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The map label for this gene is pncB1 [H]

Identifier: 38234428

GI number: 38234428

Start: 1900343

End: 1901656

Strand: Direct

Name: pncB1 [H]

Synonym: DIP1858

Alternate gene names: 38234428

Gene position: 1900343-1901656 (Clockwise)

Preceding gene: 38234419

Following gene: 38234429

Centisome position: 76.36

GC content: 55.33

Gene sequence:

>1314_bases
GTGACTCATAATCAATCAACTGCGCTTCTCACCGACATGTATGAGCTGACCATGTTACAGTCAGCGCTTGCCGACGGCAC
CGCAGAGCGCCAATGCACCTTCGAGGTCTTCGGTCGACGTCTTCCTAACGAGCGCCGCTATGGCGTTGTCGCAGGTACGC
CCCGTGTACTCGAAGCTGTTCAAAACTTCCGGTTCACCGAAGCTCAGCTTGCCAGCCTGACGTTCCTCAACGACACCACC
CTCGAATACCTGCGTAACTACCGCTTCGCAGGACATATCGACGGCTACCGCGAGGGCGAACTGTACTTCCCGCATTCCCC
CATTTTGACCGTTCGTGGCACCTTCGCCGAATGCGTGATCCTCGAAACCGTCATCTTGTCCATCATGAATGCAGACTCCG
CCGTGGCAACTGCAGCAGCTCGCATGGTCACCGCCGCCGATGGCCGTACCATCATCGAGATGGGCTCTCGTCGAACCCAC
GAATACGCAGCTGTCACTGCAACCCGTGCAGCCTATCTTGCAGGTTTTAGTGCTACTTCCAATTTGGAAGCCGTGCACCG
GTATGGCATTCCAGGATCTGGAACGGCAGCCCATGCGTGGACGCTTTTGCATGTTAACGAGGATGGCACACCCAATGAGA
AGAGTGCCTTCGAGTCTCAGGTAAGAGCCCAGGGCACTGGAACTACTTTGCTCATCGACACCTATGACATCGCTCAAGGT
GTGCGCAATGCAATCGAGGTGGCTGGCCCCGAGCTCGGCGCAGTACGAATCGACTCCGGCGATCTTGGCGTGATGACCCG
TAAGATCCGTCAAGAGTTGGATAATCTTGGTGCTCATAACACTCAAATTGTGGTGTCCTCCGATCTTGATGAATATGCCA
TCGCTGGTCTTCGCGGCAATCCAGTCGATGTTTTTGGTGTTGGCACATCTGTTGTTACTGGTTCCGGCGCTCCTACTGCT
GGCATGGTGTACAAACTGGTGGAAGTCGATGGCAATCCTGTTTCTAAACGCTCCCGTGGCAAAGGAATGCTCGGTGGCGC
TAAGCGTGCAGCCCGTACTCACCGTGCGTCTGGTACCGCTGTGGAAGAACTCGTGTTCCCTTATGAACATCCAGTCCCCC
AGGTTGGCACTCTCACGTCGGTAGAGCTCACCATTCCACTCATGCGTGATGGCGTGGTCGTGGAGGGGCTTCCTACTTTG
GAAGAATCCCGTGCTTACTTAGCGCAACAACTCGTCACCATCCCTTGGGAAGGATTGGCTTTAAGCCGAGACGAACCTGT
CTTGGCAACGCGCCATGTGGGATTCGATCAGTAA

Upstream 100 bases:

>100_bases
CACGCCAAGGGCATTCACGTCATTCGTCGCGCCATACATAGTTCACCAGCCTAGTAGGTATTGCCACCGTCACGTTGTTT
CGGGGGCTAAGCTGTGAGTC

Downstream 100 bases:

>100_bases
CTTTTAGCTGCCACGCCGTACCATATTCGGCATGAGCTCCGTTTCCCCATTGGTAGTTTCCACTGACGAACTTCTCAGTG
CAGCTGTTGCTGCATTGGGA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTHNQSTALLTDMYELTMLQSALADGTAERQCTFEVFGRRLPNERRYGVVAGTPRVLEAVQNFRFTEAQLASLTFLNDTT
LEYLRNYRFAGHIDGYREGELYFPHSPILTVRGTFAECVILETVILSIMNADSAVATAAARMVTAADGRTIIEMGSRRTH
EYAAVTATRAAYLAGFSATSNLEAVHRYGIPGSGTAAHAWTLLHVNEDGTPNEKSAFESQVRAQGTGTTLLIDTYDIAQG
VRNAIEVAGPELGAVRIDSGDLGVMTRKIRQELDNLGAHNTQIVVSSDLDEYAIAGLRGNPVDVFGVGTSVVTGSGAPTA
GMVYKLVEVDGNPVSKRSRGKGMLGGAKRAARTHRASGTAVEELVFPYEHPVPQVGTLTSVELTIPLMRDGVVVEGLPTL
EESRAYLAQQLVTIPWEGLALSRDEPVLATRHVGFDQ

Sequences:

>Translated_437_residues
MTHNQSTALLTDMYELTMLQSALADGTAERQCTFEVFGRRLPNERRYGVVAGTPRVLEAVQNFRFTEAQLASLTFLNDTT
LEYLRNYRFAGHIDGYREGELYFPHSPILTVRGTFAECVILETVILSIMNADSAVATAAARMVTAADGRTIIEMGSRRTH
EYAAVTATRAAYLAGFSATSNLEAVHRYGIPGSGTAAHAWTLLHVNEDGTPNEKSAFESQVRAQGTGTTLLIDTYDIAQG
VRNAIEVAGPELGAVRIDSGDLGVMTRKIRQELDNLGAHNTQIVVSSDLDEYAIAGLRGNPVDVFGVGTSVVTGSGAPTA
GMVYKLVEVDGNPVSKRSRGKGMLGGAKRAARTHRASGTAVEELVFPYEHPVPQVGTLTSVELTIPLMRDGVVVEGLPTL
EESRAYLAQQLVTIPWEGLALSRDEPVLATRHVGFDQ
>Mature_436_residues
THNQSTALLTDMYELTMLQSALADGTAERQCTFEVFGRRLPNERRYGVVAGTPRVLEAVQNFRFTEAQLASLTFLNDTTL
EYLRNYRFAGHIDGYREGELYFPHSPILTVRGTFAECVILETVILSIMNADSAVATAAARMVTAADGRTIIEMGSRRTHE
YAAVTATRAAYLAGFSATSNLEAVHRYGIPGSGTAAHAWTLLHVNEDGTPNEKSAFESQVRAQGTGTTLLIDTYDIAQGV
RNAIEVAGPELGAVRIDSGDLGVMTRKIRQELDNLGAHNTQIVVSSDLDEYAIAGLRGNPVDVFGVGTSVVTGSGAPTAG
MVYKLVEVDGNPVSKRSRGKGMLGGAKRAARTHRASGTAVEELVFPYEHPVPQVGTLTSVELTIPLMRDGVVVEGLPTLE
ESRAYLAQQLVTIPWEGLALSRDEPVLATRHVGFDQ

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=501, Percent_Identity=31.5369261477046, Blast_Score=159, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI71997952, Length=491, Percent_Identity=29.5315682281059, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71997947, Length=491, Percent_Identity=29.5315682281059, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71997955, Length=201, Percent_Identity=35.8208955223881, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24581587, Length=490, Percent_Identity=28.3673469387755, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI161076680, Length=205, Percent_Identity=30.7317073170732, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24581595, Length=205, Percent_Identity=30.7317073170732, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574709, Length=205, Percent_Identity=30.7317073170732, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24581593, Length=205, Percent_Identity=30.7317073170732, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24581591, Length=205, Percent_Identity=30.7317073170732, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 47113; Mature: 46982

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHNQSTALLTDMYELTMLQSALADGTAERQCTFEVFGRRLPNERRYGVVAGTPRVLEAV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCCEEEEECCHHHHHHH
QNFRFTEAQLASLTFLNDTTLEYLRNYRFAGHIDGYREGELYFPHSPILTVRGTFAECVI
HHCCCCHHHHHEEEEECHHHHHHHHCCCCEECCCCCCCCCEECCCCCEEEECCCHHHHHH
LETVILSIMNADSAVATAAARMVTAADGRTIIEMGSRRTHEYAAVTATRAAYLAGFSATS
HHHHHHHHHCCCHHHHHHHHHHEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
NLEAVHRYGIPGSGTAAHAWTLLHVNEDGTPNEKSAFESQVRAQGTGTTLLIDTYDIAQG
CCHHHHHCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECHHHHHH
VRNAIEVAGPELGAVRIDSGDLGVMTRKIRQELDNLGAHNTQIVVSSDLDEYAIAGLRGN
HHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHEECCCCC
PVDVFGVGTSVVTGSGAPTAGMVYKLVEVDGNPVSKRSRGKGMLGGAKRAARTHRASGTA
CEEEEECCCEEEECCCCCCHHEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCH
VEELVFPYEHPVPQVGTLTSVELTIPLMRDGVVVEGLPTLEESRAYLAQQLVTIPWEGLA
HHHHHCCCCCCCCCCCCEEEEEEEEEEEECCEEEECCCCHHHHHHHHHHHHHHCCCCCEE
LSRDEPVLATRHVGFDQ
ECCCCCEEEEECCCCCC
>Mature Secondary Structure 
THNQSTALLTDMYELTMLQSALADGTAERQCTFEVFGRRLPNERRYGVVAGTPRVLEAV
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCCEEEEECCHHHHHHH
QNFRFTEAQLASLTFLNDTTLEYLRNYRFAGHIDGYREGELYFPHSPILTVRGTFAECVI
HHCCCCHHHHHEEEEECHHHHHHHHCCCCEECCCCCCCCCEECCCCCEEEECCCHHHHHH
LETVILSIMNADSAVATAAARMVTAADGRTIIEMGSRRTHEYAAVTATRAAYLAGFSATS
HHHHHHHHHCCCHHHHHHHHHHEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
NLEAVHRYGIPGSGTAAHAWTLLHVNEDGTPNEKSAFESQVRAQGTGTTLLIDTYDIAQG
CCHHHHHCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECHHHHHH
VRNAIEVAGPELGAVRIDSGDLGVMTRKIRQELDNLGAHNTQIVVSSDLDEYAIAGLRGN
HHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHEECCCCC
PVDVFGVGTSVVTGSGAPTAGMVYKLVEVDGNPVSKRSRGKGMLGGAKRAARTHRASGTA
CEEEEECCCEEEECCCCCCHHEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCH
VEELVFPYEHPVPQVGTLTSVELTIPLMRDGVVVEGLPTLEESRAYLAQQLVTIPWEGLA
HHHHHCCCCCCCCCCCCEEEEEEEEEEEECCEEEECCCCHHHHHHHHHHHHHHCCCCCEE
LSRDEPVLATRHVGFDQ
ECCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]