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The map label for this gene is purM [H]

Identifier: 57233808

GI number: 57233808

Start: 1286352

End: 1287374

Strand: Direct

Name: purM [H]

Synonym: DET1416

Alternate gene names: 57233808

Gene position: 1286352-1287374 (Clockwise)

Preceding gene: 57233809

Following gene: 57233807

Centisome position: 87.52

GC content: 50.64

Gene sequence:

>1023_bases
TTGAGAGGTGGGCACATCAAAGATACATATGCCGGGGCAGGAGTAGATATAAATTCCGCCTCAAAATCAAAAGAACTCAT
CAAGCAGTACGCCAAAGCCACTTTGGGCTCCCAGGTACTGGCCGGGCCGGGATTTTTCGGCGGAATGTACGAATTCAAAG
GCTACAAAAACCCGGTGCTGGTTTCCAGTTGTGATGGAGTAGGCACCAAACTGAAACTGGCCGGGGTGCTGAATAAACAT
GACACTATAGGCATTGACATTGTCAACCACTCTGTCAATGATATACTGACCTCCGGGGCTGAACCAATCTTTTTCCTTGA
TTACATAGCCATGGGCAAACTTTCGCCTGAAAAAATAGCCGACATTGTCAAGGGACTGTCTACCGCCTGTCTAGAGGCGG
GCTGCGCCCTTATCGGCGGAGAAACGGCCGAAATGCCCGGCCTTTACCACGGGGAAGATTATGATTTGGCCGGCTTTATC
GTAGGGGTAGTTGAAAAGGAAAATATGCTTATCAACCGGGGTATCAAACCGGGAGATGTCATTTTGGGTCTGGCTTCAAA
CGGACTCCACACCAACGGTTATTCGCTGGCACGCAAAGTTCTGGGCGAAAGCCGCGAAGCTCTGGATAAATATTATCCCG
AACTGGGGCAAACCGCAGGCGAAGCCCTGCTGGTGCCTCACCGCAGTTATCTGAAAGAAATAAAGCCCAACCTCCCCCTC
ATAAAAGGGCTGGCCCACATAACCGGCGGAGGCCTGACAGACAATGTCCCCAGGACACTGCCCGAAGATGTATCCGCCCG
TTTTGAAACTAAAAACTGGGAAATACCGCCCCTCCTCCAGCTTATCCAGAAAACCGGGGGAATAGACCGCGAAGAGATGT
TCCACGTGTTTAATATGGGTATAGGCATGGTGATTATAGCCGGCAGCGAAGAGGCCGCTCTGATAATGCAAAATCTGCCG
GAAGCAAAAGTAATCGGGGAGATTGCAGCCCGCCAAAGCGGAGTGCAGGTAATAATTGAATAA

Upstream 100 bases:

>100_bases
GGAGTTATTCCGGATTTAACACCGCCCGAAGTTTTATACCTTCGGCGGTGTTTTTTCTTTGCAGTTGATAGCTATTTCTG
ATAATCTTAGTTACCACAAT

Downstream 100 bases:

>100_bases
GCAGCCGGGATTCTTTCCAGAGGCAGCTTTTTCACAGACTATACGGGCATAGCTGCCAAGAGCAGCTTGCCGCAAATATA
TTTATGCACCTGGTAAAAAT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRGGHIKDTYAGAGVDINSASKSKELIKQYAKATLGSQVLAGPGFFGGMYEFKGYKNPVLVSSCDGVGTKLKLAGVLNKH
DTIGIDIVNHSVNDILTSGAEPIFFLDYIAMGKLSPEKIADIVKGLSTACLEAGCALIGGETAEMPGLYHGEDYDLAGFI
VGVVEKENMLINRGIKPGDVILGLASNGLHTNGYSLARKVLGESREALDKYYPELGQTAGEALLVPHRSYLKEIKPNLPL
IKGLAHITGGGLTDNVPRTLPEDVSARFETKNWEIPPLLQLIQKTGGIDREEMFHVFNMGIGMVIIAGSEEAALIMQNLP
EAKVIGEIAARQSGVQVIIE

Sequences:

>Translated_340_residues
MRGGHIKDTYAGAGVDINSASKSKELIKQYAKATLGSQVLAGPGFFGGMYEFKGYKNPVLVSSCDGVGTKLKLAGVLNKH
DTIGIDIVNHSVNDILTSGAEPIFFLDYIAMGKLSPEKIADIVKGLSTACLEAGCALIGGETAEMPGLYHGEDYDLAGFI
VGVVEKENMLINRGIKPGDVILGLASNGLHTNGYSLARKVLGESREALDKYYPELGQTAGEALLVPHRSYLKEIKPNLPL
IKGLAHITGGGLTDNVPRTLPEDVSARFETKNWEIPPLLQLIQKTGGIDREEMFHVFNMGIGMVIIAGSEEAALIMQNLP
EAKVIGEIAARQSGVQVIIE
>Mature_340_residues
MRGGHIKDTYAGAGVDINSASKSKELIKQYAKATLGSQVLAGPGFFGGMYEFKGYKNPVLVSSCDGVGTKLKLAGVLNKH
DTIGIDIVNHSVNDILTSGAEPIFFLDYIAMGKLSPEKIADIVKGLSTACLEAGCALIGGETAEMPGLYHGEDYDLAGFI
VGVVEKENMLINRGIKPGDVILGLASNGLHTNGYSLARKVLGESREALDKYYPELGQTAGEALLVPHRSYLKEIKPNLPL
IKGLAHITGGGLTDNVPRTLPEDVSARFETKNWEIPPLLQLIQKTGGIDREEMFHVFNMGIGMVIIAGSEEAALIMQNLP
EAKVIGEIAARQSGVQVIIE

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=44.8071216617211, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=44.8071216617211, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=44.8071216617211, Blast_Score=276, Evalue=2e-74,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=44.3148688046647, Blast_Score=279, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17567511, Length=323, Percent_Identity=38.6996904024768, Blast_Score=201, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6321203, Length=335, Percent_Identity=39.1044776119403, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24582400, Length=296, Percent_Identity=38.5135135135135, Blast_Score=207, Evalue=9e-54,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36287; Mature: 36287

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGGHIKDTYAGAGVDINSASKSKELIKQYAKATLGSQVLAGPGFFGGMYEFKGYKNPVL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHCCCCCCCEE
VSSCDGVGTKLKLAGVLNKHDTIGIDIVNHSVNDILTSGAEPIFFLDYIAMGKLSPEKIA
EECCCCCCCEEEEEECCCCCCEEEEEEECCCHHHHHHCCCCCEEHHHHHHHCCCCHHHHH
DIVKGLSTACLEAGCALIGGETAEMPGLYHGEDYDLAGFIVGVVEKENMLINRGIKPGDV
HHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCHHHHEEEEECCCCCCEECCCCCCCE
ILGLASNGLHTNGYSLARKVLGESREALDKYYPELGQTAGEALLVPHRSYLKEIKPNLPL
EEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCHH
IKGLAHITGGGLTDNVPRTLPEDVSARFETKNWEIPPLLQLIQKTGGIDREEMFHVFNMG
HHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCC
IGMVIIAGSEEAALIMQNLPEAKVIGEIAARQSGVQVIIE
CCEEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCCEEEEC
>Mature Secondary Structure
MRGGHIKDTYAGAGVDINSASKSKELIKQYAKATLGSQVLAGPGFFGGMYEFKGYKNPVL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHCCCCCCCEE
VSSCDGVGTKLKLAGVLNKHDTIGIDIVNHSVNDILTSGAEPIFFLDYIAMGKLSPEKIA
EECCCCCCCEEEEEECCCCCCEEEEEEECCCHHHHHHCCCCCEEHHHHHHHCCCCHHHHH
DIVKGLSTACLEAGCALIGGETAEMPGLYHGEDYDLAGFIVGVVEKENMLINRGIKPGDV
HHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCHHHHEEEEECCCCCCEECCCCCCCE
ILGLASNGLHTNGYSLARKVLGESREALDKYYPELGQTAGEALLVPHRSYLKEIKPNLPL
EEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCHH
IKGLAHITGGGLTDNVPRTLPEDVSARFETKNWEIPPLLQLIQKTGGIDREEMFHVFNMG
HHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCC
IGMVIIAGSEEAALIMQNLPEAKVIGEIAARQSGVQVIIE
CCEEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA