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The map label for this gene is nuoH

Identifier: 57234303

GI number: 57234303

Start: 848133

End: 849194

Strand: Direct

Name: nuoH

Synonym: DET0927

Alternate gene names: 57234303

Gene position: 848133-849194 (Clockwise)

Preceding gene: 57234304

Following gene: 57234302

Centisome position: 57.71

GC content: 49.25

Gene sequence:

>1062_bases
ATGTCTGACTTCTGGGTTCACCTGCTAGTCTACCTGGTCATACTCTTTGGTTTTGTAATTGTGAGTGTGCTTTTATTTAT
CTGGCTGGAGCGCCGCTTTATCGGCCGTTTTCAGTTGCGCCCCGGCCCCAACAGAGCCGGTCCTTTCGGGCTGCTACAGC
CCATTGCAGATGCTATCAAGGTGCTTATTAAAGAGGATATTATCCCTACCGAGTCAGACAAAGGGGTATTCTGGTTAGCC
CCGCTGGTGGCTTTTGTACCGGTAATGCTGATGTTTGCCGCCATACCCTTTGCAGACGGAGCTATGCTGGTTGACCTGAA
TATAGGCATACTCTATATACTGGCGGTCAGCTCGGTAACGGTAATAGGTATATTTATGGCCGGCTGGAGCAGCAACAGCA
AGTATTCCCTGCTGGGTGCCATGCGTACCATAGCCCAGGAAGTCAGCTATGAAATACCGCTGGTGCTTTCAATACTTGGC
GTTGTTATGTTAACCGGTTCGCTTTCTATGAATGAGATAGTAAAAGCCCAGAGTGTCCCGTTTGTACTTTTGCAGCCTCT
GGGTTTCTTCGTTTACCTGTCCGCCGCCATGGCGGAAATAAACCGCACCCCGTTTGATTTGCTGGAAGCGGAATCTGAAA
TCATTGCCGGTTTTCATACCGAATATTCCGGCATGAAATTCGGCCTTTTTTACCTGATGGAATACGCCGAAGTACTGGCA
ATTTCGGCCATAGCCACCACCCTGTTTCTGGGGGGCTGGCAGGGGCCGCTGCTGCACCCCGTTATCTGGTTTATTACTAA
AGTCCTGATAATCTTTATGTTTATAATCTGGGTGCGTGCCACCATACCCCGTCTTCGTATAGACCAGGTGATGGCTTTCG
GCTGGAAGTTCCTTTTACCGCTGTCCCTGGCCAATCTGGTTATAACGGCATTTGAGATACTGGCTGCGCCTGACATGAAT
ACAGCAGTGCTTATCGGTATAAATATAGCGGTAATGTTCGGGCTTATCCTCCTGTTCAGCCGTTTTTACAAGCTGGGAGG
TGGACGTGTCAGCGTTAAGTAA

Upstream 100 bases:

>100_bases
ATTTATCAGCTTTGAAAGATATGGTGGTAGGCTGGAAAGTGGCTGATCTGATGGCTATATTCGGCAGCATAGACATTGTA
ATGGGTGAGGTGGACAGATA

Downstream 100 bases:

>100_bases
TACCGGGGGCGGCATTCTTAAAGGAATGCGCCTTACCTTCAAGCATCTTTTCCGCCCTTGGATAACTGTCCAGTATCCGG
AAGAAAAACTGACTATGTCA

Product: proton-translocating NADH-quinone oxidoreductase, H subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSDFWVHLLVYLVILFGFVIVSVLLFIWLERRFIGRFQLRPGPNRAGPFGLLQPIADAIKVLIKEDIIPTESDKGVFWLA
PLVAFVPVMLMFAAIPFADGAMLVDLNIGILYILAVSSVTVIGIFMAGWSSNSKYSLLGAMRTIAQEVSYEIPLVLSILG
VVMLTGSLSMNEIVKAQSVPFVLLQPLGFFVYLSAAMAEINRTPFDLLEAESEIIAGFHTEYSGMKFGLFYLMEYAEVLA
ISAIATTLFLGGWQGPLLHPVIWFITKVLIIFMFIIWVRATIPRLRIDQVMAFGWKFLLPLSLANLVITAFEILAAPDMN
TAVLIGINIAVMFGLILLFSRFYKLGGGRVSVK

Sequences:

>Translated_353_residues
MSDFWVHLLVYLVILFGFVIVSVLLFIWLERRFIGRFQLRPGPNRAGPFGLLQPIADAIKVLIKEDIIPTESDKGVFWLA
PLVAFVPVMLMFAAIPFADGAMLVDLNIGILYILAVSSVTVIGIFMAGWSSNSKYSLLGAMRTIAQEVSYEIPLVLSILG
VVMLTGSLSMNEIVKAQSVPFVLLQPLGFFVYLSAAMAEINRTPFDLLEAESEIIAGFHTEYSGMKFGLFYLMEYAEVLA
ISAIATTLFLGGWQGPLLHPVIWFITKVLIIFMFIIWVRATIPRLRIDQVMAFGWKFLLPLSLANLVITAFEILAAPDMN
TAVLIGINIAVMFGLILLFSRFYKLGGGRVSVK
>Mature_352_residues
SDFWVHLLVYLVILFGFVIVSVLLFIWLERRFIGRFQLRPGPNRAGPFGLLQPIADAIKVLIKEDIIPTESDKGVFWLAP
LVAFVPVMLMFAAIPFADGAMLVDLNIGILYILAVSSVTVIGIFMAGWSSNSKYSLLGAMRTIAQEVSYEIPLVLSILGV
VMLTGSLSMNEIVKAQSVPFVLLQPLGFFVYLSAAMAEINRTPFDLLEAESEIIAGFHTEYSGMKFGLFYLMEYAEVLAI
SAIATTLFLGGWQGPLLHPVIWFITKVLIIFMFIIWVRATIPRLRIDQVMAFGWKFLLPLSLANLVITAFEILAAPDMNT
AVLIGINIAVMFGLILLFSRFYKLGGGRVSVK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=279, Percent_Identity=39.7849462365591, Blast_Score=214, Evalue=7e-56,
Organism=Escherichia coli, GI1788618, Length=286, Percent_Identity=52.7972027972028, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1789077, Length=283, Percent_Identity=30.0353356890459, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_DEHE1 (Q3Z7Z7)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181652.1
- STRING:   Q3Z7Z7
- GeneID:   3229770
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0927
- NMPDR:   fig|243164.3.peg.1226
- TIGR:   DET0927
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   IFWICAL
- PhylomeDB:   Q3Z7Z7
- ProtClustDB:   CLSK837202
- BioCyc:   DETH243164:DET_0927-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 39156; Mature: 39025

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xcf93390)-; HASH(0xbbb2d44)-; HASH(0xc743a6c)-; HASH(0xb691fa4)-; HASH(0xd427ac0)-; HASH(0xd4702c0)-; HASH(0xd08a0b0)-; HASH(0xd368df8)-; HASH(0xd8e405c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFWVHLLVYLVILFGFVIVSVLLFIWLERRFIGRFQLRPGPNRAGPFGLLQPIADAIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCHHHHHHHHHHHH
VLIKEDIIPTESDKGVFWLAPLVAFVPVMLMFAAIPFADGAMLVDLNIGILYILAVSSVT
HHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHH
VIGIFMAGWSSNSKYSLLGAMRTIAQEVSYEIPLVLSILGVVMLTGSLSMNEIVKAQSVP
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCC
FVLLQPLGFFVYLSAAMAEINRTPFDLLEAESEIIAGFHTEYSGMKFGLFYLMEYAEVLA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ISAIATTLFLGGWQGPLLHPVIWFITKVLIIFMFIIWVRATIPRLRIDQVMAFGWKFLLP
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LSLANLVITAFEILAAPDMNTAVLIGINIAVMFGLILLFSRFYKLGGGRVSVK
HHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECH
>Mature Secondary Structure 
SDFWVHLLVYLVILFGFVIVSVLLFIWLERRFIGRFQLRPGPNRAGPFGLLQPIADAIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCHHHHHHHHHHHH
VLIKEDIIPTESDKGVFWLAPLVAFVPVMLMFAAIPFADGAMLVDLNIGILYILAVSSVT
HHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHH
VIGIFMAGWSSNSKYSLLGAMRTIAQEVSYEIPLVLSILGVVMLTGSLSMNEIVKAQSVP
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCC
FVLLQPLGFFVYLSAAMAEINRTPFDLLEAESEIIAGFHTEYSGMKFGLFYLMEYAEVLA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ISAIATTLFLGGWQGPLLHPVIWFITKVLIIFMFIIWVRATIPRLRIDQVMAFGWKFLLP
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LSLANLVITAFEILAAPDMNTAVLIGINIAVMFGLILLFSRFYKLGGGRVSVK
HHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA