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The map label for this gene is argD [H]

Identifier: 57233976

GI number: 57233976

Start: 1144710

End: 1145906

Strand: Direct

Name: argD [H]

Synonym: DET1258

Alternate gene names: 57233976

Gene position: 1144710-1145906 (Clockwise)

Preceding gene: 57233977

Following gene: 57233966

Centisome position: 77.89

GC content: 51.04

Gene sequence:

>1197_bases
ATGGATAACTGGCAAGAGCTTGAACATAAATATTACATGCAGACTTTTTACCGCGCACCCATCACTATTGTTAAGGGGCA
GGGAGCAAAGGTCTGGGATGATAAGGGTAAAGAATATCTGGATTTTGTAGCCGGCTGGGCGGTAAACAGCCTGGGGCACT
GTCACCCGGCAGTAGTCAAAGCGGTCTCAGAGCAGGCTGGCACACTTATCCAGACTTCCAACAATTTTTATACCATTCCC
CAGCTTAAACTGGCCAAACTGCTGGTTGATAACAGCGTACTGGACCGTATTTTCTTCTGCAACAGCGGCACCGAAGCTAC
CGAAGGGGCAGTTAAGCTTGCCCGCCGCTACGGTAAACTCAAACTAAAAGGGGCTTACGAAGTAATTACCGCCACCGGTT
CTTTCCACGGGCGGACCCTGGCCATGGTTTCGGCCTCCGGCCAGAGTAAATACCAGGAGCCGTATACCCCCCTGCCAACC
GGTTTTATAAACGTGGAGTACAATAATCCCCAGGCTATAAAAACGGCCATTACAGACAAAACCTGTGCCGTTATGCTTGA
ACCCATACAGGGTGAAAGCGGGGTAAACGTACCTGATAAAGGCTACCTTAAAGCTGTCCGCCAAATATGTGATGAGGCTG
GCATACTGCTGATACTGGATGAAATCCAGACCGGTATCGGCCGTACCGGCAAACTTTTTGCTTATGAACATTCCGGCATT
GAGCCGGATATTATTACTCTGGCCAAAGGGCTGGCTGGCGGCATACCCATAGGTGCATTTATGGCTAAGGAGAGCGCTTC
GGTCTTTGCCAAGGGGGAACATGGCTCTACCTTCGGCGGCAACCCGCTGGCCTGTGCCGCCGGATATGCGGCTATGAAGT
TTATTCTGGACAACCATATCTCCGAAAACGCCGGCAGCATGGGCAGCTACCTTGCTGAAGGGCTTGAAAAACTTAAAATA
AAACACAGCCTTATACAGGGCTGCCGCGGCTGCGGTCTGCTGATGGCACTGGACTTTAAAACCAATATTGCCAAAGAAAT
AGTCGAAAGCTGCCTGGAAGAAGGGCTGCTGCTGAATGCGGTTAAGCCCAATGCCCTGCGGTTTATGCCCCCGCTGAATA
TCACCCAAGCAGATATAGATGCGGCAATTGCCAAGCTGGATAGTGTGCTTACCCGGCATGAAAGCTGCGGGGTTTAG

Upstream 100 bases:

>100_bases
AATAGGCCAGCATCTTAGGCGCAGTTAGACATAGTAACCTGTTAACCCGGCAGATTGCCTTTTTAAAAAGGCGATAATAC
TATTAATAAAAGAGGTTAAA

Downstream 100 bases:

>100_bases
GGGTAGATGGACTGGGACATACTGAAAATTATTTTAGGAGTAGCCGTACTGCTGGCGGCAGGCGCTTTTTTGATTTTGCT
GGCTAATCCCCTGACCATGC

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MDNWQELEHKYYMQTFYRAPITIVKGQGAKVWDDKGKEYLDFVAGWAVNSLGHCHPAVVKAVSEQAGTLIQTSNNFYTIP
QLKLAKLLVDNSVLDRIFFCNSGTEATEGAVKLARRYGKLKLKGAYEVITATGSFHGRTLAMVSASGQSKYQEPYTPLPT
GFINVEYNNPQAIKTAITDKTCAVMLEPIQGESGVNVPDKGYLKAVRQICDEAGILLILDEIQTGIGRTGKLFAYEHSGI
EPDIITLAKGLAGGIPIGAFMAKESASVFAKGEHGSTFGGNPLACAAGYAAMKFILDNHISENAGSMGSYLAEGLEKLKI
KHSLIQGCRGCGLLMALDFKTNIAKEIVESCLEEGLLLNAVKPNALRFMPPLNITQADIDAAIAKLDSVLTRHESCGV

Sequences:

>Translated_398_residues
MDNWQELEHKYYMQTFYRAPITIVKGQGAKVWDDKGKEYLDFVAGWAVNSLGHCHPAVVKAVSEQAGTLIQTSNNFYTIP
QLKLAKLLVDNSVLDRIFFCNSGTEATEGAVKLARRYGKLKLKGAYEVITATGSFHGRTLAMVSASGQSKYQEPYTPLPT
GFINVEYNNPQAIKTAITDKTCAVMLEPIQGESGVNVPDKGYLKAVRQICDEAGILLILDEIQTGIGRTGKLFAYEHSGI
EPDIITLAKGLAGGIPIGAFMAKESASVFAKGEHGSTFGGNPLACAAGYAAMKFILDNHISENAGSMGSYLAEGLEKLKI
KHSLIQGCRGCGLLMALDFKTNIAKEIVESCLEEGLLLNAVKPNALRFMPPLNITQADIDAAIAKLDSVLTRHESCGV
>Mature_398_residues
MDNWQELEHKYYMQTFYRAPITIVKGQGAKVWDDKGKEYLDFVAGWAVNSLGHCHPAVVKAVSEQAGTLIQTSNNFYTIP
QLKLAKLLVDNSVLDRIFFCNSGTEATEGAVKLARRYGKLKLKGAYEVITATGSFHGRTLAMVSASGQSKYQEPYTPLPT
GFINVEYNNPQAIKTAITDKTCAVMLEPIQGESGVNVPDKGYLKAVRQICDEAGILLILDEIQTGIGRTGKLFAYEHSGI
EPDIITLAKGLAGGIPIGAFMAKESASVFAKGEHGSTFGGNPLACAAGYAAMKFILDNHISENAGSMGSYLAEGLEKLKI
KHSLIQGCRGCGLLMALDFKTNIAKEIVESCLEEGLLLNAVKPNALRFMPPLNITQADIDAAIAKLDSVLTRHESCGV

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=398, Percent_Identity=34.9246231155779, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=37.4581939799331, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI37574042, Length=419, Percent_Identity=32.2195704057279, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI24119277, Length=422, Percent_Identity=31.2796208530806, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI13994255, Length=435, Percent_Identity=29.6551724137931, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI226442705, Length=419, Percent_Identity=31.2649164677804, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI226442709, Length=384, Percent_Identity=32.03125, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI188536080, Length=405, Percent_Identity=23.4567901234568, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI38679950, Length=405, Percent_Identity=23.4567901234568, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI38679946, Length=405, Percent_Identity=23.4567901234568, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1789759, Length=374, Percent_Identity=41.4438502673797, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1788044, Length=383, Percent_Identity=38.6422976501305, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI145693181, Length=384, Percent_Identity=40.1041666666667, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1789016, Length=396, Percent_Identity=33.0808080808081, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1787560, Length=398, Percent_Identity=34.4221105527638, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786349, Length=315, Percent_Identity=32.0634920634921, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1786991, Length=305, Percent_Identity=31.1475409836066, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25144271, Length=387, Percent_Identity=38.7596899224806, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI25144274, Length=383, Percent_Identity=33.6814621409922, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=31.1475409836066, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=31.1627906976744, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71981843, Length=174, Percent_Identity=36.2068965517241, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17541228, Length=445, Percent_Identity=24.7191011235955, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71992985, Length=111, Percent_Identity=36.9369369369369, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=404, Percent_Identity=35.8910891089109, Blast_Score=242, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=34.0796019900498, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6321456, Length=418, Percent_Identity=25.1196172248804, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=318, Percent_Identity=26.7295597484277, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357415, Length=383, Percent_Identity=38.1201044386423, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=29.4663573085847, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161085790, Length=435, Percent_Identity=28.735632183908, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21356575, Length=426, Percent_Identity=29.3427230046948, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI281366494, Length=429, Percent_Identity=23.7762237762238, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24667139, Length=429, Percent_Identity=23.7762237762238, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24667143, Length=429, Percent_Identity=23.7762237762238, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 42943; Mature: 42943

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNWQELEHKYYMQTFYRAPITIVKGQGAKVWDDKGKEYLDFVAGWAVNSLGHCHPAVVK
CCCHHHHHHHHHHHHHHHCCEEEEECCCCEECCCCCHHHHHHHHHHHHHCCCCCCHHHHH
AVSEQAGTLIQTSNNFYTIPQLKLAKLLVDNSVLDRIFFCNSGTEATEGAVKLARRYGKL
HHHHHCCCEEEECCCEEECCHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCE
KLKGAYEVITATGSFHGRTLAMVSASGQSKYQEPYTPLPTGFINVEYNNPQAIKTAITDK
EECCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCC
TCAVMLEPIQGESGVNVPDKGYLKAVRQICDEAGILLILDEIQTGIGRTGKLFAYEHSGI
EEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCEEEEEECCCC
EPDIITLAKGLAGGIPIGAFMAKESASVFAKGEHGSTFGGNPLACAAGYAAMKFILDNHI
CCHHHHHHHHHCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SENAGSMGSYLAEGLEKLKIKHSLIQGCRGCGLLMALDFKTNIAKEIVESCLEEGLLLNA
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCEEEEC
VKPNALRFMPPLNITQADIDAAIAKLDSVLTRHESCGV
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNWQELEHKYYMQTFYRAPITIVKGQGAKVWDDKGKEYLDFVAGWAVNSLGHCHPAVVK
CCCHHHHHHHHHHHHHHHCCEEEEECCCCEECCCCCHHHHHHHHHHHHHCCCCCCHHHHH
AVSEQAGTLIQTSNNFYTIPQLKLAKLLVDNSVLDRIFFCNSGTEATEGAVKLARRYGKL
HHHHHCCCEEEECCCEEECCHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCE
KLKGAYEVITATGSFHGRTLAMVSASGQSKYQEPYTPLPTGFINVEYNNPQAIKTAITDK
EECCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCC
TCAVMLEPIQGESGVNVPDKGYLKAVRQICDEAGILLILDEIQTGIGRTGKLFAYEHSGI
EEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCEEEEEECCCC
EPDIITLAKGLAGGIPIGAFMAKESASVFAKGEHGSTFGGNPLACAAGYAAMKFILDNHI
CCHHHHHHHHHCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SENAGSMGSYLAEGLEKLKIKHSLIQGCRGCGLLMALDFKTNIAKEIVESCLEEGLLLNA
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCEEEEC
VKPNALRFMPPLNITQADIDAAIAKLDSVLTRHESCGV
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]