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The map label for this gene is nuoD

Identifier: 57234304

GI number: 57234304

Start: 847030

End: 848133

Strand: Direct

Name: nuoD

Synonym: DET0926

Alternate gene names: 57234304

Gene position: 847030-848133 (Clockwise)

Preceding gene: 57234305

Following gene: 57234303

Centisome position: 57.63

GC content: 50.82

Gene sequence:

>1104_bases
ATGGCCATTAAAACTGAAAGCTTTATTTTAAATATAGGCCCCCAGCACCCCAGCACCCACGGGGTGTTCCGTCTGCGGCT
GATTCTGGACGGTGAGGTTATTACCGACCTGGAGCCGGTTTTCGGTTATCTCCACCGGGGTATTGAAAAGCTGGCTGAGG
GACGTACCTACCTGCAGGACATACCTTTTACCGACCGACTGGATTATCTGGGCTCTATGACCAACAACCACGCTTATGTT
ATGGCGGTGGAAAAACTGGCCGGCATAACAGTGCCCGAACGGGCTGAATATATCAGGGTAATACTGGATGAGCTCCAGCG
GATAGCCAGCCACCTGGCGGGTCTGGGTTTTTTCCTGAATGATTTGGGAGCCCTTCAAACCCCGCTTTTGTACATGTTCC
GCGAACGTGAAAAGATTGTGGAACTGTTTGATATGTGCAGCGGCCAGCGCTTAAATTACAATTATTACCGTTTCGGCGGC
TTTGTTCAGGATTTGCCGGAAGAATTCCTGCCTGCCTTGAAAAAACTGCTGGACACCTTGCCCGGTTTCATAGACGAATA
CGAACAGCTTATTTCCACTAATGAAATTGTGCTTATCCGCACCAAAGGTGTGGGCGTGCTTAAGCGTGAACTGGCCATAA
ACTCCAGTGCGGCCGGGCCGGTTCTCCGTGCAAGCGGGGTAAACTGGGATATCCGCCGGAATGACCCGTATTCAATCTAT
GACCGTTTTGAGTTTGATATACCCACCGCCCAAAACGGTGATACATACGACCGCTATATGGTACGCATAAGGGAAATGCG
CCAGAGCGTGCGGATACTCCGCCAGGCAGTCAAAGACCTGCCCGAAGGTGAAATAATGGGTAAAGCACCCAAACTCCTTA
AGCCGCCTGCGGGTGAAGTTTACAGCCGCATAGAAGGGCCTAAAGGCGAACTGGGCTTTTATCTGGTTTCAGACGGCACG
GATAAGCCTTACCGCTGGCGGGTGCGTCCGCCCTGCCTTTTAAATTTATCAGCTTTGAAAGATATGGTGGTAGGCTGGAA
AGTGGCTGATCTGATGGCTATATTCGGCAGCATAGACATTGTAATGGGTGAGGTGGACAGATAA

Upstream 100 bases:

>100_bases
TATGACCTTTTCGGAGTGGTTTTTGAAAACCATATAGGCCTGAAACGCATTTTCCTGTGGGAGGGCTTTGAAGGTTATCC
TTTGCGCAAGGACTTTGCAA

Downstream 100 bases:

>100_bases
TGTCTGACTTCTGGGTTCACCTGCTAGTCTACCTGGTCATACTCTTTGGTTTTGTAATTGTGAGTGTGCTTTTATTTATC
TGGCTGGAGCGCCGCTTTAT

Product: proton-translocating NADH-quinone oxidoreductase, D subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MAIKTESFILNIGPQHPSTHGVFRLRLILDGEVITDLEPVFGYLHRGIEKLAEGRTYLQDIPFTDRLDYLGSMTNNHAYV
MAVEKLAGITVPERAEYIRVILDELQRIASHLAGLGFFLNDLGALQTPLLYMFREREKIVELFDMCSGQRLNYNYYRFGG
FVQDLPEEFLPALKKLLDTLPGFIDEYEQLISTNEIVLIRTKGVGVLKRELAINSSAAGPVLRASGVNWDIRRNDPYSIY
DRFEFDIPTAQNGDTYDRYMVRIREMRQSVRILRQAVKDLPEGEIMGKAPKLLKPPAGEVYSRIEGPKGELGFYLVSDGT
DKPYRWRVRPPCLLNLSALKDMVVGWKVADLMAIFGSIDIVMGEVDR

Sequences:

>Translated_367_residues
MAIKTESFILNIGPQHPSTHGVFRLRLILDGEVITDLEPVFGYLHRGIEKLAEGRTYLQDIPFTDRLDYLGSMTNNHAYV
MAVEKLAGITVPERAEYIRVILDELQRIASHLAGLGFFLNDLGALQTPLLYMFREREKIVELFDMCSGQRLNYNYYRFGG
FVQDLPEEFLPALKKLLDTLPGFIDEYEQLISTNEIVLIRTKGVGVLKRELAINSSAAGPVLRASGVNWDIRRNDPYSIY
DRFEFDIPTAQNGDTYDRYMVRIREMRQSVRILRQAVKDLPEGEIMGKAPKLLKPPAGEVYSRIEGPKGELGFYLVSDGT
DKPYRWRVRPPCLLNLSALKDMVVGWKVADLMAIFGSIDIVMGEVDR
>Mature_366_residues
AIKTESFILNIGPQHPSTHGVFRLRLILDGEVITDLEPVFGYLHRGIEKLAEGRTYLQDIPFTDRLDYLGSMTNNHAYVM
AVEKLAGITVPERAEYIRVILDELQRIASHLAGLGFFLNDLGALQTPLLYMFREREKIVELFDMCSGQRLNYNYYRFGGF
VQDLPEEFLPALKKLLDTLPGFIDEYEQLISTNEIVLIRTKGVGVLKRELAINSSAAGPVLRASGVNWDIRRNDPYSIYD
RFEFDIPTAQNGDTYDRYMVRIREMRQSVRILRQAVKDLPEGEIMGKAPKLLKPPAGEVYSRIEGPKGELGFYLVSDGTD
KPYRWRVRPPCLLNLSALKDMVVGWKVADLMAIFGSIDIVMGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=388, Percent_Identity=42.2680412371134, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI260898743, Length=382, Percent_Identity=41.3612565445026, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI145693162, Length=393, Percent_Identity=40.2035623409669, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI1789076, Length=360, Percent_Identity=30.8333333333333, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1788832, Length=365, Percent_Identity=29.3150684931507, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17555284, Length=387, Percent_Identity=42.6356589147287, Blast_Score=321, Evalue=4e-88,
Organism=Caenorhabditis elegans, GI17568379, Length=387, Percent_Identity=42.8940568475452, Blast_Score=318, Evalue=2e-87,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=41.9270833333333, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI24638644, Length=386, Percent_Identity=40.9326424870466, Blast_Score=319, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_DEHE1 (Q3Z7Z8)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181651.1
- HSSP:   Q56220
- ProteinModelPortal:   Q3Z7Z8
- SMR:   Q3Z7Z8
- STRING:   Q3Z7Z8
- GeneID:   3229771
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0926
- NMPDR:   fig|243164.3.peg.1225
- TIGR:   DET0926
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   FGPFLAD
- PhylomeDB:   Q3Z7Z8
- ProtClustDB:   CLSK2767660
- BioCyc:   DETH243164:DET_0926-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 41772; Mature: 41641

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKTESFILNIGPQHPSTHGVFRLRLILDGEVITDLEPVFGYLHRGIEKLAEGRTYLQD
CCCCCCEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHC
IPFTDRLDYLGSMTNNHAYVMAVEKLAGITVPERAEYIRVILDELQRIASHLAGLGFFLN
CCCCHHHHHHHCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLGALQTPLLYMFREREKIVELFDMCSGQRLNYNYYRFGGFVQDLPEEFLPALKKLLDTL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
PGFIDEYEQLISTNEIVLIRTKGVGVLKRELAINSSAAGPVLRASGVNWDIRRNDPYSIY
HHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCEEE
DRFEFDIPTAQNGDTYDRYMVRIREMRQSVRILRQAVKDLPEGEIMGKAPKLLKPPAGEV
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCHHH
YSRIEGPKGELGFYLVSDGTDKPYRWRVRPPCLLNLSALKDMVVGWKVADLMAIFGSIDI
HHHCCCCCCCEEEEEEECCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHE
VMGEVDR
EECCCCC
>Mature Secondary Structure 
AIKTESFILNIGPQHPSTHGVFRLRLILDGEVITDLEPVFGYLHRGIEKLAEGRTYLQD
CCCCCEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHC
IPFTDRLDYLGSMTNNHAYVMAVEKLAGITVPERAEYIRVILDELQRIASHLAGLGFFLN
CCCCHHHHHHHCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLGALQTPLLYMFREREKIVELFDMCSGQRLNYNYYRFGGFVQDLPEEFLPALKKLLDTL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
PGFIDEYEQLISTNEIVLIRTKGVGVLKRELAINSSAAGPVLRASGVNWDIRRNDPYSIY
HHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCEEE
DRFEFDIPTAQNGDTYDRYMVRIREMRQSVRILRQAVKDLPEGEIMGKAPKLLKPPAGEV
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCHHH
YSRIEGPKGELGFYLVSDGTDKPYRWRVRPPCLLNLSALKDMVVGWKVADLMAIFGSIDI
HHHCCCCCCCEEEEEEECCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHE
VMGEVDR
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA