=460, Evalue=1e-130, Organism=Caenorhabditis elegans, GI17556745, Length=189, Percent_Identity=34.9206349206349, Blast_Score=107, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17533571, Length=158, Percent_Identity=37.9746835443038, Blast_Score=103, Evalue=3e-22, Organism=Caenorhabditis elegans, GI71988819, Length=138, Percent_Identity=42.0289855072464, Blast_Score=97, Evalue=2e-20, Organism=Caenorhabditis elegans, GI71988811, Length=138, Percent_Identity=42.0289855072464, Blast_Score=97, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17506493, Length=154, Percent_Identity=35.7142857142857, Blast_Score=90, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17552882, Length=144, Percent_Identity=34.0277777777778, Blast_Score=86, Evalue=7e-17, Organism=Caenorhabditis elegans, GI71994658, Length=224, Percent_Identity=28.125, Blast_Score=72, Evalue=7e-13, Organism=Saccharomyces cerevisiae, GI6323320, Length=604, Percent_Identity=42.2185430463576, Blast_Score=483, Evalue=1e-137, Organism=Saccharomyces cerevisiae, GI6323098, Length=180, Percent_Identity=38.3333333333333, Blast_Score=110, Evalue=5e-25, Organism=Saccharomyces cerevisiae, GI6324707, Length=142, Percent_Identity=38.7323943661972, Blast_Score=100, Evalue=5e-22, Organism=Saccharomyces cerevisiae, GI6320593, Length=142, Percent_Identity=38.7323943661972, Blast_Score=100, Evalue=5e-22, Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=35.5704697986577, Blast_Score=96, Evalue=2e-20, Organism=Saccharomyces cerevisiae, GI6324166, Length=143, Percent_Identity=38.4615384615385, Blast_Score=86, Evalue=1e-17, Organism=Saccharomyces cerevisiae, GI6324761, Length=246, Percent_Identity=28.0487804878049, Blast_Score=77, Evalue=6e-15, Organism=Drosophila melanogaster, GI78706572, Length=605, Percent_Identity=41.6528925619835, Blast_Score=491, Evalue=1e-139, Organism=Drosophila melanogaster, GI24582462, Length=179, Percent_Identity=40.7821229050279, Blast_Score=116, Evalue=6e-26, Organism=Drosophila melanogaster, GI28574573, Length=142, Percent_Identity=42.9577464788732, Blast_Score=101, Evalue=1e-21, Organism=Drosophila melanogaster, GI221458488, Length=153, Percent_Identity=36.6013071895425, Blast_Score=95, Evalue=1e-19, Organism=Drosophila melanogaster, GI24585711, Length=146, Percent_Identity=36.3013698630137, Blast_Score=92, Evalue=8e-19, Organism=Drosophila melanogaster, GI24585713, Length=146, Percent_Identity=36.3013698630137, Blast_Score=92, Evalue=8e-19, Organism=Drosophila melanogaster, GI24585709, Length=146, Percent_Identity=36.3013698630137, Blast_Score=92, Evalue=9e-19, Organism=Drosophila melanogaster, GI21357743, Length=133, Percent_Identity=36.0902255639098, Blast_Score=82, Evalue=8e-16, Organism=Drosophila melanogaster, GI19921738, Length=252, Percent_Identity=29.7619047619048, Blast_Score=77, Evalue=3e-14, Organism=Drosophila melanogaster, GI28572034, Length=223, Percent_Identity=30.0448430493274, Blast_Score=74, Evalue=4e-13, Organism=Drosophila melanogaster, GI281363316, Length=243, Percent_Identity=28.3950617283951, Blast_Score=72, Evalue=1e-12, Organism=Drosophila melanogaster, GI17864358, Length=243, Percent_Identity=28.3950617283951, Blast_Score=72, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): LEPA_DEHE1 (Q3Z864)
Other databases:
- EMBL: CP000027 - RefSeq: YP_181585.1 - ProteinModelPortal: Q3Z864 - SMR: Q3Z864 - STRING: Q3Z864 - GeneID: 3229829 - GenomeReviews: CP000027_GR - KEGG: det:DET0859 - NMPDR: fig|243164.3.peg.1133 - TIGR: DET0859 - eggNOG: COG0481 - HOGENOM: HBG286375 - OMA: YDSYRGV - ProtClustDB: PRK05433 - BioCyc: DETH243164:DET_0859-MONOMER - GO: GO:0006412 - HAMAP: MF_00071 - InterPro: IPR009022 - InterPro: IPR006297 - InterPro: IPR013842 - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR000640 - InterPro: IPR009000 - Gene3D: G3DSA:3.30.70.240 - PRINTS: PR00315 - TIGRFAMs: TIGR01393 - TIGRFAMs: TIGR00231
Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF06421 LepA_C; SSF54980 EFG_III_V; SSF50447 Translat_factor
EC number: NA
Molecular weight: Translated: 66929; Mature: 66798
Theoretical pI: Translated: 6.47; Mature: 6.47
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSQSATRNFCIIAHIDHGKSTLADRLIEMTGTLRHDEMCEQVMDSMELERERGITIKAKA CCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEE IRLRYLSKDSHEYRLNLIDTPGHVDFSYEVSRTIAACEGAILVIDATQGIQAQTLANVYL EEEEEECCCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCHHEEEEEEE AIEYNLEIIPVINKIDLPGADIPRVMGEIKSVLGYDEDAVIQISAKLGLGVPELLEAIVA EEEECEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHH RVPAPKGDGKLPLRALIFDSHYDPYKGVVAYLRVADGNINKGDDLRLMGQGTEFKVLEAG HCCCCCCCCCCCEEEEEECCCCCCHHHHEEEEEEECCCCCCCCCEEEEECCCEEEEEECC YFAPAQVAALRLDVGDVGYVATGLKSVGECRVGDTVTLQHGGAIQPLIGYHPAKAMVFAG CCCCHHEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHCCCCCHHEEEEC IYPTQTDDYHELREAMEKLSLNDASLSYEPESSPLLGHGFRCGFLGLLHLDIIVERLERE CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH FNLSLVVTSPGVSLTVTRTSGEVLTVVNPNEMPLPHEIASIEEPWVSVVIITPSKYIGTV CCEEEEEECCCCEEEEEECCCCEEEEECCCCCCCCHHHHCCCCCCEEEEEECCCHHHHHH MDLVRENYGVYKNTEYLGQLAMSELGQRVQLHYDMPLRSILTTFHDQLKSRTQGYASLDY HHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEECCE EFVGYRIANLSKIDVLVNDVAVDAFSRIIPPDKAHEIGEALVKKLKEMIPRQLYQVTLQA EEECEEECCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH AIGSKIVARADISAKRKDVIAKCYGGDITRKRKLLDKQKEGKKKMRQIGKVEVPKEAFLS HHCCHHEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH VLKLQ HHCCC >Mature Secondary Structure SQSATRNFCIIAHIDHGKSTLADRLIEMTGTLRHDEMCEQVMDSMELERERGITIKAKA CCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEE IRLRYLSKDSHEYRLNLIDTPGHVDFSYEVSRTIAACEGAILVIDATQGIQAQTLANVYL EEEEEECCCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCHHEEEEEEE AIEYNLEIIPVINKIDLPGADIPRVMGEIKSVLGYDEDAVIQISAKLGLGVPELLEAIVA EEEECEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHH RVPAPKGDGKLPLRALIFDSHYDPYKGVVAYLRVADGNINKGDDLRLMGQGTEFKVLEAG HCCCCCCCCCCCEEEEEECCCCCCHHHHEEEEEEECCCCCCCCCEEEEECCCEEEEEECC YFAPAQVAALRLDVGDVGYVATGLKSVGECRVGDTVTLQHGGAIQPLIGYHPAKAMVFAG CCCCHHEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHCCCCCHHEEEEC IYPTQTDDYHELREAMEKLSLNDASLSYEPESSPLLGHGFRCGFLGLLHLDIIVERLERE CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH FNLSLVVTSPGVSLTVTRTSGEVLTVVNPNEMPLPHEIASIEEPWVSVVIITPSKYIGTV CCEEEEEECCCCEEEEEECCCCEEEEECCCCCCCCHHHHCCCCCCEEEEEECCCHHHHHH MDLVRENYGVYKNTEYLGQLAMSELGQRVQLHYDMPLRSILTTFHDQLKSRTQGYASLDY HHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEECCE EFVGYRIANLSKIDVLVNDVAVDAFSRIIPPDKAHEIGEALVKKLKEMIPRQLYQVTLQA EEECEEECCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH AIGSKIVARADISAKRKDVIAKCYGGDITRKRKLLDKQKEGKKKMRQIGKVEVPKEAFLS HHCCHHEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH VLKLQ HHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA