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The map label for this gene is proA

Identifier: 38234347

GI number: 38234347

Start: 1819483

End: 1820775

Strand: Reverse

Name: proA

Synonym: DIP1776

Alternate gene names: 38234347

Gene position: 1820775-1819483 (Counterclockwise)

Preceding gene: 38234348

Following gene: 38234346

Centisome position: 73.16

GC content: 56.61

Gene sequence:

>1293_bases
ATGCTTATGAATAACGCCGATGTACGGTCCCAAGAACGCAAGCAGGTCATGGTATGTGCACGTGCCGCCCATCGTGTAGC
GCCGATTGTTGCCCAATTGACCAGCGCTGATAAAAATGCGGTGCTTCTCGATGCCGCTGCGGCGTTAGAGGCCGCAGGCG
CTGAGATTATTGCCGCGAACCAGCGTGATATTGACCAAGGGCGCGCGCGTGGGCTAAGCGAGGCATTGATCGACCGCTTG
AGCCTTGATAGCGCCCGCATTGCAGGTATTGCTGGTGGTTTGCGCCAGGTGGCAGCGCTGAGTGATCCCGTGGGGGAGGT
TGTAGGCGGCAGCGTCATGCCCAATGGTATGCAGATGCGTAAGGTGCGTGTCCCGCTTGGCGTGATGGGCATGGTCTATG
AGGCCCGCCCGAATGTGACGATCGACGCTTTTGGCTTAGCACTGAAGTCCGGTAACGTGGCGTTGCTGCGTGGTTCGAAG
TCGGCGCAGCATTCGAATGCGGCGTTGGTTGCGGTTGTGCATCGTGTGCTTGAAAGCCATGGATTACCGCATGAAGTGGT
TCAGTTGCTGCCTTGTGAGACACATGAAAGTGTCCAGGATTTGATTACGGCACGCGGGCTTGTCGACGTCGTCATCCCGC
GCGGCGGTGCCGGCCTGATCGAAGCCGTGGTGACCAATGCGACGGTTCCCACCATTGAAACGGGCACTGGAAACTGCCAT
TTCTATATTGATCGGGATGTCAGCGACTTAGATCAAGCGATCGCCATGTTGCTTAACGGTAAGACGCGTCGCTGTTCTGT
GTGTAATGCGACTGAAACGGTACTGATCGATTCCGCGTTGGATTCCGCATATCAGTTGGCGATTATCACCGCCTTGCAAG
AAGCTGGTGTTACTGTGCATGGCGATGTAGCTCAGCTAGAAGCCGTGGGGGCGTCGGGAATCGTTCCTGCCGACGAGCAC
GATTGGGCAGAGGAATACTTGTCGCTTGATATTGCGTGTGCGCTGGTTGATGGTGTGGATGCCGCGATGGAGCATATTCG
CACCTATAGCACCAAGCACACTGAGGCGATCGCTACCGGCAACATTGTGACTGCTCAGCGCTTTGCAGATCGTGTGGATG
CGGCAGCGGTGATGATTAATGCGTCGACAGCGTTTACCGATGGCGAGCAGTTTGGTATGGGTGCAGAAATCGGAATTTCT
ACCCAAAAGCTGCATGCCCGCGGCCCGATGGCGTTGCCGGAGCTGACCACCACGAAGTGGATTGTCCAGGGCACGGGTCA
AACACGTCCGTAG

Upstream 100 bases:

>100_bases
AACAAACCGCGCAGCTGCCCGAGGGTCTGCAACGTCCCGTCGTCCATGCTGATTATCTTTCCGATTACGCGTCACGTGCG
TAGAGCTTTAGGTACGGTAA

Downstream 100 bases:

>100_bases
TGCACTGCTAGAATTTCACGGTTATGACACTGCCACGCCAACCCAGCCGCATCGGCATCATGGGTGGAACCTTCGATCCG
ATTCACCATGGGCACCTCGT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLMNNADVRSQERKQVMVCARAAHRVAPIVAQLTSADKNAVLLDAAAALEAAGAEIIAANQRDIDQGRARGLSEALIDRL
SLDSARIAGIAGGLRQVAALSDPVGEVVGGSVMPNGMQMRKVRVPLGVMGMVYEARPNVTIDAFGLALKSGNVALLRGSK
SAQHSNAALVAVVHRVLESHGLPHEVVQLLPCETHESVQDLITARGLVDVVIPRGGAGLIEAVVTNATVPTIETGTGNCH
FYIDRDVSDLDQAIAMLLNGKTRRCSVCNATETVLIDSALDSAYQLAIITALQEAGVTVHGDVAQLEAVGASGIVPADEH
DWAEEYLSLDIACALVDGVDAAMEHIRTYSTKHTEAIATGNIVTAQRFADRVDAAAVMINASTAFTDGEQFGMGAEIGIS
TQKLHARGPMALPELTTTKWIVQGTGQTRP

Sequences:

>Translated_430_residues
MLMNNADVRSQERKQVMVCARAAHRVAPIVAQLTSADKNAVLLDAAAALEAAGAEIIAANQRDIDQGRARGLSEALIDRL
SLDSARIAGIAGGLRQVAALSDPVGEVVGGSVMPNGMQMRKVRVPLGVMGMVYEARPNVTIDAFGLALKSGNVALLRGSK
SAQHSNAALVAVVHRVLESHGLPHEVVQLLPCETHESVQDLITARGLVDVVIPRGGAGLIEAVVTNATVPTIETGTGNCH
FYIDRDVSDLDQAIAMLLNGKTRRCSVCNATETVLIDSALDSAYQLAIITALQEAGVTVHGDVAQLEAVGASGIVPADEH
DWAEEYLSLDIACALVDGVDAAMEHIRTYSTKHTEAIATGNIVTAQRFADRVDAAAVMINASTAFTDGEQFGMGAEIGIS
TQKLHARGPMALPELTTTKWIVQGTGQTRP
>Mature_430_residues
MLMNNADVRSQERKQVMVCARAAHRVAPIVAQLTSADKNAVLLDAAAALEAAGAEIIAANQRDIDQGRARGLSEALIDRL
SLDSARIAGIAGGLRQVAALSDPVGEVVGGSVMPNGMQMRKVRVPLGVMGMVYEARPNVTIDAFGLALKSGNVALLRGSK
SAQHSNAALVAVVHRVLESHGLPHEVVQLLPCETHESVQDLITARGLVDVVIPRGGAGLIEAVVTNATVPTIETGTGNCH
FYIDRDVSDLDQAIAMLLNGKTRRCSVCNATETVLIDSALDSAYQLAIITALQEAGVTVHGDVAQLEAVGASGIVPADEH
DWAEEYLSLDIACALVDGVDAAMEHIRTYSTKHTEAIATGNIVTAQRFADRVDAAAVMINASTAFTDGEQFGMGAEIGIS
TQKLHARGPMALPELTTTKWIVQGTGQTRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=373, Percent_Identity=36.9973190348526, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI62912457, Length=399, Percent_Identity=35.5889724310777, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI1786438, Length=402, Percent_Identity=44.5273631840796, Blast_Score=347, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI17569967, Length=402, Percent_Identity=35.5721393034826, Blast_Score=234, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17569969, Length=402, Percent_Identity=35.5721393034826, Blast_Score=234, Evalue=9e-62,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=32.7868852459016, Blast_Score=241, Evalue=2e-64,
Organism=Drosophila melanogaster, GI21357643, Length=374, Percent_Identity=35.5614973262032, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_CORDI (Q6NFW0)

Other databases:

- EMBL:   BX248359
- RefSeq:   NP_940114.1
- ProteinModelPortal:   Q6NFW0
- SMR:   Q6NFW0
- GeneID:   2649401
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1776
- NMPDR:   fig|257309.1.peg.1705
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- PhylomeDB:   Q6NFW0
- ProtClustDB:   PRK00197
- BioCyc:   CDIP257309:DIP1776-MONOMER
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45151; Mature: 45151

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMNNADVRSQERKQVMVCARAAHRVAPIVAQLTSADKNAVLLDAAAALEAAGAEIIAAN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCEEEECC
QRDIDQGRARGLSEALIDRLSLDSARIAGIAGGLRQVAALSDPVGEVVGGSVMPNGMQMR
CCCCHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEE
KVRVPLGVMGMVYEARPNVTIDAFGLALKSGNVALLRGSKSAQHSNAALVAVVHRVLESH
EEECCHHHHHEEEECCCCEEEEEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHC
GLPHEVVQLLPCETHESVQDLITARGLVDVVIPRGGAGLIEAVVTNATVPTIETGTGNCH
CCCHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCEE
FYIDRDVSDLDQAIAMLLNGKTRRCSVCNATETVLIDSALDSAYQLAIITALQEAGVTVH
EEECCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEE
GDVAQLEAVGASGIVPADEHDWAEEYLSLDIACALVDGVDAAMEHIRTYSTKHTEAIATG
CCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECC
NIVTAQRFADRVDAAAVMINASTAFTDGEQFGMGAEIGISTQKLHARGPMALPELTTTKW
CEEEHHHHHHHHCCEEEEEECCCCCCCCHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCEE
IVQGTGQTRP
EEECCCCCCC
>Mature Secondary Structure
MLMNNADVRSQERKQVMVCARAAHRVAPIVAQLTSADKNAVLLDAAAALEAAGAEIIAAN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCEEEECC
QRDIDQGRARGLSEALIDRLSLDSARIAGIAGGLRQVAALSDPVGEVVGGSVMPNGMQMR
CCCCHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEE
KVRVPLGVMGMVYEARPNVTIDAFGLALKSGNVALLRGSKSAQHSNAALVAVVHRVLESH
EEECCHHHHHEEEECCCCEEEEEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHC
GLPHEVVQLLPCETHESVQDLITARGLVDVVIPRGGAGLIEAVVTNATVPTIETGTGNCH
CCCHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCEE
FYIDRDVSDLDQAIAMLLNGKTRRCSVCNATETVLIDSALDSAYQLAIITALQEAGVTVH
EEECCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEE
GDVAQLEAVGASGIVPADEHDWAEEYLSLDIACALVDGVDAAMEHIRTYSTKHTEAIATG
CCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECC
NIVTAQRFADRVDAAAVMINASTAFTDGEQFGMGAEIGISTQKLHARGPMALPELTTTKW
CEEEHHHHHHHHCCEEEEEECCCCCCCCHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCEE
IVQGTGQTRP
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910