| Definition | Corynebacterium diphtheriae NCTC 13129 chromosome, complete genome. |
|---|---|
| Accession | NC_002935 |
| Length | 2,488,635 |
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The map label for this gene is trxA [H]
Identifier: 38234907
GI number: 38234907
Start: 2481269
End: 2481592
Strand: Direct
Name: trxA [H]
Synonym: DIP2374
Alternate gene names: 38234907
Gene position: 2481269-2481592 (Clockwise)
Preceding gene: 38234906
Following gene: 38234908
Centisome position: 99.7
GC content: 49.69
Gene sequence:
>324_bases ATGTCAAACGCTATTGCTTTAACCCAGGACACGTTCAAGAGCATTGTTATCGACTCGGATAAGCCGGTGTTGGTTGATTT TTGGGCGCAGTGGTGTGGGCCGTGCAAGAAGCTTGGACCTATCATCGATGAGATCGCAGAAGAGCTTGGCGACGAAGTCC TAGTGGCCAAGGTAGACGTGGATGCGGAGCGCAATCTTGGCGCAATGTTCCAGATCATGTCTATTCCCACAGTTTTGATC TTCAAGGACGGCCAGAAGGTTTCCGAATTTGTGGGAGTTCGTCCGAAATCTGAGATCGTGGCAAAGCTGCGTTCTTTTCT ATGA
Upstream 100 bases:
>100_bases ACTACCAGCAGGCCATTACTGCGGCTGGTTCCGGTTGCCGCGGAGCTATCGACGCCGAGCATTACCTGGCAGCACTGAAT TCTTAAAGGAGCATTTACTC
Downstream 100 bases:
>100_bases CTGCTAAACTTTCCTAAGTTATGCATTTAGCGAAGGAAAGGAGCAGTGTGTCTGGCACGTTGAGAGTCGGCGACCGTAGC CCACGCATCGCCGAAGTCAG
Product: thioredoxin
Products: NA
Alternate protein names: Trx-1; Thioredoxin-M [H]
Number of amino acids: Translated: 107; Mature: 106
Protein sequence:
>107_residues MSNAIALTQDTFKSIVIDSDKPVLVDFWAQWCGPCKKLGPIIDEIAEELGDEVLVAKVDVDAERNLGAMFQIMSIPTVLI FKDGQKVSEFVGVRPKSEIVAKLRSFL
Sequences:
>Translated_107_residues MSNAIALTQDTFKSIVIDSDKPVLVDFWAQWCGPCKKLGPIIDEIAEELGDEVLVAKVDVDAERNLGAMFQIMSIPTVLI FKDGQKVSEFVGVRPKSEIVAKLRSFL >Mature_106_residues SNAIALTQDTFKSIVIDSDKPVLVDFWAQWCGPCKKLGPIIDEIAEELGDEVLVAKVDVDAERNLGAMFQIMSIPTVLIF KDGQKVSEFVGVRPKSEIVAKLRSFL
Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]
COG id: COG0526
COG function: function code OC; Thiol-disulfide isomerase and thioredoxins
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 thioredoxin domain [H]
Homologues:
Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=39.5833333333333, Blast_Score=87, Evalue=2e-18, Organism=Homo sapiens, GI4758304, Length=103, Percent_Identity=38.8349514563107, Blast_Score=71, Evalue=2e-13, Organism=Homo sapiens, GI21361657, Length=105, Percent_Identity=36.1904761904762, Blast_Score=70, Evalue=3e-13, Organism=Homo sapiens, GI5031973, Length=104, Percent_Identity=34.6153846153846, Blast_Score=69, Evalue=5e-13, Organism=Homo sapiens, GI42794771, Length=94, Percent_Identity=36.1702127659575, Blast_Score=66, Evalue=6e-12, Organism=Homo sapiens, GI224493972, Length=94, Percent_Identity=36.1702127659575, Blast_Score=66, Evalue=7e-12, Organism=Homo sapiens, GI50592994, Length=75, Percent_Identity=41.3333333333333, Blast_Score=65, Evalue=9e-12, Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=42.7184466019417, Blast_Score=94, Evalue=3e-21, Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=45.1612903225806, Blast_Score=90, Evalue=3e-20, Organism=Escherichia coli, GI87081747, Length=102, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-14, Organism=Caenorhabditis elegans, GI212646193, Length=82, Percent_Identity=46.3414634146341, Blast_Score=81, Evalue=8e-17, Organism=Caenorhabditis elegans, GI17554386, Length=101, Percent_Identity=37.6237623762376, Blast_Score=70, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=38.3720930232558, Blast_Score=68, Evalue=9e-13, Organism=Caenorhabditis elegans, GI32566189, Length=105, Percent_Identity=34.2857142857143, Blast_Score=68, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17569137, Length=105, Percent_Identity=34.2857142857143, Blast_Score=68, Evalue=1e-12, Organism=Caenorhabditis elegans, GI193209454, Length=105, Percent_Identity=34.2857142857143, Blast_Score=68, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17507915, Length=93, Percent_Identity=36.5591397849462, Blast_Score=67, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17556044, Length=105, Percent_Identity=30.4761904761905, Blast_Score=66, Evalue=3e-12, Organism=Caenorhabditis elegans, GI115532380, Length=80, Percent_Identity=37.5, Blast_Score=65, Evalue=6e-12, Organism=Caenorhabditis elegans, GI115532378, Length=80, Percent_Identity=37.5, Blast_Score=65, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17507705, Length=87, Percent_Identity=31.0344827586207, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17544108, Length=80, Percent_Identity=37.5, Blast_Score=64, Evalue=2e-11, Organism=Caenorhabditis elegans, GI25144092, Length=99, Percent_Identity=34.3434343434343, Blast_Score=63, Evalue=4e-11, Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=37.2093023255814, Blast_Score=74, Evalue=4e-15, Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=38.2716049382716, Blast_Score=70, Evalue=7e-14, Organism=Saccharomyces cerevisiae, GI6319925, Length=86, Percent_Identity=31.3953488372093, Blast_Score=62, Evalue=1e-11, Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=38.2978723404255, Blast_Score=77, Evalue=3e-15, Organism=Drosophila melanogaster, GI28573567, Length=95, Percent_Identity=36.8421052631579, Blast_Score=77, Evalue=3e-15, Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=43.5897435897436, Blast_Score=75, Evalue=9e-15, Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=43.5897435897436, Blast_Score=75, Evalue=9e-15, Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=40.5405405405405, Blast_Score=71, Evalue=1e-13, Organism=Drosophila melanogaster, GI24639068, Length=82, Percent_Identity=40.2439024390244, Blast_Score=70, Evalue=2e-13, Organism=Drosophila melanogaster, GI19921434, Length=103, Percent_Identity=35.9223300970874, Blast_Score=70, Evalue=3e-13, Organism=Drosophila melanogaster, GI17530795, Length=89, Percent_Identity=29.2134831460674, Blast_Score=69, Evalue=6e-13, Organism=Drosophila melanogaster, GI17647799, Length=87, Percent_Identity=41.3793103448276, Blast_Score=67, Evalue=3e-12, Organism=Drosophila melanogaster, GI24664525, Length=87, Percent_Identity=41.3793103448276, Blast_Score=66, Evalue=3e-12, Organism=Drosophila melanogaster, GI21358065, Length=92, Percent_Identity=34.7826086956522, Blast_Score=62, Evalue=7e-11,
Paralogues:
None
Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005746 - InterPro: IPR017936 - InterPro: IPR012336 - InterPro: IPR017937 - InterPro: IPR013766 - InterPro: IPR012335 [H]
Pfam domain/function: PF00085 Thioredoxin [H]
EC number: NA
Molecular weight: Translated: 11825; Mature: 11694
Theoretical pI: Translated: 4.49; Mature: 4.49
Prosite motif: PS00194 THIOREDOXIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.9 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 4.7 %Cys+Met (Translated Protein) 1.9 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 3.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSNAIALTQDTFKSIVIDSDKPVLVDFWAQWCGPCKKLGPIIDEIAEELGDEVLVAKVDV CCCCEECHHHHHHHEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECC DAERNLGAMFQIMSIPTVLIFKDGQKVSEFVGVRPKSEIVAKLRSFL CCCCCHHHHHHHHCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHCC >Mature Secondary Structure SNAIALTQDTFKSIVIDSDKPVLVDFWAQWCGPCKKLGPIIDEIAEELGDEVLVAKVDV CCCEECHHHHHHHEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECC DAERNLGAMFQIMSIPTVLIFKDGQKVSEFVGVRPKSEIVAKLRSFL CCCCCHHHHHHHHCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 2492995 [H]