Click here to switch to the map view.

The map label for this gene is argF [H]

Identifier: 57233867

GI number: 57233867

Start: 1260764

End: 1261699

Strand: Direct

Name: argF [H]

Synonym: DET1394

Alternate gene names: 57233867

Gene position: 1260764-1261699 (Clockwise)

Preceding gene: 57233874

Following gene: 57233850

Centisome position: 85.78

GC content: 53.1

Gene sequence:

>936_bases
GTGAACACCAAGGACCTGCTGTCTATTTCAGACCTTTCCCCTGACGATATCGGGCGTCTGCTTTCAGATGCCATTGAACT
TAAAGCCAGGGGCTGGAACAGCTGTCTTTCCGGTAAAACTCTGGCTCTGGTCTTTGAAAAACCCTCCCTGCGTACCCGGG
TCAGCTTTGAGCTGGCCATGAAGCAGCTGGGCGGGGAAGCACTGTATCTTTCACCGGCTGAGGTAGGTTTGGGCAAACGC
GAACCGGTGGCTGACGTGGCCAGAGTGCTAGCCCGTTTTGTAGACGTTATCGCCTGCCGCACCTTCGGGCATGATACCCT
GGTACAGCTGGCAAAATATGCCGATATACCTGTTATAAACGCCCTTTCAGACTTGGAGCACCCCTGCCAGGCACTGGCGG
ATATCCTGACCATTTACGAGAAAAAGGGCGAACTCAAGGGGCTTAATCTGGCTTACATAGGTGATGGCAACAACTGTGCC
AACAGCCTTTTGCTGGCCTGCGCCATGACGGGAATAAACTGCCGCTTGGCTTCACCCGAAGGCTATCTGGTAGACAAGGC
CATATTTGCTAAGGCCAAAGCTTACGCAGAAGACAGCGGGGCTGAACTATACAGCGGGACAGACCTTAAGGCCGCCCTCC
GCGGGGCTGACGTAATCTATACAGATGTCTGGACCAGTATGGGACAGGAAGCTGAAACTGAAAAACGCCTTAAGGATTTT
GCGGGTTTTCAGGTGAATGCCAAGCTGGTTTCCATGGCTGATAAAGATGCCATCATTATGCACCCTCTGCCGGCTCATTA
CGGTGAAGAGGTTGACCGGGAAATACTGGAATGCCCTCAGTCTGTTATCTTTGACCAGGCCGAAAACCGGCTGCATGCCC
AAAAGGCGGTACTAAGAGATATGCTGGGTGGACTGGAGATAGGCGGCAGGCACTAA

Upstream 100 bases:

>100_bases
CTATTTGCTACAAAAAGACCCTCTCCCGCCCGGTCATTAAAGTATCCAGATAAACACTTTAATGCTATAATTAAGGGTAA
TTGTGTGCCGGAGGCGAAAA

Downstream 100 bases:

>100_bases
GCGGCCGTGAAATATATGAATAATACTACCCCTATTATTGCCATTGTGGGGCGGCAGAACGTGGGTAAATCCACCCTGCT
TAACCGCCTTGCCCATAAGA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNTKDLLSISDLSPDDIGRLLSDAIELKARGWNSCLSGKTLALVFEKPSLRTRVSFELAMKQLGGEALYLSPAEVGLGKR
EPVADVARVLARFVDVIACRTFGHDTLVQLAKYADIPVINALSDLEHPCQALADILTIYEKKGELKGLNLAYIGDGNNCA
NSLLLACAMTGINCRLASPEGYLVDKAIFAKAKAYAEDSGAELYSGTDLKAALRGADVIYTDVWTSMGQEAETEKRLKDF
AGFQVNAKLVSMADKDAIIMHPLPAHYGEEVDREILECPQSVIFDQAENRLHAQKAVLRDMLGGLEIGGRH

Sequences:

>Translated_311_residues
MNTKDLLSISDLSPDDIGRLLSDAIELKARGWNSCLSGKTLALVFEKPSLRTRVSFELAMKQLGGEALYLSPAEVGLGKR
EPVADVARVLARFVDVIACRTFGHDTLVQLAKYADIPVINALSDLEHPCQALADILTIYEKKGELKGLNLAYIGDGNNCA
NSLLLACAMTGINCRLASPEGYLVDKAIFAKAKAYAEDSGAELYSGTDLKAALRGADVIYTDVWTSMGQEAETEKRLKDF
AGFQVNAKLVSMADKDAIIMHPLPAHYGEEVDREILECPQSVIFDQAENRLHAQKAVLRDMLGGLEIGGRH
>Mature_311_residues
MNTKDLLSISDLSPDDIGRLLSDAIELKARGWNSCLSGKTLALVFEKPSLRTRVSFELAMKQLGGEALYLSPAEVGLGKR
EPVADVARVLARFVDVIACRTFGHDTLVQLAKYADIPVINALSDLEHPCQALADILTIYEKKGELKGLNLAYIGDGNNCA
NSLLLACAMTGINCRLASPEGYLVDKAIFAKAKAYAEDSGAELYSGTDLKAALRGADVIYTDVWTSMGQEAETEKRLKDF
AGFQVNAKLVSMADKDAIIMHPLPAHYGEEVDREILECPQSVIFDQAENRLHAQKAVLRDMLGGLEIGGRH

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=304, Percent_Identity=40.1315789473684, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI18105007, Length=310, Percent_Identity=29.3548387096774, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786469, Length=327, Percent_Identity=38.5321100917431, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1790703, Length=322, Percent_Identity=37.2670807453416, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI2367364, Length=304, Percent_Identity=29.2763157894737, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI48994908, Length=317, Percent_Identity=25.5520504731861, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193204318, Length=334, Percent_Identity=26.6467065868263, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322373, Length=309, Percent_Identity=36.2459546925566, Blast_Score=190, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6322331, Length=308, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24642586, Length=311, Percent_Identity=28.6173633440514, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 33784; Mature: 33784

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTKDLLSISDLSPDDIGRLLSDAIELKARGWNSCLSGKTLALVFEKPSLRTRVSFELAM
CCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEEECCCCCHHHHHHHHH
KQLGGEALYLSPAEVGLGKREPVADVARVLARFVDVIACRTFGHDTLVQLAKYADIPVIN
HHHCCCEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHH
ALSDLEHPCQALADILTIYEKKGELKGLNLAYIGDGNNCANSLLLACAMTGINCRLASPE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCC
GYLVDKAIFAKAKAYAEDSGAELYSGTDLKAALRGADVIYTDVWTSMGQEAETEKRLKDF
CCCHHHHHHHHHHHHHCCCCCCEECCCCHHHHHCCCCEEEHHHHHHCCCCHHHHHHHHHH
AGFQVNAKLVSMADKDAIIMHPLPAHYGEEVDREILECPQSVIFDQAENRLHAQKAVLRD
CCCEECHHHEEECCCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
MLGGLEIGGRH
HHCCCCCCCCC
>Mature Secondary Structure
MNTKDLLSISDLSPDDIGRLLSDAIELKARGWNSCLSGKTLALVFEKPSLRTRVSFELAM
CCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEEECCCCCHHHHHHHHH
KQLGGEALYLSPAEVGLGKREPVADVARVLARFVDVIACRTFGHDTLVQLAKYADIPVIN
HHHCCCEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHH
ALSDLEHPCQALADILTIYEKKGELKGLNLAYIGDGNNCANSLLLACAMTGINCRLASPE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCC
GYLVDKAIFAKAKAYAEDSGAELYSGTDLKAALRGADVIYTDVWTSMGQEAETEKRLKDF
CCCHHHHHHHHHHHHHCCCCCCEECCCCHHHHHCCCCEEEHHHHHHCCCCHHHHHHHHHH
AGFQVNAKLVSMADKDAIIMHPLPAHYGEEVDREILECPQSVIFDQAENRLHAQKAVLRD
CCCEECHHHEEECCCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
MLGGLEIGGRH
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]