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The map label for this gene is dapA

Identifier: 57234208

GI number: 57234208

Start: 893291

End: 894184

Strand: Direct

Name: dapA

Synonym: DET0973

Alternate gene names: 57234208

Gene position: 893291-894184 (Clockwise)

Preceding gene: 57234209

Following gene: 57234207

Centisome position: 60.78

GC content: 50.0

Gene sequence:

>894_bases
ATGAAAGAATTAGGCAGGCTGATTACGGCCATGGTAACCCCGTTTAAAAAAGACGGGACAGTAGATTATGCCCAGGCTCA
GAAACTGGCTCTGGGACTTCTTGATTCAGGCAGTGACGGGCTGGTGGTAGTTGGCACTACCGGCGAATCACCTACCGTTA
CCTGGGAAGAAGAACACGCCCTGTTTGCAGCTGTAAAATCTGCGGTCGGCAACCGGGGAAAGGTTATTGCCGGAACAGGT
GCTAACAGCACCCAGGAAGCCCTGGAAAATACTCTCAAAGCGGAGAAGATTGGGGTAGATGCCTGTTTGCTGGTAGTGCC
CTATTACAATAAACCCACCCAGGAGGGGTTGTACCTTCATTTCAAGACTATTGCCGAGGCTACCAAGCTTCCCTGCATAC
TTTATAATGTACCCTCACGCACCATCACCCACATGAGTCCGGAAACAGTAATCCGCCTGAGCCAGATACCCAATATTGTG
GGTGTCAAGGAAGCCAGCGGCAAACTGGATGATATAGCCCAGATAATAAACAATGTCCGCCCTGATTTCACTGTCTGGAG
CGGTAATGACAGTGATACCCTGCCCATGCTGGCCATGGGGGCTTACGGCGTTATCTCGGTAGCTTCCCACATAGTGGGCA
AGCAAATAAAGGAGATGATAACCAGTTTTGTTTCGGGCAATACGGATAACGCAGCCGCTATTCACCGCCACCTGACCCCG
CTGATACGCTCACTTTTTGTAGTATCCAATCCCATACCTATCAAATACGCCCTGAATTACCTGGGGTTTGAAGTAGGCGG
GCTTAGACTGCCCATGACCGAAGCAGATGAAAAAACTGCTGCCCTGATACGCGAAAGTCTGAAGGGCTATACTATAGACC
TGCCCATAAAATAA

Upstream 100 bases:

>100_bases
GTTATGTGGGTGGTGGCGGACAATGTCCGGAAAGGCGCGGCCCTAAACGCCGTCCAGATTGCCGAAGAACTGGTCAACCG
CGGCATGATAGGAGGTTAAG

Downstream 100 bases:

>100_bases
AAATGATACAGTCTGACAATGGTCTCTACCGTTTGGAAAAAACGGATATAAAACGTCTTGCCTATGTAACTGCCGAAGCC
TTCAAAGATGACCAGCTTAC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKELGRLITAMVTPFKKDGTVDYAQAQKLALGLLDSGSDGLVVVGTTGESPTVTWEEEHALFAAVKSAVGNRGKVIAGTG
ANSTQEALENTLKAEKIGVDACLLVVPYYNKPTQEGLYLHFKTIAEATKLPCILYNVPSRTITHMSPETVIRLSQIPNIV
GVKEASGKLDDIAQIINNVRPDFTVWSGNDSDTLPMLAMGAYGVISVASHIVGKQIKEMITSFVSGNTDNAAAIHRHLTP
LIRSLFVVSNPIPIKYALNYLGFEVGGLRLPMTEADEKTAALIRESLKGYTIDLPIK

Sequences:

>Translated_297_residues
MKELGRLITAMVTPFKKDGTVDYAQAQKLALGLLDSGSDGLVVVGTTGESPTVTWEEEHALFAAVKSAVGNRGKVIAGTG
ANSTQEALENTLKAEKIGVDACLLVVPYYNKPTQEGLYLHFKTIAEATKLPCILYNVPSRTITHMSPETVIRLSQIPNIV
GVKEASGKLDDIAQIINNVRPDFTVWSGNDSDTLPMLAMGAYGVISVASHIVGKQIKEMITSFVSGNTDNAAAIHRHLTP
LIRSLFVVSNPIPIKYALNYLGFEVGGLRLPMTEADEKTAALIRESLKGYTIDLPIK
>Mature_297_residues
MKELGRLITAMVTPFKKDGTVDYAQAQKLALGLLDSGSDGLVVVGTTGESPTVTWEEEHALFAAVKSAVGNRGKVIAGTG
ANSTQEALENTLKAEKIGVDACLLVVPYYNKPTQEGLYLHFKTIAEATKLPCILYNVPSRTITHMSPETVIRLSQIPNIV
GVKEASGKLDDIAQIINNVRPDFTVWSGNDSDTLPMLAMGAYGVISVASHIVGKQIKEMITSFVSGNTDNAAAIHRHLTP
LIRSLFVVSNPIPIKYALNYLGFEVGGLRLPMTEADEKTAALIRESLKGYTIDLPIK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=269, Percent_Identity=28.996282527881, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI13540533, Length=288, Percent_Identity=26.0416666666667, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1788823, Length=282, Percent_Identity=43.6170212765958, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI87082415, Length=285, Percent_Identity=30.8771929824561, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786463, Length=240, Percent_Identity=28.75, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789620, Length=274, Percent_Identity=26.6423357664234, Blast_Score=98, Evalue=6e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_DEHE1 (Q3Z7V3)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181696.1
- HSSP:   Q81WN7
- ProteinModelPortal:   Q3Z7V3
- SMR:   Q3Z7V3
- STRING:   Q3Z7V3
- GeneID:   3229675
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0973
- NMPDR:   fig|243164.3.peg.387
- TIGR:   DET0973
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   Q3Z7V3
- ProtClustDB:   PRK03170
- BioCyc:   DETH243164:DET_0973-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31964; Mature: 31964

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 163-163 BINDING 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELGRLITAMVTPFKKDGTVDYAQAQKLALGLLDSGSDGLVVVGTTGESPTVTWEEEHA
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEECCCCCCEEEEECCCCCCEEEECHHHH
LFAAVKSAVGNRGKVIAGTGANSTQEALENTLKAEKIGVDACLLVVPYYNKPTQEGLYLH
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEE
FKTIAEATKLPCILYNVPSRTITHMSPETVIRLSQIPNIVGVKEASGKLDDIAQIINNVR
HHHHHHHHCCCEEEEECCCCCEECCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCC
PDFTVWSGNDSDTLPMLAMGAYGVISVASHIVGKQIKEMITSFVSGNTDNAAAIHRHLTP
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LIRSLFVVSNPIPIKYALNYLGFEVGGLRLPMTEADEKTAALIRESLKGYTIDLPIK
HHHHHHHHCCCCCHHHHHHHHCEEECCEECCCCCCCHHHHHHHHHHHCCEEEEECCC
>Mature Secondary Structure
MKELGRLITAMVTPFKKDGTVDYAQAQKLALGLLDSGSDGLVVVGTTGESPTVTWEEEHA
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEECCCCCCEEEEECCCCCCEEEECHHHH
LFAAVKSAVGNRGKVIAGTGANSTQEALENTLKAEKIGVDACLLVVPYYNKPTQEGLYLH
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEE
FKTIAEATKLPCILYNVPSRTITHMSPETVIRLSQIPNIVGVKEASGKLDDIAQIINNVR
HHHHHHHHCCCEEEEECCCCCEECCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCC
PDFTVWSGNDSDTLPMLAMGAYGVISVASHIVGKQIKEMITSFVSGNTDNAAAIHRHLTP
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LIRSLFVVSNPIPIKYALNYLGFEVGGLRLPMTEADEKTAALIRESLKGYTIDLPIK
HHHHHHHHCCCCCHHHHHHHHCEEECCEECCCCCCCHHHHHHHHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA