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The map label for this gene is clpP

Identifier: 38234363

GI number: 38234363

Start: 1840109

End: 1840708

Strand: Reverse

Name: clpP

Synonym: DIP1792

Alternate gene names: 38234363

Gene position: 1840708-1840109 (Counterclockwise)

Preceding gene: 38234364

Following gene: 38234362

Centisome position: 73.96

GC content: 54.33

Gene sequence:

>600_bases
ATGACTGACCAGATTCGCATGGCGCAGGCAAGTGCCGGAATGAATTTGAGCGATTCGGTATATGAGCGCCTGTTGCGTGA
GCGCATTATTTTCCTAGGCACCCAAGTGGATGACGAGATCGCTAATAAGCTGTGTGCACAGATCTTGCTGCTCTCGGCAG
AAGATCCTACGCGCGATATCTCGCTGTACATTAACTCCCCAGGTGGCTCCGTTACCGCAGGTATGGCTATTTACGACACT
ATGAAGTACTCGCCGTGCGATATTGCTACCTATGGCATGGGTTTGGCTGCGTCGATGGGCCAGTTCTTGCTTTCTGGCGG
TACCAAGGGCAAGCGATTCGCATTGCCACACGCTCGCATTATGATGCACCAGCCGTCGGCAGGCGTGGGTGGCACCGCCG
CTGACATTGCTATTCAGGCTGAGCAATTCGCGCAGACGAAGCGTGAGATGGCTGAGCTTATTGCCGAGCACACCGGTCAG
TCGTTTGAGCAGATCACTAAGGATTCTGACCGTGACCGCTGGTTTACCGCACAGCAGGCAAAGGAATACGGAATCGTAGA
CCACGTTATTGAGTCCGCGCAGGGCCCGCTTTCTAACTAG

Upstream 100 bases:

>100_bases
GAGAGCGAACAGAGAAGCTATGTGGAACAAACGGCAGGTACCCTAGGGTTGCATTTGTTATAAAGATCGTGAGTAAGTCT
AATGAAAAAGGAGCACGGGA

Downstream 100 bases:

>100_bases
GCAGGAGTAACACCGATATGAATAACAACGGAATGCAGATGCCACAGGCTCGCTACGTACTGCCATCGTTTATTGAGCAG
TCCGCGTATGGCACTAAAGA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MTDQIRMAQASAGMNLSDSVYERLLRERIIFLGTQVDDEIANKLCAQILLLSAEDPTRDISLYINSPGGSVTAGMAIYDT
MKYSPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARIMMHQPSAGVGGTAADIAIQAEQFAQTKREMAELIAEHTGQ
SFEQITKDSDRDRWFTAQQAKEYGIVDHVIESAQGPLSN

Sequences:

>Translated_199_residues
MTDQIRMAQASAGMNLSDSVYERLLRERIIFLGTQVDDEIANKLCAQILLLSAEDPTRDISLYINSPGGSVTAGMAIYDT
MKYSPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARIMMHQPSAGVGGTAADIAIQAEQFAQTKREMAELIAEHTGQ
SFEQITKDSDRDRWFTAQQAKEYGIVDHVIESAQGPLSN
>Mature_198_residues
TDQIRMAQASAGMNLSDSVYERLLRERIIFLGTQVDDEIANKLCAQILLLSAEDPTRDISLYINSPGGSVTAGMAIYDTM
KYSPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARIMMHQPSAGVGGTAADIAIQAEQFAQTKREMAELIAEHTGQS
FEQITKDSDRDRWFTAQQAKEYGIVDHVIESAQGPLSN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=171, Percent_Identity=49.1228070175439, Blast_Score=178, Evalue=3e-45,
Organism=Escherichia coli, GI1786641, Length=174, Percent_Identity=55.7471264367816, Blast_Score=210, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17538017, Length=178, Percent_Identity=50, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI20129427, Length=186, Percent_Identity=45.6989247311828, Blast_Score=178, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_CORDI (Q6NFU4)

Other databases:

- EMBL:   BX248359
- RefSeq:   NP_940130.1
- ProteinModelPortal:   Q6NFU4
- SMR:   Q6NFU4
- MEROPS:   S14.008
- GeneID:   2649417
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1792
- NMPDR:   fig|257309.1.peg.1721
- HOGENOM:   HBG558421
- OMA:   ANKLCAQ
- ProtClustDB:   PRK00277
- BioCyc:   CDIP257309:DIP1792-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21640; Mature: 21509

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQIRMAQASAGMNLSDSVYERLLRERIIFLGTQVDDEIANKLCAQILLLSAEDPTRDI
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
SLYINSPGGSVTAGMAIYDTMKYSPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARI
EEEEECCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHE
MMHQPSAGVGGTAADIAIQAEQFAQTKREMAELIAEHTGQSFEQITKDSDRDRWFTAQQA
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHEEHHHH
KEYGIVDHVIESAQGPLSN
HHCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDQIRMAQASAGMNLSDSVYERLLRERIIFLGTQVDDEIANKLCAQILLLSAEDPTRDI
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
SLYINSPGGSVTAGMAIYDTMKYSPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARI
EEEEECCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHE
MMHQPSAGVGGTAADIAIQAEQFAQTKREMAELIAEHTGQSFEQITKDSDRDRWFTAQQA
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHEEHHHH
KEYGIVDHVIESAQGPLSN
HHCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910