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The map label for this gene is pip [H]

Identifier: 38234315

GI number: 38234315

Start: 1788659

End: 1789873

Strand: Reverse

Name: pip [H]

Synonym: DIP1744

Alternate gene names: 38234315

Gene position: 1789873-1788659 (Counterclockwise)

Preceding gene: 38234321

Following gene: 38234310

Centisome position: 71.92

GC content: 53.17

Gene sequence:

>1215_bases
ATGAACACACGGACTTCGCGCTATCTGGGCCTGACAATTCACGAGCACACCCTTGGGCATATCTTTGCCAGAGAACTTGT
CCCCGATGGGGGAGAAGACTGGCCAGCGATGGTGTATTTCCAAGGCGGCCCAGGATTTGGGGCACCGCGGCCGCAATCGA
TCGACGGAGTGATCGGGCAAGCGCTCAAAACGCATCGTGTGATTTTGCTCGATCAACGCGGTACTGGCCGTTCGCAGCCT
ATCGACGTACCTCTCGCACAGCTACGCCAAGAATATATTGTGCACGACGCAGAGGAATTACGAAAAGCCTTAGGCTTTGA
GAAGTGGTCCCTCTACGGACAAAGTTTTGGTGGTTTTTGCATCACTGCTTATCAATCTATGTACCCAGAATCGGTCACCG
AGGCTTATATCACCGGTGGGTTACCCAGCCTTGACCGCCATGTGGACGACGTCTATCGAGCAACTTTTAGCAAGTTGTTG
TACCGGCACCGCCAGTTTTATACCCAGTTCCCGTGGGTAGAAGATAAGATCCGCGAGGTATGCCACCACCTTGATGTTTC
CGAGGAATTGTTGCCTACAGGGGAGCGGTTGTCGTCGAGACGCTTGCGCACCATTGGTATCGATCTTGGTCGCAGTAGTG
GTTTCTACTCGCTGGCCTATTTATTTGAAGATCCCTTTGTGAACATCCACGGCGAAAAACGACTTCGCCCCGATTTCCTG
GTTGACGTGGGACAGCGCGTCAGTTTTGCGGGCGCACCACTTTATGCTGCGATCCATGAATCTATCTACGGCGGAATCGG
CGGAACAACCACTAACTGGTCGGCACATCGTATCCGCGAAGAATTCCCTGGATGTGAAGAAAACGCAGATCCAAGATCCG
CAGAACCTTTCTACCTCACGGGCGAGCACATCTTCCCTTGGCAGTTTGACGAAGACCCAGCCCTGCAGCCCTACAAGGCT
GCCGCTGAGCAGCTCGCCACTACTCAGTGGGAGCATTCTCCTTATGATGCCGAGGTCTTAAAAGAACAAGCTGCGGTAAC
AGCTGCGTGCGTGTACCTAGATGATGCTTTTGTTCCTTTCGAACTATCCATGGATACCGCACACACCTACCGCGACCTGC
GTCTTCACGTGACTAACCGCTTCCAGCATGACGGAATCCGATGGGATGGCGCTGGAATTTTAAGCACGCTACGCGACAAG
GTTTTAGACCACTAG

Upstream 100 bases:

>100_bases
CGCTGGGCTTACGCCCAGAACGCTGAGCTGCTGCGGCGATTTTTTCAGAAACGATCTGGTAGCGGGTGCGAAAATCGGAC
ATGAATCCTACGATACACAT

Downstream 100 bases:

>100_bases
GTGTTAAAGTATCACCCATGAACAAAGTGGTTCTTAGCGGCGCAGAGCGCCAAGAATTCGAGGAACTAGTGGAGCTATTT
CATGTAGAGCGCACCGAAGA

Product: putative prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNTRTSRYLGLTIHEHTLGHIFARELVPDGGEDWPAMVYFQGGPGFGAPRPQSIDGVIGQALKTHRVILLDQRGTGRSQP
IDVPLAQLRQEYIVHDAEELRKALGFEKWSLYGQSFGGFCITAYQSMYPESVTEAYITGGLPSLDRHVDDVYRATFSKLL
YRHRQFYTQFPWVEDKIREVCHHLDVSEELLPTGERLSSRRLRTIGIDLGRSSGFYSLAYLFEDPFVNIHGEKRLRPDFL
VDVGQRVSFAGAPLYAAIHESIYGGIGGTTTNWSAHRIREEFPGCEENADPRSAEPFYLTGEHIFPWQFDEDPALQPYKA
AAEQLATTQWEHSPYDAEVLKEQAAVTAACVYLDDAFVPFELSMDTAHTYRDLRLHVTNRFQHDGIRWDGAGILSTLRDK
VLDH

Sequences:

>Translated_404_residues
MNTRTSRYLGLTIHEHTLGHIFARELVPDGGEDWPAMVYFQGGPGFGAPRPQSIDGVIGQALKTHRVILLDQRGTGRSQP
IDVPLAQLRQEYIVHDAEELRKALGFEKWSLYGQSFGGFCITAYQSMYPESVTEAYITGGLPSLDRHVDDVYRATFSKLL
YRHRQFYTQFPWVEDKIREVCHHLDVSEELLPTGERLSSRRLRTIGIDLGRSSGFYSLAYLFEDPFVNIHGEKRLRPDFL
VDVGQRVSFAGAPLYAAIHESIYGGIGGTTTNWSAHRIREEFPGCEENADPRSAEPFYLTGEHIFPWQFDEDPALQPYKA
AAEQLATTQWEHSPYDAEVLKEQAAVTAACVYLDDAFVPFELSMDTAHTYRDLRLHVTNRFQHDGIRWDGAGILSTLRDK
VLDH
>Mature_404_residues
MNTRTSRYLGLTIHEHTLGHIFARELVPDGGEDWPAMVYFQGGPGFGAPRPQSIDGVIGQALKTHRVILLDQRGTGRSQP
IDVPLAQLRQEYIVHDAEELRKALGFEKWSLYGQSFGGFCITAYQSMYPESVTEAYITGGLPSLDRHVDDVYRATFSKLL
YRHRQFYTQFPWVEDKIREVCHHLDVSEELLPTGERLSSRRLRTIGIDLGRSSGFYSLAYLFEDPFVNIHGEKRLRPDFL
VDVGQRVSFAGAPLYAAIHESIYGGIGGTTTNWSAHRIREEFPGCEENADPRSAEPFYLTGEHIFPWQFDEDPALQPYKA
AAEQLATTQWEHSPYDAEVLKEQAAVTAACVYLDDAFVPFELSMDTAHTYRDLRLHVTNRFQHDGIRWDGAGILSTLRDK
VLDH

Specific function: Higher activity toward long peptides. Acts on hydroxyproline beta-naphthylamide with almost as high an activity as on proline beta-naphthylamide [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 45853; Mature: 45853

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRTSRYLGLTIHEHTLGHIFARELVPDGGEDWPAMVYFQGGPGFGAPRPQSIDGVIGQ
CCCCCCEEEEEEEEHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH
ALKTHRVILLDQRGTGRSQPIDVPLAQLRQEYIVHDAEELRKALGFEKWSLYGQSFGGFC
HHHHCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCCCCH
ITAYQSMYPESVTEAYITGGLPSLDRHVDDVYRATFSKLLYRHRQFYTQFPWVEDKIREV
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
CHHLDVSEELLPTGERLSSRRLRTIGIDLGRSSGFYSLAYLFEDPFVNIHGEKRLRPDFL
HHHCCCCHHHCCCHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCEEEECCCCCCCCHHH
VDVGQRVSFAGAPLYAAIHESIYGGIGGTTTNWSAHRIREEFPGCEENADPRSAEPFYLT
HHHHCHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEE
GEHIFPWQFDEDPALQPYKAAAEQLATTQWEHSPYDAEVLKEQAAVTAACVYLDDAFVPF
CCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEECCCCCEE
ELSMDTAHTYRDLRLHVTNRFQHDGIRWDGAGILSTLRDKVLDH
EEECCHHHHHHHEEEEEECCCCCCCEEECCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTRTSRYLGLTIHEHTLGHIFARELVPDGGEDWPAMVYFQGGPGFGAPRPQSIDGVIGQ
CCCCCCEEEEEEEEHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH
ALKTHRVILLDQRGTGRSQPIDVPLAQLRQEYIVHDAEELRKALGFEKWSLYGQSFGGFC
HHHHCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCCCCH
ITAYQSMYPESVTEAYITGGLPSLDRHVDDVYRATFSKLLYRHRQFYTQFPWVEDKIREV
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
CHHLDVSEELLPTGERLSSRRLRTIGIDLGRSSGFYSLAYLFEDPFVNIHGEKRLRPDFL
HHHCCCCHHHCCCHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCEEEECCCCCCCCHHH
VDVGQRVSFAGAPLYAAIHESIYGGIGGTTTNWSAHRIREEFPGCEENADPRSAEPFYLT
HHHHCHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEE
GEHIFPWQFDEDPALQPYKAAAEQLATTQWEHSPYDAEVLKEQAAVTAACVYLDDAFVPF
CCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEECCCCCEE
ELSMDTAHTYRDLRLHVTNRFQHDGIRWDGAGILSTLRDKVLDH
EEECCHHHHHHHEEEEEECCCCCCCEEECCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883756 [H]