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The map label for this gene is fabF [H]

Identifier: 57234226

GI number: 57234226

Start: 881647

End: 882915

Strand: Direct

Name: fabF [H]

Synonym: DET0963

Alternate gene names: 57234226

Gene position: 881647-882915 (Clockwise)

Preceding gene: 57234237

Following gene: 57234225

Centisome position: 59.99

GC content: 52.09

Gene sequence:

>1269_bases
ATGACTGATAACCAGCCCCAAAACAGGGTTGTCATAACCGGCATCGGCATTGTCAGCCCTCTTGGACTTGATACTCAAAC
CACCTGGGAAGGCCTGATAAACGGCCGTTCAGGTATAGACCATATCAGCCTCTTTGACGCATCAAATCTGGCTGTCCGCT
TTGGCGGAGAGGTCAAAGATTTTGACCCGGCGAACTATATATCCCGCAAGGATATCCGCCGCATGGACCGTTTTGCCCAG
CTGGCGGTAGCCGCCGGCAAACAGGCACTGGAAAATTCGGGACTGGGGGCAGATGAAAGCGTCCGGCAGGATATCGGGGT
AATTGTAGGCAGCGGCATAGGCGGGCTTTCGGTTCTCTTTGAACAAATCAAAGTTTTCCTGGAACAAGGGCCGGACAGAG
TCAGCCCTTTTTTAGTACCCATGATGATTGCAGACATGGCCGGAGCCCAGGTTTCTATCCAGCTGGGTCTTAAAGGGCCT
AATTTCTGTACTACTTCGGCCTGTTCTTCTGGTTCAGACGCCATAGGCACAGCATTTGAAAAAATACGTTTTGGTTCGGC
CAAGATTATCCTGGCGGGCGGTGCCGAATCTATTATGAACCCGGTTGGTTTTGCCGGTTTTTCAGCCTTAAAAGCCCTAT
CCACCCGCAATGAAGACCCCCAGACGGCTTCGCGCCCGTTTGATGCCAACCGGGACGGCTTTGTTATTGCGGAGGGTGCG
GCGATTTTGGTTTTGGAAGAAATGGAGTCTGCCAAAGCCAGGGGAGCAAATATCATTGCCGAGATAATCGGTTACGGCGG
CTCTTCAGACGCTTTTCACATAACCCAGCCGGTGGAATCCGGTGTAGAAGCCGCCCGGGCTATAAATATTGCCCTGAATA
CCGCCGGCATCAAACCGGAAGCGGTAGACTATATAAATGCCCACGGCACATCTACCCCCCTGAATGACAAGATGGAAACC
AATGCTATTAAAGTGGCCTTCGGGGAACACGCCCGGAAACTGGCCATCAGCTCCACCAAATCCATGCTGGGGCATCTGAT
AGGCGGGGCCGGGGCTATTGAAGCCTCTATCTGCGCCCTGACTATTAAAAACGGCATTATACCGCCTACCATAAACTACA
CCACTCCTGACCCTGACTGTGATTTAGATTACACCCCCAACACCGCCCGCAGAGCCAAGGTAAGGGTGGCGCTTAATAAT
TCATTCGGTTTCGGCGGGCATAATTCGGTGCTTATCCTCAGGGAAATGGGTGATGAAAATATTGGCTAA

Upstream 100 bases:

>100_bases
TATATTAAACATCAAACCTGATTATACCAAAGCCTCCCCAAACTTGCAGTTATAATATGCCTGTGTTATAAATAGCCAAT
TTAACAACTGAGGTGAACAG

Downstream 100 bases:

>100_bases
CTGCCTCTGGAAGCTAAAACCGGCGCCTCCGGAAGAGACCAGCCAGAATTTCCCTTATCCGCCCCTGATTACCAGTCTGC
TTTACAACCGGGGTATCAAA

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTDNQPQNRVVITGIGIVSPLGLDTQTTWEGLINGRSGIDHISLFDASNLAVRFGGEVKDFDPANYISRKDIRRMDRFAQ
LAVAAGKQALENSGLGADESVRQDIGVIVGSGIGGLSVLFEQIKVFLEQGPDRVSPFLVPMMIADMAGAQVSIQLGLKGP
NFCTTSACSSGSDAIGTAFEKIRFGSAKIILAGGAESIMNPVGFAGFSALKALSTRNEDPQTASRPFDANRDGFVIAEGA
AILVLEEMESAKARGANIIAEIIGYGGSSDAFHITQPVESGVEAARAINIALNTAGIKPEAVDYINAHGTSTPLNDKMET
NAIKVAFGEHARKLAISSTKSMLGHLIGGAGAIEASICALTIKNGIIPPTINYTTPDPDCDLDYTPNTARRAKVRVALNN
SFGFGGHNSVLILREMGDENIG

Sequences:

>Translated_422_residues
MTDNQPQNRVVITGIGIVSPLGLDTQTTWEGLINGRSGIDHISLFDASNLAVRFGGEVKDFDPANYISRKDIRRMDRFAQ
LAVAAGKQALENSGLGADESVRQDIGVIVGSGIGGLSVLFEQIKVFLEQGPDRVSPFLVPMMIADMAGAQVSIQLGLKGP
NFCTTSACSSGSDAIGTAFEKIRFGSAKIILAGGAESIMNPVGFAGFSALKALSTRNEDPQTASRPFDANRDGFVIAEGA
AILVLEEMESAKARGANIIAEIIGYGGSSDAFHITQPVESGVEAARAINIALNTAGIKPEAVDYINAHGTSTPLNDKMET
NAIKVAFGEHARKLAISSTKSMLGHLIGGAGAIEASICALTIKNGIIPPTINYTTPDPDCDLDYTPNTARRAKVRVALNN
SFGFGGHNSVLILREMGDENIG
>Mature_421_residues
TDNQPQNRVVITGIGIVSPLGLDTQTTWEGLINGRSGIDHISLFDASNLAVRFGGEVKDFDPANYISRKDIRRMDRFAQL
AVAAGKQALENSGLGADESVRQDIGVIVGSGIGGLSVLFEQIKVFLEQGPDRVSPFLVPMMIADMAGAQVSIQLGLKGPN
FCTTSACSSGSDAIGTAFEKIRFGSAKIILAGGAESIMNPVGFAGFSALKALSTRNEDPQTASRPFDANRDGFVIAEGAA
ILVLEEMESAKARGANIIAEIIGYGGSSDAFHITQPVESGVEAARAINIALNTAGIKPEAVDYINAHGTSTPLNDKMETN
AIKVAFGEHARKLAISSTKSMLGHLIGGAGAIEASICALTIKNGIIPPTINYTTPDPDCDLDYTPNTARRAKVRVALNNS
FGFGGHNSVLILREMGDENIG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=44.3645083932854, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI223972627, Length=169, Percent_Identity=43.1952662721894, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI41872631, Length=426, Percent_Identity=27.2300469483568, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=48.4184914841849, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI1788663, Length=418, Percent_Identity=38.0382775119617, Blast_Score=238, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=34.2995169082126, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=38.1132075471698, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI212642053, Length=427, Percent_Identity=27.8688524590164, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17550940, Length=425, Percent_Identity=24.2352941176471, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=34.8993288590604, Blast_Score=253, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=41.3875598086124, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI19920632, Length=377, Percent_Identity=27.3209549071618, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI221330659, Length=377, Percent_Identity=27.3209549071618, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24581345, Length=285, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44293; Mature: 44162

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNQPQNRVVITGIGIVSPLGLDTQTTWEGLINGRSGIDHISLFDASNLAVRFGGEVKD
CCCCCCCCEEEEEECCEECCCCCCCCHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCC
FDPANYISRKDIRRMDRFAQLAVAAGKQALENSGLGADESVRQDIGVIVGSGIGGLSVLF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCEEEECCCCHHHHHH
EQIKVFLEQGPDRVSPFLVPMMIADMAGAQVSIQLGLKGPNFCTTSACSSGSDAIGTAFE
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCCCCCCCHHHHHHH
KIRFGSAKIILAGGAESIMNPVGFAGFSALKALSTRNEDPQTASRPFDANRDGFVIAEGA
HHCCCCEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCC
AILVLEEMESAKARGANIIAEIIGYGGSSDAFHITQPVESGVEAARAINIALNTAGIKPE
EEEEEEHHHHHHHCCHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHEEEEEEECCCCCCH
AVDYINAHGTSTPLNDKMETNAIKVAFGEHARKLAISSTKSMLGHLIGGAGAIEASICAL
HHHHEECCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEE
TIKNGIIPPTINYTTPDPDCDLDYTPNTARRAKVRVALNNSFGFGGHNSVLILREMGDEN
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCC
IG
CC
>Mature Secondary Structure 
TDNQPQNRVVITGIGIVSPLGLDTQTTWEGLINGRSGIDHISLFDASNLAVRFGGEVKD
CCCCCCCEEEEEECCEECCCCCCCCHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCC
FDPANYISRKDIRRMDRFAQLAVAAGKQALENSGLGADESVRQDIGVIVGSGIGGLSVLF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCEEEECCCCHHHHHH
EQIKVFLEQGPDRVSPFLVPMMIADMAGAQVSIQLGLKGPNFCTTSACSSGSDAIGTAFE
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCCCCCCCHHHHHHH
KIRFGSAKIILAGGAESIMNPVGFAGFSALKALSTRNEDPQTASRPFDANRDGFVIAEGA
HHCCCCEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCC
AILVLEEMESAKARGANIIAEIIGYGGSSDAFHITQPVESGVEAARAINIALNTAGIKPE
EEEEEEHHHHHHHCCHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHEEEEEEECCCCCCH
AVDYINAHGTSTPLNDKMETNAIKVAFGEHARKLAISSTKSMLGHLIGGAGAIEASICAL
HHHHEECCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEE
TIKNGIIPPTINYTTPDPDCDLDYTPNTARRAKVRVALNNSFGFGGHNSVLILREMGDEN
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCC
IG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]