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The map label for this gene is trpE [H]

Identifier: 38234886

GI number: 38234886

Start: 2458035

End: 2459588

Strand: Direct

Name: trpE [H]

Synonym: DIP2352

Alternate gene names: 38234886

Gene position: 2458035-2459588 (Clockwise)

Preceding gene: 38234885

Following gene: 38234887

Centisome position: 98.77

GC content: 52.9

Gene sequence:

>1554_bases
ATGGCAGATTTCCATGCATCCGCCCGCGAGGTGCGCTATCACGAGGATGCCGCCGACCTCTTTCATCATCTTGGCGGGAC
CTCGGCTAGTGACTCCGTTCTTTTAGAGTCCGCAGACATTAAATCCAAGAAGAACACCACATCCATGGCAGTACTTCAAT
CAGCGGTTCGCGTGACGTGCATGGGGCAAACCGTGACCGCCACGCCCCTAACATCTACGGGCCATACAATGGTGGCGCGC
CTACAGGAGCACTTTGGCACGAGCGGCACGAAATTTAGTTTCCGCCGCTCCGAGCTTCACGACGAACGCCAGCGCCTCCT
TGACACCAATAACGCCGAGATTCTTCGCCTCCTACAGTGTGAGGCCGGCTATTCCGGTGAGCAGTTACCACTTCTTGCCG
GCGGTTTCGCCTTCGACTACGTGGAGACATTTGAGCAATTACCTCCTGTACCGGTAGGGGATAATTCTTATCCCGATTAC
CAGTTTGTGGTGGCAGAAACAGTGCTGGTGACCGATCATCTCAAGCGCAGTGCGGTTATCGAGGGCGTGTCCATTGATCC
AAGCGAGTTGGAGGATCGACTAGATTCCCTTGTTGCCACGATTGACAGCCATGAAACAGTCGAGGAATGTCCCGCGACCA
CGGCAACCAATGAGATATTGACTGTGCGTGCCGATATTTCTGATGTGGATTTTTGCCAAAGCGTAAGCGCACTGCAGGAC
AATATCCAGGCGGGAGACATCTATCAGGTGGTTCCAGCACGCAGCTTTAGCGCGCCCTGTGAGAGTGCTTATGCAGCTTA
TAGACACTTGCGCACAATCAATCCCAGCCCCTATATGTTTTACGTGCGCGGCATTACCCCCATTTCATGCAATTCAAATA
AAACATATGAGCTGATAGGAGCGTCGCCGGAGTCTAATCTCAAGTTCGATTCCAGAACACGCGAGATACAATTGTATCCG
ATCGCCGGTACCCGGCCACGGGGACTTAATCCCGACGGGAGTATTAATCACGAACTCGACATTCGTGCCGAGCTGGATAT
GCGAACTAACGTCAAGGAAATCGCCGAACATACTATGCTAGTTGATCTTGCACGCAATGATCTTGCACGTGTTTCATTGC
CCACAACACGTCGCGTTGCAGAGTTATTGCAGGTAGATCGCTACTCCCGGGTGATGCATCTCGTTAGCCGTGTGGTAGCT
ACGCTGGATCCAGAGTTCGACGCTATTAACGCCTACCGTGCCTGCATGAACATGGGAACGCTAACCGGAGCACCAAAATT
GCGCGCAATTGAATTACTGCGAGGTGTGGAAGCTAAACGTCGCGGTTCCTATGGTGGTGCGGTTGGATACCTTCAAGGAG
ATGGCTCCATGGATACTTGCATTGTCATTCGTTCCGCCTTTATTCAGGATGGGGTAGCGGTGGTACAGGCCGGTGCCGGA
GTGGTGCGGGATTCTATTCCACAATCAGAGGCCGATGAAACACTCCATAAGGCCTATGCCGTTTTGCATGCCATTGCATT
GGCGGCCGGAAAGGATCTGGAGGTGGTTCGCTAA

Upstream 100 bases:

>100_bases
CTACCGAGGATCCAGCAACCTCACCAGTCACGGATCCTCATGTCGCCGAAACCCTCGTCACAATGATCGCTGAGTCCAAT
GCACGAGAGGGAGTCTAAGC

Downstream 100 bases:

>100_bases
TGAAAACTCAGCAAGCCCATGTCGTGCTCCTTGATAACCACGACTCGTTTGTTTATAACTTGGTGGACGCTTTTGCCGTC
GCCGGCTACCACTGCACAGT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MADFHASAREVRYHEDAADLFHHLGGTSASDSVLLESADIKSKKNTTSMAVLQSAVRVTCMGQTVTATPLTSTGHTMVAR
LQEHFGTSGTKFSFRRSELHDERQRLLDTNNAEILRLLQCEAGYSGEQLPLLAGGFAFDYVETFEQLPPVPVGDNSYPDY
QFVVAETVLVTDHLKRSAVIEGVSIDPSELEDRLDSLVATIDSHETVEECPATTATNEILTVRADISDVDFCQSVSALQD
NIQAGDIYQVVPARSFSAPCESAYAAYRHLRTINPSPYMFYVRGITPISCNSNKTYELIGASPESNLKFDSRTREIQLYP
IAGTRPRGLNPDGSINHELDIRAELDMRTNVKEIAEHTMLVDLARNDLARVSLPTTRRVAELLQVDRYSRVMHLVSRVVA
TLDPEFDAINAYRACMNMGTLTGAPKLRAIELLRGVEAKRRGSYGGAVGYLQGDGSMDTCIVIRSAFIQDGVAVVQAGAG
VVRDSIPQSEADETLHKAYAVLHAIALAAGKDLEVVR

Sequences:

>Translated_517_residues
MADFHASAREVRYHEDAADLFHHLGGTSASDSVLLESADIKSKKNTTSMAVLQSAVRVTCMGQTVTATPLTSTGHTMVAR
LQEHFGTSGTKFSFRRSELHDERQRLLDTNNAEILRLLQCEAGYSGEQLPLLAGGFAFDYVETFEQLPPVPVGDNSYPDY
QFVVAETVLVTDHLKRSAVIEGVSIDPSELEDRLDSLVATIDSHETVEECPATTATNEILTVRADISDVDFCQSVSALQD
NIQAGDIYQVVPARSFSAPCESAYAAYRHLRTINPSPYMFYVRGITPISCNSNKTYELIGASPESNLKFDSRTREIQLYP
IAGTRPRGLNPDGSINHELDIRAELDMRTNVKEIAEHTMLVDLARNDLARVSLPTTRRVAELLQVDRYSRVMHLVSRVVA
TLDPEFDAINAYRACMNMGTLTGAPKLRAIELLRGVEAKRRGSYGGAVGYLQGDGSMDTCIVIRSAFIQDGVAVVQAGAG
VVRDSIPQSEADETLHKAYAVLHAIALAAGKDLEVVR
>Mature_516_residues
ADFHASAREVRYHEDAADLFHHLGGTSASDSVLLESADIKSKKNTTSMAVLQSAVRVTCMGQTVTATPLTSTGHTMVARL
QEHFGTSGTKFSFRRSELHDERQRLLDTNNAEILRLLQCEAGYSGEQLPLLAGGFAFDYVETFEQLPPVPVGDNSYPDYQ
FVVAETVLVTDHLKRSAVIEGVSIDPSELEDRLDSLVATIDSHETVEECPATTATNEILTVRADISDVDFCQSVSALQDN
IQAGDIYQVVPARSFSAPCESAYAAYRHLRTINPSPYMFYVRGITPISCNSNKTYELIGASPESNLKFDSRTREIQLYPI
AGTRPRGLNPDGSINHELDIRAELDMRTNVKEIAEHTMLVDLARNDLARVSLPTTRRVAELLQVDRYSRVMHLVSRVVAT
LDPEFDAINAYRACMNMGTLTGAPKLRAIELLRGVEAKRRGSYGGAVGYLQGDGSMDTCIVIRSAFIQDGVAVVQAGAGV
VRDSIPQSEADETLHKAYAVLHAIALAAGKDLEVVR

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=508, Percent_Identity=47.244094488189, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1788114, Length=384, Percent_Identity=28.3854166666667, Blast_Score=155, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6320935, Length=387, Percent_Identity=36.9509043927649, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6324361, Length=347, Percent_Identity=25.6484149855908, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56584; Mature: 56453

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFHASAREVRYHEDAADLFHHLGGTSASDSVLLESADIKSKKNTTSMAVLQSAVRVTC
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHEEE
MGQTVTATPLTSTGHTMVARLQEHFGTSGTKFSFRRSELHDERQRLLDTNNAEILRLLQC
ECCEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHH
EAGYSGEQLPLLAGGFAFDYVETFEQLPPVPVGDNSYPDYQFVVAETVLVTDHLKRSAVI
CCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHC
EGVSIDPSELEDRLDSLVATIDSHETVEECPATTATNEILTVRADISDVDFCQSVSALQD
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
NIQAGDIYQVVPARSFSAPCESAYAAYRHLRTINPSPYMFYVRGITPISCNSNKTYELIG
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCEEEEEE
ASPESNLKFDSRTREIQLYPIAGTRPRGLNPDGSINHELDIRAELDMRTNVKEIAEHTML
CCCCCCCEECCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
VDLARNDLARVSLPTTRRVAELLQVDRYSRVMHLVSRVVATLDPEFDAINAYRACMNMGT
HHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
LTGAPKLRAIELLRGVEAKRRGSYGGAVGYLQGDGSMDTCIVIRSAFIQDGVAVVQAGAG
CCCCCHHHHHHHHHCCHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCC
VVRDSIPQSEADETLHKAYAVLHAIALAAGKDLEVVR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADFHASAREVRYHEDAADLFHHLGGTSASDSVLLESADIKSKKNTTSMAVLQSAVRVTC
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHEEE
MGQTVTATPLTSTGHTMVARLQEHFGTSGTKFSFRRSELHDERQRLLDTNNAEILRLLQC
ECCEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHH
EAGYSGEQLPLLAGGFAFDYVETFEQLPPVPVGDNSYPDYQFVVAETVLVTDHLKRSAVI
CCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHC
EGVSIDPSELEDRLDSLVATIDSHETVEECPATTATNEILTVRADISDVDFCQSVSALQD
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
NIQAGDIYQVVPARSFSAPCESAYAAYRHLRTINPSPYMFYVRGITPISCNSNKTYELIG
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCEEEEEE
ASPESNLKFDSRTREIQLYPIAGTRPRGLNPDGSINHELDIRAELDMRTNVKEIAEHTML
CCCCCCCEECCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
VDLARNDLARVSLPTTRRVAELLQVDRYSRVMHLVSRVVATLDPEFDAINAYRACMNMGT
HHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
LTGAPKLRAIELLRGVEAKRRGSYGGAVGYLQGDGSMDTCIVIRSAFIQDGVAVVQAGAG
CCCCCHHHHHHHHHCCHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCC
VVRDSIPQSEADETLHKAYAVLHAIALAAGKDLEVVR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3808947; 2263476; 12948626; 3609747; 3667535 [H]