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The map label for this gene is engA [H]

Identifier: 57233850

GI number: 57233850

Start: 1261715

End: 1263040

Strand: Direct

Name: engA [H]

Synonym: DET1395

Alternate gene names: 57233850

Gene position: 1261715-1263040 (Clockwise)

Preceding gene: 57233867

Following gene: 57233849

Centisome position: 85.85

GC content: 48.42

Gene sequence:

>1326_bases
ATGAATAATACTACCCCTATTATTGCCATTGTGGGGCGGCAGAACGTGGGTAAATCCACCCTGCTTAACCGCCTTGCCCA
TAAGAATCTGGCCATTACCGAAGACCTGCCCGGTACTACCCGTGACCGTTTGTTTACGACTGTAAGCTGGCTGGACCGCC
GGCTGATTATGGTGGATACCGGCGGGCTTGACCCGGATCTTGAGAGCATTATCGGCCAGCAGGTAAATATCCAGATAAGT
CTGGCCATAAAAGAAGCCGATCTGGTACTTTTGGTAGTAGACGTAAAAGCCGGGCTGATTACACCTGACTACGAAATGGC
AGATATTATCCGCCGCACCGGTAAACCGGTAATACTGGTGGCCAATAAAGCCGACAACCTGAAAATGGGCCAGGAAGCCG
CTGAATTTTACAGCCTGGGCTTTGGCGAACCTTCGGTTATCAGTGCCTTCCACGGCAGCGGCATTTCAGACCTGATGGAC
CGGGTGCTGGAAGAACTGCCTGACCAGCCCATTGCCACCCCAGAAGAGGACAATTCGGTTAAGCTGGCACTTGTGGGAAG
AACCAATGTAGGTAAATCCACCCTGCTTAATACCTTTATGGGACAGGAACGCTCTATAGTAAGCAATATACCCGGTACTA
CCAGAGATGCTATTGACACACCTCTTAACTTTAATGGTACTAATGTGTTACTTATAGATACTGCAGGGATAAGACGGCGC
GGTAAAGTTGAGAGCGGTGTTGAAAAATACAGCGTACTCAGAGCCTTAAAAGCTGTAGACCGGGCAGACATAGTACTGCT
GGTTATGGATACTGAAGAGCTGGTGACCGCTCAGGACACCCACATTGCCGGATATGTCCGGGATACCGCCAAGGGTATTA
TAATTATCCTGAATAAATGGGATCTGGGTAAAGGCCAGGACAAAGCTGAAGTGACACAGACTATCCAGAGTAGATTTAAG
TTTTTGGATTACGCTCCGATATTGTTTGTTTCAGGCAAAACCGGGCGTGGTGTTGATACTATTATCCCCATGGCGCTGAA
AGTTCAGGAAGAGCGCAACAAACGTATTCCCACTGCCAAGGTAAACAGCGTGGTCACCGAAGCCCTCTCTGCCCATACCC
CGCCCCATCAGGGCAAAACCCAGCTGAAAATCTATTACGCCACCCAGGCAGACACCAATCCGCCTTCATTTGTGTTTTTC
GTCAATAACCCTAAACTGGTTCATTTTTCGTATGAACGCTTTATTGAAAACCGTCTCAGGGAGTCTTTCGGATTTTTCGG
TACCCCAATCCGTTTAACTTTTAAAGCCCGAGGTGAAAAATGTTAA

Upstream 100 bases:

>100_bases
TGACCAGGCCGAAAACCGGCTGCATGCCCAAAAGGCGGTACTAAGAGATATGCTGGGTGGACTGGAGATAGGCGGCAGGC
ACTAAGCGGCCGTGAAATAT

Downstream 100 bases:

>100_bases
TTGCCAAGCTTCTGCTTGTTGTTATAGTAAGTTATCTCCTGGGTTCAATCCCCTTTGGGTATTTAGTCAGCCACCGCGGT
TCCAAAATAGATATCCGCAG

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNNTTPIIAIVGRQNVGKSTLLNRLAHKNLAITEDLPGTTRDRLFTTVSWLDRRLIMVDTGGLDPDLESIIGQQVNIQIS
LAIKEADLVLLVVDVKAGLITPDYEMADIIRRTGKPVILVANKADNLKMGQEAAEFYSLGFGEPSVISAFHGSGISDLMD
RVLEELPDQPIATPEEDNSVKLALVGRTNVGKSTLLNTFMGQERSIVSNIPGTTRDAIDTPLNFNGTNVLLIDTAGIRRR
GKVESGVEKYSVLRALKAVDRADIVLLVMDTEELVTAQDTHIAGYVRDTAKGIIIILNKWDLGKGQDKAEVTQTIQSRFK
FLDYAPILFVSGKTGRGVDTIIPMALKVQEERNKRIPTAKVNSVVTEALSAHTPPHQGKTQLKIYYATQADTNPPSFVFF
VNNPKLVHFSYERFIENRLRESFGFFGTPIRLTFKARGEKC

Sequences:

>Translated_441_residues
MNNTTPIIAIVGRQNVGKSTLLNRLAHKNLAITEDLPGTTRDRLFTTVSWLDRRLIMVDTGGLDPDLESIIGQQVNIQIS
LAIKEADLVLLVVDVKAGLITPDYEMADIIRRTGKPVILVANKADNLKMGQEAAEFYSLGFGEPSVISAFHGSGISDLMD
RVLEELPDQPIATPEEDNSVKLALVGRTNVGKSTLLNTFMGQERSIVSNIPGTTRDAIDTPLNFNGTNVLLIDTAGIRRR
GKVESGVEKYSVLRALKAVDRADIVLLVMDTEELVTAQDTHIAGYVRDTAKGIIIILNKWDLGKGQDKAEVTQTIQSRFK
FLDYAPILFVSGKTGRGVDTIIPMALKVQEERNKRIPTAKVNSVVTEALSAHTPPHQGKTQLKIYYATQADTNPPSFVFF
VNNPKLVHFSYERFIENRLRESFGFFGTPIRLTFKARGEKC
>Mature_441_residues
MNNTTPIIAIVGRQNVGKSTLLNRLAHKNLAITEDLPGTTRDRLFTTVSWLDRRLIMVDTGGLDPDLESIIGQQVNIQIS
LAIKEADLVLLVVDVKAGLITPDYEMADIIRRTGKPVILVANKADNLKMGQEAAEFYSLGFGEPSVISAFHGSGISDLMD
RVLEELPDQPIATPEEDNSVKLALVGRTNVGKSTLLNTFMGQERSIVSNIPGTTRDAIDTPLNFNGTNVLLIDTAGIRRR
GKVESGVEKYSVLRALKAVDRADIVLLVMDTEELVTAQDTHIAGYVRDTAKGIIIILNKWDLGKGQDKAEVTQTIQSRFK
FLDYAPILFVSGKTGRGVDTIIPMALKVQEERNKRIPTAKVNSVVTEALSAHTPPHQGKTQLKIYYATQADTNPPSFVFF
VNNPKLVHFSYERFIENRLRESFGFFGTPIRLTFKARGEKC

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis [H]

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain [H]

Homologues:

Organism=Homo sapiens, GI193082991, Length=134, Percent_Identity=34.3283582089552, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI193082988, Length=134, Percent_Identity=34.3283582089552, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI87082120, Length=459, Percent_Identity=38.1263616557734, Blast_Score=318, Evalue=5e-88,
Organism=Escherichia coli, GI1788919, Length=178, Percent_Identity=36.5168539325843, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI2367268, Length=164, Percent_Identity=31.7073170731707, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17507259, Length=126, Percent_Identity=37.3015873015873, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323665, Length=168, Percent_Identity=38.6904761904762, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550813, Length=120, Percent_Identity=37.5, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 48660; Mature: 48660

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTTPIIAIVGRQNVGKSTLLNRLAHKNLAITEDLPGTTRDRLFTTVSWLDRRLIMVDT
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCEEEEEEC
GGLDPDLESIIGQQVNIQISLAIKEADLVLLVVDVKAGLITPDYEMADIIRRTGKPVILV
CCCCCCHHHHCCCEEEEEEEEEEEECCEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEE
ANKADNLKMGQEAAEFYSLGFGEPSVISAFHGSGISDLMDRVLEELPDQPIATPEEDNSV
ECCCCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCE
KLALVGRTNVGKSTLLNTFMGQERSIVSNIPGTTRDAIDTPLNFNGTNVLLIDTAGIRRR
EEEEEECCCCCHHHHHHHHHCCCHHHHHCCCCCCHHHCCCCCCCCCCEEEEEECCCCCCC
GKVESGVEKYSVLRALKAVDRADIVLLVMDTEELVTAQDTHIAGYVRDTAKGIIIILNKW
CCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCEEEEEEECCCCEEEEEEECC
DLGKGQDKAEVTQTIQSRFKFLDYAPILFVSGKTGRGVDTIIPMALKVQEERNKRIPTAK
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHEEEEHHHCCCCCCHH
VNSVVTEALSAHTPPHQGKTQLKIYYATQADTNPPSFVFFVNNPKLVHFSYERFIENRLR
HHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCEEEEEECCCEEEEEEHHHHHHHHHH
ESFGFFGTPIRLTFKARGEKC
HHHCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MNNTTPIIAIVGRQNVGKSTLLNRLAHKNLAITEDLPGTTRDRLFTTVSWLDRRLIMVDT
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCEEEEEEC
GGLDPDLESIIGQQVNIQISLAIKEADLVLLVVDVKAGLITPDYEMADIIRRTGKPVILV
CCCCCCHHHHCCCEEEEEEEEEEEECCEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEE
ANKADNLKMGQEAAEFYSLGFGEPSVISAFHGSGISDLMDRVLEELPDQPIATPEEDNSV
ECCCCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCE
KLALVGRTNVGKSTLLNTFMGQERSIVSNIPGTTRDAIDTPLNFNGTNVLLIDTAGIRRR
EEEEEECCCCCHHHHHHHHHCCCHHHHHCCCCCCHHHCCCCCCCCCCEEEEEECCCCCCC
GKVESGVEKYSVLRALKAVDRADIVLLVMDTEELVTAQDTHIAGYVRDTAKGIIIILNKW
CCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCEEEEEEECCCCEEEEEEECC
DLGKGQDKAEVTQTIQSRFKFLDYAPILFVSGKTGRGVDTIIPMALKVQEERNKRIPTAK
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHEEEEHHHCCCCCCHH
VNSVVTEALSAHTPPHQGKTQLKIYYATQADTNPPSFVFFVNNPKLVHFSYERFIENRLR
HHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCEEEEEECCCEEEEEEHHHHHHHHHH
ESFGFFGTPIRLTFKARGEKC
HHHCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]