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The map label for this gene is argB

Identifier: 57233977

GI number: 57233977

Start: 1143819

End: 1144637

Strand: Direct

Name: argB

Synonym: DET1257

Alternate gene names: 57233977

Gene position: 1143819-1144637 (Clockwise)

Preceding gene: 57233978

Following gene: 57233976

Centisome position: 77.83

GC content: 55.19

Gene sequence:

>819_bases
ATGAATGTATCCCAAGTGAGTAACCATATAGTTGTAATAAAGCTGGGGGGTTCAGTCCTTAGTTCCAAGGACACCTCCCT
GAAAGATATTGCCGCCCTAAAACAGCTGGGGCTGAAGCCGGTGCTTATCCACGGCGGTGCCAGCACTGTCAGTGACTGGT
CTGCCAAGCTGGGGCTGGAAACACGCCTTGTTAACGGAGAACGGGTGACAGATGACCCTACTCTGGACGTAGTTGCCGCT
GTTTTAACGGGGCTGGTGAATAAGGAAATTGTGGCCGCCCTGCTGGATATGGGCGTACAGGCCGCCGGTATATCCGGAGT
GGACGGGGCTACCATAACCGGGCAAATGCGGGCAACCGAAACCGGCTATCTGGGAGATGTGACCGCAGTAAATACCGGGC
TTATTAACGCCCTGCTGGATAAAGATATTACTCCGGTGATTTCACCGGTCAGCTTCCACCATACAAAACGCCCGTCCGGC
AGCCGCCGTTTAATCAATATAAACGGAGACCCGGCCGCCGGAGAGATTGCAGCCGCCCTTCAGGCCGAACGGCTGGTCTT
TATGACAGATGTACCGGCCGTAAAGGGCAAAAACGGGGAGGCACTGGGTGAGATAAGTGCAGAGCACGCCGCCGAACTGC
TCTCTTCAGGCACAGCCTCAGGCGGGATGATACCCAAGCTCCGCTCATGCCTTAAGGCGACTTTGGCAGGTGCTTCCGCC
TGCATAATAGACGGCAGAATACCCCATATGCTGGTGCGTGAGCTTACCGAAGGCAATTGCGGCACTACCATAATAGGCCA
GCATCTTAGGCGCAGTTAG

Upstream 100 bases:

>100_bases
ACTGAACCTGAACCTGGGCGAAGGCAAATCTACCGCCTGGGGTTGTGACCTTTCAGCCGAATACGTAAAAATAAACGCGG
ACTACACCACTTAAACTGAA

Downstream 100 bases:

>100_bases
ACATAGTAACCTGTTAACCCGGCAGATTGCCTTTTTAAAAAGGCGATAATACTATTAATAAAAGAGGTTAAAATGGATAA
CTGGCAAGAGCTTGAACATA

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MNVSQVSNHIVVIKLGGSVLSSKDTSLKDIAALKQLGLKPVLIHGGASTVSDWSAKLGLETRLVNGERVTDDPTLDVVAA
VLTGLVNKEIVAALLDMGVQAAGISGVDGATITGQMRATETGYLGDVTAVNTGLINALLDKDITPVISPVSFHHTKRPSG
SRRLININGDPAAGEIAAALQAERLVFMTDVPAVKGKNGEALGEISAEHAAELLSSGTASGGMIPKLRSCLKATLAGASA
CIIDGRIPHMLVRELTEGNCGTTIIGQHLRRS

Sequences:

>Translated_272_residues
MNVSQVSNHIVVIKLGGSVLSSKDTSLKDIAALKQLGLKPVLIHGGASTVSDWSAKLGLETRLVNGERVTDDPTLDVVAA
VLTGLVNKEIVAALLDMGVQAAGISGVDGATITGQMRATETGYLGDVTAVNTGLINALLDKDITPVISPVSFHHTKRPSG
SRRLININGDPAAGEIAAALQAERLVFMTDVPAVKGKNGEALGEISAEHAAELLSSGTASGGMIPKLRSCLKATLAGASA
CIIDGRIPHMLVRELTEGNCGTTIIGQHLRRS
>Mature_272_residues
MNVSQVSNHIVVIKLGGSVLSSKDTSLKDIAALKQLGLKPVLIHGGASTVSDWSAKLGLETRLVNGERVTDDPTLDVVAA
VLTGLVNKEIVAALLDMGVQAAGISGVDGATITGQMRATETGYLGDVTAVNTGLINALLDKDITPVISPVSFHHTKRPSG
SRRLININGDPAAGEIAAALQAERLVFMTDVPAVKGKNGEALGEISAEHAAELLSSGTASGGMIPKLRSCLKATLAGASA
CIIDGRIPHMLVRELTEGNCGTTIIGQHLRRS

Specific function: Arginine biosynthesis; second step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI145693208, Length=227, Percent_Identity=29.9559471365639, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320913, Length=230, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGB_DEHE1 (Q3Z730)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181969.1
- HSSP:   Q9HTN2
- ProteinModelPortal:   Q3Z730
- SMR:   Q3Z730
- STRING:   Q3Z730
- GeneID:   3229442
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET1257
- NMPDR:   fig|243164.3.peg.1205
- TIGR:   DET1257
- eggNOG:   COG0548
- HOGENOM:   HBG497643
- OMA:   YLPVLTP
- PhylomeDB:   Q3Z730
- ProtClustDB:   CLSK837031
- BioCyc:   DETH243164:DET_1257-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR001057
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- PRINTS:   PR00474
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 28049; Mature: 28049

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: BINDING 68-68 BINDING 166-166

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSQVSNHIVVIKLGGSVLSSKDTSLKDIAALKQLGLKPVLIHGGASTVSDWSAKLGLE
CCHHHHHCCEEEEEECCCEECCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCE
TRLVNGERVTDDPTLDVVAAVLTGLVNKEIVAALLDMGVQAAGISGVDGATITGQMRATE
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEECEEEECC
TGYLGDVTAVNTGLINALLDKDITPVISPVSFHHTKRPSGSRRLININGDPAAGEIAAAL
CCCCCCHHHHHHHHHHHHHCCCCCHHCCCCHHCCCCCCCCCCEEEEECCCCCHHHHHHHH
QAERLVFMTDVPAVKGKNGEALGEISAEHAAELLSSGTASGGMIPKLRSCLKATLAGASA
HHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCE
CIIDGRIPHMLVRELTEGNCGTTIIGQHLRRS
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNVSQVSNHIVVIKLGGSVLSSKDTSLKDIAALKQLGLKPVLIHGGASTVSDWSAKLGLE
CCHHHHHCCEEEEEECCCEECCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCE
TRLVNGERVTDDPTLDVVAAVLTGLVNKEIVAALLDMGVQAAGISGVDGATITGQMRATE
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEECEEEECC
TGYLGDVTAVNTGLINALLDKDITPVISPVSFHHTKRPSGSRRLININGDPAAGEIAAAL
CCCCCCHHHHHHHHHHHHHCCCCCHHCCCCHHCCCCCCCCCCEEEEECCCCCHHHHHHHH
QAERLVFMTDVPAVKGKNGEALGEISAEHAAELLSSGTASGGMIPKLRSCLKATLAGASA
HHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCE
CIIDGRIPHMLVRELTEGNCGTTIIGQHLRRS
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA