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The map label for this gene is iunH [H]

Identifier: 38234324

GI number: 38234324

Start: 1797649

End: 1798587

Strand: Direct

Name: iunH [H]

Synonym: DIP1753

Alternate gene names: 38234324

Gene position: 1797649-1798587 (Clockwise)

Preceding gene: 38234323

Following gene: 38234325

Centisome position: 72.23

GC content: 56.98

Gene sequence:

>939_bases
ATGACCCGAAAAATTATTCTCGACTGCGACCCAGGACACGACGACGCCGTAGCCATGCTACTCGCCGCAGCAAACCCCAA
CATCGAACTGCTGGGAATCACCACCATCGGCGGCAACCAAACCCTGCCCAAAGTCACCCACAATGCGCAGGTTGTTGCCA
CGATCGCAGGAATCACCGCACCTATCCATGCAGGTTGTTCCCGCCCACTCGTGCGTGACGTCGAGGTCGCCGAGAGCATC
CACGGCGATACTGGAATGGAAATCCACAACTACACGCTGCCAGAGCCAGCAGTAGGAGTATCTGATACCCACGCCGTGGA
CTTTATTATCGACACCATCATGTCCCACGAGCCAGGAACTGTCACCCTTGTTCCTACCGGCCCGCTTACCAACATTGCTA
TGGCGGCGCGCAAAGAGCCCCGCATTGTCGAACGAGTCCAAGAAGTCGTGCTCATGGGCGGCGGATACCACGTAGGTAAC
TGGTCCCCTGTTGCAGAATTCAACATCAAGATCGACCCCGAAGCAGCGCACATCGTTTTCAACGAAAAATGGCCACTGAC
CATGGTGGGCCTCGACCTTACTCACCAAGCGCTTGCAACCCCAGAAGTAGAAGCACGCCTGAGCGCAATCGGCTCCGACG
TTGCCGACTTTGTAGTCGCACTCTTCGGCGCATTCCGTAAGAACTACCAAGACGCACAAGGCTTTGATAACCCACCAGTC
CACGACCCGTGCGCAGTGGCCTACGTGATCGACCCGACGGTATTTACTACGGTCAAGGTACCTATCGACGTCGAGCTGAC
CGGGGCACTGACCACCGGCATGACCGTCGCGGACTTCCGCGCACCAGCACCTGCCGACTGCCACACTCAAGCAGCTGTCG
CCCTCGACTTTGACAAGTTCTGGGGTTTGGTTGAAAGCGCTGTCAAAGAACTAAGCTAG

Upstream 100 bases:

>100_bases
CCTGCGCGCTGGGCACTTCTTTGTTGATCCCCAAACCGGAAACAATCTCCGATACGCTCGCAGCTGTCACCGCTACCGAA
ACTGCACAAGGACGCTCACT

Downstream 100 bases:

>100_bases
CCCATGTGTTAGCACTAATAGGAGCCCTAGCTGCCGCACTTTGCTACGGCATCGCCACCATTTGCGAGGCCGTAGCCGTG
GCGGCGATGTCTGCCATGCC

Product: inosine-uridine preferring nucleoside hydrolase

Products: NA

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTRKIILDCDPGHDDAVAMLLAAANPNIELLGITTIGGNQTLPKVTHNAQVVATIAGITAPIHAGCSRPLVRDVEVAESI
HGDTGMEIHNYTLPEPAVGVSDTHAVDFIIDTIMSHEPGTVTLVPTGPLTNIAMAARKEPRIVERVQEVVLMGGGYHVGN
WSPVAEFNIKIDPEAAHIVFNEKWPLTMVGLDLTHQALATPEVEARLSAIGSDVADFVVALFGAFRKNYQDAQGFDNPPV
HDPCAVAYVIDPTVFTTVKVPIDVELTGALTTGMTVADFRAPAPADCHTQAAVALDFDKFWGLVESAVKELS

Sequences:

>Translated_312_residues
MTRKIILDCDPGHDDAVAMLLAAANPNIELLGITTIGGNQTLPKVTHNAQVVATIAGITAPIHAGCSRPLVRDVEVAESI
HGDTGMEIHNYTLPEPAVGVSDTHAVDFIIDTIMSHEPGTVTLVPTGPLTNIAMAARKEPRIVERVQEVVLMGGGYHVGN
WSPVAEFNIKIDPEAAHIVFNEKWPLTMVGLDLTHQALATPEVEARLSAIGSDVADFVVALFGAFRKNYQDAQGFDNPPV
HDPCAVAYVIDPTVFTTVKVPIDVELTGALTTGMTVADFRAPAPADCHTQAAVALDFDKFWGLVESAVKELS
>Mature_311_residues
TRKIILDCDPGHDDAVAMLLAAANPNIELLGITTIGGNQTLPKVTHNAQVVATIAGITAPIHAGCSRPLVRDVEVAESIH
GDTGMEIHNYTLPEPAVGVSDTHAVDFIIDTIMSHEPGTVTLVPTGPLTNIAMAARKEPRIVERVQEVVLMGGGYHVGNW
SPVAEFNIKIDPEAAHIVFNEKWPLTMVGLDLTHQALATPEVEARLSAIGSDVADFVVALFGAFRKNYQDAQGFDNPPVH
DPCAVAYVIDPTVFTTVKVPIDVELTGALTTGMTVADFRAPAPADCHTQAAVALDFDKFWGLVESAVKELS

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788486, Length=308, Percent_Identity=43.1818181818182, Blast_Score=250, Evalue=9e-68,
Organism=Escherichia coli, GI1786871, Length=312, Percent_Identity=38.7820512820513, Blast_Score=218, Evalue=3e-58,
Organism=Escherichia coli, GI1786213, Length=301, Percent_Identity=35.5481727574751, Blast_Score=148, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI32565474, Length=267, Percent_Identity=34.4569288389513, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17565698, Length=298, Percent_Identity=28.8590604026846, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320608, Length=327, Percent_Identity=33.0275229357798, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24641839, Length=305, Percent_Identity=28.1967213114754, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583915, Length=297, Percent_Identity=26.5993265993266, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24641837, Length=200, Percent_Identity=34.5, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022977 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: =3.2.2.8 [H]

Molecular weight: Translated: 33235; Mature: 33104

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS01247 IUNH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKIILDCDPGHDDAVAMLLAAANPNIELLGITTIGGNQTLPKVTHNAQVVATIAGITA
CCCEEEEECCCCCCHHHEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCEEEEEEHHHHH
PIHAGCSRPLVRDVEVAESIHGDTGMEIHNYTLPEPAVGVSDTHAVDFIIDTIMSHEPGT
HHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCE
VTLVPTGPLTNIAMAARKEPRIVERVQEVVLMGGGYHVGNWSPVAEFNIKIDPEAAHIVF
EEEEECCCCHHHHHHHCCCCHHHHHHHHHEEECCCEECCCCCCEEEEEEEECCCEEEEEE
NEKWPLTMVGLDLTHQALATPEVEARLSAIGSDVADFVVALFGAFRKNYQDAQGFDNPPV
CCCCCEEEEECCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HDPCAVAYVIDPTVFTTVKVPIDVELTGALTTGMTVADFRAPAPADCHTQAAVALDFDKF
CCCEEEEEEECCCEEEEEEEEEEEEECCHHCCCCEEECCCCCCCCCCCCCEEEEEEHHHH
WGLVESAVKELS
HHHHHHHHHHCC
>Mature Secondary Structure 
TRKIILDCDPGHDDAVAMLLAAANPNIELLGITTIGGNQTLPKVTHNAQVVATIAGITA
CCEEEEECCCCCCHHHEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCEEEEEEHHHHH
PIHAGCSRPLVRDVEVAESIHGDTGMEIHNYTLPEPAVGVSDTHAVDFIIDTIMSHEPGT
HHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCE
VTLVPTGPLTNIAMAARKEPRIVERVQEVVLMGGGYHVGNWSPVAEFNIKIDPEAAHIVF
EEEEECCCCHHHHHHHCCCCHHHHHHHHHEEECCCEECCCCCCEEEEEEEECCCEEEEEE
NEKWPLTMVGLDLTHQALATPEVEARLSAIGSDVADFVVALFGAFRKNYQDAQGFDNPPV
CCCCCEEEEECCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HDPCAVAYVIDPTVFTTVKVPIDVELTGALTTGMTVADFRAPAPADCHTQAAVALDFDKF
CCCEEEEEEECCCEEEEEEEEEEEEECCHHCCCCEEECCCCCCCCCCCCCEEEEEEHHHH
WGLVESAVKELS
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA